JP5715569B2 - トリアゾール含有マクロライドを用いた耐性疾患の治療方法 - Google Patents

トリアゾール含有マクロライドを用いた耐性疾患の治療方法 Download PDF

Info

Publication number
JP5715569B2
JP5715569B2 JP2011533398A JP2011533398A JP5715569B2 JP 5715569 B2 JP5715569 B2 JP 5715569B2 JP 2011533398 A JP2011533398 A JP 2011533398A JP 2011533398 A JP2011533398 A JP 2011533398A JP 5715569 B2 JP5715569 B2 JP 5715569B2
Authority
JP
Japan
Prior art keywords
cem
mic
resistant
tel
strains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2011533398A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012506871A (ja
JP2012506871A5 (Direct
Inventor
ペレイラ,デイビッド,イー.
フェルナンデス,プラブハバシ,ビー.
Original Assignee
センプラ ファーマシューティカルズ,インコーポレイテッド
センプラ ファーマシューティカルズ,インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by センプラ ファーマシューティカルズ,インコーポレイテッド, センプラ ファーマシューティカルズ,インコーポレイテッド filed Critical センプラ ファーマシューティカルズ,インコーポレイテッド
Publication of JP2012506871A publication Critical patent/JP2012506871A/ja
Publication of JP2012506871A5 publication Critical patent/JP2012506871A5/ja
Application granted granted Critical
Publication of JP5715569B2 publication Critical patent/JP5715569B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/424Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08Hetero rings containing eight or more ring members, e.g. erythromycins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2011533398A 2008-10-24 2009-10-24 トリアゾール含有マクロライドを用いた耐性疾患の治療方法 Active JP5715569B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US10816808P 2008-10-24 2008-10-24
US10813408P 2008-10-24 2008-10-24
US10811208P 2008-10-24 2008-10-24
US10813708P 2008-10-24 2008-10-24
US10811008P 2008-10-24 2008-10-24
US61/108,168 2008-10-24
US61/108,137 2008-10-24
US61/108,110 2008-10-24
US61/108,134 2008-10-24
US61/108,112 2008-10-24
US16210909P 2009-03-20 2009-03-20
US61/162,109 2009-03-20
PCT/US2009/061977 WO2010048600A1 (en) 2008-10-24 2009-10-24 Methods for treating resistant diseases using triazole containing macrolides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014237428A Division JP5922210B2 (ja) 2008-10-24 2014-11-25 トリアゾール含有マクロライドを用いた耐性疾患の治療方法

Publications (3)

Publication Number Publication Date
JP2012506871A JP2012506871A (ja) 2012-03-22
JP2012506871A5 JP2012506871A5 (Direct) 2012-12-06
JP5715569B2 true JP5715569B2 (ja) 2015-05-07

Family

ID=42119711

Family Applications (10)

Application Number Title Priority Date Filing Date
JP2011533399A Expired - Fee Related JP5602748B2 (ja) 2008-10-24 2009-10-24 トリアゾール含有マクロライドを用いた生体防御
JP2011533397A Expired - Fee Related JP5711135B2 (ja) 2008-10-24 2009-10-24 胃腸疾患を治療するための方法
JP2011533398A Active JP5715569B2 (ja) 2008-10-24 2009-10-24 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2014167991A Expired - Fee Related JP6002185B2 (ja) 2008-10-24 2014-08-20 トリアゾール含有マクロライドを用いた生体防御
JP2014237346A Active JP5908569B2 (ja) 2008-10-24 2014-11-25 胃腸疾患を治療するための方法
JP2014237428A Active JP5922210B2 (ja) 2008-10-24 2014-11-25 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2016080557A Active JP6309995B2 (ja) 2008-10-24 2016-04-13 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2018047869A Pending JP2018115177A (ja) 2008-10-24 2018-03-15 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2019189322A Pending JP2020023544A (ja) 2008-10-24 2019-10-16 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2021146793A Active JP7171860B2 (ja) 2008-10-24 2021-09-09 トリアゾール含有マクロライドを用いた耐性疾患の治療方法

