JP5259976B2 - Topical preparation - Google Patents

Description

  The present invention relates to an external preparation such as a cosmetic, particularly a lotion, with improved stability.

  As a moisturizing agent that has excellent feel and moisturizing properties and maintains moisture after washing, WO 2006/038724 and JP-A 2006-282539 disclose alkylene oxides represented by the following formula (I): Derivatives are described.

（式中、
Ｚは３〜９個の水酸基を有する化合物の水酸基を除いた残基を表し；
ＡＯは炭素数３〜４のオキシアルキレン基を表し；
ＥＯはオキシエチレン基を表し；
ＢＯは炭素数４のオキシアルキレン基を表し；
ａは３〜９を表し；
ｌ、ｍ及びｎは、それぞれ、ＡＯ、ＥＯ及びＢＯの平均付加モル数であって、１≦ｌ≦５０、１≦ｍ≦５０及び０．５≦ｎ≦５であり；
ＡＯとＥＯとの重量比（ＡＯ／ＥＯ）は１／５〜５／１であり；
ＡＯ及びＥＯはランダム状又はブロック状に付加していてもよい）

(Where
Z represents a residue excluding a hydroxyl group of a compound having 3 to 9 hydroxyl groups;
AO represents an oxyalkylene group having 3 to 4 carbon atoms;
EO represents an oxyethylene group;
BO represents a oxyalkylene group having 4 carbon atoms;
a represents 3-9;
l, m and n are the average added moles of AO, EO and BO, respectively, 1 ≦ l ≦ 50, 1 ≦ m ≦ 50 and 0.5 ≦ n ≦ 5;
The weight ratio of AO to EO (AO / EO) is 1/5 to 5/1;
(AO and EO may be added in random or block form)

The alkylene oxide derivative of the above formula (I) does not have a sticky feeling and provides a refreshing feel, and therefore can be suitably used as a base for various moisturizing cosmetics, particularly a lotion.
International Publication No. 2006/038724 Pamphlet JP 2006-282539 A

  However, external preparations such as cosmetics containing an alkylene oxide derivative of the above formula (I), especially lotion, have poor stability over time, and are repeatedly exposed to cycles of rising and falling temperatures for several days to several tens of days. There is a problem that becomes unstable. In particular, in the case of lotion, the transparency and appearance uniformity are lost and the commercial value is significantly impaired.

  The above problem is remarkable when a fragrance and / or vitamin E or a derivative thereof is present together with the alkylene oxide derivative of the above formula (I).

  Therefore, there is a demand for solving the above-mentioned problems peculiar to external preparations such as the above-mentioned alkylene oxide derivatives of formula (I), perfumes and / or vitamin E or derivatives thereof, and cosmetics containing water.

  Accordingly, an object of the present invention is to provide a time-dependent application of an external preparation such as a cosmetic containing the alkylene oxide derivative of the above formula (I), a fragrance and / or vitamin E or a derivative thereof, and water, and optionally other vitamins. It is to provide a topical preparation that is stable against temperature change history. In particular, when the external preparation is a cosmetic, particularly a lotion, the present invention aims to maintain the transparency and uniformity of appearance over a long period of time.

（式中、
Ｚは３〜９個の水酸基を有する化合物の水酸基を除いた残基を表し；
ＡＯは炭素数３〜４のオキシアルキレン基を表し；
ＥＯはオキシエチレン基を表し；
ＢＯは炭素数４のオキシアルキレン基を表し；
ａは３〜９を表し；
ｌ、ｍ及びｎは、それぞれ、ＡＯ、ＥＯ及びＢＯの平均付加モル数であって、１≦ｌ≦５０、１≦ｍ≦５０及び０．５≦ｎ≦５であり；
ＡＯとＥＯとの重量比（ＡＯ／ＥＯ）は１／５〜５／１であり；
ＡＯ及びＥＯはランダム状又はブロック状に付加していてもよい）
で表される少なくとも１つのアルキレンオキシド誘導体、
（ｃ）２５〜３５のオキシエチレン単位及び４〜８のオキシプロピレン単位を有する、少なくとも１つのポリオキシエチレンポリオキシプロピレンアルキルエーテル、及び、
（ｄ）香料及び／又はビタミンＥ若しくはその誘導体
を含む外用剤によって達成される。 The purpose of the present invention is to
(A) an aqueous medium,
(B) The following formula (I):

