JP5774029B2 - Cosmetic composition - Google Patents

Description

  The present invention relates to a cosmetic composition with improved stability, which is preferably used for skin whitening.

  People with colored skin or even people with brown skin want to whiten the skin, and for this purpose it is not possible to use cosmetic or dermatological compositions containing whitening agents Often.

  The substances most commonly used as whitening agents are hydroquinone and its derivatives, kojic acid and its derivatives, azelaic acid, arbutin and its derivatives, used alone or in combination with other active agents.

  Compositions containing such whitening agents are also used by individuals who have pigmentations on their skin. This pigmentary dysfunction is due to various causes, that is, age (aging spots), exposure to UV irradiation, pregnancy lines, and the like.

  Kojic acid (2-hydroxymethyl-5-hydroxy-4H-pyran-4-one) is known to inhibit tyrosinase, which is involved in the production of melanin in the skin, and thus kojic acid whitens the skin Widely used for. For example, WO 00/7627 discloses a composition comprising kojic acid to reduce skin pigmentation in Table 7 as Example 3.

International Publication No. 00/7627

  The inventors have found that compositions containing kojic acid and large amounts of water (at least 50% by weight) become unstable over time and can form precipitates. As a result of intensive investigations, the inventors have discovered that kojic acid forms a precipitate when combined with a specific type of surfactant.

  It may be considered that no surfactant is added to the composition comprising kojic acid in order to stabilize the composition. However, it is difficult to avoid the use of one or more surfactants, especially when the composition is used as a cosmetic composition. This is because cosmetic compositions usually contain several substances such as perfumes that require the assistance of a surfactant to dissolve in the cosmetic composition.

  Accordingly, it is an object of the present invention to impart good stability over time to a cosmetic composition containing kojic acid, even if it contains one or more surfactants.

  The above object of the present invention can be realized by combining kojic acid with a carefully selected surfactant.

Thus, one aspect of the present invention is
Kojic acid,
Polyoxyethylenated (1 to 40 EO) and polyoxypropylene (1 to 30 PO) alkyl (C ₁₆ ~C ₂₄₎ ethers, polyoxyethylenated (30 to 50 EO) hydrogenated castor oil, and polyoxyethylene At least one nonionic surfactant selected from the group consisting of conjugated (15-30 EO) mono- or tri-oleates;
A cosmetic composition comprising 50% or more of water with respect to the total weight of the composition.

Polyoxyethylenated (1 to 40 EO) and polyoxypropylene (1 to 30 PO) alkyl (C ₁₆ ~C ₂₄₎ ether, PPG-6 decyltetradeceth -30, PPG-6 decyltetradeceth - 12, PPG-13 decyltetradeceth-24, PPG-6 decyltetradeceth-20, PPG-4 ceteth-1, PPG-8 ceteth-1, PPG-4 ceteth-10, PPG-4 ceteth-20, It is preferably selected from the group consisting of PPG-5 ceteth-20, PPG-8 ceteth-20 and PPG-23 steareth-34.

Polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C ₁₆ -C ₂₄ ) ethers are PPG-6 decyl tetradeceth-30, PPG-13 decyl tetradeceth- 24, can be selected from the group consisting of PPG-6 decyltetradeceth-20, PPG-5 ceteth-20, PPG-8 ceteth-20 and PPG-23 steareth-34, (15-40 EO) And polyoxypropylenated (5-30 PO) alkyl (C ₁₆ -C ₂₄ ) ethers are more preferred.

Polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C ₁₆ -C ₂₄ ) ethers are PPG-6 decyl tetradeceth-30, PPG-13 decyl tetradeceth- 24, PPG-5 ceteth-20, and PPG-8 ceteth-20, which can be selected from the group consisting of (15-40 EO) and polyoxypropylenated (5-30 PO) alkyl (C _16- Most preferred is C ₂₄ ) ether.

  The polyoxyethylenated (30-50 EO) hydrogenated castor oil is preferably selected from the group consisting of PEG-30 hydrogenated castor oil, PEG-40 hydrogenated castor oil and PEG-50 hydrogenated castor oil.

  More preferably, the polyoxyethylenated (30-50 EO) hydrogenated castor oil is PEG-40 hydrogenated castor oil.

  The polyoxyethylenated (15-30 EO) mono- or tri-oleate is preferably selected from the group consisting of polysorbate 80 and polysorbate 85.

