JP5705113B2 - Il−10産生の刺激のためのアレルゲン由来のt細胞抗原 - Google Patents

Il−10産生の刺激のためのアレルゲン由来のt細胞抗原 Download PDF

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JP5705113B2
JP5705113B2 JP2011522551A JP2011522551A JP5705113B2 JP 5705113 B2 JP5705113 B2 JP 5705113B2 JP 2011522551 A JP2011522551 A JP 2011522551A JP 2011522551 A JP2011522551 A JP 2011522551A JP 5705113 B2 JP5705113 B2 JP 5705113B2
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sequence
polypeptide
peptide
protein
allergen
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Japanese (ja)
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JP2012500194A5 (enExample
JP2012500194A (ja
Inventor
ラルシェ、マーク
ハフナー、ロデリック、ピーター
レイドラー、ポール
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サーカッシア リミテッド
サーカッシア リミテッド
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Priority claimed from GB0814986A external-priority patent/GB0814986D0/en
Priority claimed from PCT/GB2008/002781 external-priority patent/WO2009022157A2/en
Priority claimed from GB0815218A external-priority patent/GB0815218D0/en
Priority claimed from GBGB0901927.4A external-priority patent/GB0901927D0/en
Priority claimed from EP09251252.4A external-priority patent/EP2153841B2/en
Priority claimed from GB0912578A external-priority patent/GB0912578D0/en
Application filed by サーカッシア リミテッド, サーカッシア リミテッド filed Critical サーカッシア リミテッド
Publication of JP2012500194A publication Critical patent/JP2012500194A/ja
Publication of JP2012500194A5 publication Critical patent/JP2012500194A5/ja
Publication of JP5705113B2 publication Critical patent/JP5705113B2/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/35Allergens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/35Allergens
    • A61K39/36Allergens from pollen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43531Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from mites
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06Dipeptides
    • C07K5/06104Dipeptides with the first amino acid being acidic
    • C07K5/06113Asp- or Asn-amino acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1005Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1021Tetrapeptides with the first amino acid being acidic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/577Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 tolerising response

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Insects & Arthropods (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2011522551A 2008-08-15 2009-08-14 Il−10産生の刺激のためのアレルゲン由来のt細胞抗原 Expired - Fee Related JP5705113B2 (ja)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
GB0814986A GB0814986D0 (en) 2008-08-15 2008-08-15 Peptide for il10 production
PCT/GB2008/002781 WO2009022157A2 (en) 2007-08-15 2008-08-15 Peptide with improved solubility
GBPCT/GB08/002779 2008-08-15
PCT/GB2008/002779 WO2009022155A2 (en) 2007-08-15 2008-08-15 Peptide with reduced dimer formation
PCT/GB2008/002778 WO2009022154A2 (en) 2007-08-15 2008-08-15 Peptide with multiple epitopes
GBPCT/GB08/002780 2008-08-15
GBPCT/GB08/002778 2008-08-15
PCT/GB2008/002780 WO2009022156A2 (en) 2007-08-15 2008-08-15 Peptides for desensibilization against allergens
GBPCT/GB08/002781 2008-08-15
GB0814986.6 2008-08-15
GB0815218A GB0815218D0 (en) 2008-08-20 2008-08-20 Ragweed peptides for vaccine
GB0815218.3 2008-08-20
GBGB0901927.4A GB0901927D0 (en) 2009-02-05 2009-02-05 Peptide for IL10 production
GB0901927.4 2009-02-05
EP09251252.4 2009-05-01
EP09251252.4A EP2153841B2 (en) 2008-08-15 2009-05-01 Vaccine comprising Amb a 1 peptides for use in the treatment of ragweed allergy
GB0912578A GB0912578D0 (en) 2009-07-20 2009-07-20 Peptide for IL-10 production
GB0912578.2 2009-07-20
PCT/GB2009/001995 WO2010018384A1 (en) 2008-08-15 2009-08-14 T-cell antigen peptide from allergen for stimulation of il-10 production