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2011533399A Expired - Fee Related JP5602748B2 (ja) 2008-10-24 2009-10-24 トリアゾール含有マクロライドを用いた生体防御
JP2011533397A Expired - Fee Related JP5711135B2 (ja) 2008-10-24 2009-10-24 胃腸疾患を治療するための方法

Family Applications After (7)

Application Number Title Priority Date Filing Date
JP2014167991A Expired - Fee Related JP6002185B2 (ja) 2008-10-24 2014-08-20 トリアゾール含有マクロライドを用いた生体防御
JP2014237346A Active JP5908569B2 (ja) 2008-10-24 2014-11-25 胃腸疾患を治療するための方法
JP2014237428A Active JP5922210B2 (ja) 2008-10-24 2014-11-25 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2016080557A Active JP6309995B2 (ja) 2008-10-24 2016-04-13 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2018047869A Pending JP2018115177A (ja) 2008-10-24 2018-03-15 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2019189322A Pending JP2020023544A (ja) 2008-10-24 2019-10-16 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2021146793A Active JP7171860B2 (ja) 2008-10-24 2021-09-09 トリアゾール含有マクロライドを用いた耐性疾患の治療方法

Country Status (11)

Country Link
US (7) US9072759B2 (Direct)
EP (4) EP2358379B1 (Direct)
JP (10) JP5602748B2 (Direct)
CN (4) CN102245195B (Direct)
AU (4) AU2009308180B2 (Direct)
DK (1) DK2358379T3 (Direct)
ES (3) ES2676168T3 (Direct)
HK (1) HK1252140A1 (Direct)
HR (1) HRP20160222T1 (Direct)
SI (1) SI2358379T1 (Direct)
WO (3) WO2010048599A1 (Direct)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015078203A (ja) * 2008-10-24 2015-04-23 センプラ ファーマシューティカルズ,インコーポレイテッド トリアゾール含有マクロライドを用いた耐性疾患の治療方法

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2772254A3 (en) 2003-03-10 2015-03-11 Optimer Pharmaceuticals, Inc. Novel Antibacterial Agents
JP5698979B2 (ja) 2007-10-25 2015-04-08 センプラ ファーマシューティカルズ,インコーポレイテッド マクロライド系抗菌剤の調製プロセス
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
AU2011232627B2 (en) * 2010-03-22 2016-03-17 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
RU2608390C2 (ru) * 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
WO2012034058A1 (en) * 2010-09-10 2012-03-15 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
JP6208742B2 (ja) 2012-03-27 2017-10-04 センプラ ファーマシューティカルズ,インコーポレイテッド マクロライド抗生物質を投与するための非経口製剤
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
BR112015025159A2 (pt) * 2013-04-04 2017-07-18 Harvard College macrolídeos e métodos de sua preparação e uso
CN104151382B (zh) * 2014-08-08 2016-09-14 广东东阳光药业有限公司 一种固态大环内酯的晶型
CN104311611B (zh) * 2014-08-13 2017-01-18 广东东阳光药业有限公司 一种制备固态大环内酯的方法
JP2017531663A (ja) 2014-10-08 2017-10-26 プレジデント アンド フェローズ オブ ハーバード カレッジ 14員ケトライドならびにそれらの調製および使用の方法
WO2016154591A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
CN106554992A (zh) * 2015-09-28 2017-04-05 中国疾病预防控制中心传染病预防控制所 检测耐红霉素弯曲菌的试剂盒
AU2018220172A1 (en) * 2017-02-17 2019-10-03 Cempra Pharmaceuticals, Inc. Triazole-containing macrolides and ophthalmic uses therefor
US10706191B2 (en) * 2017-08-31 2020-07-07 Google Llc Systems and methods for generating a geo-level hierarchical Bayesian model
US11145299B2 (en) 2018-04-19 2021-10-12 X Development Llc Managing voice interface devices

