JP5442937B2 - Topical preparation - Google Patents

Description

  The present invention relates to an external preparation such as a cosmetic with improved stability, and particularly to a lotion.

  As a moisturizing agent that has excellent feel and moisturizing properties and maintains moisture after washing, WO 2006/038724 and JP-A 2006-282539 disclose alkylene oxides represented by the following formula (I): Derivatives are described.

(Where
Z represents a residue excluding a hydroxyl group of a compound having 3 to 9 hydroxyl groups;
AO represents an oxyalkylene group having 3 to 4 carbon atoms;
EO represents an oxyethylene group;
BO represents a oxyalkylene group having 4 carbon atoms;
a represents 3-9;
l, m and n are the average added moles of AO, EO and BO, respectively, 1 ≦ l ≦ 50, 1 ≦ m ≦ 50 and 0.5 ≦ n ≦ 5;
The weight ratio of AO to EO (AO / EO) is 1/5 to 5/1;
(AO and EO may be added in random or block form)

The alkylene oxide derivative of the above formula (I) does not have a sticky feeling and provides a refreshing feel, and therefore can be suitably used as a base for various moisturizing cosmetics, particularly a lotion.
International Publication No. 2006/038724 Pamphlet JP 2006-038724 A

  However, external preparations such as cosmetics containing an alkylene oxide derivative of the above formula (I), especially lotion, have poor stability over time, and are repeatedly exposed to cycles of rising and falling temperatures for several days to several tens of days. There is a problem that becomes unstable. In particular, in the case of lotion, the transparency and appearance uniformity are lost and the commercial value is significantly impaired.

  The above problem is remarkable when a fragrance is present together with the alkylene oxide derivative of the above formula (I).

  Therefore, there is a need for a solution to the above-mentioned problems peculiar to external preparations such as cosmetics containing an alkylene oxide derivative of formula (I), a fragrance and water.

  Therefore, the object of the present invention is to improve the temporal stability of external preparations such as cosmetics and the like containing the above-mentioned alkylene oxide derivative of formula (I), perfume and water, and optionally vitamins. And providing a stable and external preparation. In particular, when the external preparation is a cosmetic, particularly a lotion, the present invention aims to maintain the transparency and uniformity of appearance over a long period of time.

The purpose of the present invention is to
(A) an aqueous medium,
(B) The following formula (I):
(Where
Z represents a residue excluding a hydroxyl group of a compound having 3 to 9 hydroxyl groups;
AO represents an oxyalkylene group having 3 to 4 carbon atoms;
EO represents an oxyethylene group;
BO represents a oxyalkylene group having 4 carbon atoms;
a represents 3-9;
l, m and n are the average added moles of AO, EO and BO, respectively, 1 ≦ l ≦ 50, 1 ≦ m ≦ 50 and 0.5 ≦ n ≦ 5;
The weight ratio of AO to EO (AO / EO) is 1/5 to 5/1;
AO and EO may be added in a random or block form), and (c) at least one carbon of 6 wt% or more based on the total weight of the external preparation A number 2-6 alkylene glycol, and
(D) Achieved by an external preparation containing a fragrance.

  In the above formula (I), AO and EO may be added randomly, and AO is preferably an oxypropylene group. Furthermore, in the above formula (I), the compound having a hydroxyl group is preferably glycerin.

  The (c) alkylene glycol having 2 to 6 carbon atoms is preferably butylene glycol.

  The external preparation of the present invention may further contain vitamin E or a derivative thereof and / or vitamin C or a derivative thereof. Moreover, it is preferable that the external preparation of this invention contains a nonionic surfactant.

  The external preparation of the present invention can be a cosmetic (cosmetic composition) or a skin external preparation.

  The present invention also relates to a cosmetic treatment method comprising applying the above external preparation to a keratin substance.

  According to the present invention, the stability over time of an external preparation such as a cosmetic containing a alkylene oxide derivative of formula (I), a fragrance, and water is improved, and in particular, an external preparation that is stable against temperature change history is provided. can do. Therefore, according to this invention, the external preparation containing the alkylene oxide derivative of the said formula (I), a fragrance | flavor, and water can be preserve | saved over a long period of time also in the environment which receives a temperature change. In particular, when the external preparation is a lotion, the transparency and uniformity of appearance can be maintained over a long period of time.

