CN101288629B - External Preparation - Google Patents
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- CN101288629B CN101288629B CN2008100853672A CN200810085367A CN101288629B CN 101288629 B CN101288629 B CN 101288629B CN 2008100853672 A CN2008100853672 A CN 2008100853672A CN 200810085367 A CN200810085367 A CN 200810085367A CN 101288629 B CN101288629 B CN 101288629B
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Abstract
The invention provides an external agent comprising particular oxyalkylene derivatives and perfumes and/or vitamin E or other derivatives and having improved time-through stability and steady process of temperature change. Under the situation that the external agent is the water in particular, transparency and uniformity can be preserved in a long term. At least one polyoxyethylene polyoxypropylene alkyl ether having 25 to 35 oxygen ethylene units and 4 to 8 oxygen propylidene units is coexistent.
Description
Technical field
The present invention relates to external agent such as stable improved cosmetics, particularly astringent.
Background technology
After possessing excellent sense of touch and moisture retention, washing, also keep moistening wetting agent, in No. 2006/038724 pamphlet of International Publication and TOHKEMY 2006-282539 communique, disclose the oxyalkylene derivative of following formula (I) expression.
[changing 1]
Z-{O(AO)
l(EO)
m-(BO)
nH}
a (I)
(in the formula, Z representes to remove the residue that the hydroxyl of the chemical compound with 3～9 hydroxyls obtains;
AO representes that carbon number is 3～4 oxyalkylene;
EO representes the oxygen ethylidene;
BO representes that carbon number is 4 oxyalkylene;
A representes 3～9;
L, m and n are respectively the average addition molal quantitys of AO, EO and BO, 1≤l≤50,1≤m≤50 and 0.5≤n≤5;
The weight ratio of AO and EO (AO/EO) is 1/5～5/1;
AO and EO can add becomes random shape or block-wise)
The oxyalkylene derivative of following formula (I) brings salubrious sense of touch and the sense of not being clamminess, therefore suitable base as various moisture-keeping cosmetics, particularly astringent.
No. 2006/038724 pamphlet of patent documentation 1 International Publication
Patent documentation 2 TOHKEMY 2006-038724 communiques
Summary of the invention
But, contain the external agent such as cosmetics of the oxyalkylene derivative of following formula (I), particularly astringent lacks ageing stability, if be exposed to repeatedly in the circulation of rising, decline of temperature, the problem of unstable that in several days～tens days, becomes is arranged then.Particularly under the situation of astringent, the uniformity of its transparency, outward appearance is lost, and commodity value is significantly impaired.
The problems referred to above are remarkable under the situation of the oxyalkylene derivative coexistence of spice and/or vitamin E or derivatives thereof and following formula (I).
Therefore, need to solve distinctive the problems referred to above of external agent such as cosmetics of the oxyalkylene derivative, spice and/or vitamin E or derivatives thereof and the water that contain following formula (I).
Therefore; The object of the present invention is to provide and improve oxyalkylene derivative, spice and/or the vitamin E or derivatives thereof contain following formula (I) and water and the ageing stability of the external agent such as cosmetics of other vitamins arbitrarily, to the stable external agent of variations in temperature resume.Be under the situation of cosmetics, especially astringent particularly, the objective of the invention is to keep for a long time the uniformity of its transparency, outward appearance in above-mentioned external agent.
The object of the invention is reached by the external agent that contains following composition:
(a) aqueous medium,
(b) at least a oxyalkylene derivative of following formula (I) expression,
[changing 2]
Z-{O(AO)
l(EO)
m-(BO)
nH}
a (I)
(in the formula, Z representes to remove the residue that the hydroxyl of the chemical compound with 3～9 hydroxyls obtains;
AO representes that carbon number is 3～4 oxyalkylene;
EO representes the oxygen ethylidene;
BO representes that carbon number is 4 oxyalkylene;
A representes 3～9;
L, m and n are respectively the average addition molal quantitys of AO, EO and BO, 1≤l≤50,1≤m≤50 and 0.5≤n≤5;
The weight ratio of AO and EO (AO/EO) is 1/5～5/1;
AO and EO can add becomes random shape or block-wise)
(c) have 25～35 oxygen ethylidene unit and 4～8 unitary at least one polyoxyethylene polyoxy-propylene of oxygen propylidene and
(d) spice and/or vitamin E or derivatives thereof.
In following formula (I), AO and EO can add becomes random shape, and in addition, preferred AO is the oxygen propylidene.And in following formula (I), the above-claimed cpd that preferably has 3～9 hydroxyls is a glycerol.
(c) composition has preferably that carbon number is 20～28, particularly carbon number is 22～26 branched alkyl.
