JP5676600B2 - 造影剤としてのｎ−アルコキシアミド抱合体 - Google Patents

造影剤としてのｎ−アルコキシアミド抱合体 Download PDF

Info

Publication number
JP5676600B2
JP5676600B2 JP2012519544A JP2012519544A JP5676600B2 JP 5676600 B2 JP5676600 B2 JP 5676600B2 JP 2012519544 A JP2012519544 A JP 2012519544A JP 2012519544 A JP2012519544 A JP 2012519544A JP 5676600 B2 JP5676600 B2 JP 5676600B2
Authority
JP
Japan
Prior art keywords
alkyl
mmol
group
substituted
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2012519544A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012532868A5 (enExample
JP2012532868A (ja
Inventor
リチャード・アール・セサティ
トーマス・ディ・ハリス
サイモン・ピー・ロビンソン
リチャード・ジェイ・ルービー
エドワード・エイチ・チースマン
パドマジャ・ヤラマンチリ
デイビッド・エス・カセビアー
Original Assignee
ランセウス メディカル イメージング， インコーポレイテッド
ランセウス メディカル イメージング， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ランセウス メディカル イメージング， インコーポレイテッド, ランセウス メディカル イメージング， インコーポレイテッド filed Critical ランセウス メディカル イメージング， インコーポレイテッド
Publication of JP2012532868A publication Critical patent/JP2012532868A/ja
Publication of JP2012532868A5 publication Critical patent/JP2012532868A5/ja
Application granted granted Critical
Publication of JP5676600B2 publication Critical patent/JP5676600B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
JP2012519544A 2009-07-08 2010-07-08 造影剤としてのｎ−アルコキシアミド抱合体 Expired - Fee Related JP5676600B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22394609P 2009-07-08 2009-07-08
US61/223,946 2009-07-08
PCT/US2010/001926 WO2011005322A2 (en) 2009-07-08 2010-07-08 N-alkoxyamide conjugates as imaging agents

Publications (3)

Publication Number Publication Date
JP2012532868A JP2012532868A (ja) 2012-12-20
JP2012532868A5 JP2012532868A5 (enExample) 2013-08-29
JP5676600B2 true JP5676600B2 (ja) 2015-02-25

Family

ID=43429724

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012519544A Expired - Fee Related JP5676600B2 (ja) 2009-07-08 2010-07-08 造影剤としてのｎ−アルコキシアミド抱合体

Country Status (7)