  The external preparation of the present invention essentially contains (a) an aqueous medium. As the aqueous medium, water or an organic solvent miscible with water (normally water-miscible organic solvent) at normal temperature (25 ° C.) and a mixture of water can be used.

  Water may be aromatic distilled water such as cornflower water, and / or mineral water such as Vittel water, Lucas water, La Roche Posay water, and / or hot springs. It may be seawater such as water and / or deep seawater.

  The external preparation of the present invention contains water in the range of 50 to 94.9% by weight, preferably in the range of 60 to 94% by weight, more preferably in the range of 70 to 94% by weight, based on the total weight of the external preparation. be able to.

Examples of the organic solvent miscible with water at room temperature (25 ° C.) include the following.
Monoalcohols having 2 to 6 carbon atoms such as ethanol and isopropanol;
Polyols other than diols having 2 to 20 carbon atoms, preferably 2 to 10 carbon atoms, more preferably 2 to 6 carbon atoms, such as glycerin;
Glycol ethers (especially those having carbon atoms of 3 to 16), (e.g., mono -, di -, (C ₁ -C ₄₎ alkyl ethers of tripropylene glycol, and mono -, di -, tri (C ₁ -C ₄ ) alkyl ethers of ethylene glycol); and mixtures thereof.

  The external preparation of the present invention may contain the water-miscible organic solvent in an amount of 0.1 to 30% by weight, preferably 5 to 25% by weight, more preferably 10 to 20% by weight based on the total weight of the external preparation. Good.

Moreover, the external preparation of this invention is (b) following formula (I):
(Where
Z represents a residue excluding a hydroxyl group of a compound having 3 to 9 hydroxyl groups;
AO represents an oxyalkylene group having 3 to 4 carbon atoms;
EO represents an oxyethylene group;
BO represents a oxyalkylene group having 4 carbon atoms;
a represents 3-9;
l, m and n are the average added moles of AO, EO and BO, respectively, 1 ≦ l ≦ 50, 1 ≦ m ≦ 50 and 0.5 ≦ n ≦ 5;
The weight ratio of AO to EO (AO / EO) is 1/5 to 5/1;
(AO and EO may be added in random or block form)
And at least one alkylene oxide derivative represented by the formula:

  In the alkylene oxide derivative represented by the formula (I), Z is a residue excluding the hydroxyl group of the compound having 3 to 9 hydroxyl groups, and a is the number of hydroxyl groups of the compound of Z and is 3 to 9. As a compound having 3 to 9 hydroxyl groups, for example, if a = 3, glycerin, trimethylolpropane, if a = 4, erythritol, pentaerythritol, sorbitan, alkylglycoside, diglycerin, a = 5 Examples include xylitol, dipentaerythritol, sorbitol, inositol if a = 6, sucrose, trehalose if a = 8, maltitol if a = 9, and mixtures thereof. Preferably, Z is a residue excluding the hydroxyl group of the compound having 3 to 6 hydroxyl groups, and satisfies 3 ≦ a ≦ 6. As the compound having 3 to 9 hydroxyl groups, glycerol and trimethylolpropane are preferable, and glycerol is particularly preferable. In addition, in a <= 2, there exists a tendency for the mixing | blending stability to an oil-based formulation to deteriorate that it is inferior to compatibility with oil-based components, such as fats and oils. When 10 ≦ a, a sticky feeling is generated.

  AO is an oxyalkylene group having 3 to 4 carbon atoms. Examples include oxypropylene group, oxybutylene group (oxy n-butylene group, oxyisobutylene group, oxy t-butylene group), oxytrimethylene group, oxytetramethylene group. Groups and the like. An oxypropylene group, an oxybutylene group, and more preferably an oxypropylene group.

  l is the average added mole number of AO, and 1 ≦ l ≦ 50, preferably 2 ≦ l ≦ 20. m is an average added mole number of EO, and 1 ≦ m ≦ 50, preferably 2 ≦ m ≦ 20. If l is 0, a sticky feeling is produced, and if it exceeds 50, the moisturizing effect is lowered. Further, if m is 0, the moisturizing effect is lowered, and if it exceeds 50, a sticky feeling is produced.