External agent of the present invention can also contain the vitamin C or derivatives thereof.But in this case, the use level of above-mentioned (c) composition is that benchmark is necessary for more than 0.3% with the gross weight of external agent.
External agent of the present invention is cosmetics (cosmetic composition) or skin preparations for extenal use.
In addition, the invention still further relates to the cosmetic treatments method, this method is included in the above-mentioned external agent of coating on the keratin substances.
According to the present invention, the ageing stability of the external agent such as cosmetics that improve oxyalkylene derivative, water and the spice contain following formula (I) and/or vitamin E or derivatives thereof can be provided, particularly to the stable external agent of variations in temperature resume.Therefore, even the present invention is receiving under the environment of variations in temperature, also can long preservation contain the external agent of oxyalkylene derivative, water and spice and/or the vitamin E or derivatives thereof of following formula (I) simultaneously.Special is under the situation of astringent in above-mentioned external agent, can keep the uniformity of its transparency, outward appearance for a long time.
The specific embodiment
External agent of the present invention must contain (a) aqueous medium.As aqueous medium, can make water, perhaps descend the mixture that blended organic solvent (water Combination organic solvent) and water are arranged with glassware for drinking water at room temperature (25 ℃).
Water also can be the water of fragrant distilled water such as the water of Centaurea cyanus and/or Sebastian Vettel (Vittel), the water of Lucas (Lucas), the mineral water and/or the sea water such as thermal water and/or deep seawater such as water of reason skin spring (La Roche Posay).
With respect to the gross weight of external agent, external agent of the present invention contains the water of 50～99.5 weight % scopes, preferred 60～99 weight % scopes, further preferred 70～95 weight % scopes.
As following glassware for drinking water to blended organic solvent is arranged, for example can enumerate following organic solvent at room temperature (25 ℃):
Ethanol, isopropyl alcohol etc. have the unary alcohol of 2～6 carbon atoms;
Have 2～20 carbon atoms, preferred 2～10 carbon atoms, the more preferably polyalcohols of 2～6 carbon atoms, for example glycerol, propylene glycol, butanediol, pentanediol, hexanediol, dipropylene glycol and diethylene glycol;
Glycol ethers (particularly having 3～16 carbon atoms), the ((C of propylene glycol, dipropylene glycol, tripropylene glycol for example
1-C
4) alkyl ether and single-, two-, (C of triethylene glycol
1-C
4) alkyl ether); With
Their mixture.
With respect to the gross weight of external agent, external agent of the present invention can contain 0.1～30 weight %, preferred 5～25 weight %, the more preferably above-mentioned water Combination organic solvent of 10～20 weight %.
In addition, external agent of the present invention also must contain at least one oxyalkylene derivative of (b) following formula (I) expression:
[changing 3]
Z-{O(AO)
l(EO)
m-(BO)
nH}
a (I)
(in the formula,
Z representes to remove the residue that the hydroxyl of the chemical compound with 3～9 hydroxyls obtains;
AO representes that carbon number is 3～4 oxyalkylene;
EO representes the oxygen ethylidene;
BO representes that carbon number is 4 oxyalkylene;
A representes 3～9;
L, m and n are respectively the average addition molal quantitys of AO, EO and BO, 1≤l≤50,1≤m≤50 and 0.5≤n≤5;
The weight ratio of AO and EO (AO/EO) is 1/5～5/1;
AO and EO can add becomes random shape or block-wise).
In the oxyalkylene derivative of formula (I) expression, Z removes the residue that the hydroxyl of the chemical compound with 3～9 hydroxyls obtains, and a is the hydroxyl value of the chemical compound of Z, is 3～9.As chemical compound with 3～9 hydroxyls, glycerol, trimethylolpropane in the time of can enumerating a=3 for example; Erythritol during a=4, tetramethylolmethane, sorbitan, alkyl glycocide, diglycerol; Xylitol during a=5; Dipentaerythritol during a=6, Sorbitol, inositol; Sucrose during a=8, trehalose; Maltose alcohol during a=9 and their mixture etc.Preferred Z removes the residue that the hydroxyl of the chemical compound with 3～6 hydroxyls obtains, and satisfies 3≤a≤6.As chemical compound with 3～9 hydroxyls, preferably glycerine, trimethylolpropane, special preferably glycerine.Be noted that in a≤2 o'clock that it is poor to exist with the compatibility of oiliness composition such as oils and fats, the tendency of the fitment stability deterioration in Oily preparation.When 10≤a, produce the sense of being clamminess.
AO is that carbon number is 3～4 oxyalkylene, can enumerate for example oxygen propylidene, oxygen butylidene (the inferior normal-butyl of oxygen, oxygen isobutylidene, the inferior tert-butyl group of oxygen), oxygen trimethylene, oxygen tetramethylene etc.Preferred oxygen propylidene, oxygen butylidene, more preferably oxygen propylidene.