(Where
Z represents a residue excluding a hydroxyl group of a compound having 3 to 9 hydroxyl groups;
AO represents an oxyalkylene group having 3 to 4 carbon atoms;
EO represents an oxyethylene group;
BO represents a oxyalkylene group having 4 carbon atoms;
a represents 3-9;
l, m and n are the average added moles of AO, EO and BO, respectively, 1 ≦ l ≦ 50, 1 ≦ m ≦ 50 and 0.5 ≦ n ≦ 5;
The weight ratio of AO to EO (AO / EO) is 1/5 to 5/1;
(AO and EO may be added in random or block form)
At least one alkylene oxide derivative represented by:
(C) at least one polyoxyethylene polyoxypropylene alkyl ether having 25 to 35 oxyethylene units and 4 to 8 oxypropylene units, and
(D) Achieved by an external preparation containing a flavor and / or vitamin E or a derivative thereof.

  In the above formula (I), AO and EO may be added randomly, and AO is preferably an oxypropylene group. Furthermore, in the above formula (I), the compound having 3 to 9 hydroxyl groups is preferably glycerin.

  The component (c) preferably has a branched alkyl group having 20 to 28 carbon atoms, particularly 22 to 26 carbon atoms.

  The external preparation of the present invention can further contain vitamin C or a derivative thereof. However, in that case, the amount of the component (c) needs to be 0.3% or more based on the total weight of the external preparation.

  The external preparation of the present invention can be a cosmetic (cosmetic composition) or a skin external preparation.

  The present invention also relates to a cosmetic treatment method comprising applying the above external preparation to a keratin substance.

  According to the present invention, it is possible to improve the temporal stability of an external preparation such as a cosmetic containing the alkylene oxide derivative of the above formula (I), water, and a fragrance and / or vitamin E or a derivative thereof. An external preparation that is stable against history can be provided. Therefore, according to the present invention, an external preparation containing the alkylene oxide derivative of the above formula (I) together with water and a fragrance and / or vitamin E or a derivative thereof is stored for a long time even in an environment subject to a temperature change. be able to. In particular, when the external preparation is a lotion, the transparency and uniformity of appearance can be maintained over a long period of time.

  The external preparation of the present invention essentially contains (a) an aqueous medium. As the aqueous medium, water or an organic solvent miscible with water (normally water-miscible organic solvent) at normal temperature (25 ° C.) and a mixture of water can be used.

  Water may be aromatic distilled water such as cornflower water, and / or mineral water such as Vittel water, Lucas water, La Roche Posay water, and / or hot springs. It may be seawater such as water and / or deep seawater.

  The external preparation of the present invention contains water in the range of 50 to 99.5% by weight, preferably in the range of 60 to 99% by weight, more preferably in the range of 70 to 95% by weight, based on the total weight of the external preparation. be able to.

Examples of the organic solvent miscible with water at room temperature (25 ° C.) include the following.
Monoalcohols having 2 to 6 carbon atoms such as ethanol and isopropanol;
Polyols having 2 to 20 carbon atoms, preferably 2 to 10 carbon atoms, more preferably 2 to 6 carbon atoms, such as glycerin, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, di- Propylene glycol and diethylene glycol;
Glycol ethers (especially those having carbon atoms of 3 to 16), (e.g., mono -, di -, (C ₁ -C ₄₎ alkyl ethers of tripropylene glycol, and mono -, di -, tri (C ₁ -C ₄ ) alkyl ethers of ethylene glycol); and mixtures thereof.

  The external preparation of the present invention may contain the water-miscible organic solvent in an amount of 0.1 to 30% by weight, preferably 5 to 25% by weight, more preferably 10 to 20% by weight based on the total weight of the external preparation. Good.