Family Cites Families (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1354753A (en) 1919-02-11 1920-10-05 E M Lannes Portable building
US2180006A (en) 1936-09-09 1939-11-14 Eastman Kodak Co Process for the separation and refining of amines
GB891817A (en) 1959-04-07 1962-03-21 Upjohn Co Improvements in or relating to injectable tetracyclic preparations
US3843787A (en) 1969-01-15 1974-10-22 Pierrel Spa Water soluble derivative of erythromycin
US3668282A (en) 1970-05-08 1972-06-06 Stauffer Chemical Co Stabilized mixture employing n-(beta-0,0-dialkyldithiophosphoryl) aryl sulfonamides
SE458505B (sv) 1979-07-10 1989-04-10 Lepetit Spa Anvaendningen av rifamycin sv och salter daerav foer framstaellning av en beredning foer behandling av reumatoid artrit samt vissa av salterna och deras framstaellning
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
JPS59175414A (ja) 1983-03-23 1984-10-04 Toyo Jozo Co Ltd マクロライド抗生物質の安定な経口用製剤および安定化法
US4742049A (en) 1986-06-04 1988-05-03 Abbott Laboratories Semisynthetic erythromycin antibiotics
KR960000434B1 (ko) 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
DE3860503D1 (de) 1987-09-03 1990-10-04 Pliva Pharm & Chem Works 10-dihydro-10-deoxo-11-azaerythronolid-a-verbindungen,verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln und in deren herstellung.
BE1001869A3 (fr) 1988-10-12 1990-04-03 Franz Legros Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine.
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of erythromycin derivatives
US5985844A (en) 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5834428A (en) 1995-04-14 1998-11-10 1149336 Ontario Inc. Glucagon-like peptide-2 and its therapeutic use
US5968977A (en) * 1995-06-28 1999-10-19 Tokuyama Corporation Ketonitrile derivatives and antibacterial agent and drugs containing the same
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
US6274715B1 (en) 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
US5742049A (en) * 1995-12-21 1998-04-21 Bruker-Franzen Analytik Gmbh Method of improving mass resolution in time-of-flight mass spectrometry
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745290B1 (fr) * 1996-02-28 1998-04-03 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US5719272A (en) 1996-04-02 1998-02-17 Abbott Laboratories 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
DE69733370T2 (de) 1996-09-04 2006-02-02 Abbott Laboratories, Abbott Park 6-o-Substituierte Ketoliden mit antibakteriellen Wirkung
BR9714394A (pt) 1996-12-13 2000-05-16 Lilly Co Eli Inibidores da atividade enzimática de psa
HN1998000086A (es) 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
US6407074B1 (en) * 1997-06-11 2002-06-18 Pfizer Inc C-4″-substituted macrolide derivatives
EP0988308A1 (en) 1997-06-11 2000-03-29 Pfizer Products Inc. 9-oxime erythromycin derivatives
HN1998000074A (es) 1997-06-11 1999-01-08 Pfizer Prod Inc Derivados de macrolidos c-4 sustituidos
HN1998000159A (es) 1997-10-29 1999-02-09 Monsanto Co Derivados de 9- amino - 3 ceto eritromicina
IL135792A0 (en) 1997-12-01 2001-05-20 Abbott Lab 6-o-alkyl derivatives of erythronolide b
DE69918074T2 (de) * 1998-03-26 2004-11-04 Fujisawa Pharmaceutical Co., Ltd. Makrolid-formulierung mit verzögerter wirkstoffabgabe