L is the average addition molal quantity of AO, satisfies 1≤l≤50, preferably satisfies 2≤l≤20.M is the average addition molal quantity of EO, satisfies 1≤m≤50, preferably satisfies 2≤m≤20.If l is 0, then produce the sense of being clamminess, if surpass 50, then moistening effect reduces.In addition, if m is 0, then moistening effect reduces, if surpass 50, then produces the sense of being clamminess.
The weight ratio of AO and EO (AO/EO) is 1/5～5/1, preferred 1/4～4/1.If littler than 1/5, then produce the sense of being clamminess, if bigger than 5/1, the sense of then preserving moisture reduces.Addition to AO and EO does not have special appointment in proper order, and both can add becomes block-wise, and also can add becomes random shape.In order to obtain more excellent anti-pachylosis effect, preferably adding becomes random shape.
BO is that carbon number is 4 oxyalkylene, can enumerate for example oxygen butylidene (the inferior normal-butyl of oxygen, oxygen isobutylidene, the inferior tert-butyl group of oxygen), oxygen tetramethylene etc.The preferred oxygen butylidene.
N is the average addition molal quantity of BO, satisfies 0.5＜n≤5, preferred 0.8≤n≤3, more preferably 1≤n≤3.If be below 0.5, then produce the sense of being clamminess, if surpass 5, the sense of then preserving moisture reduces.In addition, in formula (I), (BO)
nMust be bonded on the terminal hydrogen atom.
Can make the oxyalkylene derivative of formula (I) expression with known method.For example, after addition polymerization ethylene oxide and carbon number are 3～4 oxyalkylene on the chemical compound with 3～9 hydroxyls, with carbon number be that 4 reactions of alkylene oxide obtains.In addition, addition polymerization ethylene oxide and carbon number are the stage of 3～4 oxyalkylene on the chemical compound with 3～9 hydroxyls, both can be with ethylene oxide and oxyalkylene atactic polymerization, and also can block polymerization.
In the oxyalkylene derivative of formula (I) expression; As preferred above-mentioned oxyalkylene derivative, can enumerate the for example oxyalkylene derivative of following formula (II) (polyoxy butylene polyoxyethylene polyoxypropylene glycerol (polyoxybutylenepolyoxyethylenepolyoxypropyleneglycerol)):
[changing 4]
Gly-[O(PO)
s(EO)
t-(BO)
uH]
3 (II)
(in the formula, Gly representes to remove the residue that hydroxyl obtains from glycerol;
PO representes the oxygen propylidene;
EO representes the oxygen ethylidene;
S and t are respectively the average addition molal quantity of PO and EO, are 1～50 value,
The mass ratio of PO and EO (PO/EO) is 1/5～5/1,
BO representes that carbon number is 4 oxyalkylene;
U is the average addition molal quantity of BO, is 0.5～5 value)
The oxyalkylene derivative (a) of formula (II) can obtain as follows: with propylene oxide and ethylene oxide respectively with after with respect to glycerol being the ratio and glycerol addition of 3～150 molar equivalents, being that the ratio addition carbon number of 1.5～15 molar equivalents is 4 oxyalkylene with respect to glycerol.
Under situation, use base catalyst, phase transfer catalyst, lewis acid catalyst etc. to carry out additive reaction with these oxyalkylenes and glycerol addition.Base catalysts such as usually preferred potassium hydroxide.
In the oxyalkylene derivative of formula (I) expression, further preferably behind the propylene oxide and glycerol addition with 6～10 moles ethylene oxide and 3～7 moles, the butylene oxide that addition is 2～4 moles obtains.
In the oxyalkylene derivative of formula (I) expression; Further more preferably behind the propylene oxide and glycerol addition with 8 moles ethylene oxide and 5 moles; The polyoxy butylene polyoxyethylene polyoxypropylene glycerol that the butylene oxide that addition is 3 moles obtains, the INCI name is called PEG/PPG/ polytetramethylene glycol-8/5/3 glycerol.PEG/PPG/ polytetramethylene glycol-8/5/3 glycerol is commercially available by NOF Corp with the title of WILBRIDE S-753.
Use level to the oxyalkylene derivative of (a) formula (I) in the external agent of the present invention expression does not have special qualification, and the gross weight with the external agent is a benchmark usually, is 0.1～20 weight %, preferred 0.1～10 weight %, more preferably 0.2～5 weight %.
In addition, external agent of the present invention also must contain (c) and has 25～35 oxygen ethylidene unit and 4～8 unitary at least one polyoxyethylene polyoxy-propylene of oxygen propylidene.As required, also can use polyoxyethylene polyoxy-propylene more than 2 kinds.