（式中、
Ｚは３〜９個の水酸基を有する化合物の水酸基を除いた残基を表し；
ＡＯは炭素数３〜４のオキシアルキレン基を表し；
ＥＯはオキシエチレン基を表し；
ＢＯは炭素数４のオキシアルキレン基を表し；
ａは３〜９を表し；
ｌ、ｍ及びｎは、それぞれ、ＡＯ、ＥＯ及びＢＯの平均付加モル数であって、１≦ｌ≦５０、１≦ｍ≦５０及び０．５≦ｎ≦５であり；
ＡＯとＥＯとの重量比（ＡＯ／ＥＯ）は１／５〜５／１であり；
ＡＯ及びＥＯはランダム状又はブロック状に付加していてもよい）
で表される少なくとも１つのアルキレンオキシド誘導体をも必須に含むものである。 Moreover, the external preparation of this invention is (b) following formula (I):

(Where
Z represents a residue excluding a hydroxyl group of a compound having 3 to 9 hydroxyl groups;
AO represents an oxyalkylene group having 3 to 4 carbon atoms;
EO represents an oxyethylene group;
BO represents a oxyalkylene group having 4 carbon atoms;
a represents 3-9;
l, m and n are the average added moles of AO, EO and BO, respectively, 1 ≦ l ≦ 50, 1 ≦ m ≦ 50 and 0.5 ≦ n ≦ 5;
The weight ratio of AO to EO (AO / EO) is 1/5 to 5/1;
(AO and EO may be added in random or block form)
And at least one alkylene oxide derivative represented by the formula:

  In the alkylene oxide derivative represented by the formula (I), Z is a residue excluding the hydroxyl group of the compound having 3 to 9 hydroxyl groups, and a is the number of hydroxyl groups of the compound of Z and is 3 to 9. As a compound having 3 to 9 hydroxyl groups, for example, if a = 3, glycerin, trimethylolpropane, if a = 4, erythritol, pentaerythritol, sorbitan, alkylglycoside, diglycerin, a = 5 Examples include xylitol, dipentaerythritol, sorbitol, inositol if a = 6, sucrose, trehalose if a = 8, maltitol if a = 9, and mixtures thereof. Preferably, Z is a residue excluding the hydroxyl group of the compound having 3 to 6 hydroxyl groups, and satisfies 3 ≦ a ≦ 6. As the compound having 3 to 9 hydroxyl groups, glycerol and trimethylolpropane are preferable, and glycerol is particularly preferable. In addition, in a <= 2, there exists a tendency for the mixing | blending stability to an oil-based formulation to deteriorate that it is inferior to compatibility with oil-based components, such as fats and oils. When 10 ≦ a, a sticky feeling is generated.

  AO is an oxyalkylene group having 3 to 4 carbon atoms. Examples include oxypropylene group, oxybutylene group (oxy n-butylene group, oxyisobutylene group, oxy t-butylene group), oxytrimethylene group, oxytetramethylene group. Groups and the like. An oxypropylene group, an oxybutylene group, and more preferably an oxypropylene group.

  l is the average added mole number of AO, and 1 ≦ l ≦ 50, preferably 2 ≦ l ≦ 20. m is an average added mole number of EO, and 1 ≦ m ≦ 50, preferably 2 ≦ m ≦ 20. If l is 0, a sticky feeling is produced, and if it exceeds 50, the moisturizing effect is lowered. Further, if m is 0, the moisturizing effect is lowered, and if it exceeds 50, a sticky feeling is produced.

  The weight ratio (AO / EO) between AO and EO is 1/5 to 5/1, preferably 1/4 to 4/1. If it is less than 1/5, a sticky feeling is produced, and if it is greater than 5/1, the moisturizing feeling is lowered. The order in which AO and EO are added is not particularly specified, and they may be added in blocks or randomly. In order to obtain a more excellent rough skin prevention effect, those added randomly are preferable.

  BO is an oxyalkylene group having 4 carbon atoms, and examples thereof include an oxybutylene group (oxy n-butylene group, oxyisobutylene group, oxy t-butylene group), an oxytetramethylene group, and the like. An oxybutylene group is preferred.

n is the average added mole number of BO, 0.5 <n ≦ 5, preferably 0.8 ≦ n ≦ 3, and more preferably 1 ≦ n ≦ 3. If it is 0.5 or less, a sticky feeling is produced, and if it exceeds 5, the moisturizing feeling is lowered. In the formula (I), (BO) _n needs to be bonded to a terminal hydrogen atom.