  The weight ratio (AO / EO) between AO and EO is 1/5 to 5/1, preferably 1/4 to 4/1. If it is less than 1/5, a sticky feeling is produced, and if it is greater than 5/1, the moisturizing feeling is lowered. The order in which AO and EO are added is not particularly specified, and they may be added in blocks or randomly. In order to obtain a more excellent rough skin prevention effect, those added randomly are preferable.

  BO is an oxyalkylene group having 4 carbon atoms, and examples thereof include an oxybutylene group (oxy n-butylene group, oxyisobutylene group, oxy t-butylene group), an oxytetramethylene group, and the like. An oxybutylene group is preferred.

n is the average added mole number of BO, 0.5 <n ≦ 5, preferably 0.8 ≦ n ≦ 3, and more preferably 1 ≦ n ≦ 3. If it is 0.5 or less, a sticky feeling is produced, and if it exceeds 5, the moisturizing feeling is lowered. In the formula (I), (BO) _n needs to be bonded to a terminal hydrogen atom.

  The alkylene oxide derivative represented by the formula (I) can be produced by a known method. For example, it can be obtained by subjecting a compound having 3 to 9 hydroxyl groups to addition polymerization of ethylene oxide and an alkylene oxide having 3 to 4 carbon atoms and then reacting the alkylene oxide having 4 carbon atoms. In addition, in the stage of addition polymerization of ethylene oxide and alkylene oxide having 3 to 4 carbon atoms to a compound having 3 to 9 hydroxyl groups, ethylene oxide and alkylene oxide may be randomly polymerized, or block polymerization. May be.

Among the alkylene oxide derivatives represented by the formula (I), preferable alkylene oxide derivatives include, for example, the following formula (II):
(Where
Gly represents a residue obtained by removing a hydroxyl group from glycerin;
PO represents an oxypropylene group;
EO represents an oxyethylene group;
s and t are the average added moles of PO and EO, respectively, and have a value of 1-50,
The mass ratio of PO to EO (PO / EO) is 1/5 to 5/1,
BO represents a oxyalkylene group having 4 carbon atoms;
u is the average number of moles added of BO, and is a value of 0.5 to 5)
And alkylene oxide derivatives (polyoxybutylene polyoxyethylene polyoxypropylene glycerol).

  In the alkylene oxide derivative (a) of the formula (II), propylene oxide and ethylene oxide are added to glycerin at a ratio of 3 to 150 molar equivalents with respect to glycerin, respectively. It is obtained by adding at a ratio of 5 to 15 molar equivalents.

  When these alkylene oxides are added to glycerin, an addition reaction is performed using an alkali catalyst, a phase transfer catalyst, a Lewis acid catalyst, or the like. In general, it is preferable to use an alkali catalyst such as potassium hydroxide.

  Of the alkylene oxide derivatives represented by the formula (I), more preferred are those in which 6 to 10 mol of ethylene oxide and 3 to 7 mol of propylene oxide are added to glycerin, and then 2 to 4 mol of butylene oxide is added. It is a thing.

  Even more preferred among the alkylene oxide derivatives of formula (I) is polyoxybutylene in which 8 moles of ethylene oxide and 5 moles of propylene oxide are added to glycerin and then 3 moles of butylene oxide are added. It is polyoxyethylene polyoxypropylene glycerol and is called PEG / PPG / polybutylene glycol-8 / 5/3 glycerin under the INCI name. PEG / PPG / polybutylene glycol-8 / 5/3 glycerin is commercially available from Nippon Oil & Fat Co., Ltd. under the name WILBRIDE S-753.

  The blending amount of the alkylene oxide derivative represented by the formula (I) in the external preparation of the present invention is not particularly limited, but is usually 0.1 to 20% by weight based on the total weight of the external preparation, preferably Is 0.1 to 10% by weight, more preferably 0.2 to 5% by weight.

  Moreover, the external preparation of this invention also contains (c) C2-C6 alkylene glycol essential. Examples of the alkylene glycol include diols having 2 to 6 carbon atoms, such as ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, dipropylene glycol, and diethylene glycol. Diols are preferred, diols having 4 carbon atoms are more preferred, and butylene glycol is particularly preferred. As the alkylene glycol having 2 to 6 carbon atoms, one kind may be used alone, or two or more kinds may be mixed and used.

