JP5718313B2 - 哺乳類由来の非生理活性添加剤を含まないタンパク質安定化製剤 - Google Patents
哺乳類由来の非生理活性添加剤を含まないタンパク質安定化製剤 Download PDFInfo
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- JP5718313B2 JP5718313B2 JP2012505092A JP2012505092A JP5718313B2 JP 5718313 B2 JP5718313 B2 JP 5718313B2 JP 2012505092 A JP2012505092 A JP 2012505092A JP 2012505092 A JP2012505092 A JP 2012505092A JP 5718313 B2 JP5718313 B2 JP 5718313B2
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Description
◇ジストニア、
・頭蓋ジストニア、
−眼瞼けいれん、
−顎口腔ジストニア
−−あご開放型、
−−あご閉鎖型、
−歯ぎしり、
−メージュ症候グループ、
−舌ジストニア、
−開眼失行、
・頸部ジストニア、
−前頸部ジストニア(antecollis)
−後頸部ジストニア(retrocollis)
−側頸部ジストニア(laterocollis)
−斜頸、
・咽頭ジストニア、
・喉頭ジストニア、
−痙攣性発声障害/内転型、
−痙攣性発声障害/外転型、
−痙攣性呼吸困難、
・四肢ジストニア、
−腕ジストニア、
−−作業課題特異性ジストニア、
−−−書痙、
−−−ミュージシャンのけいれん、
−−−ゴルファーのけいれん、
−脚ジストニア、
−−太ももの内転及び外転、
−−膝の屈曲及び伸展、
−−足首の屈曲及び伸展、
−−内反尖足変形、
−足のジストニア、
−−線条体つま先、
−−つま先の屈曲、
−−つま先の伸展、
−軸性ジストニア、
−−ピサ症候グループ、
−−ベリーダンサージストニア、
−分節性ジストニア、
−片側ジストニア、
−全身性ジストニア、
・Lubag型ジストニア、
・大脳基底核変性症のジストニア、
・Lubag型ジストニア、
・遅発性ジストニア、
・脊髄小脳失調症ジストニア、
・パーキンソン病ジストニア、
・ハンチントン病ジストニア、
・ハレルフォルデン‐スパッツ症ジストニア、
・ドーパ誘発性ジスキネジア/ドーパ誘発性ジストニア、
・遅発性ジスキネジア/遅発性ジストニア、
・発作性ジスキネジア/ジストニア、
−運動起源性、
−非運動起源性、
−動作誘発性、
◇口蓋ミオクローヌス、
◇ミオクローヌス、
◇ミオキミア、
◇硬直、
◇良性筋肉けいれん、
◇遺伝性あごけいれん、
◇奇異性筋肉痙攣
◇片側咀嚼痙攣、
◇肥大性鰓ミオパチー、
◇Maseteric肥大症、
◇脛骨前部肥大症、
◇眼振、
◇動揺視、
◇多汗症、
◇核上性注視麻痺、
◇持続性部分てんかん、
◇痙性斜頸動作、
◇予定痙性斜頸動作、
◇転声帯麻痺、
◇不応性突然変異発声、
◇上部食道括約筋機能不全、
◇声帯肉芽腫、
◇吃音、
◇ジルドイアトゥレット症候グループ、
◇中耳ミオクローヌス、
◇保護喉頭閉鎖、
◇喉頭摘出後の音声障害、
◇保護眼瞼下垂、
◇眼瞼内反症、
◇オッディ括約筋障害、
◇疑似アカラシア、
◇非アカラシア食道運動障害、
◇膣痙、
◇術後不動、
◇振戦、
◇膀胱機能障害、
−排尿筋括約筋協調不全、
−膀胱括約筋のけいれん、
◇片側顔面けいれん、
◇神経再支配ジスキネジア、
◇化粧用、
−カラスの足、
−しかめっ面、
−顔面非対称、
−オトガイえくぼ、
◇スティッフパーソン症候グループ、
◇破傷風、
◇前立腺肥大症、
◇肥満症治療、
◇小児脳性麻痺、
◇斜視、
−混合、
−麻痺性、
−随伴性、
−網膜剥離手術後、
−白内障手術後、
−網膜剥離手術後、
−無水晶体、
−筋炎性斜視、
−筋性斜視、
−交代性上斜位、
−斜視手術の補助として、
−内斜視、
−外斜視、
◇アカラシア、
◇肛門亀裂、
◇外分泌腺の亢進、
−フレイ症候グループ、
−ワニの涙症候グループ、
−多汗症、
−−腋窩、
−−掌、
−−足裏、
◇鼻漏、
◇比較的唾液分泌過多、
−発作中、
−パーキンソン病中、
−筋萎縮性側索硬化症中、
◇けいれん症、
−脳炎及び脊髄炎で、
−−自己免疫性プロセス、
−−−多発性硬化症、
−−−横断性脊髄炎、
−−−Devic症候グループ、
−−ウイルス感染、
−−細菌感染、
−−寄生虫感染、
−−真菌感染、
−遺伝性痙攣不全対麻痺で、
−脳卒中後症候グループ、
−−片側梗塞、
−−脳幹梗塞、
−−脊髄梗塞、
−中枢神経系外傷で、
−−片側梗塞、
−−脳幹梗塞、
−−脊髄梗塞、
−中枢神経系出血で、
−−脳内出血、
−−くも膜下出血、
−−硬膜下出血、
−腫瘍で、
−−片側腫瘍、
−−脳幹腫瘍、
−−脊髄腫瘍。
Claims (8)
- (a) ボツリヌス毒素、
(b) ヒアルロン酸、ポリビニルピロリドン(PVP)、及び、これらの混合物から選択される親水性ポリマー、
(c) 多価アルコールと糖類化合物との、重量比が2:1〜5:1(wt-%)の混合物、及び、
(d) 非イオン界面活性剤
を含み、
多価アルコールは、マンニトール、キシリトール、エリスリトール、ソルビトール、及び、これらの混合物よりなるグループから選択され、糖類化合物は、グルコース、フルクトース、ガラクトース、トレハロース、スクロース、マルトース、及び、これらの混合物よりなるグループから選択されるものであり、
安定化タンパク質を含まないことを特徴とする製剤。 - 前記非イオン界面活性剤が、ソルビタンエステル(ソルビタン・モノラウレート、ソルビタン・モノパルミテート、ソルビタン・モノステアレート、ソルビタン・トリステアレート、ソルビタン・モノオレエート、ソルビタン・トリオレエート)、ポリソルベート(ポリオキシエチレン(20)ソルビタン・モノラウレート(ポリソルベート20)、ポリオキシエチレン(20)ソルビタン・モノパルミテート、ポリオキシエチレン(20) ソルビタンモノステアレート、ポリオキシエチレン(20) ソルビタン・トリステアレート、ポリオキシエチレン(20) ソルビタン・トリオレエート、ポリオキシエチレン(20)ソルビタン・モノオレエート(トゥイーン80/ポリソルベート 80))、ポロキサマー(poloxamer 407、poloxamer 188)、ポリオキシエチレン・ヒマシ油(クレモホール)、または、これらの混合物である請求項1に記載の製剤。