  The alkylene oxide derivative represented by the formula (I) can be produced by a known method. For example, it can be obtained by subjecting a compound having 3 to 9 hydroxyl groups to addition polymerization of ethylene oxide and an alkylene oxide having 3 to 4 carbon atoms and then reacting the alkylene oxide having 4 carbon atoms. In addition, in the stage of addition polymerization of ethylene oxide and alkylene oxide having 3 to 4 carbon atoms to a compound having 3 to 9 hydroxyl groups, ethylene oxide and alkylene oxide may be randomly polymerized, or block polymerization. May be.

（式中、
Ｇｌｙはグリセリンから水酸基を除いた残基を表し；
ＰＯはオキシプロピレン基を表し；
ＥＯはオキシエチレン基を表し；
ｓおよびｔはそれぞれＰＯおよびＥＯの平均付加モル数であって、１〜５０の値であり、
ＰＯとＥＯとの質量比（ＰＯ／ＥＯ）は１／５〜５／１であって、
ＢＯは炭素数４のオキシアルキレン基を表し；
ｕはＢＯの平均付加モル数であって、０．５〜５の値である）
のアルキレンオキシド誘導体（ポリオキシブチレンポリオキシエチレンポリオキシプロピレングリセロール）が挙げられる。 Among the alkylene oxide derivatives represented by the formula (I), preferable alkylene oxide derivatives include, for example, the following formula (II):

(Where
Gly represents a residue obtained by removing a hydroxyl group from glycerin;
PO represents an oxypropylene group;
EO represents an oxyethylene group;
s and t are the average added moles of PO and EO, respectively, and have values of 1 to 50
The mass ratio of PO to EO (PO / EO) is 1/5 to 5/1,
BO represents a oxyalkylene group having 4 carbon atoms;
u is the average number of moles added of BO, and is a value of 0.5 to 5)
And alkylene oxide derivatives (polyoxybutylene polyoxyethylene polyoxypropylene glycerol).

  In the alkylene oxide derivative (a) of the formula (II), propylene oxide and ethylene oxide are added to glycerin at a ratio of 3 to 150 molar equivalents with respect to glycerin, respectively. It is obtained by adding at a ratio of 5 to 15 molar equivalents.

  When these alkylene oxides are added to glycerin, an addition reaction is performed using an alkali catalyst, a phase transfer catalyst, a Lewis acid catalyst, or the like. In general, it is preferable to use an alkali catalyst such as potassium hydroxide.

  Of the alkylene oxide derivatives represented by the formula (I), more preferred are those in which 6 to 10 mol of ethylene oxide and 3 to 7 mol of propylene oxide are added to glycerin, and then 2 to 4 mol of butylene oxide is added. It is a thing.

  Even more preferred among the alkylene oxide derivatives of formula (I) is polyoxybutylene in which 8 moles of ethylene oxide and 5 moles of propylene oxide are added to glycerin and then 3 moles of butylene oxide are added. It is polyoxyethylene polyoxypropylene glycerol and is called PEG / PPG / polybutylene glycol-8 / 5/3 glycerin under the INCI name. PEG / PPG / polybutylene glycol-8 / 5/3 glycerin is commercially available from Nippon Oil & Fat Co., Ltd. under the name WILBRIDE S-753.

  The blending amount of the alkylene oxide derivative represented by the formula (I) in the external preparation of the present invention is not particularly limited, but is usually 0.1 to 20% by weight based on the total weight of the external preparation. Preferably 0.1 to 10% by weight, more preferably 0.2 to 5% by weight.

The external preparation of the present invention is
(C) Essentially also contains at least one polyoxyethylene polyoxypropylene alkyl ether having 25 to 35 oxyethylene units and 4 to 8 oxypropylene units. If necessary, two or more polyoxyethylene polyoxypropylene alkyl ethers may be used.

