AU2010271097B2 - N-alkoxyamide conjugates as imaging agents - Google Patents
N-alkoxyamide conjugates as imaging agents Download PDFInfo
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- AU2010271097B2 AU2010271097B2 AU2010271097A AU2010271097A AU2010271097B2 AU 2010271097 B2 AU2010271097 B2 AU 2010271097B2 AU 2010271097 A AU2010271097 A AU 2010271097A AU 2010271097 A AU2010271097 A AU 2010271097A AU 2010271097 B2 AU2010271097 B2 AU 2010271097B2
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- MHNSOHQNBYCQOZ-HXUWFJFHSA-N tert-butyl n-[(2r)-1-[[4-(aminomethyl)phenyl]methoxyamino]-1-oxo-4-phenylbutan-2-yl]carbamate Chemical compound C([C@@H](NC(=O)OC(C)(C)C)C(=O)NOCC=1C=CC(CN)=CC=1)CC1=CC=CC=C1 MHNSOHQNBYCQOZ-HXUWFJFHSA-N 0.000 description 1
- MYRSQNCTRDCQAY-OAQYLSRUSA-N tert-butyl n-[(2r)-1-[[4-(aminomethyl)phenyl]methoxyamino]-3-(1h-indol-2-yl)-1-oxopropan-2-yl]carbamate Chemical compound O=C([C@@H](CC=1NC2=CC=CC=C2C=1)NC(=O)OC(C)(C)C)NOCC1=CC=C(CN)C=C1 MYRSQNCTRDCQAY-OAQYLSRUSA-N 0.000 description 1
- SVPHVUGHAFJVRW-LJQANCHMSA-N tert-butyl n-[(2r)-1-[[4-(aminomethyl)phenyl]methoxyamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]carbamate Chemical compound C([C@@H](NC(=O)OC(C)(C)C)C(=O)NOCC=1C=CC(CN)=CC=1)C1=CC=C(O)C=C1 SVPHVUGHAFJVRW-LJQANCHMSA-N 0.000 description 1
- KFFDHFBTQPJGQX-HSZRJFAPSA-N tert-butyl n-[(2r)-1-[[4-(aminomethyl)phenyl]methoxyamino]-3-naphthalen-2-yl-1-oxopropan-2-yl]carbamate Chemical compound O=C([C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(=O)OC(C)(C)C)NOCC1=CC=C(CN)C=C1 KFFDHFBTQPJGQX-HSZRJFAPSA-N 0.000 description 1
- VYWIXKJFSUMRDD-MRXNPFEDSA-N tert-butyl n-[(2r)-1-[[4-(aminomethyl)phenyl]methoxyamino]-4-methyl-1-oxopentan-2-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@H](CC(C)C)C(=O)NOCC1=CC=C(CN)C=C1 VYWIXKJFSUMRDD-MRXNPFEDSA-N 0.000 description 1
- ZOAUNLIMLPQOAB-LBPRGKRZSA-N tert-butyl n-[(2s)-1-(hydroxyamino)-1-oxo-4-phenylbutan-2-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@H](C(=O)NO)CCC1=CC=CC=C1 ZOAUNLIMLPQOAB-LBPRGKRZSA-N 0.000 description 1
- MHNSOHQNBYCQOZ-FQEVSTJZSA-N tert-butyl n-[(2s)-1-[[4-(aminomethyl)phenyl]methoxyamino]-1-oxo-4-phenylbutan-2-yl]carbamate Chemical compound C([C@H](NC(=O)OC(C)(C)C)C(=O)NOCC=1C=CC(CN)=CC=1)CC1=CC=CC=C1 MHNSOHQNBYCQOZ-FQEVSTJZSA-N 0.000 description 1
- DRDVJQOGFWAVLH-UHFFFAOYSA-N tert-butyl n-hydroxycarbamate Chemical compound CC(C)(C)OC(=O)NO DRDVJQOGFWAVLH-UHFFFAOYSA-N 0.000 description 1
- XBXCNNQPRYLIDE-UHFFFAOYSA-N tert-butylcarbamic acid Chemical compound CC(C)(C)NC(O)=O XBXCNNQPRYLIDE-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- MHXBHWLGRWOABW-UHFFFAOYSA-N tetradecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC MHXBHWLGRWOABW-UHFFFAOYSA-N 0.000 description 1
- CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 125000000464 thioxo group Chemical group S=* 0.000 description 1
- UIERETOOQGIECD-ONEGZZNKSA-N tiglic acid Chemical compound C\C=C(/C)C(O)=O UIERETOOQGIECD-ONEGZZNKSA-N 0.000 description 1
- LMYRWZFENFIFIT-UHFFFAOYSA-N toluene-4-sulfonamide Chemical compound CC1=CC=C(S(N)(=O)=O)C=C1 LMYRWZFENFIFIT-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- 125000006000 trichloroethyl group Chemical group 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- KAKQVSNHTBLJCH-UHFFFAOYSA-N trifluoromethanesulfonimidic acid Chemical compound NS(=O)(=O)C(F)(F)F KAKQVSNHTBLJCH-UHFFFAOYSA-N 0.000 description 1
- PQDJYEQOELDLCP-UHFFFAOYSA-N trimethylsilane Chemical compound C[SiH](C)C PQDJYEQOELDLCP-UHFFFAOYSA-N 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- BZVJOYBTLHNRDW-UHFFFAOYSA-N triphenylmethanamine Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(N)C1=CC=CC=C1 BZVJOYBTLHNRDW-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-M valerate Chemical compound CCCCC([O-])=O NQPDZGIKBAWPEJ-UHFFFAOYSA-M 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 201000009371 venous hemangioma Diseases 0.000 description 1