  More preferably, the polyoxyethylenated (15-30 EO) mono- or tri-oleate is polysorbate 80.

  The nonionic surfactant should be present in an amount of 0.01 wt% to 10 wt%, preferably 0.01 wt% to 5 wt%, more preferably 0.01 wt% to 2.5 wt%, relative to the total weight of the composition. Can do.

  Kojic acid can be present in an amount of 0.01 wt% to 5 wt%, preferably 0.1 wt% to 3.0 wt%, more preferably 0.5 wt% to 2.0 wt%, relative to the total weight of the composition.

  The cosmetic composition according to the present invention may further comprise at least one fragrance.

  The perfume can be present in an amount of 0.01 wt% to 1 wt%, preferably 0.01 wt% to 0.5 wt%, more preferably 0.01 wt% to 0.3 wt%, relative to the total weight of the composition.

  The cosmetic composition according to the present invention contains at least one fatty compound in an amount of 0.01% to 10% by weight, preferably 0.01% to 5% by weight, more preferably 0.01% to 5% by weight relative to the total weight of the composition. It can further be included in an amount of 1% by weight.

  The cosmetic composition according to the present invention is preferably intended for skin whitening.

  A cosmetic composition comprising kojic acid according to the present invention is stable over time.

  Another aspect of the present invention is a skin cosmetic treatment method comprising the step of applying a cosmetic composition according to the present invention on the skin.

  The inventors have found that it is possible to impart good stability to a cosmetic composition containing kojic acid by using a specific nonionic surfactant carefully selected after intensive studies. discovered.

Therefore, the cosmetic composition according to the present invention comprises:
(A) kojic acid;
(B) polyoxyethylenated (1 to 40 EO) and polyoxypropylene (1 to 30 PO) alkyl (C ₁₆ ~C ₂₄₎ ethers, polyoxyethylenated (30 to 50 EO) hydrogenated castor oil, and And at least one nonionic surfactant selected from the group consisting of polyoxyethylenated (15-30 EO) mono- or tri-oleates.

In addition, the cosmetic composition according to the present invention comprises:
(C) It further contains water in an amount of 50% or more based on the total weight of the composition.

  In the following, the cosmetic composition according to the present invention will be described in more detail.

(A) Kojic acid Kojic acid is a heterocyclic compound having the following chemical formula.

  The cosmetic composition according to the present invention comprises kojic acid in an amount of 0.01% to 5% by weight, preferably 0.1% to 3.0% by weight, more preferably 0.5% to 2.0% by weight relative to the total weight of the composition. Can be included in quantity.

(B) The cosmetic composition according to the nonionic surfactant present invention, polyoxyethylenated (1 to 40 EO) and polyoxypropylene (1 to 30 PO) alkyl (C ₁₆ ~C ₂₄₎ ether, polyoxyethylene (30-50 EO) hydrogenated castor oil, and at least one nonionic surfactant selected from the group consisting of polyoxyethylenated (15-30 EO) mono- or tri-oleate.

  Two or more nonionic surfactants may be used.

Polyoxyethylenated (1 to 40 EO) and polyoxypropylene (1 to 30 PO) alkyl (C ₁₆ ~C ₂₄₎ ether,
PPG-6 decyltetradeces-30, that is, polyoxyethylene (30) polyoxypropylene (6) tetradecyl ether, for example, Nikkol PEN-4630 sold by Nikko Chemicals Co., Ltd.
PPG-6 decyltetradeces-12, i.e., polyoxyethylene (12) polyoxypropylene (6) tetradecyl ether, for example, Nikkol PEN-4612 sold by Nikko Chemicals,
PPG-13decyltetradeces-24, that is, polyoxyethylene (24) polyoxypropylene (13) decyltetradecyl ether, for example, sold as NOILUBE 50MT-2200B from NOF Corporation,
PPG-6 decyltetradeces-20, that is, polyoxyethylene (20) polyoxypropylene (6) decyltetradecyl ether, for example, Nikkol PEN-4620 sold by Nikko Chemicals Co., Ltd.
PPG-4 ceteth-1, that is, polyoxyethylene (1) polyoxypropylene (4) cetyl ether, for example, Nikkol PBC-31 sold by Nikko Chemicals Co., Ltd.
PPG-8 ceteth-1, that is, polyoxyethylene (1) polyoxypropylene (8) cetyl ether, for example, Nikkol PBC-41 sold by Nikko Chemicals Co., Ltd.
PPG-4 ceteth-10, that is, polyoxyethylene (10) polyoxypropylene (4) cetyl ether, for example, Nikkol PBC-33 sold by Nikko Chemicals Co., Ltd.
PPG-4 ceteth-20, i.e., polyoxyethylene (20) polyoxypropylene (4) cetyl ether, for example, Nikkol PBC-34 sold by Nikko Chemicals Co., Ltd.
PPG-5 ceteth-20, i.e., polyoxyethylene (20) polyoxypropylene (5) cetyl ether, such as that sold by Croda Inc. as Procetyl AWS,
PPG-8 ceteth-20, i.e., polyoxyethylene (20) polyoxypropylene (8) cetyl ether, for example, Nikkol PBC-44 sold by Nikko Chemicals Co., Ltd.
as well as
Preferably selected from the group consisting of PPG-23 steareth-34, ie polyoxyethylene polyoxypropylene stearyl ether (34 EO) (23 PO), such as that sold as Unisafe 34S-23 by Polar Chemical Industries, Ltd. be able to. These can impart stability to the composition for a long period of time, even if the temperature of the composition rises and falls in a relatively short period of time.

Polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C ₁₆ -C ₂₄ ) ethers are PPG-6 decyl tetradeceth-30, PPG-13 decyl tetradeceth- 24, can be selected from the group consisting of PPG-6 decyltetradeceth-20, PPG-5 ceteth-20, PPG-8 ceteth-20 and PPG-23 steareth-34, (15-40 EO) And polyoxypropylenated (5-30 PO) alkyl (C ₁₆ -C ₂₄ ) ethers are more preferred.

Polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C ₁₆ -C ₂₄ ) ethers are PPG-6 decyl tetradeceth-30, PPG-13 decyl tetradeceth- 24, PPG-5 ceteth-20, and PPG-8 ceteth-20, which can be selected from the group consisting of (15-40 EO) and polyoxypropylenated (5-30 PO) alkyl (C _16- Most preferred is C ₂₄ ) ether. They can also impart long-term transparency to the composition.

Polyoxyethylenated (30-50 EO) hydrogenated castor oil
PEG-30 hydrogenated castor oil, that is, polyoxyethylene (30) hydrogenated castor oil, for example, Nikkol HCO-30 sold by Nikko Chemicals Co., Ltd.
PEG-40 hydrogenated castor oil, that is, polyoxyethylene (40) hydrogenated castor oil, for example, Nikkol HCO-40 sold by Nikko Chemicals,
as well as
PEG-50 hydrogenated castor oil, ie, polyoxyethylene (50) hydrogenated castor oil, preferably selected from the group consisting of, for example, Nikkol HCO-50 sold by Nikko Chemicals Corporation. These can impart stability to the composition for a long period of time, even if the temperature of the composition rises and falls in a relatively short period of time.

  More preferably, the polyoxyethylenated (30-50 EO) hydrogenated castor oil is PEG-40 hydrogenated castor oil. This can also impart long-term transparency to the composition.

  The HLB value of the polyoxyethylenated (30-50 EO) hydrogenated castor oil is preferably 14.5 or less, more preferably 14 or less, even more preferably 13.5 or less, and most preferably 13.0 or less.

Polyoxyethylenated (15-30 EO) mono- or tri-oleates are
Polysorbate 80, i.e., polyoxyethylene sorbitan oleate (20E.O.), such as that sold by Croda Inc. as Tween 80,
And polysorbate 85, ie, polyoxyethylene sorbitan trioleate (20E.O.), such as that sold by Croda Inc. as Tween 85, is preferably selected. These can impart stability to the composition for a long period of time, even if the temperature of the composition rises and falls in a relatively short period of time.

  More preferably, the polyoxyethylenated (15-30 EO) mono- or tri-oleate is polysorbate 80. This can also impart long-term transparency to the composition.

  The cosmetic composition according to the present invention comprises 0.01% to 10% by weight, preferably 0.01% to 5% by weight, more preferably 0.01% to 2.5% by weight, based on the total weight of the composition. May be included in an amount of%.

(C) Water The cosmetic composition according to the present invention contains water in an amount of 50% or more based on the total weight of the composition.

  The water may be floral water such as cornflower water and / or mineral water such as Vittel water, Lucas water, or La Roche Posay water, and / or hot spring water, and / or seawater such as deep sea water.

  The amount of water can range from 50 to 99.5% by weight, preferably from 60 to 99% by weight, more preferably from 70 to 95% by weight, based on the total weight of the composition.