  The (c) C2-C6 alkylene glycol needs to be blended in an amount of 6 wt% or more based on the total weight of the external preparation, and is preferably blended appropriately in the range of 6-20 wt%. .

  Furthermore, the external preparation of this invention contains a fragrance | flavor. As perfumes, natural or synthetic fragrances and aromas, and mixtures thereof can be used.

  Naturally based fragrances and aromas include, for example, extracts from flowers (lily, lavender, rose, jasmine or ylang ylang), extracts from stems and extracts from leaves (patcholi, geranium or pettigrain), fruits Extract (coriander, anise, caraway or pepper), extract from pericarp (bergamot, lemon or orange), extract from root (angelica, celery, cardamom, iris or agate), extract from wood (pine) , Sandalwood, grasshopper or pink cedar), extracts from grass and grasses (tarragon, lemongrass, sage or mulberry), extracts from needles and branches Products (spruce, cinnamon, pine or dwarf pine), extracts from resins and Extracts from balsam include (galbanum, elemi, benzoin, myrrh, olibanum or opopanax) or the like.

  Synthetic fragrances and aromas include, for example, esters, ethers, aldehydes, ketones, aromatic alcohols and hydrocarbon type compounds.

  Specific examples of the ester include benzyl acetate, benzyl benzoate, phenoxyethyl isobutyrate, pt-butylcyclohexyl acetate, citronellyl acetate, citronellyl formate, geranyl acetate, linalyl acetate, dimethylbenzylcarbonyl acetate, phenylethyl acetate, benzoic acid Linalyl, benzyl formate, ethyl methyl phenyl glycinate, alkyl cyclohexyl propionate, styryl propionate, benzyl salicylate, and the like.

  Examples of the ether include benzyl ethyl ether.

  Examples of the aldehyde include straight-chain alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lyrial, and bourdiolal.

  Examples of the ketone include ionones such as α-isomethylionone and methyl cedryl ketone.

  Examples of the aromatic alcohol, particularly terpene alcohol, include anethole, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol, and terpineol.

  Examples of the hydrocarbon type compound include terpenes. These compounds are often used in the form of a blend of two or more of these odorous substances.

  It is also possible to use essential oils as aroma components, for example, sage oil, camomil oil, clove oil, balsam oil, mint oil, cinnamon leaf oil, lime blossom oil, pepper oil, vetiver oil, olibanum oil, galvanum oil, labranum Oil, lavandin oil and the like are used.

  Furthermore, the following fragrance | flavors can be used individually or in a blend. Bergamot oil, dihydromyrsenol, lyral, rilal, citronellol, phenylethyl alcohol, α-hexyl cinnamaldehyde, geraniol, benzylacetone, cyclamenaldehyde, linalool, ambroxan, indole, hedione, sandelis, lemon oil, mandarin and Oils from orange, allylamine glycol, cyclobeltal, lavender oil, sage oil, β-damascone, geranium oil, cyclohexyl salicylate, phenylacetic acid, geranyl acetate, benzyl acetate or rose oxide can be used.

  According to a preferred embodiment of the present invention, various fragrances can be blended and used, thereby producing a fragrance generally favored by consumers.

  Although the compounding quantity of the fragrance | flavor to the external preparation of this invention is not specifically limited, Usually, it is 0.01 to 1 weight% on the basis of the total weight of an external preparation, Preferably it is 0.01 to 0.5 weight. %, More preferably 0.01 to 0.3% by weight.

  The external preparation of the present invention is a topical composition applied to the surface of a human body, and is preferably a cosmetic or an external preparation for skin. Here, the external preparation for skin should be applied onto the skin and can correspond to both dermatological drugs or quasi drugs. The external preparation of the present invention can be used, for example, as a humectant.

  The form of the cosmetic is not particularly limited, and may take any form such as a water-in-oil emulsified cosmetic, an oil-in-water emulsified cosmetic, an aqueous gel, an aqueous solution, and a multiple emulsion. Further, the cosmetic may be any of skin cosmetics, hair cosmetics, makeup cosmetics, cleansing cosmetics, nail cosmetics, and mucosal cosmetics such as lips. The present invention is particularly suitable as a lotion.