- LVLANIHJQRZTPY-UHFFFAOYSA-N vinyl carbamate Chemical compound NC(=O)OC=C LVLANIHJQRZTPY-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
- A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US22394609P | 2009-07-08 | 2009-07-08 | |
| US61/223,946 | 2009-07-08 | ||
| PCT/US2010/001926 WO2011005322A2 (en) | 2009-07-08 | 2010-07-08 | N-alkoxyamide conjugates as imaging agents |
Publications (2)
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| AU2010271097A1 AU2010271097A1 (en) | 2012-03-01 |
| AU2010271097B2 true AU2010271097B2 (en) | 2015-12-10 |
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| US (2) | US8877157B2 (enExample) |
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| JP (1) | JP5676600B2 (enExample) |
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| AU (1) | AU2010271097B2 (enExample) |
| CA (1) | CA2803520C (enExample) |
| WO (1) | WO2011005322A2 (enExample) |
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| CN105622463B (zh) | 2006-12-26 | 2019-02-22 | 兰休斯医疗成像公司 | 用于使心脏神经支配成像的配体 |
| WO2009089022A1 (en) | 2008-01-08 | 2009-07-16 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| AU2010271097B2 (en) | 2009-07-08 | 2015-12-10 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| BR122020018186B1 (pt) | 2010-05-11 | 2021-07-27 | Lantheus Medical Imaging, Inc | Uso de agentes de imagiologia para preparação de uma composição para detecção do transportador de norepinefrina (net) e método para a detecção de net |
| GB201102189D0 (en) | 2011-02-08 | 2011-03-23 | King S College London | Materials and methods relating to cardiovascular imaging |
| BR122019017259B1 (pt) | 2011-09-09 | 2022-05-10 | Lantheus Medical Imaging, Inc | Compostos úteis como agentes de imageamento, composições que os compreende, métodos, e uso de agentes de imageamento |
| WO2013070471A1 (en) | 2011-11-11 | 2013-05-16 | Lantheus Medical Imaging, Inc. | Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| BR112019010064A2 (pt) | 2016-11-18 | 2019-10-01 | Astellas Pharma Inc | novo fragmento fab do anticorpo muc1 anti-humano |
| TWI795415B (zh) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段 |
| BR112020023420A8 (pt) | 2018-05-17 | 2022-07-05 | Astellas Pharma Inc | Complexo tendo fragmento fab de anticorpo anti-muc1 humano, peptídeo ligador e/ou ligante |
| EP3865154A4 (en) | 2018-10-10 | 2022-11-09 | Astellas Pharma Inc. | PHARMACEUTICAL COMPOSITION CONTAINING ANTIBODY FAB FRAGMENT COMPLEX AT LABELED ANTI-HUMAN SITE |
| CN113301920B (zh) * | 2019-01-07 | 2025-01-14 | 安斯泰来制药株式会社 | 包含配体、间隔物、肽接头和生物分子的复合物 |
| CN117486698B (zh) * | 2023-10-30 | 2025-08-19 | 国网安徽省电力有限公司电力科学研究院 | 烯醇硅醚类化合物制备c-c键偶联产物的方法与sf6的应用 |
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| JPS5122885A (en) | 1974-08-13 | 1976-02-23 | Sagami Chem Res | Ashiru ll aminosan oo chikanhidorokisamidono seizohoho |
| JPS5910322B2 (ja) | 1975-07-30 | 1984-03-08 | 三井東圧化学株式会社 | 殺草剤 |
| US4859777A (en) | 1981-07-01 | 1989-08-22 | Eastman Kodak Company | Terpyridine chelating agents |
| US4957939A (en) | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
| JPH07110815B2 (ja) | 1985-11-18 | 1995-11-29 | ボ−ド・オブ・リ−ジェンツ、ザ・ユニバ−シティ−・オブ・テキサス・システム | 画像及びスペクトル向上（およびスペクトルシフト）のためのポリキレ−ト剤 |
| DE3768523D1 (de) | 1986-02-18 | 1991-04-18 | Squibb & Sons Inc | ((2,2,2-trichloroethoxy)methoxy)amin. |
| US5064956A (en) | 1987-06-24 | 1991-11-12 | The Dow Chemical Company | Process for preparing mono-n-alkylated polyazamacrocycles |
| IT1224627B (it) | 1988-04-12 | 1990-10-04 | Guidotti & C Spa Labor | Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono. |
