JP5674211B2 - インダゾリル置換のジヒドロイソオキサゾロピリジンおよびその使用方法 - Google Patents

インダゾリル置換のジヒドロイソオキサゾロピリジンおよびその使用方法 Download PDF

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JP5674211B2
JP5674211B2 JP2012518822A JP2012518822A JP5674211B2 JP 5674211 B2 JP5674211 B2 JP 5674211B2 JP 2012518822 A JP2012518822 A JP 2012518822A JP 2012518822 A JP2012518822 A JP 2012518822A JP 5674211 B2 JP5674211 B2 JP 5674211B2
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compound
formula
cancer
met
mmol
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Japanese (ja)
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JP2012532170A (ja
JP2012532170A5 (https=
Inventor
マルティン・ミヒェルス
マルクス・フォルマン
アレクサンドロス・ヴァカロポウロス
カトヤ・ツィンマーマン
ニコレ・トイシュ
マリオ・ロベル
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2012518822A 2009-07-10 2010-07-07 インダゾリル置換のジヒドロイソオキサゾロピリジンおよびその使用方法 Expired - Fee Related JP5674211B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09008996 2009-07-10
EP09008996.2 2009-07-10
PCT/EP2010/004147 WO2011003604A1 (en) 2009-07-10 2010-07-07 Indazolyl-substituted dihydroisoxa-zolopyridines and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2012532170A JP2012532170A (ja) 2012-12-13
JP2012532170A5 JP2012532170A5 (https=) 2013-08-22
JP5674211B2 true JP5674211B2 (ja) 2015-02-25

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ID=42584913

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JP2012518822A Expired - Fee Related JP5674211B2 (ja) 2009-07-10 2010-07-07 インダゾリル置換のジヒドロイソオキサゾロピリジンおよびその使用方法

Country Status (7)

Country Link
US (1) US9073939B2 (https=)
EP (1) EP2451817B1 (https=)
JP (1) JP5674211B2 (https=)
CN (1) CN102639537B (https=)
CA (1) CA2767476A1 (https=)
ES (1) ES2433228T3 (https=)
WO (1) WO2011003604A1 (https=)

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635977A (en) 1969-11-03 1972-01-18 American Cyanamid Co Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil
JP2634640B2 (ja) 1988-07-29 1997-07-30 三共株式会社 縮環ジヒドロピリジン誘導体
US5274167A (en) 1989-01-26 1993-12-28 Bayer Aktiengesellschaft Polymeriable optically active (meth) acrylic acid derivatives
DE59009485D1 (de) 1989-01-26 1995-09-14 Bayer Ag Optisch aktive (Meth)Acrylsäure-Derivate, ihre Herstellung, ihre Polymerisation zu optisch aktiven Polymeren und deren Verwendung.
DE19546136A1 (de) 1995-12-11 1997-06-12 Bayer Ag Chirale stationäre Phasen für die chromatographische Trennung von optischen Isomeren
DE60103615T2 (de) 2000-03-03 2005-06-09 Abbott Laboratories, Abbott Park Tricyclische dihydropyrazolone und tricyclische dihydroisoaxazolone als kaliumkanalöffner
US7429609B2 (en) 2002-05-31 2008-09-30 Eisai R & D Management Co., Ltd. Pyrazole compound and medicinal composition containing the same
GB0220962D0 (en) * 2002-09-10 2002-10-23 Bayer Ag Heterocyclic derivatives
DK1638941T3 (da) * 2003-05-22 2010-10-11 Abbott Lab Indazol-, benzisoxazol- og benzisothiazolkinaseinhibitorer
TW200524601A (en) 2003-12-05 2005-08-01 Bristol Myers Squibb Co Heterocyclic anti-migraine agents
JP4825194B2 (ja) * 2004-02-26 2011-11-30 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト １，４−ジアリール−ジヒドロピリミジン−２−オン化合物およびヒト好中球エラスターゼ阻害剤としてのそれらの使用
JP2007526324A (ja) 2004-03-02 2007-09-13 スミスクライン・ビーチャム・コーポレイション Ａｋｔ活性のある阻害剤
EP1722792A1 (de) 2004-03-03 2006-11-22 Boehringer Ingelheim International GmbH Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
KR20070087602A (ko) 2004-12-13 2007-08-28 아이알엠 엘엘씨 화합물 및 스테로이드성 수용체 및 칼슘 채널 활성의조절제로서의 조성물
EP1858325A4 (en) 2005-01-07 2010-06-30 Roskamp Res Llc COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS FOR IDENTIFYING THESE COMPOUNDS
NZ567858A (en) * 2005-11-01 2011-08-26 Array Biopharma Inc Pyridine compounds useful as Glucokinase activators
AU2007240496A1 (en) 2006-04-19 2007-11-01 Novartis Ag Indazole compounds and methods for inhibition of CDC7
EA200900779A1 (ru) * 2006-12-14 2010-02-26 Байер Шеринг Фарма Акциенгезельшафт Производные дигидропиридина, полезные как ингибиторы протеинкиназы
WO2009006580A1 (en) 2007-07-05 2009-01-08 Cv Therapeutics, Inc. Optionally condensed dihydropyridine, dihydropyrimidine and dihydropyrane derivatives acting as late sodium channel blockers
WO2009149836A1 (en) * 2008-06-09 2009-12-17 Bayer Schering Pharma Aktiengesellschaft Annellated 4- (indazolyl) -1,4-dihydropyridine derivatives and methods of use thereof
JP5506788B2 (ja) * 2008-06-09 2014-05-28 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 置換４−（インダゾリル）−１，４−ジヒドロピリジン類およびそれらの使用方法
CN102574834B (zh) 2009-10-06 2014-04-09 拜耳知识产权有限责任公司 氟化的2,6-二烷基-3,5-二氰基-4-(1h-吲唑-5-基)-1,4-二氢吡啶及其使用方法

Also Published As

Publication number Publication date
CN102639537A (zh) 2012-08-15
JP2012532170A (ja) 2012-12-13
EP2451817B1 (en) 2013-09-04
CA2767476A1 (en) 2011-01-13
HK1174620A1 (zh) 2013-06-14
ES2433228T3 (es) 2013-12-10
CN102639537B (zh) 2015-07-22
EP2451817A1 (en) 2012-05-16
US20120190709A1 (en) 2012-07-26
WO2011003604A1 (en) 2011-01-13
US9073939B2 (en) 2015-07-07

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