JP5802760B2 - 生体高分子クロマトグラフィーのためのシステム及びプロセス - Google Patents

生体高分子クロマトグラフィーのためのシステム及びプロセス Download PDF

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Publication number
JP5802760B2
JP5802760B2 JP2013541961A JP2013541961A JP5802760B2 JP 5802760 B2 JP5802760 B2 JP 5802760B2 JP 2013541961 A JP2013541961 A JP 2013541961A JP 2013541961 A JP2013541961 A JP 2013541961A JP 5802760 B2 JP5802760 B2 JP 5802760B2
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column
outlet
tank
biopolymer
tanks
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JP2014505236A (ja
JP2014505236A5 (enExample
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ホール，マーティン
ラッキ，キャロル
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Cytiva Sweden AB
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Amersham Bioscience AB
GE Healthcare Bio Sciences Corp
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/24—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the treatment of the fractions to be distributed
    • B01D15/242—Intermediate storage of effluents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3847—Multimodal interactions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/44—Flow patterns using recycling of the fraction to be distributed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/465—Flow patterns using more than one column with serial coupling of separation columns with specially adapted interfaces between the columns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/42—Flow patterns using counter-current

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2013541961A 2010-12-03 2011-12-02 生体高分子クロマトグラフィーのためのシステム及びプロセス Active JP5802760B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE1051279 2010-12-03
SE1051279-6 2010-12-03
PCT/SE2011/051468 WO2012074481A1 (en) 2010-12-03 2011-12-02 System and process for biopolymer chromatography

Publications (3)

Publication Number Publication Date
JP2014505236A JP2014505236A (ja) 2014-02-27
JP2014505236A5 JP2014505236A5 (enExample) 2015-01-22
JP5802760B2 true JP5802760B2 (ja) 2015-11-04

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JP2013541961A Active JP5802760B2 (ja) 2010-12-03 2011-12-02 生体高分子クロマトグラフィーのためのシステム及びプロセス

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US (1) US20130248451A1 (enExample)
EP (1) EP2675540B1 (enExample)
JP (1) JP5802760B2 (enExample)
CN (1) CN103221105B (enExample)
WO (1) WO2012074481A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10343083B2 (en) 2012-08-24 2019-07-09 Ge Healthcare Bio-Sciences Ab System and method for controlling a liquid chromatography systems

