CN102781909B - 作为显像剂的n-烷氧基酰胺共轭物 - Google Patents

作为显像剂的n-烷氧基酰胺共轭物 Download PDF

Info

Publication number
CN102781909B
CN102781909B CN201080040596.8A CN201080040596A CN102781909B CN 102781909 B CN102781909 B CN 102781909B CN 201080040596 A CN201080040596 A CN 201080040596A CN 102781909 B CN102781909 B CN 102781909B
Authority
CN
China
Prior art keywords
alkyl
aryl
mmol
amino
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201080040596.8A
Other languages
English (en)
Chinese (zh)
Other versions
CN102781909A (zh
Inventor
R·R·切萨蒂
T·D·哈里斯
S·P·罗宾逊
R·J·卢比
E·H·基斯曼
P·亚拉曼基利
D·S·凯斯比尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lantheus Medical Imaging Inc
Original Assignee
Lantheus Medical Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lantheus Medical Imaging Inc filed Critical Lantheus Medical Imaging Inc
Publication of CN102781909A publication Critical patent/CN102781909A/zh
Application granted granted Critical
Publication of CN102781909B publication Critical patent/CN102781909B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CN201080040596.8A 2009-07-08 2010-07-08 作为显像剂的n-烷氧基酰胺共轭物 Expired - Fee Related CN102781909B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22394609P 2009-07-08 2009-07-08
US61/223,946 2009-07-08
US61/223946 2009-07-08
PCT/US2010/001926 WO2011005322A2 (en) 2009-07-08 2010-07-08 N-alkoxyamide conjugates as imaging agents

Publications (2)

Publication Number Publication Date
CN102781909A CN102781909A (zh) 2012-11-14
CN102781909B true CN102781909B (zh) 2015-06-17

Family

ID=43429724

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080040596.8A Expired - Fee Related CN102781909B (zh) 2009-07-08 2010-07-08 作为显像剂的n-烷氧基酰胺共轭物

Country Status (7)

