JP5663135B2 - 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法 - Google Patents

腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法 Download PDF

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JP5663135B2
JP5663135B2 JP2008501411A JP2008501411A JP5663135B2 JP 5663135 B2 JP5663135 B2 JP 5663135B2 JP 2008501411 A JP2008501411 A JP 2008501411A JP 2008501411 A JP2008501411 A JP 2008501411A JP 5663135 B2 JP5663135 B2 JP 5663135B2
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JP2008536487A (ja
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マーク ダブリュー. ローデル,
マーク ダブリュー. ローデル,
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ユーシーエル ビジネス ピーエルシー
ユーシーエル ビジネス ピーエルシー
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0646Natural killers cells [NK], NKT cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/15Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61K40/42Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48Blood cells, e.g. leukemia or lymphoma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/49Breast
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/50Cellular immunotherapy characterised by the use of allogeneic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50Cell markers; Cell surface determinants
    • C12N2501/599Cell markers; Cell surface determinants with CD designations not provided for elsewhere

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Compounds Of Unknown Constitution (AREA)
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JP2008501411A 2005-03-17 2006-03-16 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法 Expired - Fee Related JP5663135B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0505508.2 2005-03-17
GB0505508A GB0505508D0 (en) 2005-03-17 2005-03-17 Method
GB0514288.0 2005-07-12
GB0514288A GB0514288D0 (en) 2005-07-12 2005-07-12 Method
PCT/GB2006/000960 WO2006097743A2 (en) 2005-03-17 2006-03-16 Method for actvating natural killer cells by tumor cell preparation in vitro

Related Child Applications (2)

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JP2012224042A Division JP5906168B2 (ja) 2005-03-17 2012-10-09 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法
JP2014212302A Division JP2015012876A (ja) 2005-03-17 2014-10-17 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法

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JP2008536487A JP2008536487A (ja) 2008-09-11
JP2008536487A5 JP2008536487A5 (https=) 2009-03-12
JP5663135B2 true JP5663135B2 (ja) 2015-02-04

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JP2008501411A Expired - Fee Related JP5663135B2 (ja) 2005-03-17 2006-03-16 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法
JP2012224042A Expired - Lifetime JP5906168B2 (ja) 2005-03-17 2012-10-09 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法
JP2014212302A Withdrawn JP2015012876A (ja) 2005-03-17 2014-10-17 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法

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JP2014212302A Withdrawn JP2015012876A (ja) 2005-03-17 2014-10-17 腫瘍細胞調製物によってinvitroでナチュラルキラー細胞を活性化させるための方法

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US (3) US8257970B2 (https=)
EP (2) EP2399594B1 (https=)
JP (3) JP5663135B2 (https=)
AU (1) AU2006224313B2 (https=)
CA (1) CA2601197C (https=)
DK (1) DK1863905T3 (https=)
ES (1) ES2566335T3 (https=)
PL (1) PL1863905T3 (https=)
WO (1) WO2006097743A2 (https=)