Country Link
US (2) US8877157B2 (enExample)
EP (1) EP2451776B1 (enExample)
JP (1) JP5676600B2 (enExample)
CN (1) CN102781909B (enExample)
AU (1) AU2010271097B2 (enExample)
CA (1) CA2803520C (enExample)
WO (1) WO2011005322A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105622463B (zh) 2006-12-26 2019-02-22 兰休斯医疗成像公司 用于使心脏神经支配成像的配体
WO2009089022A1 (en) 2008-01-08 2009-07-16 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
AU2010271097B2 (en) 2009-07-08 2015-12-10 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
BR122020018186B1 (pt) 2010-05-11 2021-07-27 Lantheus Medical Imaging, Inc Uso de agentes de imagiologia para preparação de uma composição para detecção do transportador de norepinefrina (net) e método para a detecção de net
GB201102189D0 (en) 2011-02-08 2011-03-23 King S College London Materials and methods relating to cardiovascular imaging
BR122019017259B1 (pt) 2011-09-09 2022-05-10 Lantheus Medical Imaging, Inc Compostos úteis como agentes de imageamento, composições que os compreende, métodos, e uso de agentes de imageamento
WO2013070471A1 (en) 2011-11-11 2013-05-16 Lantheus Medical Imaging, Inc. Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
BR112019010064A2 (pt) 2016-11-18 2019-10-01 Astellas Pharma Inc novo fragmento fab do anticorpo muc1 anti-humano
TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段
BR112020023420A8 (pt) 2018-05-17 2022-07-05 Astellas Pharma Inc Complexo tendo fragmento fab de anticorpo anti-muc1 humano, peptídeo ligador e/ou ligante
EP3865154A4 (en) 2018-10-10 2022-11-09 Astellas Pharma Inc. PHARMACEUTICAL COMPOSITION CONTAINING ANTIBODY FAB FRAGMENT COMPLEX AT LABELED ANTI-HUMAN SITE
CN113301920B (zh) * 2019-01-07 2025-01-14 安斯泰来制药株式会社 包含配体、间隔物、肽接头和生物分子的复合物
CN117486698B (zh) * 2023-10-30 2025-08-19 国网安徽省电力有限公司电力科学研究院 烯醇硅醚类化合物制备c-c键偶联产物的方法与sf6的应用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5122885A (en) 1974-08-13 1976-02-23 Sagami Chem Res Ashiru ll aminosan oo chikanhidorokisamidono seizohoho
JPS5910322B2 (ja) 1975-07-30 1984-03-08 三井東圧化学株式会社 殺草剤
US4859777A (en) 1981-07-01 1989-08-22 Eastman Kodak Company Terpyridine chelating agents
US4957939A (en) 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
JPH07110815B2 (ja) 1985-11-18 1995-11-29 ボ−ド・オブ・リ−ジェンツ、ザ・ユニバ−シティ−・オブ・テキサス・システム 画像及びスペクトル向上（およびスペクトルシフト）のためのポリキレ−ト剤
DE3768523D1 (de) 1986-02-18 1991-04-18 Squibb & Sons Inc ((2,2,2-trichloroethoxy)methoxy)amin.
US5064956A (en) 1987-06-24 1991-11-12 The Dow Chemical Company Process for preparing mono-n-alkylated polyazamacrocycles
IT1224627B (it) 1988-04-12 1990-10-04 Guidotti & C Spa Labor Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.
US5087440A (en) 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
JP2927532B2 (ja) * 1989-11-09 1999-07-28 塩野義製薬株式会社 含窒素異項環オキシーフェノキシ酢酸誘導体およびその除草剤としての用途
JPH0491070A (ja) 1990-08-06 1992-03-24 Kanebo Ltd カリックスアレーン誘導体
US5274129A (en) 1991-06-12 1993-12-28 Idaho Research Foundation, Inc. Hydroxamic acid crown ethers
GB9115375D0 (en) 1991-07-17 1991-09-04 Salutar Inc Compounds
US5639746A (en) 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
TW319763B (enExample) 1995-02-01 1997-11-11 Epix Medical Inc
CN1203899C (zh) 1995-06-26 2005-06-01 螯合剂有限公司 对第一过渡系元素具有螯合亲和力和选择性的化合物及它们在医学冶疗中的用途
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
US6461587B1 (en) 1999-03-22 2002-10-08 Schering Aktiengesellschaft Perfluoroalkylamides, their production and their use in diagnosis
US6989139B2 (en) 2000-02-15 2006-01-24 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
US6656448B1 (en) 2000-02-15 2003-12-02 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
US20020002152A1 (en) * 2000-04-14 2002-01-03 Craig Richard A. Hydrazide and alkoxyamide angiogenesis inhibitors
IL157444A0 (en) 2001-02-23 2004-03-28 Bristol Myers Squibb Pharma Co Labeled macrophase scavenger receptor antagonists and diagnostic and pharmaceutical compositions containing the same
US20040146964A1 (en) 2001-03-21 2004-07-29 Maxwell Patrick Henry Assays, methods and means
TWI240632B (en) 2001-07-30 2005-10-01 Epix Medical Inc Purified peptides for peptide-based multimeric targeted contrast agents
WO2005001415A2 (en) 2003-05-23 2005-01-06 Epix Pharmaceuticals, Inc. Optically pure and enriched isomers of chelating ligands and contrast agents
US7662856B2 (en) 2003-08-29 2010-02-16 The University Of Houston System Compositions having antimycrobial activity including a hydroxamate or a hydroxamate and a hydroxlyamine
US20050106100A1 (en) 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
WO2005084179A2 (en) * 2003-12-01 2005-09-15 Immunomedics, Inc. Improved method for preparing conjugates of proteins and chelating agents
US20070142417A1 (en) 2005-05-11 2007-06-21 Aventis Pharmaceuticals Inc Substantially Pure 2-{[2-(2-Methylamino-Pyrimidin-4-YL)-1H-Indole-5-Carbonyl]-Amino}-3-Phenylpyridin-2-YL-Amino)-Propionic Acid as an IkB Kinase Inhibitor
EP1896086A1 (en) 2005-06-30 2008-03-12 Bristol-Myers Squibb Pharma Company Hydrazide conjugates as imaging agents
US7618957B2 (en) 2005-07-15 2009-11-17 Bayer Schering Pharma Aktiengesellschaft Perfluoroalkyl-containing complexes, process for their production as well as their use
WO2009089022A1 (en) 2008-01-08 2009-07-16 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
AU2010271097B2 (en) 2009-07-08 2015-12-10 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents

Also Published As

Publication number Publication date
US20150078997A1 (en) 2015-03-19
CA2803520C (en) 2019-10-22
HK1178511A1 (en) 2013-09-13
AU2010271097A1 (en) 2012-03-01
EP2451776A2 (en) 2012-05-16
CN102781909A (zh) 2012-11-14
AU2010271097B2 (en) 2015-12-10
WO2011005322A2 (en) 2011-01-13
CA2803520A1 (en) 2011-01-13
US20120328514A1 (en) 2012-12-27
EP2451776A4 (en) 2015-04-15
CN102781909B (zh) 2015-06-17
US9393329B2 (en) 2016-07-19
EP2451776B1 (en) 2019-09-18
WO2011005322A3 (en) 2011-04-21
US8877157B2 (en) 2014-11-04
JP2012532868A (ja) 2012-12-20

Similar Documents

Publication Publication Date Title
JP5676600B2 (ja) 造影剤としてのｎ−アルコキシアミド抱合体
US20250170283A1 (en) Compositions, methods, and systems for the synthesis and use of imaging agents
ES2763815T3 (es) Composiciones, métodos y sistemas para la síntesis y uso de agentes de formación de imágenes
US10201623B2 (en) HSP90-targeted cardiac imaging and therapy
JP2014531434A (ja) 造影剤の合成および使用のための組成物、方法およびシステム
US20140058106A1 (en) System for fluorinating organic compounds
US8686158B2 (en) High-valent palladium fluoride complexes and uses thereof
EP2606056A2 (en) High-valent palladium fluoride complexes and uses thereof
JP6087386B2 (ja) 造影剤としてのｎ−アルコキシアミド抱合体
HK1178511B (en) N-alkoxyamide conjugates as imaging agents
HK1171216B (en) N-alkoxyamide conjugates as imaging agents
HK1171216A (en) N-alkoxyamide conjugates as imaging agents
HK1200823B (en) N-alkoxyamide conjugates as imaging agents
HK1245782A1 (en) Compositions, methods, and systems for the synthesis and use of imaging agents
HK1203941B (en) Compositions, methods, and systems for the synthesis and use of imaging agents

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130708

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130708

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20140807

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140812

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141111

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20141209

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20141225

R150 Certificate of patent or registration of utility model

Ref document number: 5676600

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees