JP5844508B2 - メシル酸イマチニブのｆ結晶形 - Google Patents
メシル酸イマチニブのｆ結晶形 Download PDFInfo
- Publication number
- JP5844508B2 JP5844508B2 JP2008541641A JP2008541641A JP5844508B2 JP 5844508 B2 JP5844508 B2 JP 5844508B2 JP 2008541641 A JP2008541641 A JP 2008541641A JP 2008541641 A JP2008541641 A JP 2008541641A JP 5844508 B2 JP5844508 B2 JP 5844508B2
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- Japan
- Prior art keywords
- compound
- formula
- acid addition
- addition salt
- methanesulfonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0524061.9 | 2005-11-25 | ||
| GB0524062A GB0524062D0 (en) | 2005-11-25 | 2005-11-25 | Organic compounds |
| GB0524061A GB0524061D0 (en) | 2005-11-25 | 2005-11-25 | Organic compounds |
| GB0524062.7 | 2005-11-25 | ||
| US74001605P | 2005-11-28 | 2005-11-28 | |
| US74001805P | 2005-11-28 | 2005-11-28 | |
| US74001705P | 2005-11-28 | 2005-11-28 | |
| US60/740,016 | 2005-11-28 | ||
| US60/740,017 | 2005-11-28 | ||
| US60/740,018 | 2005-11-28 | ||
| PCT/EP2006/011240 WO2007059963A1 (en) | 2005-11-25 | 2006-11-23 | F,g,h,i and k crystal forms of imatinib mesylate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| PE20051096A1 (es) | 2004-02-04 | 2006-01-23 | Novartis Ag | Formas de sal de 4-(4-metilpiperazin-1-ilmetil)-n-[4-metil-3-(4-piridin-3-il)pirimidin-2-ilamino)fenil]-benzamida |
| KR20080078804A (ko) * | 2005-11-25 | 2008-08-28 | 노파르티스 아게 | 이마티니브 메실레이트의 ｆ, ｇ, ｈ, ｉ 및 ｋ 결정형 |
| US8414918B2 (en) | 2007-09-25 | 2013-04-09 | Teva Pharmaceutical Industries Ltd. | Stable imatinib compositions |
| RU2365587C1 (ru) * | 2008-02-22 | 2009-08-27 | Закрытое Акционерное Общество "Фарм-Синтез" | Рентгеноаморфная безводная модификация 4-[(4-метил-1-пиперазинил)метил]-n-[4-метил-3-[[4-(3-пиридинил)-2-пиримидинил]-амино]-фенил]бензамида метансульфоната и способ ее получения |
| CZ2009570A3 (cs) | 2009-08-26 | 2011-03-09 | Zentiva, K. S. | Príprava, stabilizace a využití polymorfu imatinib mesylátu pro vývoj lékových forem |
| PL389357A1 (pl) | 2009-10-22 | 2011-04-26 | Tomasz Koźluk | Sole imatinibu z pochodnymi kwasów winowych i sposób ich wytwarzania |
| AU2011213936A1 (en) | 2010-02-15 | 2012-09-06 | Sharma Ashwani | Process for the preparation of alpha form of imatinib mesylate |
| PL390611A1 (pl) | 2010-03-04 | 2011-09-12 | Tomasz Koźluk | Sposób otrzymywania polimorficznej formy alfa i nowa forma polimorficzna mesylanu imatinibu |
| WO2012090221A1 (en) | 2010-12-29 | 2012-07-05 | Cadila Healthcare Limited | Novel salts of imatinib |
| EP2604596A1 (en) * | 2011-12-16 | 2013-06-19 | Deva Holding Anonim Sirketi | Polymorphs of imatinib |
| US9221789B2 (en) | 2012-06-22 | 2015-12-29 | Basf Se | Multicomponent crystals comprising imatinib mesilate and selected co-crystal formers |
| KR101242955B1 (ko) * | 2012-06-25 | 2013-03-12 | 제일약품주식회사 | 이마티닙 메실레이트 결정형 α의 제조 방법 |
| ES2683361T3 (es) | 2013-05-14 | 2018-09-26 | Hetero Research Foundation | Composiciones de Imatinib |
| US10478290B2 (en) * | 2013-11-26 | 2019-11-19 | Children's Medical Center Corporation | Expandable stent valve |
| WO2018089404A1 (en) | 2016-11-11 | 2018-05-17 | Mallinckrodt Nuclear Medicine Llc | Processes for generating germanium-68 with reduced volatiles |
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| TW225528B (enExample) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| US20060073185A1 (en) | 2002-12-13 | 2006-04-06 | Bausch & Lomb Incorporated | Method and composition for contact lenses |
| WO2004106326A1 (en) * | 2003-06-02 | 2004-12-09 | Hetero Drugs Limited | Novel polymorphs of imatinib mesylate |
| PE20051096A1 (es) | 2004-02-04 | 2006-01-23 | Novartis Ag | Formas de sal de 4-(4-metilpiperazin-1-ilmetil)-n-[4-metil-3-(4-piridin-3-il)pirimidin-2-ilamino)fenil]-benzamida |
| US8048883B2 (en) * | 2004-02-11 | 2011-11-01 | Natco Pharma Limited | Polymorphic form of imatinib mesylate and a process for its preparation |
| UA84462C2 (ru) * | 2004-04-02 | 2008-10-27 | Институт Фармацевтични | Полиморфные модификации кислотно-аддитивных солей иматиниба с метансульфоновой кислотой |
| CN102085202A (zh) | 2004-06-04 | 2011-06-08 | 比奥尼斯生命科学公司 | 伊马替尼在治疗肝脏疾病和病毒感染中的用途 |
| TR200701870T1 (tr) * | 2004-09-02 | 2007-05-21 | Cipla Limited | İmatinib mesilatın kararlı kristal formu ve bu formun hazırlanması için işlem. |
| WO2006048890A1 (en) * | 2004-11-04 | 2006-05-11 | Sun Pharmaceutical Industries Limited | Imatinib mesylate crystal form and process for preparation thereof |
| WO2006054314A1 (en) * | 2004-11-17 | 2006-05-26 | Natco Pharma Limited | Polymorphic forms of imatinib mesylate |
| US9804295B2 (en) | 2005-05-05 | 2017-10-31 | Novartis Ag | Ophthalmic devices for sustained delivery of active compounds |
| GB0511066D0 (en) | 2005-05-31 | 2005-07-06 | Novartis Ag | Organic compounds |
| AR055613A1 (es) * | 2005-08-26 | 2007-08-29 | Novartis Ag | Formas cristalinas delta y epsilon de mesilato de imatinib |
| KR20080078804A (ko) * | 2005-11-25 | 2008-08-28 | 노파르티스 아게 | 이마티니브 메실레이트의 ｆ, ｇ, ｈ, ｉ 및 ｋ 결정형 |
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2006
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- 2006-11-23 KR KR1020137031545A patent/KR20130137721A/ko not_active Ceased
- 2006-11-23 EP EP06818763A patent/EP1960380A1/en not_active Withdrawn
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- 2006-11-23 EP EP12177131.5A patent/EP2578580A1/en not_active Withdrawn
- 2006-11-23 UY UY29964A patent/UY29964A1/es not_active Application Discontinuation
- 2006-11-23 MY MYPI20081624A patent/MY146403A/en unknown
- 2006-11-23 CA CA2628330A patent/CA2628330C/en not_active Expired - Fee Related
- 2006-11-23 KR KR1020137031544A patent/KR20130140909A/ko not_active Ceased
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- 2006-11-23 AU AU2006316823A patent/AU2006316823A1/en not_active Abandoned
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