As the alkyl of above-mentioned (c) composition, preferred C
1-C
30Alkyl, more preferably C
10-C
30Alkyl, further more preferably C
20-C
28Alkyl.The preferred straight or branched alkyl of alkyl, cycloalkyl or the ring alkylidene (alkylidene (C such as preferred methylene, ethylidene that comprise straight or branched
1-C
6Alkylidene) and carbocyclic ring (C
3-C
8The alkyl of combination ring etc.)) any one in.
As straight chain shape or branched-chain alkyl, preferred straight chain shape or branched C
1-C
30Alkyl can be enumerated for example methyl, ethyl, n-pro-pyl, isopropyl, butyl, the tert-butyl group, amyl group, hexyl etc., and preferred carbon number is 20～28 straight chain shape or branched-chain alkyl, and more preferably carbon number is 22～26 straight chain shape or branched-chain alkyl.As cycloalkyl, preferred C
4-C
30Alkyl can be enumerated for example cyclobutyl, cyclopenta, cyclohexyl etc.
Polyoxyethylene (25～35EO) polyoxypropylenes (4～8PO) ethers of the alcohol that therefore,, preferably have carbon number and be 20～28, preferred carbon number is 22～26 branched-chain alkyl as above-mentioned (c) composition.As above-mentioned (c) composition, particularly preferably be polyoxyethylene (30) polyoxypropylene (6) decyl myristyl ether.
As above-mentioned (c) composition, preferred especially INCI name is called polyoxyethylene (30EO) polyoxypropylene (6PO) ether (polyoxyethylene (30) polyoxypropylene (6) decyl myristyl ether) of the decyl tetradecanol of PPG-6 decyltetradeceth-30.PPG-6decyltetradeceth-30 is commercially available by daylight ケ ミ カ Le ズ (strain) with the title of NIKKOL PEN-4630.
Use level to above-mentioned (c) composition in the external agent of the present invention does not have special qualification, and the gross weight with the external agent is a benchmark usually, is 0.01～10 weight %, is preferably 0.05～5 weight %, more preferably 0.1～3 weight %.
Further, external agent of the present invention contains spice and/or vitamin E or derivatives thereof.
As spice, can use natural or synthetic essence (fragrance) and aromatic (aroma) and their mixture.
As the essence and the aromatic of natural perfume base, can enumerate the extract of for example spending (Bulbus Lilii, Garden lavender, Flos Rosae Multiflorae, jasmine or clothing are blue), the extract of stem and the extract (Herba Pogostemonis, geranium or petit grain (ペ チ グ レ ィ Application)) of leaf, the extract (coriander, Fructus Foeniculi, caroway (カ ロ ゥ ェ ィ) or Juniperus rigida Sieb.et Zucc.) of fruit, the extract (bergamot, Fructus Citri Limoniae or orange) of peel, the extract (Radix Angelicae Sinensis, Herba Apii graveolentis, Elettaria cardamomum (L.) Maton, Rhizoma Iridis Tectori or Rhizoma Acori Graminei) of root, the extract (pine, sandalwood, guaiaci lignum or Cedrus deoclar (Roxb.) G. Don (ピ Application Network シ ダ one)) of timber, extract and the extract (tarragon, lemon grass (Cymbopogon citratus), Salvia japonica Thunb. (sage) or Herba thymi vulgaris (ジ ャ コ ゥ ソ ゥ)) of paddy rice, the extract of needle and extract (PiceameyeriRehd. Et Wils., fir, pine or pinon pine (De ヮ one Off パ ィ Application)), the extract of resin and the extract (galbanum, elemi, Benzoinum, Myrrha, Olibanum or opopanax) of face cream etc. of branch of grass.
As synthetic essence and aromatic, can enumerate the for example chemical compound of ester, ether, aldehyde, ketone, aromatic alcohol and hydro carbons.
For above-mentioned ester, can enumerate any ester, benzyl formate, glycine ethyl-methyl phenyl ester, propanoic acid alkyl cyclohexyl, styralyl propionate and benzyl salicylate etc. in benzyl acetate, benzyl benzoate, phenoxyethyl isobutanoate, vertenex, geraniol acetate, geraniol formate, geranyl acetate, linalyl acetate, dimethyl benzyl carbonylic acetic acid ester, ethyl phenyl acetate, the benzoic acid especially.
As above-mentioned ether, can enumerate benzylisoeugenol.
As above-mentioned aldehyde, can enumerate straight chain alkanal, citral, citronellal, citronellyl oxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilestralis and the bougeonal (Block one Le ジ ォ Na one Le) etc. that for example have 8～18 carbon atoms.