  When this invention is a lotion, it is preferable that the said lotion is transparent or the external appearance is uniform. Here, “transparent” means passing light without causing deflection due to refraction or reflection. The transparency of a composition such as lotion can be measured using a turbidimeter. The Hach portable turbidimeter model 2100P® can be used, for example, to measure the transparency limit of the composition. A composition is considered transparent when the measured turbidity is between 0 and 250 NTU.

  The external preparation of the present invention preferably contains vitamins or derivatives thereof. As vitamins, general-purpose ingredients can be used as components of external preparations such as vitamin A, vitamin B, vitamin C, vitamin D, vitamin E and the like. As vitamins, vitamin E and / or vitamin C and derivatives thereof, particularly vitamin C or derivatives thereof are preferable.

  The derivative of vitamin E is not particularly limited, and examples thereof include tocopherol acetate.

  The derivative of vitamin C is not particularly limited, and examples thereof include ascorbyl glucoside, ascorbyl phosphate Mg, and ascorbyl phosphate Na.

  Although the compounding quantity of vitamins or those derivatives to the external preparation of this invention is not specifically limited, 0.01-5 weight% is preferable on the basis of the total weight of an external preparation.

  The external preparation of the present invention preferably contains a nonionic surfactant. The type of the nonionic surfactant is not particularly limited, but a hydrophilic nonionic surfactant is preferable.

  Examples of the hydrophilic nonionic surfactant include polyoxyethylene castor oil and hardened castor oil derivatives such as polyoxyethylene castor oil and polyoxyethylene castor oil; polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan Polyoxyethylene sorbitan fatty acid esters such as tetraoleate; fatty acid esters of polyoxyethylene glycol such as polyoxyethylene glyceryl monoisostearate, polyoxyethylene glyceryl triisostearate; polyoxyethylene octyldodecyl ether, polyoxyethylene lauryl Polyoxyethylene alkyl ethers such as ether polyoxyethylene cetyl ether, polyoxyethylene stearyl ether and polyoxyethylene nonylphenyl ether Other polyoxyethylene-added surfactants such as Le, polyglycerol alkyl ethers, polyglycerol fatty acid esters, sucrose fatty acid esters. These can be used alone or in combination of two or more.

  Of these hydrophilic nonionic surfactants, polyoxyethylene addition type nonionic surfactants having an addition mole number of ethylene oxide of 20 to 120 are preferred, such as polyoxyethylene glyceryl triisostearate, monostearic acid Polyoxyethylene glycerin, polyoxyethylene glyceryl monostearate, polyoxyethylene octyldodecyl ether, polyoxyethylene stearyl ether, polyoxyethylene behenyl ether, polyoxyethylene hexyl decyl ether, polyoxyethylene polyoxypropylene decyl tetradecyl ether, Polyoxyethylene hydrogenated castor oil, lauric acid polyoxyethylene hydrogenated castor oil, isostearic acid polyoxyethylene hydrogenated castor oil, hydrogenated castor oil pyroglutamate iso Stearic acid, pyroglutamic acid isostearate, polyoxyethylene glyceryl, polyoxyethylene sorbitan monolaurate, polyoxyethylene monostearate, polyoxyethylene monooleate, and the like. Specifically, for example, polyoxyethylene hydrogenated castor oil (60EO) (INCI name: PEG-60 hydrogenated castor oil, etc.), polyoxyethylene dioleic acid methyl glucoside (120EO) (INCI name: dioleic acid PEG-120) Methyl glucose), polyoxyethylene (30) polyoxypropylene (6) decyltetradecyl ether (INCI name: PPG-6 decyltetradeces-30), polyoxyethylene (20) polyoxypropylene (6) decyltetradecyl Ether (INCI name: PPG-6 decyltetradeceth-20), polyglutamate isoxystearate polyoxyethylene (25) glyceryl (INCI name: PCA isostearic acid glyceres-25) and the like.

The hydrophilic nonionic surfactant includes a polycondensate of ethylene oxide and propylene oxide, particularly a copolymer comprising a polyethylene glycol block and a polypropylene glycol block, such as a polyethylene glycol / polypropylene glycol / polyethylene glycol triblock polycondensate. Can also be suitably used. These triblock polycondensates have, for example, the following chemical structures:
Wherein a is in the range of 2 to 150, b is in the range of 1 to 100; preferably a is in the range of 10 to 130, and b is in the range of 20 to 80.