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
JP6348493B2 (ja) 2012-08-22 2018-06-27 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 汎用回転弁
US9322014B1 (en) * 2012-11-28 2016-04-26 Sandia Corporation Multiplexed microfluidic approach for nucleic acid enrichment
HK1219964A1 (zh) 2013-03-08 2017-04-21 Genzyme Corporation 治疗性蛋白药物物质的整合连续制造
CN103157295B (zh) * 2013-03-19 2014-12-24 利穗科技(苏州)有限公司 一种双柱循环色谱系统
US10099156B2 (en) † 2013-04-08 2018-10-16 Chromacon Ag Chromatographic purification method
CA2935960C (en) 2014-01-08 2023-01-10 Bart Lipkens Acoustophoresis device with dual acoustophoretic chamber
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
GB201401010D0 (en) 2014-01-21 2014-03-05 Nat Nuclear Lab Ltd Improved separation apparatus and method
WO2015117883A1 (en) * 2014-02-07 2015-08-13 Cmc Biologics A/S A bioreactor arrangement and continuous process for producing and capturing a biopolymer
CN105980847B (zh) * 2014-02-14 2018-12-04 通用电气健康护理生物科学股份公司 自动多步纯化系统
EP3132050A1 (en) 2014-04-16 2017-02-22 CMC Biologics A/S A high cell density fill and draw fermentation process
WO2016098169A1 (ja) * 2014-12-15 2016-06-23 株式会社島津製作所 液体クロマトグラフ
ES2897581T3 (es) 2014-12-18 2022-03-01 Cytiva Sweden Ab Método y sistema para determinar el nivel de saturación de una columna de cromatografía basado en la detección de presión
CN104614458B (zh) * 2015-01-21 2016-06-22 柳仁民 一种带多通阀的循环制备高效液相色谱仪
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
EP3037513A1 (de) * 2015-05-13 2016-06-29 Bayer Technology Services GmbH Verfahren zur kontinuierlichen elution eines produktes von chromatographiesäulen
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
GB201515339D0 (en) 2015-08-28 2015-10-14 Ge Healthcare Bio Sciences Ab A seperation matrix and a method of seperating antibodies
CN108700558B (zh) * 2016-03-07 2022-07-12 沃特世科技公司 用于减少色谱法中带色散的系统、方法和设备
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
WO2018063981A1 (en) * 2016-09-29 2018-04-05 Bio-Rad Laboratories, Inc. Protein-nanoparticle conjugate purification methods
CN110494543A (zh) 2016-10-19 2019-11-22 弗洛设计声能学公司 通过声学的亲和细胞提取
GB201703116D0 (en) 2017-02-27 2017-04-12 Ge Healthcare Bioprocess R&D Ab A seperation matrix and a method of seperating antibodies
EP3381530A1 (fr) 2017-03-29 2018-10-03 EMD Millipore Corporation Installation de traitement de liquide biologique
EP3381529A1 (fr) 2017-03-29 2018-10-03 EMD Millipore Corporation Installation de traitement de liquide biologique
JP6790963B2 (ja) * 2017-03-30 2020-11-25 株式会社島津製作所 液体クロマトグラフ
CN108854158B (zh) * 2017-05-16 2023-11-07 湖北生物医药产业技术研究院有限公司 树脂柱洗脱液收集装置
GB201710130D0 (en) 2017-06-26 2017-08-09 Ge Healthcare Bioprocess R & D Ab A Method of seperation
SG11202003440SA (en) * 2017-11-16 2020-05-28 Chromacon Ag Method for monitoring, evaluating, and controlling a cyclic chromatographic purification process
US12029999B2 (en) 2017-11-30 2024-07-09 Corning Incorporated Package for batch chromatography
KR20220066413A (ko) 2017-12-14 2022-05-24 프로디자인 소닉스, 인크. 음향 트랜스듀서 구동기 및 제어기
GB202006310D0 (en) 2020-04-29 2020-06-10 Puridify Ltd Preparative chromatography system and method for chromatography separations
CN111957072A (zh) * 2020-09-10 2020-11-20 北京莱伯泰科仪器股份有限公司 不锈钢自密封凝胶净化柱装置
US12458908B2 (en) * 2020-11-30 2025-11-04 PAK Biosolutions Inc. End-to-end continuous purification system
GB202109015D0 (en) * 2021-06-23 2021-08-04 Puridify Ltd A method for purifying a feed in a chromatography system
WO2023165947A1 (en) 2022-03-03 2023-09-07 Chromacon Ag Chromatographic purification method and uses thereof
CN115015458A (zh) * 2022-07-01 2022-09-06 江苏汉邦科技股份有限公司 一种分流色谱系统和利用分流色谱系统制备二十碳五烯酸乙酯的方法
CN116474419B (zh) * 2023-06-09 2025-07-18 焦作市华康糖醇科技有限公司 一种木糖生产连续脱色系统及其使用方法
WO2025031868A1 (en) 2023-08-08 2025-02-13 Cytiva Sweden Ab Multi modular chromatography system
CN119345745B (zh) * 2024-12-23 2025-03-14 成都英德生物医药设备有限公司 一种生产级连续流层析系统及方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US39398A (en) * 1863-08-04 Improvement in blow-pipes
US5683916A (en) * 1988-10-31 1997-11-04 Hemasure Inc. Membrane affinity apparatus and purification methods related thereto
US20060273013A1 (en) * 2004-03-01 2006-12-07 Chin Nien-Hwa L Versatile simulated moving bed systems
US8920645B2 (en) * 2005-12-07 2014-12-30 Tarpon Biosystems Inc. Disposable chromatography valves and system
US20080116122A1 (en) * 2006-11-22 2008-05-22 Genitope Corporation Chromatography systems comprising single-use components
CN101053705A (zh) * 2007-05-24 2007-10-17 江苏汉邦科技有限公司 五分区模拟移动床色谱装置
JP5571552B2 (ja) * 2007-06-15 2014-08-13 ジーイー・ヘルスケア・バイオ−サイエンシズ・アーベー クロマトグラフィー法
US20090149638A1 (en) * 2007-10-03 2009-06-11 Ley Arthur C Systems and methods for purifying proteins

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10343083B2 (en) 2012-08-24 2019-07-09 Ge Healthcare Bio-Sciences Ab System and method for controlling a liquid chromatography systems

Also Published As

Publication number Publication date
JP2014505236A (ja) 2014-02-27
WO2012074481A1 (en) 2012-06-07
EP2675540A1 (en) 2013-12-25
US20130248451A1 (en) 2013-09-26
EP2675540A4 (en) 2016-12-28
EP2675540B1 (en) 2018-03-21
CN103221105A (zh) 2013-07-24
CN103221105B (zh) 2015-11-25

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