FR2777282B1 (fr) 1998-04-08 2001-04-20 Hoechst Marion Roussel Inc Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
US6387885B1 (en) 1998-08-26 2002-05-14 Abbott Laboratories 3′,3′-N-bis-desmethyl-3′-N-cycloalkyl erythromycin derivatives as LHRH antagonists
US6020521A (en) * 1998-08-26 2000-02-01 Abbott Laboratories Macrolide LHRH antagonists
FR2785612A1 (fr) 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2786188B1 (fr) 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
KR100317907B1 (ko) 1998-11-24 2001-12-24 김 완 주 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
TR200102129T2 (tr) * 1998-12-10 2002-01-21 Pfizer Products Inc. Karbamat ve karbazat ketolid antibiyotikleri.
TR200102128T2 (tr) 1999-01-27 2001-12-21 Pfizer Products Inc. Ketolid antibiyotikler
CA2292359C (en) 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
FR2789392B1 (fr) 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
AR023264A1 (es) 1999-04-08 2002-09-04 Hokuriku Pharmaceutical Derivados de eritromicina
JP2000351794A (ja) 1999-04-08 2000-12-19 Hokuriku Seiyaku Co Ltd エリスロマイシン誘導体
KR100710605B1 (ko) 1999-04-16 2007-04-24 코산 바이오사이언시즈, 인코포레이티드 매크롤라이드 항감염제
CA2370743A1 (en) 1999-04-16 2000-10-26 Dennis Hlasta Ketolide antibacterials
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6420535B1 (en) 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
AU6183700A (en) 1999-08-06 2001-03-05 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
AU3337900A (en) 1999-08-09 2001-03-05 Eric Au An apparatus for treating wastewater
US6096922A (en) 1999-11-01 2000-08-01 Air Products And Chemicals, Inc. Process for the synthesis of dialkyl, diaryl, and arylalkyl aminosulfur trifluorides
KR100336447B1 (ko) 1999-11-24 2002-05-15 민경윤 클라리스로마이신의 개선된 제조방법
JP2001261694A (ja) 2000-03-06 2001-09-26 Pfizer Prod Inc ケトライド抗生物質
ATE338053T1 (de) 2000-03-15 2006-09-15 Hanmi Pharm Ind Co Ltd Verfahren zur herstellung von clarythromycin mit nicht pharmazeutischer qualität
NZ523693A (en) 2000-07-10 2004-08-27 Chiron Corp Macrolide formulations for inhalation and methods of treatment of endobronchial infections
US20020115621A1 (en) * 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
GB0031312D0 (en) 2000-12-21 2001-02-07 Glaxo Group Ltd Macrolides
ES2261735T3 (es) 2001-05-18 2006-11-16 Chiron Corporation Sistema para la administracion de una formulacion de tobramicina.
AU2002316550A1 (en) 2001-07-03 2003-01-21 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
US20030176327A1 (en) * 2001-10-25 2003-09-18 Cassell Gail Houston Antibiotics for treating biohazardous bacterial agents
BR0307898A (pt) 2002-02-22 2004-12-07 Pharmacia Corp Formulações de droga antibiótica oftálmica contendo um composto de ciclodextrina e cloreto de cetil piridìnio
JP4638225B2 (ja) 2002-05-30 2011-02-23 ザ スクリプス リサーチ インスティテュート 銅を触媒とするアジドとアセチレンのライゲーション
AU2003276836B2 (en) 2002-06-17 2007-05-10 Epigenesis Pharmaceuticals, Llc. Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof
RS20050008A (sr) 2002-07-08 2007-06-04 Pliva-Istraživački Institut D.O.O., Nova jedinjenja,kompozicije i metode za lečenje inflamatornih oboljenja i stanja