  The polycondensate preferably has a weight average molecular weight in the range of 1000 to 15000, preferably in the range of 1500 to 15000, in particular in the range of 1500 to 10,000, more preferably in the range of 1500 to 5000.

  Advantageously, the polycondensate has a cloud point temperature of 10 g / l in distilled water and above 20 ° C., preferably above 60 ° C. The cloud point temperature is measured according to ISO standard 1065.

  As the polycondensate, for example, the name “SYNPERONIC” by UNIQEMA, for example, “SYNPERONIC (registered trademark) PE / F32” (INCI name: Poloxamer 108), “SYNPERONIC (registered trademark) PE / F108” (INCI) Name: Poloxamer 338), “SYNPERONIC® PE / L44” (INCI name: Poloxamer 124), “SYNPERONIC® PE / L42” (INCI name: Poloxamer 122), “SYNPERONIC® PE / F127 ”(INCI name: Poloxamer 407),“ SYNPERONIC® PE / F88 ”(INCI name: Poloxamer 238), and“ SYNPERONIC® PE / L64 ”(INCI name: Poloxamer 184), Another example is a polyethylene glycol / polypropylene glycol / polyethylene glycol triblock polycondensate marketed under the name “LUTROL® F68” (INCI name: Poloxamer 188) by the company BASF.

  Although the compounding quantity of the nonionic surfactant to the external preparation of this invention is not specifically limited, 0.01 to 3 weight% is preferable, 0.05 to 1 weight% is more preferable, and 0.0. 1 to 0.5% by weight is even more preferred.

  The external preparation of the present invention includes the essential components (a), (b), (c) and (d), the above vitamins or derivatives thereof, and a nonionic surfactant, External preparations, for example, components usually used in cosmetics, specifically water-soluble polymers, acids, bases, salts, dyes, antioxidants, UV absorbers, whitening agents, blood circulation promoters, metal chelating agents , Sebum inhibitor, powder, astringent, skin softener, anionic surfactant, cationic surfactant, amphoteric surfactant, oil, organic solvent other than the above (c), silicone, silicone derivative, Natural extracts and waxes derived from animals and plants can be appropriately selected and used within a range not impairing the effects of the present invention.

  The external preparation of the present invention, particularly a cosmetic, is used in a cosmetic treatment method including a step of applying to a keratin substance. A keratin substance is a substance containing keratin as a main constituent, and examples thereof include skin, hair, nails and lips. The beauty treatment method can be, for example, a moisturizing method for moisturizing the skin or mucous membrane.

  EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited to an Example.

[Reference Examples 1-3]
The skin lotions of Reference Examples 1 to 3 comprising the components shown in Table 1 below were prepared by the following method.
(1) Mix Phase B ingredients and stir until uniform.
(2) Mix Phase A ingredients, heat to 75 ° C., stir until uniform, then cool to room temperature.
(3) Add Phase B to Phase A and stir.
(4) Add Phase C and stir.

  Each lotion of Reference Example 1 to Reference Example 3 was subjected to a thermal stability test, and the appearance was visually observed. In the thermal stability test, each lotion was introduced into a transparent glass container, the container was maintained in an incubator at + 20 ° C. for 6 hours, cooled from + 20 ° C. to −20 ° C. over 6 hours, and −20 ° C. This cycle was repeated for 10 days under the condition of maintaining for 6 hours and heating from −20 ° C. to + 20 ° C. over 6 hours, and the appearance uniformity of each lotion after 10 days was visually observed. The results are also shown in Table 1. In addition, all the numerical values in Table 1 show weight%.

Polyoxyethylene hydrogenated castor oil (60EO): NIKKOL HCO60 (Nikko Chemicals Corporation)
Polyoxyethylene geomethyl glycolate (120EO): GLUCAMATE DOE 120 (NOVEON)
Polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin): WILBRIDE S-753 (Nippon Yushi Co., Ltd.)

  From the results in Table 1, the stability of the lotion over time decreases under the conditions where polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin) and fragrance are present. And it turns out that an opaque part appears.