(D) Other ingredients The cosmetic composition according to the present invention may further comprise at least one fragrance.

  Natural or synthetic fragrances or aromas and mixtures thereof can be used as perfumes.

  Examples of natural fragrances and aromas include, for example, flower extracts (lily, lavender, rose, jasmine, ylang ylang), stem and leaf extracts (patcholi, geranium or petit glen), fruit extracts (coriander, anise) , Caraway, or Atlantic), pericarp extract (bergamot, lemon or orange), root extract (angelica, celery, cardamom, iris or shobu), wood extract (pine wood, sandalwood, grasshopper or pink cedar) ), Grass and grass extracts (tarragon, lemongrass, sage or thyme), needle and branch extracts (spruce, fir, pine or pine), resin and balsam extracts (galvanum, elemi, Benzoin, pills, frankincense or opopanax) and the like.

  Examples of synthetic fragrances and aromas include, for example, esters, ethers, aldehydes, ketones, aromatic alcohols and hydrocarbon compounds.

  Specific examples of the above esters include benzyl acetate, benzyl benzoate, phenoxyethyl isobutyrate, pt-butylcyclohexyl acetate, citronellyl acetate, citronellyl formate, geranyl acetate, linalyl acetate, dimethylbenzylcarbonyl acetate, phenylethyl acetate, benzoate Examples thereof include linalyl acid, benzyl formate, ethyl methyl phenyl glycinate, alkyl cyclohexyl propionate, styryl propionate, benzyl salicylate and the like.

  Examples of the ether include benzyl ethyl ether.

  Examples of the aldehyde include, for example, linear alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lilyal, burgeonal and the like.

  As examples of the above-mentioned ketone, for example, ionone such as α-isomethylionone and methylcedrylketone can be given.

  Examples of the aromatic alcohol and particularly terpene alcohol include anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol, terpineol and the like.

  As examples of the above hydrocarbon compounds, terpenes can be mentioned in particular. The above compounds are often provided in the form of blend products having two or more scented substances.

  Essential oil can also be used as an aroma component. For example, sage oil, chamomile oil, clove oil, balsam oil, mint oil, cinnamon leaf oil, lime blossom oil, horsetail oil, vetiver oil, balm oil, galvanum oil, labdanum oil, lavandin oil and the like are used.

  Furthermore, the following fragrance | flavors can be used individually or in combination. Bergamot oil, dihydromyrsenol, lyral, rilal, citronellol, phenylethyl alcohol, α-hexylcinnamaldehyde, geraniol, benzylacetone, cyclamenaldehyde, linalool, ambroxan, indole, hedione, sandelice, lemon oil, mandarin And oils derived from orange, allylamine glycolate, cyclovertal, lavender oil, sage oil, β-damascone, geranium oil, cyclohexyl salicylate, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, and the like.

  In accordance with a preferred form for practicing the present invention, various fragrances can be used by blending. As a result, an aroma that satisfies the user can be obtained.

  The cosmetic composition according to the present invention comprises a fragrance in an amount of 0.01% to 1%, preferably 0.01% to 0.5%, more preferably 0.01% to 0.3% by weight relative to the total weight of the composition. Can be included.

  The cosmetic composition according to the present invention may further comprise at least one organic solvent that is miscible with water at room temperature (25 ° C.).

Examples of organic solvents that are miscible with water at room temperature (25 ° C.)
Monoalcohols having 2 to 6 carbon atoms, such as ethanol and isopropanol,
Polyols having 2 to 20 carbon atoms, preferably 2 to 10 carbon atoms, more preferably 2 to 6 carbon atoms, such as glycerin, as well as propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, di- Alkylene glycols such as propylene glycol and diethylene glycol;
Glycol ethers (especially, carbon atoms 3 to 16) (e.g. mono -, di- - or tripropylene glycol (C ₁ -C ₄₎ alkyl ethers and mono-, - di - or triethylene glycol (C ₁ ~ C ₄ ) alkyl ethers), and mixtures thereof.

  The cosmetic composition according to the present invention contains the above water-miscible organic solvent in a range of 0.1 to 30% by weight, preferably 5 to 25% by weight, more preferably 10 to 20%, based on the total weight of the composition. It can be included in amounts ranging from wt%. In particular, when ethanol is present in the composition, ethanol is preferably contained in an amount of 0.1 to 15% by weight. When alkylene glycol is present in the composition, it is also preferred that the alkylene glycol is contained in an amount of 0.1 to 25% by weight relative to the total weight of the composition.