The alkyl group of the component (c) _is preferably a C 1 -C ₃₀ alkyl group, more preferably a C ₁₀ -C ₃₀ alkyl group, _{C 20} -C ₂₈ alkyl group more preferred. The alkyl group is a linear or branched alkyl group, a cycloalkyl group, or a cycloalkylene group (a linear or branched alkylene group (preferably a C ₁ -C ₆ alkylene group such as a methylene group or an ethylene group). ) And a carbon ring (an alkyl group composed of a combination of C ₃ -C ₈ ring and the like).

As the linear or branched alkyl group, a linear or branched C ₁ -C ₃₀ alkyl group is preferable. For example, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, a butyl group, t- Examples thereof include a butyl group, a pentyl group, and a hexyl group. A linear or branched alkyl group having 20 to 28 carbon atoms is preferable, and a linear or branched alkyl group having 22 to 26 carbon atoms is more preferable. . As the cycloalkyl group is preferably a C ₄ -C ₃₀ alkyl group, for example, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group.

  Therefore, as the component (c), an alcohol having a branched alkyl group having 20 to 28 carbon atoms, preferably 22 to 26 carbon atoms, polyoxyethylene (25 to 35 EO) polyoxypropylene (4 to 8 PO). Ether is preferred. Particularly preferred as the component (c) is polyoxyethylene (30) polyoxypropylene (6) decyltetradecyl ether.

  As the component (c), a polyoxyethylene (30EO) polyoxypropylene (6PO) ether (polyoxyethylene (30)) of decyltetradecanol, particularly referred to as PPG-6 decyltetradeceth-30 under the INCI name. 30) Polyoxypropylene (6) decyl tetradecyl ether) is preferred. PPG-6 decyltetradeces-30 is the name of NIKKOL PEN-4630 and is commercially available from Nikko Chemicals.

  The blending amount of the component (c) in the external preparation of the present invention is not particularly limited, but is usually 0.01 to 10% by weight based on the total weight of the external preparation, preferably 0.05 to 5% by weight, more preferably 0.1 to 3% by weight.

  Furthermore, the external preparation of this invention contains a fragrance | flavor and / or vitamin E or its derivative (s).

  As perfumes, natural or synthetic fragrances and aromas, and mixtures thereof can be used.

  Naturally based fragrances and aromas include, for example, extracts from flowers (lily, lavender, rose, jasmine or ylang ylang), extracts from stems and extracts from leaves (patcholi, geranium or pettigrain), fruits Extract (coriander, anise, caraway or pepper), extract from pericarp (bergamot, lemon or orange), extract from root (angelica, celery, cardamom, iris or agate), extract from wood (pine) , Sandalwood, grasshopper or pink cedar), extracts from grass and grasses (tarragon, lemongrass, sage or mulberry), extracts from needles and branches Products (spruce, cinnamon, pine or dwarf pine), extracts from resins and Extracts from balsam include (galbanum, elemi, benzoin, myrrh, olibanum or opopanax) or the like.

  Synthetic fragrances and aromas include, for example, esters, ethers, aldehydes, ketones, aromatic alcohols and hydrocarbon type compounds.

  Specific examples of the ester include benzyl acetate, benzyl benzoate, phenoxyethyl isobutyrate, pt-butylcyclohexyl acetate, citronellyl acetate, citronellyl formate, geranyl acetate, linalyl acetate, dimethylbenzylcarbonyl acetate, phenylethyl acetate, benzoic acid Linalyl, benzyl formate, ethyl methyl phenyl glycinate, alkyl cyclohexyl propionate, styryl propionate, benzyl salicylate, and the like.

  Examples of the ether include benzyl ethyl ether.

  Examples of the aldehyde include straight-chain alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lyrial, and bourdiolal.

  Examples of the ketone include ionones such as α-isomethylionone and methyl cedryl ketone.

  Examples of the aromatic alcohol, particularly terpene alcohol, include anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol, and terpineol.

  Examples of the hydrocarbon type compound include terpenes. These compounds are often used in the form of a blend of two or more of these odorous substances.

  It is also possible to use essential oils as aroma components, for example, sage oil, camomil oil, clove oil, balsam oil, mint oil, cinnamon leaf oil, lime blossom oil, pepper oil, vetiver oil, olibanum oil, galvanum oil, labranum Oil, lavandin oil and the like are used.