Country Link
US (2) US8877157B2 (enExample)
EP (1) EP2451776B1 (enExample)
JP (1) JP5676600B2 (enExample)
CN (1) CN102781909B (enExample)
AU (1) AU2010271097B2 (enExample)
CA (1) CA2803520C (enExample)
WO (1) WO2011005322A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105622463B (zh) 2006-12-26 2019-02-22 兰休斯医疗成像公司 用于使心脏神经支配成像的配体
WO2009089022A1 (en) 2008-01-08 2009-07-16 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
AU2010271097B2 (en) 2009-07-08 2015-12-10 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
BR122020018186B1 (pt) 2010-05-11 2021-07-27 Lantheus Medical Imaging, Inc Uso de agentes de imagiologia para preparação de uma composição para detecção do transportador de norepinefrina (net) e método para a detecção de net
GB201102189D0 (en) 2011-02-08 2011-03-23 King S College London Materials and methods relating to cardiovascular imaging
BR122019017259B1 (pt) 2011-09-09 2022-05-10 Lantheus Medical Imaging, Inc Compostos úteis como agentes de imageamento, composições que os compreende, métodos, e uso de agentes de imageamento
WO2013070471A1 (en) 2011-11-11 2013-05-16 Lantheus Medical Imaging, Inc. Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
BR112019010064A2 (pt) 2016-11-18 2019-10-01 Astellas Pharma Inc novo fragmento fab do anticorpo muc1 anti-humano
TWI795415B (zh) 2017-07-07 2023-03-11 日商安斯泰來製藥股份有限公司 新穎的抗人類ＣＥＡＣＡＭ５抗體Ｆａｂ片段
BR112020023420A8 (pt) 2018-05-17 2022-07-05 Astellas Pharma Inc Complexo tendo fragmento fab de anticorpo anti-muc1 humano, peptídeo ligador e/ou ligante
EP3865154A4 (en) 2018-10-10 2022-11-09 Astellas Pharma Inc. PHARMACEUTICAL COMPOSITION CONTAINING ANTIBODY FAB FRAGMENT COMPLEX AT LABELED ANTI-HUMAN SITE
CN113301920B (zh) * 2019-01-07 2025-01-14 安斯泰来制药株式会社 包含配体、间隔物、肽接头和生物分子的复合物
CN117486698B (zh) * 2023-10-30 2025-08-19 国网安徽省电力有限公司电力科学研究院 烯醇硅醚类化合物制备c-c键偶联产物的方法与sf6的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1189105A (zh) * 1995-06-26 1998-07-29 康凯有限公司 对第一过渡系元素具有螯合亲和力和选择性的化合物及它们在医学治疗和诊断中的用途
WO2001060416A2 (en) * 2000-02-15 2001-08-23 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors as targeting components in diagnostic agents
WO2005001415A2 (en) * 2003-05-23 2005-01-06 Epix Pharmaceuticals, Inc. Optically pure and enriched isomers of chelating ligands and contrast agents
US20070189969A1 (en) * 2005-07-15 2007-08-16 Heiko Schirmer Perfluoroalkyl-containing complexes, process for their production as well as their use
WO2009089022A1 (en) * 2008-01-08 2009-07-16 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5122885A (en) 1974-08-13 1976-02-23 Sagami Chem Res Ashiru ll aminosan oo chikanhidorokisamidono seizohoho
JPS5910322B2 (ja) 1975-07-30 1984-03-08 三井東圧化学株式会社 殺草剤
US4859777A (en) 1981-07-01 1989-08-22 Eastman Kodak Company Terpyridine chelating agents
US4957939A (en) 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
JPH07110815B2 (ja) 1985-11-18 1995-11-29 ボ−ド・オブ・リ−ジェンツ、ザ・ユニバ−シティ−・オブ・テキサス・システム 画像及びスペクトル向上（およびスペクトルシフト）のためのポリキレ−ト剤
DE3768523D1 (de) 1986-02-18 1991-04-18 Squibb & Sons Inc ((2,2,2-trichloroethoxy)methoxy)amin.
US5064956A (en) 1987-06-24 1991-11-12 The Dow Chemical Company Process for preparing mono-n-alkylated polyazamacrocycles
IT1224627B (it) 1988-04-12 1990-10-04 Guidotti & C Spa Labor Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.
US5087440A (en) 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
JP2927532B2 (ja) * 1989-11-09 1999-07-28 塩野義製薬株式会社 含窒素異項環オキシーフェノキシ酢酸誘導体およびその除草剤としての用途
JPH0491070A (ja) 1990-08-06 1992-03-24 Kanebo Ltd カリックスアレーン誘導体
US5274129A (en) 1991-06-12 1993-12-28 Idaho Research Foundation, Inc. Hydroxamic acid crown ethers
GB9115375D0 (en) 1991-07-17 1991-09-04 Salutar Inc Compounds
US5639746A (en) 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
TW319763B (enExample) 1995-02-01 1997-11-11 Epix Medical Inc
DE19914101C1 (de) * 1999-03-22 2000-10-12 Schering Ag Perfluoralkylamide, ihre Herstellung und ihre Verwendung in der Diagnostik
US6461587B1 (en) 1999-03-22 2002-10-08 Schering Aktiengesellschaft Perfluoroalkylamides, their production and their use in diagnosis
US6989139B2 (en) 2000-02-15 2006-01-24 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
US20020002152A1 (en) * 2000-04-14 2002-01-03 Craig Richard A. Hydrazide and alkoxyamide angiogenesis inhibitors
IL157444A0 (en) 2001-02-23 2004-03-28 Bristol Myers Squibb Pharma Co Labeled macrophase scavenger receptor antagonists and diagnostic and pharmaceutical compositions containing the same
US20040146964A1 (en) 2001-03-21 2004-07-29 Maxwell Patrick Henry Assays, methods and means
TWI240632B (en) 2001-07-30 2005-10-01 Epix Medical Inc Purified peptides for peptide-based multimeric targeted contrast agents
US7662856B2 (en) 2003-08-29 2010-02-16 The University Of Houston System Compositions having antimycrobial activity including a hydroxamate or a hydroxamate and a hydroxlyamine
US20050106100A1 (en) 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
WO2005084179A2 (en) * 2003-12-01 2005-09-15 Immunomedics, Inc. Improved method for preparing conjugates of proteins and chelating agents
US20070142417A1 (en) 2005-05-11 2007-06-21 Aventis Pharmaceuticals Inc Substantially Pure 2-{[2-(2-Methylamino-Pyrimidin-4-YL)-1H-Indole-5-Carbonyl]-Amino}-3-Phenylpyridin-2-YL-Amino)-Propionic Acid as an IkB Kinase Inhibitor
EP1896086A1 (en) 2005-06-30 2008-03-12 Bristol-Myers Squibb Pharma Company Hydrazide conjugates as imaging agents
AU2010271097B2 (en) 2009-07-08 2015-12-10 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1189105A (zh) * 1995-06-26 1998-07-29 康凯有限公司 对第一过渡系元素具有螯合亲和力和选择性的化合物及它们在医学治疗和诊断中的用途
US5874573A (en) * 1995-06-26 1999-02-23 Concat, Inc. Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy
WO2001060416A2 (en) * 2000-02-15 2001-08-23 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors as targeting components in diagnostic agents
WO2005001415A2 (en) * 2003-05-23 2005-01-06 Epix Pharmaceuticals, Inc. Optically pure and enriched isomers of chelating ligands and contrast agents
US20070189969A1 (en) * 2005-07-15 2007-08-16 Heiko Schirmer Perfluoroalkyl-containing complexes, process for their production as well as their use
WO2009089022A1 (en) * 2008-01-08 2009-07-16 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
CN101970015A (zh) * 2008-01-08 2011-02-09 兰休斯医疗成像公司 作为显像剂的n-烷氧基酰胺共轭物

Also Published As

Publication number Publication date
US20150078997A1 (en) 2015-03-19
CA2803520C (en) 2019-10-22
HK1178511A1 (en) 2013-09-13
AU2010271097A1 (en) 2012-03-01
EP2451776A2 (en) 2012-05-16
CN102781909A (zh) 2012-11-14
AU2010271097B2 (en) 2015-12-10
WO2011005322A2 (en) 2011-01-13
JP5676600B2 (ja) 2015-02-25
CA2803520A1 (en) 2011-01-13
US20120328514A1 (en) 2012-12-27
EP2451776A4 (en) 2015-04-15
US9393329B2 (en) 2016-07-19
EP2451776B1 (en) 2019-09-18
WO2011005322A3 (en) 2011-04-21
US8877157B2 (en) 2014-11-04
JP2012532868A (ja) 2012-12-20

Similar Documents

Publication Publication Date Title
CN102781909B (zh) 作为显像剂的n-烷氧基酰胺共轭物
JP6087386B2 (ja) 造影剤としてのｎ−アルコキシアミド抱合体
HK1178511B (en) N-alkoxyamide conjugates as imaging agents
HK1171216B (en) N-alkoxyamide conjugates as imaging agents
HK1171216A (en) N-alkoxyamide conjugates as imaging agents
HK1200823B (en) N-alkoxyamide conjugates as imaging agents

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1178511

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1178511

Country of ref document: HK

CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20150617

Termination date: 20210708

CF01 Termination of patent right due to non-payment of annual fee