  The cosmetic composition according to the present invention may further comprise vitamin E or a derivative thereof.

  The vitamin E derivative is not particularly limited, and examples thereof include tocopherol acetate and the like.

  The amount of vitamin E or a derivative thereof blended into the cosmetic composition according to the present invention is not particularly limited, and preferably ranges from 0.01 to 5% by weight based on the total weight of the composition.

  The cosmetic composition according to the present invention may further comprise at least one fatty compound.

  The fatty compound may be in liquid or solid form. Here, “liquid” means that the fatty compound is in the form of a liquid or a paste (non-solid) at room temperature (25 ° C.) and atmospheric pressure (760 mmHg). As liquid fatty compounds, oils usually used in cosmetics can be used alone or in combination.

  The oil may be a non-polar oil such as a hydrocarbon oil or silicone oil, a polar oil such as a vegetable oil and an ester oil, or a mixture thereof.

  Examples of hydrocarbon oils include, for example, linear or branched hydrocarbons such as mineral oil (liquid paraffin), liquid petrolatum, and liquid naphthalene; hydrogenated polyisobutene, isoeicosane, squalane, squalene, and decene / butene copolymers; and these Can be mentioned.

  Examples of silicone oils include, for example, linear organopolysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, and methylhydrogenpolysiloxane; octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane Cyclic organopolysiloxanes; and mixtures thereof.

  Examples of vegetable oils include, for example, linseed oil, camellia oil, macadamia nut oil, corn oil, mink oil, olive oil, avocado oil, sasanqua oil, castor oil, safflower oil, jojoba oil, sunflower oil, almond oil, rapeseed oil Sesame oil, soybean oil, peanut oil and mixtures thereof.

  Examples of ester oils include, for example, diisopropyl adipate, dioctyl adipate, 2-ethylhexyl hexanoate, ethyl laurate, cetyl octanoate, octyldodecyl octanoate, isodecyl neopentanoate, myristyl propionate, 2-ethyl hexanoate 2- Ethylhexyl, 2-ethylhexyl octoate, caprylic acid / 2-ethylhexyl caprate, methyl palmitate, ethyl palmitate, isohexyl laurate, hexyl laurate, isocetyl stearate, isopropyl isostearate, isodecyl oleate, tri (2- Mention may be made of glyceryl ethylhexanoate, pentaerythrityl tetra (2-ethylhexanoate), 2-ethylhexyl succinate, diethyl sebacate, and mixtures thereof.

  The fatty compound may be a wax. Here, “wax” means that the fatty compound is in a substantially solid form at room temperature (25 ° C.) and atmospheric pressure (760 mmHg), and generally has a melting point of 35 ° C. or higher. As waxy and fatty substances, waxes commonly used in cosmetics can be used alone or in combination.

For example, waxes include carnauba wax, microcrystalline wax, ozokerite, hydrogenated jojoba oil, polyethylene wax such as the wax marketed by the company New Phase Technologies under the name “Performalene 400 Polyethylene”, silicone waxes such as Goldschmidt Wax poly products such as that sold under the name 9810 "(C ₂₄ ~C ₂₈₎ alkyl methyl dimethylpolysiloxane, palm butter, C ₂₀ -C company Kester Keunen is sold under the name" Kester Wax K82H " It can be selected from ₄₀ alkyl stearates, stearyl benzoate, shellac wax, and mixtures thereof. For example, a wax selected from carnauba wax, candelilla wax, ozokerite, hydrogenated jojoba oil and polyethylene wax is used. In at least one embodiment, the wax is preferably selected from candelilla wax and ozokerite, and mixtures thereof.

  The cosmetic composition according to the present invention comprises the fatty compound in an amount of 0.01% to 10% by weight, preferably 0.01% to 5% by weight, more preferably 0.01% to 1% by weight relative to the total weight of the composition. Can be included in quantity.

  The fatty compound can be combined with a fatty acid such as stearic acid or myristic acid and a higher alcohol such as cetyl alcohol, stearyl alcohol or octyldodecanol.

  The cosmetic composition according to the present invention is preferably intended for skin whitening.

  The whitening cosmetic composition of the present invention is a topical composition for applying to the human body surface for the purpose of whitening, preferably a cosmetic composition for topical application to the skin. The term “whitening” means any effect that suppresses the production and / or deposition of melanin, including the inhibition of melanin production and reduction of the produced melanin, as well as the color thinning.