  Furthermore, the following fragrance | flavors can be used individually or in a blend. Bergamot oil, dihydromyrsenol, lyral, rilal, citronellol, phenylethyl alcohol, α-hexyl cinnamaldehyde, geraniol, benzylacetone, cyclamenaldehyde, linalool, ambroxan, indole, hedione, sandelis, lemon oil, mandarin and Oils from orange, allylamine glycol, cyclobeltal, lavender oil, sage oil, β-damascone, geranium oil, cyclohexyl salicylate, phenylacetic acid, geranyl acetate, benzyl acetate or rose oxide can be used.

  According to a preferred embodiment of the present invention, various fragrances can be blended and used, thereby producing a fragrance generally favored by consumers.

  Although the compounding quantity of the fragrance | flavor to the external preparation of this invention is not specifically limited, Usually, it is 0.01 to 1 weight% on the basis of the total weight of an external preparation, Preferably it is 0.01 to 0.5 weight. %, More preferably 0.01 to 0.3% by weight.

  The derivative of vitamin E is not particularly limited, and examples thereof include tocopherol acetate.

  Although the compounding quantity of vitamin E or its derivative to the external preparation of this invention is not specifically limited, 0.01-5 weight% is preferable on the basis of the total weight of an external preparation.

  The external preparation of the present invention is a topical composition applied to the surface of a human body, and is preferably a cosmetic or an external preparation for skin. Here, the external preparation for skin should be applied onto the skin and can correspond to both dermatological drugs or quasi drugs. The external preparation of the present invention can be used, for example, as a humectant.

  The form of the cosmetic is not particularly limited, and may take any form such as a water-in-oil emulsified cosmetic, an oil-in-water emulsified cosmetic, an aqueous gel, an aqueous solution, and a multiple emulsion. Further, the cosmetic may be any of skin cosmetics, hair cosmetics, makeup cosmetics, cleansing cosmetics, nail cosmetics, and mucosal cosmetics such as lips. The present invention is particularly suitable as a lotion.

  When this invention is a lotion, it is preferable that the said lotion is transparent or the external appearance is uniform. Here, “transparent” means passing light without causing deflection due to refraction or reflection. The transparency of a composition such as lotion can be measured using a turbidimeter. The Hach portable turbidimeter model 2100P® can be used, for example, to measure the transparency limit of the composition. A composition is considered transparent when the measured turbidity is between 0 and 250 NTU.

  The external preparation of this invention can further contain vitamins other than vitamin E or its derivative (s), or those derivatives. As such vitamins that can be optionally blended, general-purpose ones can be used as components of external preparations such as vitamin A, vitamin B, vitamin C, vitamin D and the like. As vitamins contained in the external preparation of the present invention, vitamin C or a derivative thereof is preferable.

  The derivative of vitamin C is not particularly limited, and examples thereof include ascorbyl glucoside, ascorbyl phosphate Mg, and ascorbyl phosphate Na.

  The amount of vitamins or derivatives thereof that can be optionally added to the external preparation of the present invention is not particularly limited, but is preferably 0.01 to 5% by weight based on the total weight of the external preparation.

  When the external preparation of this invention contains vitamin C or its derivative (s), the compounding quantity of the said (c) component needs 0.3% or more on the basis of the total weight of an external preparation. If it is less than 0.3%, the stability of the (b) alkylene oxide derivative may be lowered.

  In addition to the essential components (a), (b), (c) and (d) and the vitamins or derivatives thereof, the external preparation of the present invention is usually used for external preparations such as cosmetics. Components used, specifically water-soluble polymers, acids, bases, salts, dyes, antioxidants, UV absorbers, whitening agents, blood circulation promoters, metal chelators, sebum suppressors, powders, astringents Agents, emollients, surfactants other than the above (c), oils, organic solvents, silicones, silicone derivatives, natural extracts derived from animals and plants, waxes and the like are appropriately selected and used within a range not impairing the effects of the present invention. be able to.