Publications (3)

Publication Number Publication Date
JP2012500194A JP2012500194A (ja) 2012-01-05
JP2012500194A5 JP2012500194A5 (enExample) 2012-10-04
JP5705113B2 true JP5705113B2 (ja) 2015-04-22

Family

ID=41112622

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011522551A Expired - Fee Related JP5705113B2 (ja) 2008-08-15 2009-08-14 Il−10産生の刺激のためのアレルゲン由来のt細胞抗原

Country Status (4)

Country Link
US (2) US8821887B2 (enExample)
EP (1) EP2331124A1 (enExample)
JP (1) JP5705113B2 (enExample)
WO (1) WO2010018384A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103784952B (zh) 2009-02-05 2016-08-17 切尔卡西亚有限公司 用于疫苗的草肽
GB201002559D0 (en) 2010-02-15 2010-03-31 Circassia Ltd Birch peptides for vaccine
CN103501812A (zh) 2011-04-29 2014-01-08 西莱克塔生物科技公司 用于过敏症治疗的致耐受性合成纳米载体
CN109172819A (zh) 2011-07-29 2019-01-11 西莱克塔生物科技公司 产生体液和细胞毒性t淋巴细胞(ctl)免疫应答的合成纳米载体
GB201209862D0 (en) * 2012-06-01 2012-07-18 Circassia Ltd Cladosporium peptides
DK2914286T3 (da) 2012-10-30 2021-11-08 Aravax Pty Ltd Hidtil ukendte immunterapeutiske molekyler og anvendelser deraf
CA2910584A1 (en) 2013-05-03 2014-11-06 Selecta Biosciences, Inc. Use of immunosuppressants attached to synthetic nanocarriers to enhance levels of cd4+ regulatory t cells
KR20160075532A (ko) 2013-09-25 2016-06-29 아라백스 피티와이 엘티디 신규한 면역치료제 조성물 및 이의 용도
CA2933552A1 (en) * 2013-12-23 2015-07-02 Alk-Abello A/S Peptide combinations and uses thereof in treating dust mite allergy
WO2016037163A1 (en) 2014-09-07 2016-03-10 Selecta Biosciences, Inc. Methods and compositions for attenuating gene therapy anti-viral transfer vector immune responses
EP3556778A1 (en) * 2015-03-30 2019-10-23 Osaka University Immunizing peptide, method for producing immunizing peptide, pharmaceutical composition for immune disorders containing same, and method for treating immune disorders
EP3592389B1 (en) 2017-03-11 2025-05-07 Cartesian Therapeutics, Inc. Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant
JP7220489B2 (ja) * 2019-10-18 2023-02-10 沛爾生技醫藥股▲分▼有限公司 炎症性疾患および疼痛を治療するためのペプチドを含有する薬剤

