JP5722524B2 - 補体活性を抑制することによる同種移植片の生存の延長 - Google Patents

補体活性を抑制することによる同種移植片の生存の延長 Download PDF

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Publication number
JP5722524B2
JP5722524B2 JP2008557383A JP2008557383A JP5722524B2 JP 5722524 B2 JP5722524 B2 JP 5722524B2 JP 2008557383 A JP2008557383 A JP 2008557383A JP 2008557383 A JP2008557383 A JP 2008557383A JP 5722524 B2 JP5722524 B2 JP 5722524B2
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antibody
composition
allograft
drug
complement
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Expired - Fee Related
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JP2009528369A (ja
JP2009528369A5 (https=
Inventor
ラッセル ピー． ローター，
ラッセル ピー． ローター，
ハオ ワン，
ハオ ワン，
チェン チョン，
チェン チョン，
Original Assignee
アレクシオン ファーマシューティカルズ， インコーポレイテッド
アレクシオン ファーマシューティカルズ， インコーポレイテッド
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Application filed by アレクシオン ファーマシューティカルズ， インコーポレイテッド, アレクシオン ファーマシューティカルズ， インコーポレイテッド filed Critical アレクシオン ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2008557383A 2006-03-02 2007-03-02 補体活性を抑制することによる同種移植片の生存の延長 Expired - Fee Related JP5722524B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77885906P 2006-03-02 2006-03-02
US60/778,859 2006-03-02
PCT/US2007/005290 WO2007103134A2 (en) 2006-03-02 2007-03-02 Prolongation of survival of an allograft by inhibiting complement activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013105946A Division JP2013155202A (ja) 2006-03-02 2013-05-20 補体活性を抑制することによる同種移植片の生存の延長

Publications (3)

Publication Number Publication Date
JP2009528369A JP2009528369A (ja) 2009-08-06
JP2009528369A5 JP2009528369A5 (https=) 2011-02-24
JP5722524B2 true JP5722524B2 (ja) 2015-05-20

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ID=38475394

Family Applications (2)

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JP2008557383A Expired - Fee Related JP5722524B2 (ja) 2006-03-02 2007-03-02 補体活性を抑制することによる同種移植片の生存の延長
JP2013105946A Withdrawn JP2013155202A (ja) 2006-03-02 2013-05-20 補体活性を抑制することによる同種移植片の生存の延長

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JP2013105946A Withdrawn JP2013155202A (ja) 2006-03-02 2013-05-20 補体活性を抑制することによる同種移植片の生存の延長

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Country Link
US (1) US20100135992A1 (https=)
EP (2) EP1988882B1 (https=)
JP (2) JP5722524B2 (https=)
KR (2) KR101527225B1 (https=)
CN (1) CN101437501B (https=)
AU (1) AU2007224250B2 (https=)
BR (1) BRPI0708424A2 (https=)
CA (1) CA2644020C (https=)
DK (1) DK1988882T3 (https=)
ES (1) ES2530637T3 (https=)
HR (1) HRP20150182T1 (https=)
IL (1) IL193623A0 (https=)
MX (1) MX2008011054A (https=)
NZ (1) NZ570802A (https=)
PL (1) PL1988882T3 (https=)
PT (1) PT1988882E (https=)
RS (1) RS53864B1 (https=)
RU (1) RU2445975C2 (https=)
SG (1) SG171578A1 (https=)
SI (1) SI1988882T1 (https=)
WO (1) WO2007103134A2 (https=)

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Also Published As

Publication number Publication date
PL1988882T3 (pl) 2015-04-30
WO2007103134A2 (en) 2007-09-13
CA2644020C (en) 2016-05-10
EP1988882B1 (en) 2014-12-17
BRPI0708424A2 (pt) 2011-05-31
JP2009528369A (ja) 2009-08-06
HRP20150182T1 (hr) 2015-06-05
NZ570802A (en) 2012-03-30
ES2530637T3 (es) 2015-03-04
JP2013155202A (ja) 2013-08-15
CN101437501A (zh) 2009-05-20
DK1988882T3 (en) 2015-02-23
SI1988882T1 (sl) 2015-07-31
KR101650264B1 (ko) 2016-08-22
WO2007103134A3 (en) 2008-09-12
HK1120444A1 (en) 2009-04-03
IL193623A0 (en) 2009-08-03
AU2007224250B2 (en) 2012-05-03
PT1988882E (pt) 2015-02-17
MX2008011054A (es) 2009-03-03
AU2007224250A1 (en) 2007-09-13
RU2445975C2 (ru) 2012-03-27
RS53864B1 (sr) 2015-08-31
KR101527225B1 (ko) 2015-06-08
US20100135992A1 (en) 2010-06-03
KR20080098543A (ko) 2008-11-10
EP2918269A1 (en) 2015-09-16
KR20140124023A (ko) 2014-10-23
CN101437501B (zh) 2012-09-05
SG171578A1 (en) 2011-06-29
EP1988882A2 (en) 2008-11-12
CA2644020A1 (en) 2007-09-13
RU2008139118A (ru) 2010-04-10

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