  The external preparation of the present invention, particularly a cosmetic, is used in a cosmetic treatment method including a step of applying to a keratin substance. A keratin substance is a substance containing keratin as a main constituent, and examples thereof include skin, hair, nails and lips. The beauty treatment method can be, for example, a moisturizing method for moisturizing the skin or mucous membrane.

  EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited to an Example.

[Reference Examples 1-3]
The skin lotions of Reference Examples 1 to 3 comprising the components shown in Table 1 below were prepared by the following method.
(1) Mix Phase B ingredients and stir until uniform.
(2) Mix Phase A ingredients, heat to 75 ° C., stir until uniform, then cool to room temperature.
(3) Add Phase B to Phase A and stir.
(4) Add Phase C and stir.

  Each lotion of Reference Example 1 to Reference Example 3 was subjected to a thermal stability test, and the appearance was visually observed. In the thermal stability test, each lotion was introduced into a transparent glass container, the container was maintained in an incubator at + 20 ° C. for 6 hours, cooled from + 20 ° C. to −20 ° C. over 6 hours, and −20 ° C. This cycle was repeated for 10 days under the condition of maintaining for 6 hours and heating from −20 ° C. to + 20 ° C. over 6 hours, and the appearance uniformity of each lotion after 10 days was visually observed. The results are also shown in Table 1. In addition, all the numerical values in Table 1 show weight%.

Polyoxyethylene hydrogenated castor oil (60EO): NIKKOL HCO60 (Nikko Chemicals Corporation)
Polyoxyethylene geomethyl glycolate (120EO): GLUCAMATE DOE 120 (NOVEON)
Polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin): WILBRIDE S-753 (Nippon Yushi Co., Ltd.)

  From the results shown in Table 1, the stability of the lotion over time is found under the condition where both polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin) and a fragrance are present. It turns out that an opaque part appears.

[Example 1] and [Comparative Examples 1 to 7]
The skin lotions of Example 1 and Comparative Examples 1 to 7 comprising the components shown in Table 2 below were prepared by the following method.
(1) Mix Phase B ingredients and stir until uniform.
(2) Mix Phase A ingredients, heat to 75 ° C., stir until uniform, then cool to room temperature.
(3) Add Phase B to Phase A and stir.
(4) Add Phase C and stir.

  About each lotion of Example 1 and Comparative Examples 1-7, the heat stability test similar to the above was done, and the external appearance was observed visually. The results are also shown in Table 2. In addition, all the numerical values in Table 2 indicate weight%.

Polyoxyethylene (30) Polyoxypropylene (6) Decyltetradecyl ether (PPG-6 Decyltetradec-30): NIKKOL PEN-4630 (Nikko Chemicals Corporation)
Polyoxyethylene hydrogenated castor oil (60EO): NIKKOL HCO60 (Nikko Chemicals Corporation)
Polyoxyethylene geoleoic acid methyl glucoside (120EO): GLUCAMATE DOE 120 (NOVEON)
POLOXAMER 124: SYNPERONIC PE-L 44 (UNIQEMA AMERICA)
Polyglutamic acid isostearic acid polyoxyethylene glyceryl (PCA isostearic acid glyceres-25): PYROTER GPI-25 (Ajinomoto USA)
Polyoxyethylene oleyl ether (Oles-20): BRIJ 98V (UNIQEMA)
Polyoxyethylene (20) Polyoxypropylene (6) Decyltetradecyl ether (PPG-6 Decyltetradec-20): NIKKOL PEN 4620 (Nikko Chemicals Corporation)
Polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin): WILBRIDE S-753 (Nippon Yushi Co., Ltd.)

  From the results shown in Table 2, under the conditions where polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin) is present together with the fragrance, polyoxyethylene (30) polyoxy It can be seen that only propylene (6) decyl tetradecyl ether (PPG-6 decyl tetradeces-30) provides a transparent and uniform lotion.

[Example 2] and [Comparative Example 8]
The skin lotions of Example 2 and Comparative Example 8 comprising the components shown in Table 3 below were prepared by the same operation as in Example 1, and the thermal stability test similar to the above was performed, and the appearance was visually observed. . The results are also shown in Table 3. In addition, all the numerical values in Table 3 show weight%.

