JP5796872B2 - 第Ｘａ因子阻害剤の結晶性塩 - Google Patents

第Ｘａ因子阻害剤の結晶性塩 Download PDF

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Publication number
JP5796872B2
JP5796872B2 JP2012544856A JP2012544856A JP5796872B2 JP 5796872 B2 JP5796872 B2 JP 5796872B2 JP 2012544856 A JP2012544856 A JP 2012544856A JP 2012544856 A JP2012544856 A JP 2012544856A JP 5796872 B2 JP5796872 B2 JP 5796872B2
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compound
salt
crystalline form
crystalline
mesylate
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Japanese (ja)
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JP2013514981A5 (https=
JP2013514981A (ja
Inventor
アンジャリー パンディー，
アンジャリー パンディー，
ルイーザ ジェーン キューゲン，
ルイーザ ジェーン キューゲン，
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Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2012544856A 2009-12-17 2010-12-16 第Ｘａ因子阻害剤の結晶性塩 Expired - Fee Related JP5796872B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28768309P 2009-12-17 2009-12-17
US61/287,683 2009-12-17
PCT/US2010/060885 WO2011084652A2 (en) 2009-12-17 2010-12-16 Salts and crystalline forms of a factor xa inhibitor

Publications (3)

Publication Number Publication Date
JP2013514981A JP2013514981A (ja) 2013-05-02
JP2013514981A5 JP2013514981A5 (https=) 2014-01-30
JP5796872B2 true JP5796872B2 (ja) 2015-10-21

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ID=43618959

Family Applications (1)

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JP2012544856A Expired - Fee Related JP5796872B2 (ja) 2009-12-17 2010-12-16 第Ｘａ因子阻害剤の結晶性塩

Country Status (6)

Country Link
US (1) US8530501B2 (https=)
EP (1) EP2513094B1 (https=)
JP (1) JP5796872B2 (https=)
CN (1) CN102762550B (https=)
CA (1) CA2784921A1 (https=)
WO (1) WO2011084652A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8742120B2 (en) * 2009-12-17 2014-06-03 Millennium Pharmaceuticals, Inc. Methods of preparing factor xa inhibitors and salts thereof
AR079491A1 (es) 2009-12-17 2012-02-01 Millennium Pharm Inc Metodos de sintesis de inhibidores del factor xa tal como el betrixaban y composiciones farmaceuticas que contienen la base libre de betrixaban o su sal sustancialmente pura.
CN120633248B (zh) * 2025-08-08 2025-10-17 成都理工大学 超临界地热流体体系KCl-H2O的电导率计算方法

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KR101509829B1 (ko) 2007-05-02 2015-04-06 포톨라 파마슈티컬스, 인코포레이티드 혈소판 ａｄｐ 수용체 억제제로 작용하는 화합물을 이용한 병용요법
EP2915564B1 (en) 2007-09-28 2020-11-04 Portola Pharmaceuticals, Inc. Antidotes for factor XA inhibitors and methods of using the same
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ES2605801T3 (es) 2009-07-15 2017-03-16 Portola Pharmaceuticals, Inc. Formulación de dosis unitaria de antídoto para inhibidores del factor Xa para su uso en la prevención de la hemorragia

Also Published As

Publication number Publication date
WO2011084652A3 (en) 2011-09-09
CA2784921A1 (en) 2011-07-14
US20110178135A1 (en) 2011-07-21
EP2513094A2 (en) 2012-10-24
CN102762550B (zh) 2015-04-01
JP2013514981A (ja) 2013-05-02
WO2011084652A2 (en) 2011-07-14
HK1177459A1 (zh) 2013-08-23
CN102762550A (zh) 2012-10-31
US8530501B2 (en) 2013-09-10
EP2513094B1 (en) 2015-12-16

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