- 凍結乾燥されたことを特徴とする請求項1または2に記載の製剤。
- ボツリヌス毒素、ヒアルロン酸、マンニトール、スクロース及びポリソルベート80を含んでおり、これらに加えて注射用蒸留水を含み得る請求項1〜3のいずれかに記載の製剤。
- 請求項1〜4のいずれかの製剤からなる注射剤。
- 請求項1〜5のいずれかの製剤からなる薬物、化粧品、薬用化粧品または診断薬。
- 機能亢進性の、筋肉のコリン作動性神経支配または外分泌腺によって引き起こされるか、または、関連した病気または状態の治療に用いるための、請求項1〜5のいずれかの製剤からなる治療剤。
- (a) 請求項1〜4のいずれかの製剤、請求項5の注射剤、請求項6に記載の薬物、化粧品、薬用化粧品または診断薬、または請求項7の治療剤を含む一つまたは2つ以上の容器、及び、
(b) 前記製剤についての使用説明書、並びに、場合により追加される、
(c) 薬剤学的に許容可能な滅菌溶剤
からなるキット。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21295209P | 2009-04-17 | 2009-04-17 | |
EP09005470A EP2248518B1 (en) | 2009-04-17 | 2009-04-17 | Formulation for stabilizing proteins, peptides or mixtures thereof. |
EP09005470.1 | 2009-04-17 | ||
US61/212,952 | 2009-04-17 | ||
PCT/EP2010/002360 WO2010118888A1 (en) | 2009-04-17 | 2010-04-16 | Formulation for stabilizing proteins, which is free of mammalian excipients |
Publications (2)
Publication Number | Publication Date |
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JP2012524035A JP2012524035A (ja) | 2012-10-11 |
JP5718313B2 true JP5718313B2 (ja) | 2015-05-13 |
Family
ID=41082346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2012505092A Active JP5718313B2 (ja) | 2009-04-17 | 2010-04-16 | 哺乳類由来の非生理活性添加剤を含まないタンパク質安定化製剤 |
Country Status (16)
Country | Link |
---|---|
US (2) | US9198856B2 (ja) |
EP (2) | EP2248518B1 (ja) |
JP (1) | JP5718313B2 (ja) |
KR (1) | KR101708952B1 (ja) |
CN (2) | CN107789620A (ja) |
AU (1) | AU2010237270B2 (ja) |
BR (1) | BRPI1014034A2 (ja) |
CA (1) | CA2758754A1 (ja) |
ES (1) | ES2606567T3 (ja) |
HK (1) | HK1248556A1 (ja) |
IL (1) | IL215354A0 (ja) |
IN (1) | IN2011KN04251A (ja) |
MX (1) | MX2011010801A (ja) |
RU (1) | RU2539388C2 (ja) |
WO (1) | WO2010118888A1 (ja) |
ZA (1) | ZA201108433B (ja) |
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MX2011010801A (es) | 2011-10-28 |
AU2010237270B2 (en) | 2015-02-05 |
CA2758754A1 (en) | 2010-10-21 |
US20160184413A1 (en) | 2016-06-30 |
ZA201108433B (en) | 2013-06-26 |
IN2011KN04251A (ja) | 2015-07-10 |
RU2011146541A (ru) | 2013-05-27 |
ES2606567T3 (es) | 2017-03-24 |
KR20120022777A (ko) | 2012-03-12 |
EP2248518B1 (en) | 2013-01-16 |
JP2012524035A (ja) | 2012-10-11 |
EP2419089A1 (en) | 2012-02-22 |
AU2010237270A1 (en) | 2011-10-20 |
RU2539388C2 (ru) | 2015-01-20 |
BRPI1014034A2 (pt) | 2016-04-12 |
KR101708952B1 (ko) | 2017-02-21 |
US20120093866A1 (en) | 2012-04-19 |
WO2010118888A1 (en) | 2010-10-21 |
IL215354A0 (en) | 2011-12-29 |
HK1248556A1 (zh) | 2018-10-19 |
EP2248518A1 (en) | 2010-11-10 |
EP2419089B1 (en) | 2016-11-16 |
CN102387791A (zh) | 2012-03-21 |
US9198856B2 (en) | 2015-12-01 |
CN107789620A (zh) | 2018-03-13 |
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