As above-mentioned ketone, can enumerate for example violet ketone and vertofix coeur such as α-Yi Jiajiziluolantong.
For above-mentioned aromatic alcohol, particularly terpenol, can enumerate anethole, citronellol, acetaminol, isoeugenol, geraniol, linalool, phenethanol and terpineol.
As the chemical compound of above-mentioned hydro carbons, can enumerate terpenoid especially.These chemical compounds also often use with the form of the mixture more than 2 kinds of these odoriferous substances.
Also can use quintessence oil as fragrance component, can use for example sage oil, chamomile oil, Oleum Caryophylli, face cream oil (バ Le サ system oil), Oleum menthae, Cortex Cinnamomi leaf oil, lime blossom oil (ラ ィ system Block ロ ッ サ system oil), cade oil, vetiver oil, Olibanum oil, galbanum oil, labolanum oil (ラ ボ ラ ヌ system oil) and Lavandula hybrida wet goods.
Can also separately or mix and use following spice.That is, can use oleum bergamottae, dihydromyrcenol, lilestralis, LYRAL, citronellol, phenethanol, α-hexyl cinnamic aldehyde, geraniol, benzylacetone, cyclamen aldehyde, linalool, imperial saliva furan (ambroxan), indole, MDJ (hedione), sandelice (サ Application デ リ ス), Fructus Citri Limoniae oil, Fructus Citri tangerinae and orange oil, hydroxyacetic acid allyl amine, cyclovertal (シ Network ロ ベ Le タ one Le), Essential lavender oil, sage oil, β-damascone, Oleum Pelargonii Graveolentis, salicylic acid cyclohexyl, phenylacetate, geranyl acetate, benzyl acetate or rose oxide etc.
According to the preferred embodiment of the present invention, can mix and use various spice, thus, totally can produce the fragrance of consumer's hobby.
Use level to the spice in the external agent of the present invention does not have special qualification, and the gross weight with the external agent is a benchmark usually, is 0.01～1 weight %, preferred 0.01～0.5 weight %, more preferably 0.01～0.3 weight %.
Derivant to vitamin E does not have special qualification, can enumerate for example tocopheryl acetate etc.
Use level to the vitamin E or derivatives thereof in the external agent of the present invention does not have special qualification, is benchmark with the gross weight of external agent, preferred 0.01～5 weight %.
External agent of the present invention is to use (topical) compositions, preferably cosmetics or skin preparations for extenal use in the part of people's body surface coating.At this, skin preparations for extenal use is the material that on skin, is coated with, can be equivalent to bentoquatam article or quasi drug (medicine part outer article) the two.External agent of the present invention can be as for example wetting agent.
Form to cosmetics does not have special qualification, and the emulsification cosmetic, aqueous gel, aqueous solution, multilayer emulsion etc. that can take emulsification cosmetic, the oil-in-water type of water-in-oil type are form arbitrarily.In addition, cosmetics also can be any one cosmetics during mucosas such as cosmetics for skin, cosmetic hair, cosmetic (makeup) cosmetics, cleaning cosmetics, fingernail apply some make up, lip apply some make up.The present invention is particularly suitable for astringent.
The present invention is under the situation of astringent, and preferably this astringent is transparent or its outward appearance is even.At this, " transparent " be instigate light through and do not cause refraction or the deflection that causes of reflection.Can use scopometer to measure the transparency of the such compositions of astringent.For example, can use the portable turbidimeter Model 2100P (registered trade mark) of Hach society in order to measure the transparent limit of compositions.The turbidity of measuring thinks that compositions is transparent between 0～250NTU the time.
External agent of the present invention can further contain vitamins or their derivant beyond the vitamin E or derivatives thereof.As this vitamins that can cooperate arbitrarily, can use vitamin A, vitamin B, vitamin C, vitamin D etc. to be widely used as the vitamin of the composition of external agent.As contained vitamins in external agent of the present invention, preferred vitamin C or derivatives thereof.
As ascorbic derivant, there is not special qualification, can enumerate for example ascorbic acid glucoside, phosphoric acid Magnesium ascorbate (リ Application acid ァ ス コ Le PVC Le M g), phosphoric acid sodium ascorbate (リ Application acid ァ ス コ Le PVC Le Na) etc.
This vitamins that can in external agent of the present invention, cooperate arbitrarily or the use level of their derivant are not had special qualification, are benchmark with the gross weight of external agent, preferred 0.01～5 weight %.
When external agent of the present invention contains the vitamin C or derivatives thereof, be benchmark with the gross weight of external agent, the use level of above-mentioned (c) composition must be for more than 0.3%.Be lower than 0.3%, (b) stability of oxyalkylene derivative might reduce.