Polyoxyethylene (30) Polyoxypropylene (6) Decyltetradecyl ether (PPG-6 Decyltetradec-30): NIKKOL PEN-4630 (Nikko Chemicals Corporation)
Polyoxyethylene hydrogenated castor oil (60EO): NIKKOL HCO60 (Nikko Chemicals Corporation)
Polyoxyethylene geoleoic acid methyl glucoside (120EO): GLUCAMATE DOE 120 (NOVEON)
Polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin): WILBRIDE S-753 (Nippon Yushi Co., Ltd.)

  From the results shown in Table 3, under the conditions where polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin) is present, vitamin E derivative (tocopheryl acetate) is used instead of the fragrance. In addition, the stability of the skin lotion deteriorates, and only polyoxyethylene (30) polyoxypropylene (6) decyltetradecyl ether (PPG-6 decyltetradeceth-30) is transparent and uniform. It turns out that it brings about a lotion.

[Examples 3 to 4] and [Comparative Example 9]
The skin lotion of Example 3 and Example 4 which consists of a component shown in the following Table 4, and the comparative example 9 was prepared with the following method.
(1) Dissolve ascorbic acid glucoside in a portion of water and add potassium hydroxide to prepare Phase B.
(2) Mix all ingredients of Phase C and stir until uniform.
(3) Mix Phase A ingredients, heat to 75 ° C., stir until uniform, then cool to room temperature.
(4) Add Phase B to Phase A and stir.
(5) Add more Phase C and stir.
(6) Add more phase D and stir.

  About each lotion of Examples 3-4 and Comparative Example 9, the same thermal stability test as the above was done, and the external appearance was visually observed. The results are also shown in Table 4. In addition, all the numerical values in Table 4 show weight%.

Polyoxyethylene (30) Polyoxypropylene (6) Decyltetradecyl ether (PPG-6 Decyltetradec-30): NIKKOL PEN-4630 (Nikko Chemicals Corporation)
Polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin): WILBRIDE S-753 (Nippon Yushi Co., Ltd.)

  From the results in Table 4, when a vitamin C derivative (ascorbic acid glucoside) is used, a condition in which polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin) exists is present. Then, when the blending amount of polyoxyethylene (30) polyoxypropylene (6) decyltetradecyl ether (PPG-6 decyltetradeces-30) blended as a surfactant is 0.3% by weight or more It can be seen that only a clear and uniform lotion results.

Claims (7)

(A) an aqueous medium,
(B) The following formula (I):

(Where
Z represents a residue excluding the hydroxyl group of glycerin ;
AO represents an oxyalkylene group having 3 to 4 carbon atoms;
EO represents an oxyethylene group;
BO represents a oxyalkylene group having 4 carbon atoms;
a represents 3 ;
l, m and n are the average added moles of AO, EO and BO, respectively, 1 ≦ l ≦ 50, 1 ≦ m ≦ 50 and 0.5 ≦ n ≦ 5;
The weight ratio of AO to EO (AO / EO) is 1/5 to 5/1;
(AO and EO may be added in random or block form)
At least one alkylene oxide derivative represented by:
(C) at least one polyoxyethylene polyoxypropylene alkyl ether having 25 to 35 oxyethylene units and 4 to 8 oxypropylene units, and
(D) An external preparation containing a fragrance and / or vitamin E or a derivative thereof (however, when containing vitamin C or a derivative thereof, the amount of the component (c) is 0.3% based on the total weight of the external preparation) That's it) The external preparation according to claim 1, wherein in the formula (I), AO and EO are randomly added. The external preparation according to claim 1 or 2, wherein in the formula (I), AO is an oxypropylene group. The external preparation according to any one of claims 1 to 3 , wherein the component (c) has a branched alkyl group having 20 to 28 carbon atoms. The external preparation according to any one of claims 1 to 4 , further comprising vitamin C or a derivative thereof, wherein the amount of the component (c) is 0.3% or more based on the total weight of the external preparation. The external preparation according to any one of claims 1 to 5 , which is a cosmetic or an external preparation for skin. A cosmetic treatment method comprising applying the external preparation according to any one of claims 1 to 6 to a keratin substance.