AR043050A1 (es) 2002-09-26 2005-07-13 Rib X Pharmaceuticals Inc Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos
ITMI20022292A1 (it) 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
EP2772254A3 (en) * 2003-03-10 2015-03-11 Optimer Pharmaceuticals, Inc. Novel Antibacterial Agents
CA2523134A1 (en) 2003-04-25 2004-11-11 Chiron Corporation Pyridyl substituted ketolide antibiotics
US7163924B2 (en) 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
DE602004003809T2 (de) 2003-05-13 2007-10-11 Glaxo Group Ltd., Greenford Neue 14- und 15-gliedrige ringverbindungen
WO2005007143A2 (en) 2003-07-14 2005-01-27 The Board Of Trustees Of The University Of Illinois Use of makrolides and ketolides for the treatment of tuberculosis
US7457520B2 (en) 2003-07-24 2008-11-25 Time Warner Cable, Inc. Technique for providing a virtual digital video recorder service through a communications network
GB0402578D0 (en) 2004-02-05 2004-03-10 Cambridge Theranostics Ltd Methods of treatment of atherosclerosis
US20060116336A1 (en) 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
PL1742957T3 (pl) 2004-04-28 2008-05-30 Alembic Ltd Sposób otrzymywania telitromycyny
EP1756135B1 (en) 2004-05-06 2009-08-12 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. Ester linked macrolides useful for the treatment of microbial infections
EP1794171A2 (en) 2004-07-28 2007-06-13 Ranbaxy Laboratories, Ltd. Ketolide derivatives as antibacterial agents
GB0424959D0 (en) 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424958D0 (en) 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
US20080113926A1 (en) 2005-01-14 2008-05-15 Zrinka Ivezic 9A-Carbamoyl-Y-Aminopropyl- And 9A-Thiocabamoyl-Y-Aminopropyl-Azalides With Antimalarial Activity
EP1841437B1 (en) 2005-01-14 2009-04-29 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-carbamoyl and thiocarbamoyl azalides with antimalarial activity
WO2006106440A1 (en) 2005-01-14 2006-10-12 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Macrolide compounds containing biotin and photo-affinity group for macrolide target identification
WO2006102308A2 (en) 2005-03-22 2006-09-28 Azevan Pharmaceuticals, Inc. Beta-lactamyl vasopressin v1b antagonists
EP1904041A2 (en) 2005-07-07 2008-04-02 Elan Pharma International Limited Nanoparticulate clarithromycin formulations
JP5328349B2 (ja) 2005-07-19 2013-10-30 アゼヴァン ファーマスーティカルズ,インコーポレイテッド ベータ−ラクタミルフェニルアラニン、システイン、およびセリン・バソプレッシン拮抗剤
DK1945654T3 (en) 2005-10-31 2015-11-30 Leo Pharma As CREATING A antibiotic, CRYSTALLINE fusidic
GB0522715D0 (en) 2005-11-08 2005-12-14 Helperby Therapeutics Ltd New use
US20070167382A1 (en) 2005-11-15 2007-07-19 Nina Finkelstein Crystalline and amorphous forms of telithromycin
US20090075916A1 (en) 2005-11-23 2009-03-19 Upadhyay Dilip J Use of Macrolide Derivatives for Treating Acne
US20090005325A1 (en) * 2005-11-23 2009-01-01 Biswajit Bas Ketolide Derivatives as Antibacterial Agents
DOP2006000268A (es) 2005-12-22 2007-07-31 Pfizer Prod Inc Agentes antibacterianos
CN101045063B (zh) 2006-03-28 2011-01-26 广州朗圣药业有限公司 注射用克拉霉素水溶性制剂
CN103193840A (zh) 2006-05-01 2013-07-10 大正制药株式会社 大环内酯衍生物
CA2654450A1 (en) 2006-06-05 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted erythromycin analogs
