JP5674211B2 - インダゾリル置換のジヒドロイソオキサゾロピリジンおよびその使用方法 - Google Patents

インダゾリル置換のジヒドロイソオキサゾロピリジンおよびその使用方法 Download PDF

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JP5674211B2
JP5674211B2 JP2012518822A JP2012518822A JP5674211B2 JP 5674211 B2 JP5674211 B2 JP 5674211B2 JP 2012518822 A JP2012518822 A JP 2012518822A JP 2012518822 A JP2012518822 A JP 2012518822A JP 5674211 B2 JP5674211 B2 JP 5674211B2
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compound
formula
cancer
met
mmol
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Japanese (ja)
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JP2012532170A (ja
JP2012532170A5 (https=
Inventor
マルティン・ミヒェルス
マルクス・フォルマン
アレクサンドロス・ヴァカロポウロス
カトヤ・ツィンマーマン
ニコレ・トイシュ
マリオ・ロベル
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2012518822A 2009-07-10 2010-07-07 インダゾリル置換のジヒドロイソオキサゾロピリジンおよびその使用方法 Expired - Fee Related JP5674211B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09008996 2009-07-10
EP09008996.2 2009-07-10
PCT/EP2010/004147 WO2011003604A1 (en) 2009-07-10 2010-07-07 Indazolyl-substituted dihydroisoxa-zolopyridines and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2012532170A JP2012532170A (ja) 2012-12-13
JP2012532170A5 JP2012532170A5 (https=) 2013-08-22
JP5674211B2 true JP5674211B2 (ja) 2015-02-25

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JP2012518822A Expired - Fee Related JP5674211B2 (ja) 2009-07-10 2010-07-07 インダゾリル置換のジヒドロイソオキサゾロピリジンおよびその使用方法

Country Status (7)

Country Link
US (1) US9073939B2 (https=)
EP (1) EP2451817B1 (https=)
JP (1) JP5674211B2 (https=)
CN (1) CN102639537B (https=)
CA (1) CA2767476A1 (https=)
ES (1) ES2433228T3 (https=)
WO (1) WO2011003604A1 (https=)

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635977A (en) 1969-11-03 1972-01-18 American Cyanamid Co Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil
JP2634640B2 (ja) 1988-07-29 1997-07-30 三共株式会社 縮環ジヒドロピリジン誘導体
ES2077591T3 (es) 1989-01-26 1995-12-01 Bayer Ag Derivados de acido (met)acrilico opticamente activos, su fabricacion, su polimerizacion para dar polimeros opticamente activos y su uso.
US5274167A (en) 1989-01-26 1993-12-28 Bayer Aktiengesellschaft Polymeriable optically active (meth) acrylic acid derivatives
DE19546136A1 (de) 1995-12-11 1997-06-12 Bayer Ag Chirale stationäre Phasen für die chromatographische Trennung von optischen Isomeren
ES2222357T3 (es) 2000-03-03 2005-02-01 Abbott Laboratories Agentes abridores de los canales de potasio a base de dihidropirazolona triciclica y de dihidroisoxazolona triciclica.
CA2482838A1 (en) 2002-05-31 2003-12-11 Eisai Co., Ltd. Pyrazole compounds and pharmaceutical compositions containing the compound
GB0220962D0 (en) * 2002-09-10 2002-10-23 Bayer Ag Heterocyclic derivatives
JP4810427B2 (ja) * 2003-05-22 2011-11-09 アボット・ラボラトリーズ インダゾール、ベンズイソオキサゾールおよびベンズイソチアゾールキナーゼ阻害剤
US7569578B2 (en) 2003-12-05 2009-08-04 Bristol-Meyers Squibb Company Heterocyclic anti-migraine agents
CA2557271C (en) * 2004-02-26 2012-08-21 Bayer Healthcare Ag 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors
US20070185152A1 (en) 2004-03-02 2007-08-09 Smithkline Beecham Corporation Inhibitors of akt activity
EP1722792A1 (de) 2004-03-03 2006-11-22 Boehringer Ingelheim International GmbH Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
US20090298872A1 (en) 2004-12-13 2009-12-03 Irm Llc Compounds and compositions as modulators of steroidal receptors and calcium channel activities
US20060188938A1 (en) 2005-01-07 2006-08-24 Mullan Michael J Compounds for inhibiting beta-amyloid production and methods of identifying the compounds
NZ567858A (en) * 2005-11-01 2011-08-26 Array Biopharma Inc Pyridine compounds useful as Glucokinase activators
RU2008145225A (ru) * 2006-04-19 2010-05-27 Новартис АГ (CH) Соединения индазола и способы ингибирования cd7
ES2396160T3 (es) 2006-12-14 2013-02-19 Bayer Intellectual Property Gmbh Derivados de DIHIDROPIRIDINA que utiliza como inhibidores de la proteina quinasa
WO2009006580A1 (en) 2007-07-05 2009-01-08 Cv Therapeutics, Inc. Optionally condensed dihydropyridine, dihydropyrimidine and dihydropyrane derivatives acting as late sodium channel blockers
US8551989B2 (en) * 2008-06-09 2013-10-08 Bayer Intellectual Property Gmbh Substituted 4-(indazolyl)-1,4-dihydropyridines and methods of use thereof
EP2300482B1 (en) * 2008-06-09 2012-01-04 Bayer Pharma Aktiengesellschaft ANNELLATED 4-(INDAZOLYL)-1,4-DIHYDROPYRIDINE DERIVATIVES AS c-Met MEDIATORS
US20120270905A1 (en) 2009-10-06 2012-10-25 Bayer Pharma Aktiengesellschaft Fluorinated 2,6-dialkyl-3,5-dicyano-4-(1h-indazol-5-yl)-1,4-dihydropyridines and methods of use thereof

Also Published As

Publication number Publication date
US9073939B2 (en) 2015-07-07
CA2767476A1 (en) 2011-01-13
US20120190709A1 (en) 2012-07-26
CN102639537B (zh) 2015-07-22
ES2433228T3 (es) 2013-12-10
JP2012532170A (ja) 2012-12-13
HK1174620A1 (zh) 2013-06-14
EP2451817A1 (en) 2012-05-16
CN102639537A (zh) 2012-08-15
WO2011003604A1 (en) 2011-01-13
EP2451817B1 (en) 2013-09-04

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