  In addition to kojic acid, the cosmetic composition according to the invention may further comprise at least one additional whitening active ingredient.

  Examples of the above-mentioned additional whitening active ingredients include, for example, ascorbic acid or a derivative thereof, tranexamic acid or a derivative thereof, resorcinol or a derivative thereof, alkoxysalicylic acid or a salt thereof, adenosine phosphoric acid or a salt thereof, hydroquinone or a glycoside thereof, or Derivatives such as glutathione, 4- (4-hydroxyphenyl) -2-butanol, magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol), placenta extract, and chamomilla recutita be able to.

  Ascorbic acid includes D-form and L-form, and it is preferable to use L-form. Ascorbic acid is also called vitamin C and has the effect of suppressing the production of melanin by the strong reducing effect of ascorbic acid. The derivative of ascorbic acid may be a salt of ascorbic acid, and the salt of ascorbic acid is preferably selected from sodium ascorbate, magnesium ascorbyl phosphate and sodium ascorbyl phosphate. The derivative of ascorbic acid may be a glycoside of ascorbic acid or an ester of ascorbic acid. As an example of a glycoside of ascorbic acid, for example, ascorbyl glucoside can be mentioned. Examples of esters of ascorbic acid include silyl ascorbate, tocopheryl ascorbate and alkyl ascorbate. As alkyl ascorbate, it is preferable to use methyl ascorbate or ethyl ascorbate. In particular, ascorbyl glucoside is preferred. Ascorbic acid or a derivative thereof can be used alone or in combination of two or more thereof.

  Detailed examples of derivatives of ascorbic acid include, for example, 5,6-di-O-dimethylsilylascorbate commercially available as PRO-AA from Exsymol SAM; dl-commercially available as SEPIVITAL EPC from Senju Pharmaceutical Co., Ltd. α-tocopheryl-2-l-ascorbyl phosphate; sodium ascorbyl phosphate commercially available as Stay-C 50 from Roche; ascorbylglucoside commercially available from Hayashibara Biochemical Laboratories; 3-O-ethylascorbine An acid etc. can be mentioned.

  Ascorbic acid or a derivative thereof is preferably used in combination with a copolymer of styrene and maleic anhydride. In particular, it is preferable that at least a part of the maleic anhydride unit of the copolymer is hydrolyzed. The hydrolyzed maleic anhydride unit may be in the form of an alkali salt such as sodium salt, potassium salt or lithium salt. The maleic anhydride units preferably occupy 0.4 to 0.9 moles per mole of the entire copolymer, and the ratio of maleic anhydride units to styrene units is preferably 50:50. In particular, the ratio of maleic anhydride units to styrene units is 50:50, and it is preferable to use ammonium salts or sodium salts. By using ascorbic acid or a derivative thereof in combination with the above copolymer, the stability of ascorbic acid or a derivative thereof is improved. For example, a copolymer of styrene and maleic anhydride in the form of a 30% ammonium salt dissolved in water, commercially available from Atofina Chemicals Inc. as product number SMA 1000 HTM 50), or a copolymer of styrene and maleic anhydride, commercially available from Atofina Chemicals Inc. as product number SMA 1000 H NaTM, in the form of a 40% sodium salt dissolved in water (50/50 ) Can be used. The copolymer is used at a concentration in the range of 0.1 to 20% by weight, preferably in the range of 0.1 to 10% by weight, based on the total weight of the whitening agent for topical application.

  Examples of derivatives of tranexamic acid include dimers of tranexamic acid (such as trans-4- (trans-aminomethylcyclohexanecarbonyl) aminomethylcyclohexanecarboxylic acid), ester of tranexamic acid and hydroquinone (4'-hydroxyphenyl trans -4-aminomethylcyclohexanecarboxylate), esters of tranexamic acid and gentisic acid (2- (trans-4-aminomethylcyclohexanecarbonyloxy) -5-hydroxybenzoic acid and its salts), amides of tranexamic acid (trans-4-aminomethylcyclohexanecarboxylic acid methylamide and its salt, trans-4- (p-methoxybenzoyl) aminomethylcyclohexanecarboxylic acid and its salt, and trans-4-guanidinomethylcyclohexanecarboxylic acid and its salt), etc. Can be mentioned.

  Examples of resorcinol derivatives include, for example, 4-n-butylresorcinol (lucinol).