DE102006036199B4 (de) * 2006-08-03 2016-01-07 Deere & Company Förderzusammenbau und Presse
CN101129383B (zh) 2006-08-25 2014-04-02 天津和美生物技术有限公司 含氨基糖苷类抗生素的抗生素复方
JP5698979B2 (ja) 2007-10-25 2015-04-08 センプラ ファーマシューティカルズ,インコーポレイテッド マクロライド系抗菌剤の調製プロセス
US20090209547A1 (en) * 2008-02-15 2009-08-20 In Jong Kim C-8 halogenated macrolides
EP2358379B1 (en) * 2008-10-24 2015-12-16 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9814657B2 (en) 2009-04-27 2017-11-14 Premier Dental Products Company Buffered microencapsulated compositions and methods
CA2767614C (en) 2009-07-13 2019-01-15 Cempra Pharmaceuticals Inc. Fusidic acid dosing regimens for treatment of bacterial infections
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
US20110119604A1 (en) 2009-11-19 2011-05-19 Clevest Solutions Inc. System and method for a configurable and extensible allocation and scheduling tool
CN109091489A (zh) 2010-03-10 2018-12-28 森普拉制药公司 大环内酯类抗生素的肠胃外制剂
AU2011232627B2 (en) 2010-03-22 2016-03-17 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
RU2608390C2 (ru) 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
US8247394B2 (en) 2010-06-02 2012-08-21 Cempra Pharmaceuticals Inc. Methods of treating urethritis and related infections using fusidic acid
WO2012012257A2 (en) 2010-07-19 2012-01-26 Virginia Commonwealth University BIVALENT MULTIFUNCTIONAL LIGANDS TARGETING Aβ OLIGOMERS AS TREATMENT FOR ALZHEIMER'S DISEASE
WO2012030513A2 (en) 2010-08-30 2012-03-08 Cempra Pharmaceuticals Inc. Methods of treating bacterial infections through pulmonary delivery of fusidic acid
WO2012034058A1 (en) 2010-09-10 2012-03-15 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
WO2012042534A2 (en) 2010-09-28 2012-04-05 Glenmark Generics Limited Processes for the preparation of r-sitagliptin and intermediates thereof
JP6072778B2 (ja) 2011-05-23 2017-02-01 シーイーエム—102 ファーマシューティカルズ,インコーポレイテッド フシジン酸を含む組成物およびそのためのパッケージ
US8822450B2 (en) 2011-08-27 2014-09-02 Wockhardt Ltd. 1,6-diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections
CN103998442B (zh) 2011-08-29 2016-09-14 无限药品股份有限公司 杂环化合物及其用途
US8461188B2 (en) 2011-10-20 2013-06-11 Trius Therapeutics, Inc. Therapeutic combination of daptomycin and protein synthesis inhibitor antibiotic, and methods of use
JP6208742B2 (ja) 2012-03-27 2017-10-04 センプラ ファーマシューティカルズ,インコーポレイテッド マクロライド抗生物質を投与するための非経口製剤
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
BR112015025159A2 (pt) 2013-04-04 2017-07-18 Harvard College macrolídeos e métodos de sua preparação e uso
RU2016133471A (ru) 2014-02-14 2018-03-19 Семпра Фармасьютикалс, Инк. Композиции и способы для лечения диабета и заболеваний печени
US20170101365A1 (en) 2014-05-27 2017-04-13 Dipharma Francis S.R.L. Azidoalkylamine salts and their use as intermediates
EP3185864A4 (en) 2014-08-05 2018-03-28 Cempra Pharmaceuticals, Inc. Powder oral suspension formulations of antibacterial agents
WO2016144833A1 (en) 2015-03-06 2016-09-15 Cempra Pharmaceuticals, Inc. Processes for preparing fluoroketolides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015078203A (ja) * 2008-10-24 2015-04-23 センプラ ファーマシューティカルズ,インコーポレイテッド トリアゾール含有マクロライドを用いた耐性疾患の治療方法

