FR2931824B1 - Procede de synthese d'arn par voie chimique. - Google Patents

Procede de synthese d'arn par voie chimique.

Info

Publication number
FR2931824B1
FR2931824B1 FR0802928A FR0802928A FR2931824B1 FR 2931824 B1 FR2931824 B1 FR 2931824B1 FR 0802928 A FR0802928 A FR 0802928A FR 0802928 A FR0802928 A FR 0802928A FR 2931824 B1 FR2931824 B1 FR 2931824B1
Authority
FR
France
Prior art keywords
chemical
rna synthesis
rna
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR0802928A
Other languages
English (en)
French (fr)
Other versions
FR2931824A1 (fr
Inventor
Francoise Debart
Jean Jacques Vasseur
Thomas Lavergne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ChemGenes Corp
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR0802928A priority Critical patent/FR2931824B1/fr
Priority to BRPI0910689A priority patent/BRPI0910689A2/pt
Priority to EP09754068A priority patent/EP2303905B1/fr
Priority to US12/995,001 priority patent/US8536318B2/en
Priority to PCT/FR2009/000624 priority patent/WO2009144418A1/fr
Priority to JP2011511053A priority patent/JP5689054B2/ja
Priority to CA2726260A priority patent/CA2726260C/fr
Publication of FR2931824A1 publication Critical patent/FR2931824A1/fr
Application granted granted Critical
Publication of FR2931824B1 publication Critical patent/FR2931824B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0802928A 2008-05-29 2008-05-29 Procede de synthese d'arn par voie chimique. Active FR2931824B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR0802928A FR2931824B1 (fr) 2008-05-29 2008-05-29 Procede de synthese d'arn par voie chimique.
BRPI0910689A BRPI0910689A2 (pt) 2008-05-29 2009-04-28 processo de síntese de rna por via química
US12/995,001 US8536318B2 (en) 2008-05-29 2009-05-28 Chemical RNA synthesis method
PCT/FR2009/000624 WO2009144418A1 (fr) 2008-05-29 2009-05-28 Procede de synthese d'arn par voie chimique
EP09754068A EP2303905B1 (fr) 2008-05-29 2009-05-28 Procede de synthese d'arn par voie chimique
JP2011511053A JP5689054B2 (ja) 2008-05-29 2009-05-28 Ｒｎａ化学合成方法
CA2726260A CA2726260C (fr) 2008-05-29 2009-05-28 Procede de synthese d'arn par voie chimique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0802928A FR2931824B1 (fr) 2008-05-29 2008-05-29 Procede de synthese d'arn par voie chimique.

Publications (2)

Publication Number Publication Date
FR2931824A1 FR2931824A1 (fr) 2009-12-04
FR2931824B1 true FR2931824B1 (fr) 2014-11-28

Family

ID=39712442

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0802928A Active FR2931824B1 (fr) 2008-05-29 2008-05-29 Procede de synthese d'arn par voie chimique.

Country Status (7)

Country Link
US (1) US8536318B2 (cg-RX-API-DMAC7.html)
EP (1) EP2303905B1 (cg-RX-API-DMAC7.html)
JP (1) JP5689054B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0910689A2 (cg-RX-API-DMAC7.html)
CA (1) CA2726260C (cg-RX-API-DMAC7.html)
FR (1) FR2931824B1 (cg-RX-API-DMAC7.html)
WO (1) WO2009144418A1 (cg-RX-API-DMAC7.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011028218A1 (en) 2009-09-02 2011-03-10 Alnylam Pharmaceuticals, Inc. Process for triphosphate oligonucleotide synthesis
EP2600901B1 (en) 2010-08-06 2019-03-27 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
MX2013003681A (es) 2010-10-01 2013-11-20 Moderna Therapeutics Inc Ácidos nucleicos manipulados y métodos de uso de los mismos.
WO2012135805A2 (en) 2011-03-31 2012-10-04 modeRNA Therapeutics Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9428535B2 (en) 2011-10-03 2016-08-30 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
SMT202200355T1 (it) 2011-12-16 2022-11-18 Modernatx Inc Composizioni di mrna modificato
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US10501512B2 (en) 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
EP2834260A4 (en) 2012-04-02 2016-08-10 Moderna Therapeutics Inc MODIFIED POLYNUCLEOTIDES FOR THE PREPARATION OF MEMBRANE PROTEINS
WO2014017615A1 (ja) 2012-07-25 2014-01-30 国立大学法人高知大学 Ｒｎａ合成用モノマー、その製造方法、およびｒｎａの製造方法
EP2922554B1 (en) 2012-11-26 2022-02-23 ModernaTX, Inc. Terminally modified rna
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
PL221806B1 (pl) 2013-03-21 2016-05-31 Inst Chemii Bioorg Polskiej Akademii Nauk Sposób wprowadzania acetalowych i acetaloestrowych grup ochronnych oraz związki do realizacji tego sposobu
CA2923029A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Chimeric polynucleotides
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
JP2016538829A (ja) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低密度リポタンパク質受容体をコードするポリヌクレオチド
ES2806575T3 (es) 2013-11-01 2021-02-18 Curevac Ag ARN modificado con propiedades inmunoestimuladoras disminuidas
EP3542802A1 (en) 2013-11-01 2019-09-25 CureVac AG Modified rna with decreased immunostimulatory properties
US20170204152A1 (en) 2014-07-16 2017-07-20 Moderna Therapeutics, Inc. Chimeric polynucleotides
WO2023097308A1 (en) * 2021-11-29 2023-06-01 Hongene Biotech Corporation Synthesis of 2' acetyl-ester protected nucleosides
CN114685572B (zh) * 2022-06-02 2022-08-30 上海百力格生物技术有限公司 用于mgb核酸探针合成的氧化剂组合物及探针的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4458066A (en) * 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
EP1386925A1 (en) * 2002-07-31 2004-02-04 Girindus AG Method for preparing oligonucleotides
CN100484949C (zh) * 2005-07-18 2009-05-06 张必良 用于rna寡核苷酸合成中的核苷亚磷酰胺及其合成方法