  Alkoxysalicylic acid is a compound in which any one of the hydrogen atoms at the 3-position, 4-position or 5-position of salicylic acid is substituted with an alkoxy group. The aforementioned alkoxy group is preferably any one of a methoxy group, an ethoxy group, a propoxy group, an isopropoxy group, a butoxy group and an isobutoxy group, and more preferably a methoxy group or an ethoxy group. Specific examples of such compounds include, for example, 3-methoxysalicylic acid, 3-ethoxysalicylic acid, 4-methoxysalicylic acid, 4-ethoxysalicylic acid, 4-propoxysalicylic acid, 4-isopropoxysalicylic acid, 4-butoxysalicylic acid, 5-methoxy Examples include salicylic acid, 5-ethoxysalicylic acid, and 5-propoxysalicylic acid. The salt of alkoxysalicylic acid is not particularly limited. Examples thereof include alkali metal salts or alkaline earth metal salts such as sodium salts, potassium salts, calcium salts, ammonium salts, amino acid salts, and the like. The potassium salt of 4-methoxysalicylic acid is preferred.

  Examples of adenosine phosphate or a salt thereof include, for example, disodium adenosine phosphate.

  Examples of hydroquinone glycosides include, for example, hexose glycosides such as hydroquinone α-D-glucose, hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α- D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, etc .; pentose glycosides such as hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α -L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-arabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, etc .; amino sugar glycosides such as hydroquinone α -D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L-gluco , Hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, etc .; urocanic acid glycosides such as hydroquinone α-D-glucuronic acid, hydroquinone β-D -Glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L-galacturon And the like; and others. Among these compounds, hydroquinone β-D-glucose (hereinafter referred to as “arbutin”) is preferable. Examples of hydroquinone or a derivative of its glycoside include hydroquinone or a salt of its glycoside. In particular, examples of arbutin derivatives include 6-O-caffeoyl arbutin.

  As an additional whitening active ingredient, L-ascorbic acid or a derivative thereof, tranexamic acid or a derivative thereof, arbutin or a derivative thereof, and lucinol are preferable, and an ascorbic acid glycoside such as L-ascorbic acid glucoside is more preferable.

  The amount of additional whitening active ingredient blended into the topical whitening agent of the present invention is not particularly limited and is typically 0.01 to 20% by weight based on the total weight of the topical whitening agent. The range is preferably 0.01 to 15% by weight, more preferably 0.01 to 10% by weight.

  In the cosmetic composition according to the present invention, in addition to the above essential components (A), (B) and (C) and the above additional components, components usually used in cosmetics, particularly water-soluble polymers, acids , Bases, salts, pigments, antioxidants, UV absorbers, whitening agents, blood circulation promoters, sequestering agents, sebum regulators, powders, astringents, emollients, surfactants other than the above component (B) Agents, oils, organic solvents, silicones, silicone derivatives, natural extracts derived from animals or plants, waxes and the like can be appropriately selected and used within a range that does not impair the effects of the present invention.

  The form of the cosmetic composition is not particularly limited, and may take various forms such as a W / O emulsion, an O / W emulsion, an aqueous gel, and an aqueous solution. Furthermore, the cosmetic composition may be any of skin cosmetics, hair cosmetics, finishing cosmetics, cleaning cosmetics, nail cosmetics, cosmetics for use on mucous membranes such as lips, etc., but skin cosmetics are preferred. . The cosmetic composition according to the present invention is preferably not in the form of an emulsion but in the form of an aqueous solution such as a lotion.

  When this invention is a lotion, it is preferable that the above-mentioned lotion is transparent or has a uniform appearance. Here, the expression “transparent” means that light can pass through without causing any deflection due to refraction or reflection. The transparency of a composition such as lotion can be measured using a turbidimeter. For example, a portable turbidimeter model 2100 P ™ from Hach can be used to measure the transmission range of the composition. A composition can be considered transparent if the turbidity value measured for the composition is in the range of 0 to 250 NTU.

  The cosmetic composition according to the present invention can be used in a cosmetic treatment method comprising the step of applying the cosmetic composition onto the skin. This method is particularly suitable for removing brownish pigmentation spots caused by external factors such as ultraviolet radiation and / or spots caused by internal factors such as aging and / or Suitable for lightening the color of brown skin.

(Example)
The invention will be described in more detail through examples, but the following examples should not be construed to limit the scope of the invention.

