JP5705432B2 - 光学アッセイシステム - Google Patents
光学アッセイシステム Download PDFInfo
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- JP5705432B2 JP5705432B2 JP2009501380A JP2009501380A JP5705432B2 JP 5705432 B2 JP5705432 B2 JP 5705432B2 JP 2009501380 A JP2009501380 A JP 2009501380A JP 2009501380 A JP2009501380 A JP 2009501380A JP 5705432 B2 JP5705432 B2 JP 5705432B2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6465—Angular discrimination
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Optics & Photonics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Description
sinαref=n1/n2×sinαin
式中、αrefは、基板内の屈折光線と表面法線との間の角度であり、αinは、空気中の衝突する光線と前記表面法線との間の角度である。したがって、屈折光の角度は、n1/n2が約1/1.55=0.65になることにより限定されて、αinが90度未満であることになり、その結果、次式となる。
Claims (8)
- 反応サイト表面(2)と対向する基板表面(3)とを有している試料基板(1)と、前記試料基板(1)のための蛍光式読み取り装置(10)と、を備える光学アッセイシステムであって、前記蛍光式読み取り装置は、
励起光線を前記基板表面(3)に入射させるよう配置された、励起光源(5)と、
前記反応サイト表面上に位置する蛍光体から放射され、前記基板表面を通じて伝送される蛍光を検出するよう配置された、検出装置(6)と、を含んでおり、
前記基板表面(3)が、前記検出装置(6)による検出のための、前記基板表面を通じた伝送を、増加するために、前記放射蛍光の光路中に配置された、全内部反射抑制手段(12、15、16)を、備え、
前記全内部反射抑制手段は、前記検出装置(6)による検出のための前記試料基板(1)内に捕獲された放射蛍光を放出するように配置され、
前記全内部反射抑制手段は、前記試料基板(1)からの前記放射蛍光光線を屈折または回折するように設計されている表面起伏構造を有する出口部分(12)、光集光体(15)、または、光学的濡れ層(16)、のうち少なくとも1つまたはそれ以上を含み、
前記基板表面(3)は、前記励起光線の光路中に配置された、入射角制御手段(11)を、備え、
前記入射角制御手段(11)は、前記反応サイト表面の法線に対する拡大された入射角(7)で、励起光が前記試料基板(1)内に入るように設計された、表面起伏構造の入口部分(9)を含み、
前記出口部分(12)は、前記入口部分(9)を囲む、
ことを特徴とする光学アッセイシステム。 - 前記全内部反射抑制手段が、前記検出装置(6)による検出のための、前記試料基板(1)内に捕獲された放射蛍光を、放出するように配置されていることを特徴とする請求項1に記載の光学アッセイシステム。
- 前記光源(5)が、入射角(7)で、励起光線を前記基板表面(3)に入射させるように配置されており、入射角(7)は、前記反応サイト表面の法線に対して、前記放射蛍光の最大放射角(8)と実質的に一致していることを特徴とする請求項1又は2に記載の光学アッセイシステム。
- 前記全内部反射抑制手段が、前記試料基板(1)からの前記放射蛍光光線を回折又は屈折させるように設計された、表面起伏構造の出口部分(12)を、含むことを特徴とする請求項1〜3のいずれか1項に記載の光学アッセイシステム。
- 前記表面起伏構造の設計が、衝突する蛍光の変化する放射角(8)に相応して、前記出口部分(12)の表面上で変化するように、設定されていることを特徴とする請求項1〜4のいずれか1項に記載の光学アッセイシステム。
- 前記全内部反射抑制手段が、前記基板表面と光学的に濡れて接触するように配置された、集光体(15)を、含むことを特徴とする請求項1〜5のいずれか1項に記載の光学アッセイシステム。
- 前記放射の励起及び測定が、直交して配置された異なる幾何学形状の平面で行われることを特徴とする請求項1〜6のいずれか1項に記載の光学アッセイシステム。
- 請求項1〜7のいずれか1項に記載の光学アッセイシステムの使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0600642A SE529711C2 (sv) | 2006-03-22 | 2006-03-22 | Fluorescensläsare |
SE0600642-3 | 2006-03-22 | ||
PCT/SE2007/000275 WO2007108752A1 (en) | 2006-03-22 | 2007-03-21 | Fluorescence reader |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2009530637A JP2009530637A (ja) | 2009-08-27 |
JP2009530637A5 JP2009530637A5 (ja) | 2010-04-22 |
JP5705432B2 true JP5705432B2 (ja) | 2015-04-22 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009501380A Active JP5705432B2 (ja) | 2006-03-22 | 2007-03-21 | 光学アッセイシステム |
Country Status (8)
Country | Link |
---|---|
US (2) | US8691153B2 (ja) |
EP (1) | EP1996922B1 (ja) |
JP (1) | JP5705432B2 (ja) |
CN (2) | CN101405594B (ja) |
AU (1) | AU2007227809B2 (ja) |
BR (1) | BRPI0709018A2 (ja) |
SE (1) | SE529711C2 (ja) |
WO (1) | WO2007108752A1 (ja) |
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SE529711C2 (sv) * | 2006-03-22 | 2007-11-06 | Aamic Ab | Fluorescensläsare |
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KR20130085992A (ko) | 2012-01-20 | 2013-07-30 | 오르토-클리니칼 다이아그노스틱스, 인코포레이티드 | 제어가능한 샘플 크기를 갖는 분석 장치 |
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JP2015529199A (ja) | 2012-08-21 | 2015-10-05 | オルソ−クリニカル ダイアグノスティクス,インコーポレイティド | パリペリドンハプテンに対する抗体及びその使用 |
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SE529711C2 (sv) * | 2006-03-22 | 2007-11-06 | Aamic Ab | Fluorescensläsare |
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- 2007-03-21 CN CN2007800096888A patent/CN101405594B/zh active Active
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AU2007227809B2 (en) | 2012-10-04 |
US8691153B2 (en) | 2014-04-08 |
EP1996922A4 (en) | 2012-10-24 |
BRPI0709018A2 (pt) | 2011-06-21 |
JP2009530637A (ja) | 2009-08-27 |
US20140212984A1 (en) | 2014-07-31 |
US20070231883A1 (en) | 2007-10-04 |
CN102636469A (zh) | 2012-08-15 |
CN101405594B (zh) | 2012-06-27 |
CN102636469B (zh) | 2016-07-06 |
EP1996922B1 (en) | 2018-11-21 |
WO2007108752A1 (en) | 2007-09-27 |
EP1996922A1 (en) | 2008-12-03 |
CN101405594A (zh) | 2009-04-08 |
SE0600642L (sv) | 2007-09-23 |
SE529711C2 (sv) | 2007-11-06 |
AU2007227809A1 (en) | 2007-09-27 |
US9279768B2 (en) | 2016-03-08 |
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