Also Published As

Publication number Publication date
US20110275793A1 (en) 2011-11-10
EP2303905A1 (fr) 2011-04-06
BRPI0910689A2 (pt) 2016-11-01
CA2726260C (fr) 2017-04-04
JP2011521930A (ja) 2011-07-28
WO2009144418A1 (fr) 2009-12-03
CA2726260A1 (fr) 2009-12-03
US8536318B2 (en) 2013-09-17
JP5689054B2 (ja) 2015-03-25
FR2931824A1 (fr) 2009-12-04
EP2303905B1 (fr) 2012-11-28

Similar Documents

Publication Publication Date Title
FR2931824B1 (fr) Procede de synthese d'arn par voie chimique.
FR2912741B1 (fr) Procede de synthese d'acides omega-amino-alcanoiques
FR2912742B1 (fr) Procede de synthese d'acrylonitrile a partir de glycerol
FR2881735B1 (fr) Procede de synthese de nanotubes de carbone
EP1901741A4 (en) PROCESS FOR SYNTHESIS OF A CETP HEMMER
BRPI0923225A2 (pt) metodo para sintese de acidos nucleicos modificados no atomo de fosforo
FR2930777B1 (fr) Procede de synthese de materiaux supramoleculaires
FR2911878B1 (fr) Procede de preparation de polyhydroxy-urethanes.
FR2917085B1 (fr) Procede de preparation d'un aldehyde hydroxyaromatique.
FR2938264B1 (fr) Procede de fabrication d'une composition auto-obturante.
FR2934857B1 (fr) Nouveau procede de synthese de l'agomelatine
MA31416B1 (fr) Nouveau procede de synthese de l'agomelatine
FR2906530B1 (fr) Procede de synthese d'esters d'estolides.
FR2877948B1 (fr) Procede de synthese de poudres de polyamide
BRPI0817738A2 (pt) Sistema de reação de síntese
FR2919607B1 (fr) Procede pour la conversion catalytique de 2-hydroxy-4- methylthiobutanenitrile (hmtbn) en 2-hydroxy-4- methylthiobutanamide (hmtbm).
FR2961209B1 (fr) Procede de synthese de la ferroquine par amination reductrice convergente.
FR2954311B1 (fr) Procede de synthese perfectionne d'acroleine a partir de glycerol
FR2931819B1 (fr) Procede de synthese de diacoxyalcanes par oxydation selective d'alcools
FR2926080B1 (fr) Procede de synthese de derives d'acide hydroxy-bisphosphonique
MA31830B1 (fr) Nouveau procede de synthese de l'agomelatine
FR2921921B1 (fr) Procede de synthese de composes polyhydroxystilbeniques.
EP1849763A4 (en) METHOD FOR SYNTHESIS OF (METH) ACRYLIC ACID T-BUTYL SAMPLE
FR2921656B1 (fr) Procede de synthese d'arylamines
FR2929947B1 (fr) Procede de preparation d'une composition photoreticulable.

Legal Events

Date Code Title Description
TQ Partial transmission of property
PLFP Fee payment

Year of fee payment: 8

PLFP Fee payment

Year of fee payment: 9

PLFP Fee payment

Year of fee payment: 10

PLFP Fee payment

Year of fee payment: 11

TP Transmission of property

Owner name: CHEMGENES CORPORATION, US

Effective date: 20180504

PLFP Fee payment

Year of fee payment: 12

ST Notification of lapse

Effective date: 20200114

RN Application for restoration

Effective date: 20200310

FC Decision of inpi director general to approve request for restoration

Effective date: 20200616

PLFP Fee payment

Year of fee payment: 13

PLFP Fee payment

Year of fee payment: 14

PLFP Fee payment

Year of fee payment: 15

PLFP Fee payment

Year of fee payment: 16

PLFP Fee payment

Year of fee payment: 17

PLFP Fee payment

Year of fee payment: 18