(Examples 1 to 9 and Comparative Examples 1 to 4)
The following compositions according to Examples 1 to 9 and Comparative Examples 1 to 4 shown in Tables 1 and 2 were prepared in the following steps.
(a) heating the ingredients of phase A to about 80 ° C. and homogenizing with a propeller;
(b) heating the ingredients of phase B to about 60 ° C;
(c) cooling the mixture obtained in step (a) to about 60 ° C.,
(d) injecting phase B ingredients into the mixture of phase A ingredients after step (c);
(e) homogenizing the mixture obtained in step (d) with a propeller for 10 minutes;
(f) cooling the mixture obtained in step (e) to about 30 ° C .;
as well as
(g) Injecting the components of phase C and phase D into the mixture obtained in step (f).

  The stability of Examples 1 to 9 and Comparative Examples 1 to 4 was observed at room temperature for 6 months and evaluated after 6 months according to the following criteria.

Good: stable (no sediment was observed)
X: Unstable (precipitation was observed)

  The results are shown in Tables 1 and 2.

  From Comparative Example 1, it is clear that the presence of kojic acid is responsible for destabilizing the composition. It is also clear that the combination of kojic acid and a selected nonionic surfactant stabilizes the composition, and other nonionic surfactants cannot stabilize the composition over time.

Claims (13)

Kojic acid,
Polyoxyethylenated (1 to 40 EO) and polyoxypropylene (1 to 30 PO) alkyl (C ₁₆ -C ₂₄₎ ethers, polyoxyethylenated (30 or 40 EO) hydrogenated castor oil, and polyoxyethylene At least one nonionic surfactant selected from the group consisting of conjugated (15-30 EO) mono- or tri-oleates;
70-95% water by weight with respect to the total weight of the composition
A cosmetic composition comprising 1% by weight or less of a fatty substance relative to the total weight of the composition. The polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C ₁₆ -C ₂₄ ) ethers are PPG-6 decyl tetradec-30, PPG-6 decyl tetradeces -12, PPG-13 decyltetradeceth-24, PPG-6 decyltetradeceth-20, PPG-4 ceteth-1, PPG-8 ceteth-1, PPG-4 ceteth-10, PPG-4 ceteth-20 The cosmetic composition of claim 1, wherein the cosmetic composition is selected from the group consisting of: PPG-5 ceteth-20, PPG-8 ceteth-20 and PPG-23 steareth-34. The polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C ₁₆ -C ₂₄ ) ethers are PPG-6 decyl tetradec-30, PPG-13 decyl tetradeces The cosmetic composition according to claim 2, selected from the group consisting of -24, PPG-6 decyltetradeceth-20, PPG-5 ceteth-20, PPG-8 ceteth-20 and PPG-23 steareth-34. . The polyoxyethylenated (1-40 EO) and polyoxypropylenated (1-30 PO) alkyl (C ₁₆ -C ₂₄ ) ethers are PPG-6 decyl tetradec-30, PPG-13 decyl tetradeces The cosmetic composition according to claim 3, selected from the group consisting of -24, PPG-5 ceteth-20, and PPG-8 ceteth-20. The cosmetic composition according to any one of claims 1 to 4, wherein the polyoxyethylenated (30 or 40 EO) hydrogenated castor oil is PEG-40 hydrogenated castor oil. The cosmetic composition according to any one of claims 1 to 5 , wherein the polyoxyethylenated (15-30 EO) mono- or tri-oleate is selected from the group consisting of polysorbate 80 and polysorbate 85. . The cosmetic composition according to claim 6 , wherein the polyoxyethylenated (15-30 EO) mono- or tri-oleate is polysorbate 80. It said non-ionic surfactant, relative to the total weight of the composition, is present in an amount of 0.01 wt% to 10 wt%, the cosmetic composition according to any one of claims 1 to 7. The kojic acid, relative to the total weight of the composition, is present in an amount of 0.01 wt% to 5 wt%, the cosmetic composition according to any one of claims 1 to 8. 10. The cosmetic composition according to any one of claims 1 to 9 , further comprising at least one fragrance. The perfume, relative to the total weight of the composition, is present in an amount of 0.01 wt% to 1 wt%, the cosmetic composition according to claim 10. The cosmetic composition according to any one of claims 1 to 11 , which is intended for skin whitening. A method for cosmetic treatment of skin, comprising a step of applying the cosmetic composition according to any one of claims 1 to 12 on the skin.