External agent of the present invention is except above-mentioned (a) and (b), (c) and necessary composition (d) and said vitamin class or their derivant; In the scope of not damaging effect of the present invention; Also can suitably select other external agent to use; The composition that for example in cosmetics, uses usually; Specifically, the natural extract of in addition surfactant of water soluble polymer, acid, alkali, salt, pigment, antioxidant, UV absorbent, whitening agent, blood circulation accelerant, metal-chelator, sebum inhibitor, powder body, astringent, skin softening agent, above-mentioned (c), oil, organic solvent, siloxanes, silicone derivative, plant and animal material, wax class etc.
External agent of the present invention is cosmetics particularly, are used for comprising the cosmetic treatments method of the step that is coated on the keratin substances.So-called keratin substances is to contain the material of keratin as the main composition key element, can enumerate for example skin, hair, fingernail, lip etc.This cosmetic treatments method can be for example to be used to make skin or the moistening method for moisturizing of mucosa.
Embodiment
Below, illustrate the present invention in more detail through embodiment, but the present invention does not receive the qualification of embodiment.
[reference example 1～3]
In order to following method, preparation comprises the astringent of the reference example 1～reference example 3 of composition shown in the following table 1.
(1) composition of mixed phase B stirs until becoming even.
(2) composition of mixed phase A is heated to 75 ℃, stirs until becoming evenly, is cooled to room temperature then.
(3) add among the phase A phase B and stirring.
(4) add phase C and stirring.
Each astringent to reference example 1～reference example 3 carries out heat stabilization test, its outward appearance of visualization.Heat stabilization test is implemented as follows: each astringent is imported in the transparent glass container; This container was kept 6 hours at 20 ℃ in incubator; Be cooled to-20 ℃ with 6 hours from+20 ℃, kept 6 hours at-20 ℃, with 6 hours from-20 ℃ be heated to+20 ℃; Repeat this circulation 10 days, the uniformity of the outward appearance of each astringent of visualization after 10 days.The result is shown in Table 1 in the lump.Numerical value in the table 1 all is expressed as weight %.
Table 1
Polyoxyethylene hardened castor oil (60EO): NIKKOL HC060 (daylight ケ ミ カ Le ズ (strain))
Methyl glucoside polyoxyethylene ether dioleate (Port リ オ キ シ エ チ レ Application ジ オ レ イ Application acid メ チ Le ダ Le コ シ De) is (120EO): GLUCAMATE DOE 120 (NOVEON society)
Polyoxy butylene polyoxyethylene polyoxypropylene glycerol (PEG/PPG/ polytetramethylene glycol-8/5/3 glycerol): WILBRIDE S-753 (Japanese oils and fats (strain))
Can find out that from the result of table 1 under the condition of polyoxy butylene polyoxyethylene polyoxypropylene glycerol (PEG/PPG/ polytetramethylene glycol-8/5/3 glycerol) and spice coexistence, the ageing stability of astringent reduces, and opaque part occurs.
[embodiment 1] and [comparative example 1～7]
Comprise the embodiment 1 of composition shown in the following table 2 and the astringent of comparative example 1～comparative example 7 in order to the preparation of below method.
(1) composition of mixed phase B stirs until becoming even.
(2) composition of mixed phase A is heated to 75 ℃, stirs until becoming evenly, is cooled to room temperature then.
(3) add among the phase A phase B and stirring.
(4) add phase C and stirring.
Each astringent to embodiment 1 and comparative example 1～comparative example 7 carries out and above-mentioned the same heat stabilization test.Its outward appearance of visualization.The result is shown in table 2 in the lump.Numerical value in the table 2 all is expressed as weight %.
Table 2
Polyoxyethylene (30) polyoxypropylene (6) decyl myristyl ether (PPG-6decyltetradeceth-30): NIKKOL PEN-4630 (daylight ケ ミ カ Le ズ (strain))
Polyoxyethylene hardened castor oil (60EO): NIKKOL HC060 (daylight ケ ミ カ Le ズ (strain))
Methyl glucoside polyoxyethylene ether dioleate (120EO): GLUCAMATE DOE120 (NOVEON)
Poloxamer-124:SYNPERONIC PE-L 44 (UNIQEMA AMERICA)
Pyroglutamic acid isostearic acid polyoxyethylene glyceride (ピ ロ グ Le タ ミ Application acid ィ ソ ス テ ァ リ Application acid Port リ ォ キ シ ェ チ レ Application グ リ セ リ Le) (PCA isostearic acid Glycereth-25:PYROTER GP I-25 (aginomoto USA)
Polyoxyethylene oleyl ether (Oleth-20): BRIJ 98V (UNIQEMA)
Polyoxyethylene (20) polyoxypropylene (6) decyl myristyl ether (PPG-6decyltetradeceth-20): NIKKOL PEN-4620 (daylight ケ ミ カ Le ズ (strain))
Polyoxy butylene polyoxyethylene polyoxypropylene glycerol (PEG/PPG/ polytetramethylene glycol-8/5/3 glycerol): WILBRIDE S-753 (Japanese oils and fats (strain))
Can find out from the result shown in the table 2; Under the condition that polyoxy butylene polyoxyethylene polyoxypropylene glycerol (PEG/PPG/ polytetramethylene glycol-8/5/3 glycerol) and spice coexist, have only polyoxyethylene (30) polyoxypropylene (6) decyl myristyl ether (PPG-6 decyltetradeceth-30) that transparent and uniform astringent is provided.
