JP5689054B2 - Ｒｎａ化学合成方法 - Google Patents

Ｒｎａ化学合成方法 Download PDF

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Publication number
JP5689054B2
JP5689054B2 JP2011511053A JP2011511053A JP5689054B2 JP 5689054 B2 JP5689054 B2 JP 5689054B2 JP 2011511053 A JP2011511053 A JP 2011511053A JP 2011511053 A JP2011511053 A JP 2011511053A JP 5689054 B2 JP5689054 B2 JP 5689054B2
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group
formula
natural
protected
modified
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JP2011511053A
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Japanese (ja)
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JP2011521930A (ja
JP2011521930A5 (cg-RX-API-DMAC7.html
Inventor
フランソワーズ ドゥバール
フランソワーズ ドゥバール
ジャン−ジャック ヴァセール
ジャン−ジャック ヴァセール
トマ ラヴェルニュ
トマ ラヴェルニュ
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Centre National de la Recherche Scientifique CNRS
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Centre National de la Recherche Scientifique CNRS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011511053A 2008-05-29 2009-05-28 Ｒｎａ化学合成方法 Expired - Fee Related JP5689054B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0802928 2008-05-29
FR0802928A FR2931824B1 (fr) 2008-05-29 2008-05-29 Procede de synthese d'arn par voie chimique.
PCT/FR2009/000624 WO2009144418A1 (fr) 2008-05-29 2009-05-28 Procede de synthese d'arn par voie chimique

Publications (3)

Publication Number Publication Date
JP2011521930A JP2011521930A (ja) 2011-07-28
JP2011521930A5 JP2011521930A5 (cg-RX-API-DMAC7.html) 2014-07-24
JP5689054B2 true JP5689054B2 (ja) 2015-03-25

Family

ID=39712442

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011511053A Expired - Fee Related JP5689054B2 (ja) 2008-05-29 2009-05-28 Ｒｎａ化学合成方法

Country Status (7)

Country Link
US (1) US8536318B2 (cg-RX-API-DMAC7.html)
EP (1) EP2303905B1 (cg-RX-API-DMAC7.html)
JP (1) JP5689054B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0910689A2 (cg-RX-API-DMAC7.html)
CA (1) CA2726260C (cg-RX-API-DMAC7.html)
FR (1) FR2931824B1 (cg-RX-API-DMAC7.html)
WO (1) WO2009144418A1 (cg-RX-API-DMAC7.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011028218A1 (en) 2009-09-02 2011-03-10 Alnylam Pharmaceuticals, Inc. Process for triphosphate oligonucleotide synthesis
EP2600901B1 (en) 2010-08-06 2019-03-27 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
MX2013003681A (es) 2010-10-01 2013-11-20 Moderna Therapeutics Inc Ácidos nucleicos manipulados y métodos de uso de los mismos.
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9428535B2 (en) 2011-10-03 2016-08-30 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
SMT202200355T1 (it) 2011-12-16 2022-11-18 Modernatx Inc Composizioni di mrna modificato
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
EP2834260A4 (en) 2012-04-02 2016-08-10 Moderna Therapeutics Inc MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF MEMBRANE PROTEINS
WO2014017615A1 (ja) 2012-07-25 2014-01-30 国立大学法人高知大学 Ｒｎａ合成用モノマー、その製造方法、およびｒｎａの製造方法
EP2922554B1 (en) 2012-11-26 2022-02-23 ModernaTX, Inc. Terminally modified rna
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
PL221806B1 (pl) 2013-03-21 2016-05-31 Inst Chemii Bioorg Polskiej Akademii Nauk Sposób wprowadzania acetalowych i acetaloestrowych grup ochronnych oraz związki do realizacji tego sposobu
CA2923029A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Chimeric polynucleotides
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
JP2016538829A (ja) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低密度リポタンパク質受容体をコードするポリヌクレオチド
ES2806575T3 (es) 2013-11-01 2021-02-18 Curevac Ag ARN modificado con propiedades inmunoestimuladoras disminuidas
EP3542802A1 (en) 2013-11-01 2019-09-25 CureVac AG Modified rna with decreased immunostimulatory properties
US20170204152A1 (en) 2014-07-16 2017-07-20 Moderna Therapeutics, Inc. Chimeric polynucleotides
WO2023097308A1 (en) * 2021-11-29 2023-06-01 Hongene Biotech Corporation Synthesis of 2' acetyl-ester protected nucleosides
CN114685572B (zh) * 2022-06-02 2022-08-30 上海百力格生物技术有限公司 用于mgb核酸探针合成的氧化剂组合物及探针的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
EP1386925A1 (en) * 2002-07-31 2004-02-04 Girindus AG Method for preparing oligonucleotides
CN100484949C (zh) * 2005-07-18 2009-05-06 张必良 用于rna寡核苷酸合成中的核苷亚磷酰胺及其合成方法

Also Published As

Publication number Publication date
US20110275793A1 (en) 2011-11-10
EP2303905A1 (fr) 2011-04-06
FR2931824B1 (fr) 2014-11-28
BRPI0910689A2 (pt) 2016-11-01
CA2726260C (fr) 2017-04-04
JP2011521930A (ja) 2011-07-28
WO2009144418A1 (fr) 2009-12-03
CA2726260A1 (fr) 2009-12-03
US8536318B2 (en) 2013-09-17
FR2931824A1 (fr) 2009-12-04
EP2303905B1 (fr) 2012-11-28

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