[Examples 1-2] and [Comparative Examples 1-4]
The skin lotions of Examples 1 and 2 and Comparative Examples 1 to 4 comprising the components shown in Table 2 below were prepared by the following method.
(1) Mix Phase B ingredients and stir until uniform.
(2) Mix Phase A ingredients, heat to 75 ° C., stir until uniform, then cool to room temperature.
(3) Add Phase B to Phase A and stir.
(4) Add Phase C and stir.

  About each lotion of Example 1, Example 2, and Comparative Examples 1 to 4, the same heat stability test as described above was performed, and the appearance was visually observed. The results are also shown in Table 2. In addition, all the numerical values in Table 2 indicate weight%.

Polyoxyethylene hydrogenated castor oil (60EO): NIKKOL HCO60 (Nikko Chemicals Corporation)
Polyoxyethylene geomethyl glycolate (120EO): GLUCAMATE DOE 120 (NOVEON)
Polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin): WILBRIDE S-753 (Nippon Yushi Co., Ltd.)

  From the results shown in Table 2, under the condition that polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin) is present together with the fragrance, 6% by weight or more of butylene glycol is present. It turns out that it provides a transparent and uniform lotion.

[Examples 3 to 4] and [Comparative Example 5]
The lotions of Examples 3 and 4 and Comparative Example 5 comprising the components shown in Table 3 below were prepared by the following method.
(1) Dissolve ascorbic acid glucoside in a portion of water and add potassium hydroxide to prepare Phase B.
(2) Mix all ingredients of Phase C and stir until uniform.
(3) Mix Phase A ingredients, heat to 75 ° C., stir until uniform, then cool to room temperature.
(4) Add Phase B to Phase A and stir.
(5) Add more Phase C and stir.
(6) Add more phase D and stir.

  About each lotion of Example 3, Example 4, and Comparative Example 5, the heat stability test similar to the above was done, and the external appearance was visually observed. The results are also shown in Table 3. In addition, all the numerical values in Table 3 show weight%.

Polyoxyethylene (30) Polyoxypropylene (6) Decyltetradecyl ether (PPG-6 Decyltetradec-30): NIKKOL PEN-4630 (Nikko Chemicals Corporation)
Polyoxyethylene hydrogenated castor oil (60EO): NIKKOL HCO60 (Nikko Chemicals Corporation)
Polyoxyethylene geomethyl glycolate (120EO): GLUCAMATE DOE 120 (NOVEON)
Polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin): WILBRIDE S-753 (Nippon Yushi Co., Ltd.)

  From the results of Table 3, when a vitamin C derivative (ascorbic acid glucoside) is used, polyoxybutylene polyoxyethylene polyoxypropylene glycerol (PEG / PPG / polybutylene glycol-8 / 5/3 glycerin) is present together with a flavor. Under the conditions, it can be seen that a transparent and uniform lotion is produced only when the amount of butylene glycol blended is 6% by weight or more.

Claims (7)

(A) an aqueous medium,
(B) The following formula (I):
(Where
Z represents a residue excluding the hydroxyl group of glycerin;
AO represents an oxypropylene group;
EO represents an oxyethylene group;
BO represents a oxyalkylene group having 4 carbon atoms;
a represents 3;
l, m and n are the average added moles of AO, EO and BO, respectively, 1 ≦ l ≦ 50, 1 ≦ m ≦ 50 and 0.5 ≦ n ≦ 5;
The weight ratio of AO to EO (AO / EO) is 1/5 to 5/1;
(AO and EO may be added in random or block form)
At least one alkylene oxide derivative represented by:
(C) An external preparation containing 6% by weight or more of at least one alkylene glycol having 3 to 5 carbon atoms and (d) a fragrance, based on the total weight of the external preparation. The external preparation according to claim 1, wherein in the formula (I), AO and EO are randomly added. The external preparation according to claim 1 or 2, wherein the (c) alkylene glycol having 3 to 6 carbon atoms is butylene glycol. Furthermore, the external preparation in any one of Claims 1 thru | or 3 containing a vitamin C or its derivative (s). Furthermore, the external preparation in any one of Claims 1 thru | or 4 containing a nonionic surfactant. The external preparation according to any one of claims 1 to 5 , which is a cosmetic or an external preparation for skin. A cosmetic treatment method comprising applying the external preparation according to any one of claims 1 to 6 to a keratin substance.