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2049921C (en) * 1989-03-17 2004-06-15 Bruce Rogers Allergenic proteins from ragweed and uses therefor
US5776761A (en) 1989-03-17 1998-07-07 Immulogic Pharmaceutical Corporation Nucleic acids encoding allergenic proteins from ragweed
DK0548200T3 (da) * 1990-09-11 1999-10-25 Inst Child Health Research Kloning og sekventering af allergener fra dermatophagoides (husstøvmide)
WO1994001560A1 (en) 1991-07-12 1994-01-20 Immulogic Pharmaceutical Corporation Allergenic proteins and peptides from japanese cedar pollen
WO1994024281A1 (en) 1993-04-14 1994-10-27 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from dermatophagoides (house dust mite)
EP0623168B1 (en) 1991-10-16 2009-09-30 Merck Patent GmbH T cell epitopes of the major allergens from dermatophagoides (house dust mite)
US6441157B1 (en) 1991-11-15 2002-08-27 University Of Melbourne Nucleic acid sequences encoding protein allergens of the species Cynodon dactylon
EP0770681A3 (en) 1992-04-09 1997-06-04 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from ambrosia artemisiifolia
JPH09501043A (ja) * 1993-04-14 1997-02-04 イミュロジク ファーマスーティカル コーポレイション Dermatophagoides(室内塵ダニ)由来の主要アレルゲンのt細胞エピトープ
WO1995028424A1 (en) 1994-04-14 1995-10-26 Immulogic Pharmaceutical Corporation Pharmaceutical peptide formulations for treatment of dust mite allergy
US5820862A (en) 1994-04-14 1998-10-13 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from dermatophagoides (house dust mite)
US7112333B1 (en) 1994-08-05 2006-09-26 Heska Corporation T cell epitopes of ryegrass pollen allergen
WO1996013589A1 (en) 1994-10-27 1996-05-09 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from ambrosia artemisiifolia
IL115744A (en) 1994-10-27 2000-07-16 Akzo Nobel Nv Peptides comprising a subsequence of human cartilage glycoprotein - 39
JP2002500198A (ja) 1998-01-09 2002-01-08 サーカシア リミテッド 脱感作のための方法及び組成物
US6989146B2 (en) 2000-08-09 2006-01-24 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
GB0108752D0 (en) 2001-04-06 2001-05-30 Isis Innovation Peptide epitopes and uses thereof
JP4874522B2 (ja) 2001-12-05 2012-02-15 サーカッシア リミテッド 免疫療法および系
AUPS148202A0 (en) 2002-04-02 2002-05-09 Monash University Immunotherapeutic and immunoprophylactic reagents
AU2003228133A1 (en) 2002-04-22 2003-11-03 Umc Utrecht Holding B.V. Reduction of unwanted immune reactions
GB0210741D0 (en) 2002-05-10 2002-06-19 Medical Res Council Methods of therapy
FR2841906B1 (fr) 2002-07-05 2006-08-18 Stallergenes Sa Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes
GB0308988D0 (en) 2003-04-17 2003-05-28 Univ Singapore Molecule
WO2006075253A2 (en) 2005-01-11 2006-07-20 Commissariat A L'energie Atomique Peptides for desensitizing subjects allergic to dog hair and dander and compositions containing said peptides.
US20090130130A1 (en) 2005-06-10 2009-05-21 National University Of Singapore Mutant allergen(s)
US20070092532A1 (en) 2005-10-25 2007-04-26 Board Of Trustees Operating Michigan State University Arthritis vaccines and methods
ES2405552T3 (es) 2005-11-29 2013-05-31 Actogenix N.V. Inducción de tolerancia mucosa a antiantígenos de células beta de islotes pancreáticos
EP1958645A1 (en) 2007-02-13 2008-08-20 Biomay AG Peptides derived from the major allergen of ragweed (Ambrosia artemisiifolia) and uses thereof
EP2156183B1 (en) 2007-05-09 2013-08-07 Circassia Limited Prognostic assay for determining t cell response to hla antigens and use thereof in field of tissue transplantation
GB0710529D0 (en) 2007-06-01 2007-07-11 Circassia Ltd Vaccine
ES2402956T3 (es) 2007-08-15 2013-05-10 Circassia Limited Péptido con formación de dímeros reducida
EP2042193A1 (en) 2007-09-28 2009-04-01 Biomay AG RNA Vaccines
EP2153841B2 (en) * 2008-08-15 2015-11-11 Circassia Limited Vaccine comprising Amb a 1 peptides for use in the treatment of ragweed allergy

Also Published As

Publication number Publication date
US20110206709A1 (en) 2011-08-25
EP2331124A1 (en) 2011-06-15
JP2012500194A (ja) 2012-01-05
US20140328868A1 (en) 2014-11-06
WO2010018384A1 (en) 2010-02-18
US8821887B2 (en) 2014-09-02

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