JP5715241B2 - 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法 - Google Patents

新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法 Download PDF

Info

Publication number
JP5715241B2
JP5715241B2 JP2013510364A JP2013510364A JP5715241B2 JP 5715241 B2 JP5715241 B2 JP 5715241B2 JP 2013510364 A JP2013510364 A JP 2013510364A JP 2013510364 A JP2013510364 A JP 2013510364A JP 5715241 B2 JP5715241 B2 JP 5715241B2
Authority
JP
Japan
Prior art keywords
compound
brd4
cell
certain embodiments
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013510364A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013532130A (ja
JP2013532130A5 (enExample
Inventor
ブラドナー，ジェームズ，エリオット
チー，チュン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dana Farber Cancer Institute Inc
Original Assignee
Dana Farber Cancer Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Institute Inc filed Critical Dana Farber Cancer Institute Inc
Priority claimed from PCT/US2011/036701 external-priority patent/WO2011143669A2/en
Publication of JP2013532130A publication Critical patent/JP2013532130A/ja
Publication of JP2013532130A5 publication Critical patent/JP2013532130A5/ja
Application granted granted Critical
Publication of JP5715241B2 publication Critical patent/JP5715241B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2013510364A 2010-05-14 2011-05-16 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法 Active JP5715241B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US33499110P 2010-05-14 2010-05-14
US61/334,991 2010-05-14
US37074510P 2010-08-04 2010-08-04
US61/370,745 2010-08-04
US37586310P 2010-08-22 2010-08-22
US61/375,863 2010-08-22
PCT/US2011/036701 WO2011143669A2 (en) 2010-05-14 2011-05-16 Compositions and methods for treating neoplasia, inflammatory disease and other disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015049960A Division JP5937247B2 (ja) 2010-05-14 2015-03-12 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法

Publications (3)

Publication Number Publication Date
JP2013532130A JP2013532130A (ja) 2013-08-15
JP2013532130A5 JP2013532130A5 (enExample) 2014-11-06
JP5715241B2 true JP5715241B2 (ja) 2015-05-07

Family

ID=49052897

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013510364A Active JP5715241B2 (ja) 2010-05-14 2011-05-16 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法
JP2015049960A Active JP5937247B2 (ja) 2010-05-14 2015-03-12 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015049960A Active JP5937247B2 (ja) 2010-05-14 2015-03-12 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法

Country Status (1)

Country Link
JP (2) JP5715241B2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3182721B2 (ja) 1997-08-06 2001-07-03 理兆 上田 自動車のペダル装置
ES2606958T3 (es) 2010-05-14 2017-03-28 Dana-Farber Cancer Institute, Inc. Compuestos de tienotriazolodiazepina para tratar una neoplasia
WO2011143651A1 (en) * 2010-05-14 2011-11-17 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating metabolism
CA2877434A1 (en) * 2012-06-25 2014-01-03 Oncoethix Sa Method of treating lymphoma using thienotriazolodiazepine compounds
CN105899212A (zh) * 2013-08-06 2016-08-24 翁科埃斯克斯有限公司 利用β溴结构域抑制剂治疗弥漫性大B细胞淋巴瘤(DLBCL)的方法
US11446309B2 (en) 2013-11-08 2022-09-20 Dana-Farber Cancer Institute, Inc. Combination therapy for cancer using bromodomain and extra-terminal (BET) protein inhibitors
WO2015131113A1 (en) 2014-02-28 2015-09-03 Tensha Therapeutics, Inc. Treatment of conditions associated with hyperinsulinaemia
AU2016283020A1 (en) * 2015-06-26 2018-01-04 Tensha Therapeutics, Inc. Treatment of nut midline carcinoma
RU2018112953A (ru) 2015-09-11 2019-10-14 Дана-Фарбер Кэнсер Инститьют, Инк. Ацетамидтиенотриазолодиазепины и пути их применения
US11306105B2 (en) * 2015-09-11 2022-04-19 Dana-Farber Cancer Institute, Inc. Cyano thienotriazolodiazepines and uses thereof
MA43037A (fr) * 2015-10-02 2018-08-08 Dana Farber Cancer Inst Inc Polythérapie par inhibiteurs de bromodomaine et blocage de point de contrôle
CA3014644A1 (en) * 2016-02-15 2017-08-24 The Regents Of The University Of Michigan Fused 1,4-oxazepines and related analogs as bet bromodomain inhibitors
MX2019006956A (es) * 2016-12-16 2019-08-01 Hoffmann La Roche Proceso para la fabricacion de derivados de diazepina.
CN109503618A (zh) * 2017-09-14 2019-03-22 成都海创药业有限公司 一种brd4抑制剂
EA202092635A1 (ru) * 2018-06-13 2021-03-23 Дибли Аг Получение конденсированных производных триазепина и их применение в качестве ингибиторов bet

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL330635A1 (en) * 1996-06-12 1999-05-24 Japan Tobacco Inc Inhibitor of cytokin production, triazepin compound and intermediate compounds used for obtaining the last mentioned one
US7589167B2 (en) * 2000-02-22 2009-09-15 J. David Gladstone Institutes ZA loops of bromodomains
PL378116A1 (pl) * 2003-02-27 2006-03-06 Abbott Laboratories Heterocykliczne inhibitory kinazy
CN101910182B (zh) * 2007-12-28 2013-07-17 田边三菱制药株式会社 抗癌剂
AU2010317096B2 (en) * 2009-11-05 2015-03-26 Glaxosmithkline Llc Benzodiazepine bromodomain inhibitor

Also Published As

Publication number Publication date
JP2013532130A (ja) 2013-08-15
JP2015147777A (ja) 2015-08-20
JP5937247B2 (ja) 2016-06-22

Similar Documents

Publication Publication Date Title
JP5937247B2 (ja) 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法
CN103037865B (zh) 用于治疗瘤形成、炎性疾病和其他失调的化合物
JP5913292B2 (ja) 代謝を調節する組成物および方法
TWI583689B (zh) 治療腫瘤形成、發炎疾病及其他病症之組成物及方法
JP2018520124A (ja) Ｎｕｔ正中線癌の治療
AU2015201727B2 (en) Compositions and methods for treating neoplasia, inflammatory disease and other disorders
HK1212627B (en) Thienotriazolodiazepine compounds for treating neoplasia
HK1183620B (en) Compositions and their use in treating neoplasia, inflammatory disease and other disorders

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140514

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140514

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140919

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150213

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20150219

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150312

R150 Certificate of patent or registration of utility model

Ref document number: 5715241

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250