JP5777115B2 - 多能性幹細胞から中胚葉細胞への分化誘導法 - Google Patents

多能性幹細胞から中胚葉細胞への分化誘導法 Download PDF

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JP5777115B2
JP5777115B2 JP2012542287A JP2012542287A JP5777115B2 JP 5777115 B2 JP5777115 B2 JP 5777115B2 JP 2012542287 A JP2012542287 A JP 2012542287A JP 2012542287 A JP2012542287 A JP 2012542287A JP 5777115 B2 JP5777115 B2 JP 5777115B2
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cells
cell
mesoderm
hematopoietic
stem cells
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JP2013521762A5 (cg-RX-API-DMAC7.html
JP2013521762A (ja
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明 丹羽
明 丹羽
中畑　龍俊
龍俊 中畑
俊男 平家
俊男 平家
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Kyoto University NUC
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012542287A 2010-03-18 2011-03-18 多能性幹細胞から中胚葉細胞への分化誘導法 Expired - Fee Related JP5777115B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31517010P 2010-03-18 2010-03-18
US61/315,170 2010-03-18
PCT/JP2011/057503 WO2011115308A1 (en) 2010-03-18 2011-03-18 Method for inducing differentiation of pluripotent stem cells into mesodermal cells

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JP2013521762A JP2013521762A (ja) 2013-06-13
JP2013521762A5 JP2013521762A5 (cg-RX-API-DMAC7.html) 2014-06-19
JP5777115B2 true JP5777115B2 (ja) 2015-09-09

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US (1) US8652845B2 (cg-RX-API-DMAC7.html)
EP (1) EP2547764B1 (cg-RX-API-DMAC7.html)
JP (1) JP5777115B2 (cg-RX-API-DMAC7.html)
WO (1) WO2011115308A1 (cg-RX-API-DMAC7.html)

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WO2014100779A1 (en) * 2012-12-21 2014-06-26 Advanced Cell Technology, Inc. Methods ofr production of platelets from pluripotent stem cells and compositions thereof
WO2014200030A1 (ja) 2013-06-12 2014-12-18 国立大学法人京都大学 人工多能性幹細胞の選別方法および血球への分化誘導方法
FR3024462A1 (fr) * 2014-07-29 2016-02-05 Univ Pierre Et Marie Curie Paris 6 Procede de production in vitro de progeniteurs adipocytaires et d'adipocytes
AU2015353853B2 (en) 2014-11-25 2020-10-15 President And Fellows Of Harvard College Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
JP6800859B2 (ja) * 2015-01-26 2020-12-16 フェイト セラピューティクス，インコーポレイテッド 造血細胞分化を誘導するための方法および組成物
WO2017014165A1 (ja) 2015-07-17 2017-01-26 国立大学法人京都大学 血管内皮細胞の誘導方法
JP6646311B2 (ja) * 2015-07-17 2020-02-14 国立大学法人京都大学 多能性幹細胞から中胚葉前駆細胞および血液血管前駆細胞への分化誘導法
KR20250033315A (ko) 2015-11-04 2025-03-07 페이트 세러퓨틱스, 인코포레이티드 조혈 세포 분화를 유도하기 위한 방법 및 조성물
EP3371314B1 (en) * 2015-11-04 2023-07-05 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
US11136547B2 (en) 2016-03-23 2021-10-05 Kyoto University Mesoderm induction method having high blood cell differentiation capacity
US11559548B2 (en) 2017-03-14 2023-01-24 Kyoto University Method for producing helper T cells from pluripotent stem cells
SG11202106642YA (en) 2018-12-20 2021-07-29 Sumitomo Chemical Co Embryonic erythroblast-containing cell population and method for producing same, cell culture composition, and compound test method
GB201911957D0 (en) * 2019-08-20 2019-10-02 Adaptimmune Ltd Methods of producing haemogenic progenitor cells from pluripotent stem cells
WO2021107117A1 (ja) * 2019-11-28 2021-06-03 国立大学法人京都大学 多能性幹細胞からの造血細胞の製造法
JP7072756B2 (ja) * 2019-12-27 2022-05-23 国立大学法人京都大学 多能性幹細胞から中胚葉前駆細胞および血液血管前駆細胞への分化誘導法
WO2021173458A1 (en) * 2020-02-28 2021-09-02 Purdue Research Foundation Generating aorta-gonad-mesonephros-like hematopoietic cells from human pluripotent stem cells under a defined condition
US11591381B2 (en) 2020-11-30 2023-02-28 Crispr Therapeutics Ag Gene-edited natural killer cells
CN112574944A (zh) * 2020-12-14 2021-03-30 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） 基于体外诱导eps发育形成类囊胚结构的方法
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
GB202102297D0 (en) * 2021-02-18 2021-04-07 Adaptimmune Ltd Methods of Producing Haemogenic Endothelial Cells from Pluripotent Stem Cells
CN113249303B (zh) * 2021-05-07 2022-07-29 华中农业大学 血管内皮细胞生长因子在促进鸡原始生殖细胞增殖和迁移中的应用
CN114457006B (zh) * 2022-02-21 2023-07-28 广州华越肾科再生医学科技有限公司 一种通过不连续分化制备肾脏足细胞的方法
CN115247152B (zh) * 2022-09-21 2022-12-27 呈诺再生医学科技(北京)有限公司 制备造血干细胞或造血干祖细胞的方法及培养长期再生造血干细胞的方法
CN120826462A (zh) * 2023-03-02 2025-10-21 R.P.谢勒技术有限责任公司 多能干细胞分化为间充质基质细胞的方法

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MXPA04005010A (es) * 2001-11-26 2005-04-08 Advanced Cell Tech Inc METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS.
US7452718B2 (en) * 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
EP2013331A2 (en) * 2006-04-14 2009-01-14 Advanced Cell Technology, Inc. Hemangio-colony forming cells
JP5067949B2 (ja) * 2006-11-09 2012-11-07 独立行政法人国立国際医療研究センター 霊長類動物胚性幹細胞の培養及び継代方法、並びにその分化誘導方法
WO2009116951A2 (en) * 2008-03-17 2009-09-24 Agency For Science, Technology And Research Microcarriers for stem cell culture
SG10201610881UA (en) 2008-03-27 2017-03-30 Asterias Biotherapeutics Inc Differentiation of primate pluripotent stem cells to hematopoietic lineage cells
JPWO2010008100A1 (ja) * 2008-07-17 2012-01-05 国立大学法人名古屋大学 骨格筋細胞又は骨細胞の誘導法

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EP2547764B1 (en) 2019-01-23
US8652845B2 (en) 2014-02-18
EP2547764A4 (en) 2014-01-22
WO2011115308A1 (en) 2011-09-22
US20130011924A1 (en) 2013-01-10
JP2013521762A (ja) 2013-06-13
EP2547764A1 (en) 2013-01-23

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