JP5777281B2 - 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン - Google Patents

血管新生及び脈管形成のモジュレーターとしてのｒスポンジン Download PDF

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JP5777281B2
JP5777281B2 JP2009532732A JP2009532732A JP5777281B2 JP 5777281 B2 JP5777281 B2 JP 5777281B2 JP 2009532732 A JP2009532732 A JP 2009532732A JP 2009532732 A JP2009532732 A JP 2009532732A JP 5777281 B2 JP5777281 B2 JP 5777281B2
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rspondin
angiogenesis
polypeptide
antibody
nucleic acid
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JP2010506871A (ja
JP2010506871A5 (es
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ニエフルス クフリストフ
ニエフルス クフリストフ
カザンスカヤ オルガ
カザンスカヤ オルガ
美静 大河原
美静 大河原
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デウトスクフエス クレブスフオルスチュングスゼントルム ストイフトウング デス オフフエントリクヘンレクフトス
デウトスクフエス クレブスフオルスチュングスゼントルム ストイフトウング デス オフフエントリクヘン レクフトス
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
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JP2009532732A 2006-10-20 2007-10-19 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン Expired - Fee Related JP5777281B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06022070 2006-10-20
EP06022070.4 2006-10-20
PCT/EP2007/009105 WO2008046649A1 (en) 2006-10-20 2007-10-19 Rspondins as modulators of angiogenesis and vasculogenesis

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JP2013247353A Division JP5822897B2 (ja) 2006-10-20 2013-11-29 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン

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JP2010506871A JP2010506871A (ja) 2010-03-04
JP2010506871A5 JP2010506871A5 (es) 2010-11-25
JP5777281B2 true JP5777281B2 (ja) 2015-09-09

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JP2009532732A Expired - Fee Related JP5777281B2 (ja) 2006-10-20 2007-10-19 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン
JP2013247353A Expired - Fee Related JP5822897B2 (ja) 2006-10-20 2013-11-29 血管新生及び脈管形成のモジュレーターとしてのｒスポンジン

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US (6) US8088374B2 (es)
EP (2) EP2081586B2 (es)
JP (2) JP5777281B2 (es)
AU (1) AU2007312538B2 (es)
CA (1) CA2664828A1 (es)
DK (1) DK2081586T4 (es)
ES (1) ES2564794T5 (es)
HK (1) HK1222799A1 (es)
HU (1) HUE027179T2 (es)
MX (1) MX2009003726A (es)
PL (1) PL2081586T5 (es)
SI (1) SI2081586T2 (es)
WO (1) WO2008046649A1 (es)

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US8088374B2 (en) * 2006-10-20 2012-01-03 Deutsches Krebsforschungszentrum Stiftung Des Offenlichen Rechts Methods for inhibition of angiogenesis and vasculogenesis via rspondin antagonists
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AU2013204484B2 (en) * 2011-07-15 2016-05-12 Oncomed Pharmaceuticals, Inc. RSPO binding agents and uses thereof
CN106167526A (zh) * 2011-07-15 2016-11-30 昂考梅德药品有限公司 Rspo结合剂和其应用
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US20130209473A1 (en) * 2012-02-11 2013-08-15 Genentech, Inc. R-spondin translocations and methods using the same
AU2013289990B2 (en) * 2012-07-13 2018-06-14 Oncomed Pharmaceuticals, Inc. RSPO3 binding agents and uses thereof
CN105744954B (zh) 2013-10-18 2021-03-05 豪夫迈·罗氏有限公司 抗rspo2和/或抗rspo3抗体及其用途
WO2015173425A1 (en) 2014-05-16 2015-11-19 Koninklijke Nederlandse Akademie Van Wetenschappen Improved culture method for organoids
CA2961374A1 (en) 2014-09-16 2016-03-24 Oncomed Pharmaceuticals, Inc. Treatment of fibrotic diseases
GB201421094D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201421092D0 (en) 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
US20190008859A1 (en) 2015-08-21 2019-01-10 Acerta Pharma B.V. Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
WO2017180864A1 (en) 2016-04-14 2017-10-19 Genentech, Inc. Anti-rspo3 antibodies and methods of use
KR102531265B1 (ko) * 2019-10-24 2023-05-12 가톨릭대학교 산학협력단 Rspo3 억제제를 포함하는 심장 판막 질환의 예방 또는 치료용 조성물
WO2022020544A1 (en) * 2020-07-23 2022-01-27 The Board Of Trustees Of The University Of Illinois Method of treating an inflammatory condition

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PL2081586T5 (pl) 2019-04-30
SI2081586T2 (sl) 2019-01-31
MX2009003726A (es) 2009-04-22
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AU2007312538B2 (en) 2012-10-04
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US10538563B2 (en) 2020-01-21
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US20140056894A1 (en) 2014-02-27
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US9226963B2 (en) 2016-01-05
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US8088374B2 (en) 2012-01-03
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US8580736B2 (en) 2013-11-12
US8926970B2 (en) 2015-01-06
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