Also Published As

Publication number Publication date
CN107854477A (zh) 2018-03-30
WO2010048601A1 (en) 2010-04-29
CN102245195B (zh) 2016-01-13
JP2021193117A (ja) 2021-12-23
AU2009308182A1 (en) 2010-04-29
JP7171860B2 (ja) 2022-11-15
US9669046B2 (en) 2017-06-06
EP2362727B1 (en) 2018-04-11
JP2012506872A (ja) 2012-03-22
JP6002185B2 (ja) 2016-10-05
CN102223794A (zh) 2011-10-19
US20150105339A1 (en) 2015-04-16
US8791080B2 (en) 2014-07-29
AU2009308180A1 (en) 2010-04-29
EP3031460A1 (en) 2016-06-15
JP5922210B2 (ja) 2016-05-24
JP2015061858A (ja) 2015-04-02
CN102223794B (zh) 2017-12-22
SI2358379T1 (sl) 2016-05-31
AU2009308180B2 (en) 2016-01-07
US20160082028A1 (en) 2016-03-24
EP2358379A4 (en) 2012-05-09
JP5602748B2 (ja) 2014-10-08
EP2362727A4 (en) 2012-05-02
US9439918B2 (en) 2016-09-13
WO2010048599A1 (en) 2010-04-29
AU2009308181A1 (en) 2010-04-29
CN102245195A (zh) 2011-11-16
HK1252140A1 (zh) 2019-05-17
EP2358379B1 (en) 2015-12-16
US20180369262A1 (en) 2018-12-27
JP5908569B2 (ja) 2016-04-26
WO2010048600A1 (en) 2010-04-29
JP6309995B2 (ja) 2018-04-11
JP5711135B2 (ja) 2015-04-30
JP2016166224A (ja) 2016-09-15
ES2676168T3 (es) 2018-07-17
US8796232B2 (en) 2014-08-05
ES2677007T3 (es) 2018-07-27
HRP20160222T1 (hr) 2016-04-08
US9072759B2 (en) 2015-07-07
JP2012506871A (ja) 2012-03-22
JP2020023544A (ja) 2020-02-13
AU2009308182B2 (en) 2016-05-19
US20150111845A1 (en) 2015-04-23
ES2565083T3 (es) 2016-03-31
EP2365747A4 (en) 2012-06-13
EP2365747A1 (en) 2011-09-21
EP2365747B1 (en) 2018-04-11
JP2014237710A (ja) 2014-12-18
CN105616437A (zh) 2016-06-01
US9901592B2 (en) 2018-02-27
EP2362727A1 (en) 2011-09-07
US20110237534A1 (en) 2011-09-29
US20110201566A1 (en) 2011-08-18
JP2015078203A (ja) 2015-04-23
CN102245022A (zh) 2011-11-16
JP2012506870A (ja) 2012-03-22
JP2018115177A (ja) 2018-07-26
DK2358379T3 (en) 2016-03-07
AU2016202707A1 (en) 2016-05-19
EP2358379A1 (en) 2011-08-24
US20110195920A1 (en) 2011-08-11
AU2009308181B2 (en) 2015-12-03

Similar Documents

Publication Publication Date Title
JP6309995B2 (ja) トリアゾール含有マクロライドを用いた耐性疾患の治療方法
Neu The development of macrolides: clarithromycin in perspective
Rafie et al. Cethromycin: a promising new ketolide antibiotic for respiratory infections
Guay Update on clindamycin in the management of bacterial, fungal and protozoal infections
Lindsay et al. Safety and efficacy of temafloxacin versus ciprofloxacin in lower respiratory tract infections a randomized, double-blind trial
Xu et al. Macrolides and ketolides
Van Bambeke Erythromycin
CN102245022B (zh) 治疗胃肠病的方法
Bryskier Ketolides
Dalhoff Interaction of Quinolones with Host—Parasite Relationship
JP2002154971A (ja) 抗メチシリン耐性ブドウ球菌剤

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121022

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20121022

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131224

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140324

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140331

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140624

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140625

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140722

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141125

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20150116

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150203

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150216

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150310

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150313

R150 Certificate of patent or registration of utility model

Ref document number: 5715569

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250