JP5736171B2 - チアゾロピリミジンｐｉ３ｋ阻害剤化合物および使用方法 - Google Patents

チアゾロピリミジンｐｉ３ｋ阻害剤化合物および使用方法 Download PDF

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Publication number
JP5736171B2
JP5736171B2 JP2010526059A JP2010526059A JP5736171B2 JP 5736171 B2 JP5736171 B2 JP 5736171B2 JP 2010526059 A JP2010526059 A JP 2010526059A JP 2010526059 A JP2010526059 A JP 2010526059A JP 5736171 B2 JP5736171 B2 JP 5736171B2
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Japan
Prior art keywords
pyrimidin
morpholinothiazolo
cancer
alkyl
amine
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Japanese (ja)
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JP2010540458A (ja
JP2010540458A5 (OSRAM
Inventor
カスタネド，ジョーゼット，エム．
グンズナー，ジャネット，エル．
マレスキー，キンバリー
マシュー，シモン
オリベロ，アラン，ジー．
スザリン，ダニエル，ピー．
ワン，シュメイ
シュ，ビン−ヤン
チュクコウリ，イリナ
フォルクス，アドリアン
オックスンフォード，サリー
キー ワン，ナン
キー ワン，ナン
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2010526059A 2007-09-24 2008-09-23 チアゾロピリミジンｐｉ３ｋ阻害剤化合物および使用方法 Active JP5736171B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97470807P 2007-09-24 2007-09-24
US60/974,708 2007-09-24
PCT/US2008/077394 WO2009042607A1 (en) 2007-09-24 2008-09-23 Thiazolopyrimidine p13k inhibitor compounds and methods of use

Publications (3)

Publication Number Publication Date
JP2010540458A JP2010540458A (ja) 2010-12-24
JP2010540458A5 JP2010540458A5 (OSRAM) 2011-11-10
JP5736171B2 true JP5736171B2 (ja) 2015-06-17

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JP2010526059A Active JP5736171B2 (ja) 2007-09-24 2008-09-23 チアゾロピリミジンｐｉ３ｋ阻害剤化合物および使用方法

Country Status (7)

Country Link
US (2) US7893059B2 (OSRAM)
EP (1) EP2207781B1 (OSRAM)
JP (1) JP5736171B2 (OSRAM)
CN (1) CN101932587A (OSRAM)
CA (1) CA2704711C (OSRAM)
ES (1) ES2399774T3 (OSRAM)
WO (1) WO2009042607A1 (OSRAM)

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Also Published As

Publication number Publication date
US8158626B2 (en) 2012-04-17
CN101932587A (zh) 2010-12-29
US7893059B2 (en) 2011-02-22
CA2704711A1 (en) 2009-04-02
US20090118275A1 (en) 2009-05-07
CA2704711C (en) 2016-07-05
US20110112085A1 (en) 2011-05-12
ES2399774T3 (es) 2013-04-03
EP2207781B1 (en) 2012-11-28
JP2010540458A (ja) 2010-12-24
EP2207781A1 (en) 2010-07-21
WO2009042607A1 (en) 2009-04-02

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