| US5087440A (en) | 1989-07-31 | 1992-02-11 | Salutar, Inc. | Heterocyclic derivatives of DTPA used for magnetic resonance imaging |
| JP2927532B2 (ja) * | 1989-11-09 | 1999-07-28 | 塩野義製薬株式会社 | 含窒素異項環オキシーフェノキシ酢酸誘導体およびその除草剤としての用途 |
| JPH0491070A (ja) | 1990-08-06 | 1992-03-24 | Kanebo Ltd | カリックスアレーン誘導体 |
| US5274129A (en) | 1991-06-12 | 1993-12-28 | Idaho Research Foundation, Inc. | Hydroxamic acid crown ethers |
| GB9115375D0 (en) | 1991-07-17 | 1991-09-04 | Salutar Inc | Compounds |
| US5639746A (en) | 1994-12-29 | 1997-06-17 | The Procter & Gamble Company | Hydroxamic acid-containing inhibitors of matrix metalloproteases |
| TW319763B (enExample) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| CN1203899C (zh) | 1995-06-26 | 2005-06-01 | 螯合剂有限公司 | 对第一过渡系元素具有螯合亲和力和选择性的化合物及它们在医学冶疗中的用途 |
| DE19914101C1 (de) * | 1999-03-22 | 2000-10-12 | Schering Ag | Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik |
| US6461587B1 (en) | 1999-03-22 | 2002-10-08 | Schering Aktiengesellschaft | Perfluoroalkylamides, their production and their use in diagnosis |
| US6989139B2 (en) | 2000-02-15 | 2006-01-24 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
| US6656448B1 (en) | 2000-02-15 | 2003-12-02 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
| US20020002152A1 (en) * | 2000-04-14 | 2002-01-03 | Craig Richard A. | Hydrazide and alkoxyamide angiogenesis inhibitors |
| IL157444A0 (en) | 2001-02-23 | 2004-03-28 | Bristol Myers Squibb Pharma Co | Labeled macrophase scavenger receptor antagonists and diagnostic and pharmaceutical compositions containing the same |
| US20040146964A1 (en) | 2001-03-21 | 2004-07-29 | Maxwell Patrick Henry | Assays, methods and means |
| TWI240632B (en) | 2001-07-30 | 2005-10-01 | Epix Medical Inc | Purified peptides for peptide-based multimeric targeted contrast agents |
| WO2005001415A2 (en) | 2003-05-23 | 2005-01-06 | Epix Pharmaceuticals, Inc. | Optically pure and enriched isomers of chelating ligands and contrast agents |
| US7662856B2 (en) | 2003-08-29 | 2010-02-16 | The University Of Houston System | Compositions having antimycrobial activity including a hydroxamate or a hydroxamate and a hydroxlyamine |
| US20050106100A1 (en) | 2003-09-03 | 2005-05-19 | Harris Thomas D. | Compounds containing matrix metalloproteinase substrates and methods of their use |
| WO2005084179A2 (en) * | 2003-12-01 | 2005-09-15 | Immunomedics, Inc. | Improved method for preparing conjugates of proteins and chelating agents |
| US20070142417A1 (en) | 2005-05-11 | 2007-06-21 | Aventis Pharmaceuticals Inc | Substantially Pure 2-{[2-(2-Methylamino-Pyrimidin-4-YL)-1H-Indole-5-Carbonyl]-Amino}-3-Phenylpyridin-2-YL-Amino)-Propionic Acid as an IkB Kinase Inhibitor |
| EP1896086A1 (en) | 2005-06-30 | 2008-03-12 | Bristol-Myers Squibb Pharma Company | Hydrazide conjugates as imaging agents |
| US7618957B2 (en) | 2005-07-15 | 2009-11-17 | Bayer Schering Pharma Aktiengesellschaft | Perfluoroalkyl-containing complexes, process for their production as well as their use |
| WO2009089022A1 (en) | 2008-01-08 | 2009-07-16 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| AU2010271097B2 (en) | 2009-07-08 | 2015-12-10 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
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| HK1178511A1 (en) | 2013-09-13 |
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| EP2451776A2 (en) | 2012-05-16 |
| CN102781909A (zh) | 2012-11-14 |
| WO2011005322A2 (en) | 2011-01-13 |
| JP5676600B2 (ja) | 2015-02-25 |
| CA2803520A1 (en) | 2011-01-13 |
| US20120328514A1 (en) | 2012-12-27 |
| EP2451776A4 (en) | 2015-04-15 |
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| EP2451776B1 (en) | 2019-09-18 |
| WO2011005322A3 (en) | 2011-04-21 |
| US8877157B2 (en) | 2014-11-04 |
| JP2012532868A (ja) | 2012-12-20 |
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