[embodiment 2] and [comparative example 8]
Through the operation the same with embodiment 1, preparation comprises the embodiment 2 of composition shown in the following table 3 and the astringent of comparative example 8, and carries out and above-mentioned the same heat stabilization test its outward appearance of visualization.The result is shown in table 3 in the lump.In addition, the numerical value in the table 3 all is expressed as weight %.
Table 3
Polyoxyethylene (30) polyoxypropylene (6) decyl myristyl ether (PPG-6decyltetradeceth-30): NIKKOL PEN-4630 (daylight ケ ミ カ Le ズ (strain))
Polyoxyethylene hardened castor oil (60EO): NIKKOL HC060 (daylight ケ ミ カ Le ズ (strain))
Methyl glucoside polyoxyethylene ether dioleate (120EO): GLUCAMATE DOE120 (NOVEON)
Polyoxy butylene polyoxyethylene polyoxypropylene glycerol (PEG/PPG/ polytetramethylene glycol-8/5/3 glycerol): WILBRIDE S-753 (Japanese oils and fats (strain))
Can find out from the result of table 3; Under the condition that polyoxy butylene polyoxyethylene polyoxypropylene glycerol (PEG/PPG/ polytetramethylene glycol-8/5/3 glycerol) exists; Even using vitamin e derivative (tocopheryl acetate) to replace under the situation of spice; The stability of astringent is variation also, and has only polyoxyethylene (30) polyoxypropylene (6) decyl myristyl ether (PPG-6 decyltetradeceth-30) to obtain transparent and uniform astringent.
[embodiment 3～4] and [comparative example 9]
Comprise the embodiment 3 of composition shown in the following table 4 and the astringent of embodiment 4 and comparative example 9 with following method preparation.
(1) ascorbic acid glucoside is dissolved in a part of water, adds potassium hydroxide, preparation phase B.
(2) all the components of mixed phase C stirs until becoming even.
(3) composition of mixed phase A is heated to 75 ℃, and stirs until becoming evenly, then cool to room temperature.
(4) add among the phase A phase B and stirring.
(5) further add phase C and stirring.
(6) further add phase D and stirring.
Each astringent for embodiment 3～4 and comparative example 9 carries out and above-mentioned the same heat stabilization test its outward appearance of visualization.The result is shown in table 4 in the lump.In addition, the numerical value in the table 4 all is expressed as weight %.
Table 4
Polyoxyethylene (30) polyoxypropylene (6) decyl myristyl ether (PPG-6decyltetradeceth-30): NIKKOL PEN-4630 (daylight Network ミ カ Le ズ (strain))
Polyoxy butylene polyoxyethylene polyoxypropylene glycerol (PEG/PPG/ polytetramethylene glycol-8/5/3 glycerol): WILBRIDE S-753 (Japanese oils and fats (strain))
Can find out from the result of table 4; When using vitamin C derivatives (ascorbic acid glucoside); Under the condition that polyoxy butylene polyoxyethylene polyoxypropylene glycerol (PEG/PPG/ polytetramethylene glycol-8/5/3 glycerol) exists, be that 0.3 weight % obtains transparent and uniform astringent when above only in the use level of polyoxyethylene (30) polyoxypropylene (6) the decyl myristyl ether (PPG-6 decyltetradeceth-30) that cooperates as surfactant.
Claims (6)
1. external agent, it contains:
(a) aqueous medium,
(b) at least a oxyalkylene derivative of following formula (I) expression with the gross weight of external agent be benchmark be 0.1～10 weight %,
[changing 1]
Z-{O(AO)
l(EO)
m-(BO)
nH}
a (I)
In the formula, Z representes the residue that the hydroxyl of deglycerizin obtains;
AO representes that carbon number is 3～4 oxyalkylene;
EO representes the oxygen ethylidene;
BO representes that carbon number is 4 oxyalkylene;
A representes 3;
L, m and n are respectively the average addition molal quantitys of AO, EO and BO, 2≤l≤20,2≤m≤20 and 0.8≤n≤3;
The weight ratio of AO and EO (AO/EO) is 1/4～4/1;
AO and EO add becomes random shape or block-wise;
(c) have 25～35 oxygen ethylidene unit, 4～8 oxygen propylidene unit and carbon number be 22～26 branched alkyl at least a polyoxyethylene polyoxy-propylene with the gross weight of external agent be benchmark be 0.05～5 weight % and
(d) spice and/or vitamin E or tocopheryl acetate.
2. the described external agent of claim 1, wherein, in following formula (I), AO and EO add becomes random shape.
3. the described external agent of claim 1, in following formula (I), AO is the oxygen propylidene.
4. the described external agent of claim 1; It also contains the vitamin C or derivatives thereof; Its derivant is selected from ascorbic acid glucoside, phosphoric acid Magnesium ascorbate, phosphoric acid sodium ascorbate, and is benchmark with the gross weight of external agent, and the use level of above-mentioned (c) composition is more than 0.3%.
5. the described external agent of claim 1, it is cosmetics or skin preparations for extenal use.
6. cosmetic treatments method, it is included in the described external agent of coating claim 1 on the keratin substances.
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| JP2007112096A JP5259976B2 (en) | 2007-04-20 | 2007-04-20 | Topical preparation |
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| FR2948872B1 (en) * | 2009-08-04 | 2011-10-21 | Oreal | COSMETIC COMPOSITION COMPRISING AN OXYALKYLENE DERIVATIVE |
| JP5528875B2 (en) * | 2010-03-26 | 2014-06-25 | 日本メナード化粧品株式会社 | Transparent liquid skin preparation |
| FR2969924B1 (en) * | 2010-12-30 | 2013-11-15 | Lvmh Rech | COMPOSITION COMPRISING A TOCOPHEROL PHOSPHATE |
| JP5790054B2 (en) * | 2011-03-22 | 2015-10-07 | 日油株式会社 | Skin cosmetics |
| JP5843137B2 (en) * | 2011-08-05 | 2016-01-13 | 日油株式会社 | Topical skin preparation |
| JP5843138B2 (en) * | 2011-08-05 | 2016-01-13 | 日油株式会社 | Topical skin preparation |
| JP5850394B2 (en) * | 2011-11-08 | 2016-02-03 | 日油株式会社 | Cosmetics |
| JP5906839B2 (en) * | 2012-03-13 | 2016-04-20 | 日油株式会社 | Cosmetics |
| JP2014237708A (en) * | 2014-08-15 | 2014-12-18 | ロレアル | Whitening external preparation, skin penetration accelerator of water-soluble whitening component, and skin whitening method |
| KR102509210B1 (en) | 2017-05-29 | 2023-03-13 | 니치유 가부시키가이샤 | Alkylene oxide derivatives, wetting agents, solubilizing agents and solubilizing compositions |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1679500A (en) * | 2004-02-12 | 2005-10-12 | 株式会社资生堂 | Liquid cosmetics |
| CN1708283A (en) * | 2002-10-25 | 2005-12-14 | 株式会社资生堂 | Skin preparations for external use |
| WO2006038724A1 (en) * | 2004-10-06 | 2006-04-13 | Nof Corporation | Cosmetic bases and cosmetics containing the same |
| JP2006282539A (en) * | 2005-03-31 | 2006-10-19 | Nof Corp | Cosmetic base and cosmetic compounded with the same |
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| JP2002332233A (en) * | 2001-05-11 | 2002-11-22 | Lion Corp | Skin care preparation composition |
| JP2002338459A (en) * | 2001-05-16 | 2002-11-27 | Nikko Chemical Co Ltd | Method for solubilizing ceramide and ceramide- formulated skin care preparation obtained by using the method |
| JP2003342116A (en) * | 2002-05-24 | 2003-12-03 | Utena:Kk | Translucent cosmetic |
| JP4670366B2 (en) * | 2005-01-24 | 2011-04-13 | 日油株式会社 | Skin cosmetics |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1708283A (en) * | 2002-10-25 | 2005-12-14 | 株式会社资生堂 | Skin preparations for external use |
| CN1679500A (en) * | 2004-02-12 | 2005-10-12 | 株式会社资生堂 | Liquid cosmetics |
| WO2006038724A1 (en) * | 2004-10-06 | 2006-04-13 | Nof Corporation | Cosmetic bases and cosmetics containing the same |
| JP2006282539A (en) * | 2005-03-31 | 2006-10-19 | Nof Corp | Cosmetic base and cosmetic compounded with the same |
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| JP2008266217A (en) | 2008-11-06 |
| JP5259976B2 (en) | 2013-08-07 |
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