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CN106434527A (zh) 2006-04-14 2017-02-22 安斯泰来再生医药协会 血管瘤集落形成细胞
CN102046196B (zh) * 2008-05-29 2014-07-30 特朗斯吉有限公司 用于选择患者的生物标志物及相关方法
WO2011004201A1 (en) * 2009-07-10 2011-01-13 Mark Lowdell Preserved compositions of activated nk cells and methods of using the same
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
SI2785359T1 (sl) 2011-11-30 2018-11-30 Astellas Institute For Regenerative Medicine Mezenhimske stromalne celice in uporabe povezane z njimi
WO2013132256A1 (en) 2012-03-07 2013-09-12 Ucl Business Plc Compositions and methods for treating viral-mediated infection and disease in immunocompromised individuals
US9938498B2 (en) 2012-05-07 2018-04-10 Nkmax Co., Ltd. Method for the induction and expansion of natural killer cells derived from peripheral blood mononuclear cells
WO2013168978A1 (ko) * 2012-05-07 2013-11-14 고려대학교 산학협력단 말초혈액단핵구 유래 자연 살해세포의 유도 및 증식 방법
HK1208054A1 (en) 2012-07-12 2016-02-19 爱姆斯坦生物技术公司 Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
CA2896053A1 (en) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
CN106687584B (zh) * 2014-09-04 2021-08-13 干细胞技术公司 用于t细胞或nk细胞活化和扩增的可溶性抗体复合物
US10758567B2 (en) 2015-09-16 2020-09-01 Immune Ventures LLC In vivo priming of natural killer cells
ES2871100T3 (es) * 2015-12-07 2021-10-28 Immune Ventures LLC Cebado in vivo de linfocitos citolíticos naturales
US20200101106A1 (en) * 2017-03-15 2020-04-02 Immune Ventures, Llc In vivo priming of natural killer cells
IL276365B2 (en) 2018-02-01 2023-10-01 Nkmax Co Ltd A method for the production of natural killer cells and a preparation for cancer treatment
CN120365435A (zh) * 2018-08-30 2025-07-25 免疫生物公司 单链嵌合多肽和多链嵌合多肽以及其用途
CN112996805A (zh) 2018-08-30 2021-06-18 Hcw生物科技公司 多链嵌合多肽和其用途
EP3843788A1 (en) 2018-08-30 2021-07-07 HCW Biologics, Inc. Single-chain chimeric polypeptides and uses thereof
JP6838750B2 (ja) * 2019-01-21 2021-03-03 株式会社ガイアバイオメディシン Nk細胞を含む細胞集団の製造方法
JP7713393B2 (ja) * 2019-06-21 2025-07-25 イミュニティーバイオ インコーポレイテッド 多鎖キメラポリペプチドおよびその使用
KR20220140535A (ko) 2020-02-11 2022-10-18 에이치씨더블유 바이올로직스, 인크. 크로마토그래피 수지 및 이의 용도
US12115191B2 (en) 2020-02-11 2024-10-15 Immunitybio, Inc. Methods of treating age-related and inflammatory diseases
EP4103599A1 (en) 2020-02-11 2022-12-21 HCW Biologics, Inc. Methods of activating regulatory t cells
EP4143231A1 (en) 2020-04-29 2023-03-08 HCW Biologics, Inc. Anti-cd26 proteins and uses thereof
US12024545B2 (en) 2020-06-01 2024-07-02 HCW Biologics, Inc. Methods of treating aging-related disorders
EP4507711A1 (en) 2022-04-13 2025-02-19 ImmunityBio, Inc. Multi-chain chimeric polypeptide for use in the treatment of treating neuroinflammatory disorder
KR20250118299A (ko) * 2024-01-29 2025-08-06 인하대학교 산학협력단 전기자극 시스템을 활용한 자연살해세포의 암세포 살상 능력 증진 방법

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US7435596B2 (en) * 2004-11-04 2008-10-14 St. Jude Children's Research Hospital, Inc. Modified cell line and method for expansion of NK cell

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AU2006224313A1 (en) 2006-09-21
JP2008536487A (ja) 2008-09-11
CA2601197C (en) 2017-06-06
US8257970B2 (en) 2012-09-04
US8637308B2 (en) 2014-01-28
AU2006224313B2 (en) 2011-08-11
US9655925B2 (en) 2017-05-23
EP1863905A2 (en) 2007-12-12
WO2006097743A2 (en) 2006-09-21
CA2601197A1 (en) 2006-09-21
PL1863905T3 (pl) 2016-07-29
WO2006097743A3 (en) 2006-12-14
EP1863905B1 (en) 2016-01-20
ES2566335T3 (es) 2016-04-12
DK1863905T3 (en) 2016-04-04
JP2015012876A (ja) 2015-01-22
US20140079678A1 (en) 2014-03-20
US20080166326A1 (en) 2008-07-10
EP2399594B1 (en) 2019-08-14
JP5906168B2 (ja) 2016-04-20
EP2399594A1 (en) 2011-12-28
JP2013009686A (ja) 2013-01-17
US20120328587A1 (en) 2012-12-27
HK1112483A1 (zh) 2008-09-05

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