JP5658152B2 - 非細胞毒性融合タンパク質 - Google Patents

非細胞毒性融合タンパク質 Download PDF

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Publication number
JP5658152B2
JP5658152B2 JP2011523457A JP2011523457A JP5658152B2 JP 5658152 B2 JP5658152 B2 JP 5658152B2 JP 2011523457 A JP2011523457 A JP 2011523457A JP 2011523457 A JP2011523457 A JP 2011523457A JP 5658152 B2 JP5658152 B2 JP 5658152B2
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Japan
Prior art keywords
egf
amino acid
seq
polypeptide
sequence
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JP2011523457A
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English (en)
Japanese (ja)
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JP2012500018A (ja
JP2012500018A5 (enExample
Inventor
コシンズ,エイミー
バーチ−マチン,イアン
スタンクーム,パトリック
チャドック,ジョン
ビアード,マシュー
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Ipsen Bioinnovation Ltd
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Ipsen Bioinnovation Ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/485Epidermal growth factor [EGF], i.e. urogastrone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
JP2011523457A 2008-08-21 2009-08-19 非細胞毒性融合タンパク質 Expired - Fee Related JP5658152B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0815264.7A GB0815264D0 (en) 2008-08-21 2008-08-21 Non-cytotoxic proteins
GB0815264.7 2008-08-21
PCT/GB2009/051036 WO2010020811A1 (en) 2008-08-21 2009-08-19 Non-cytotoxic fusion proteins comprising egf muteins

Publications (3)

Publication Number Publication Date
JP2012500018A JP2012500018A (ja) 2012-01-05
JP2012500018A5 JP2012500018A5 (enExample) 2014-08-07
JP5658152B2 true JP5658152B2 (ja) 2015-01-21

Family

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Family Applications (1)

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JP2011523457A Expired - Fee Related JP5658152B2 (ja) 2008-08-21 2009-08-19 非細胞毒性融合タンパク質

Country Status (9)

Country Link
US (1) US8614069B2 (enExample)
EP (1) EP2326665B1 (enExample)
JP (1) JP5658152B2 (enExample)
DK (1) DK2326665T3 (enExample)
ES (1) ES2436816T3 (enExample)
GB (1) GB0815264D0 (enExample)
PL (1) PL2326665T3 (enExample)
PT (1) PT2326665E (enExample)
WO (1) WO2010020811A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9617671D0 (en) * 1996-08-23 1996-10-02 Microbiological Res Authority Recombinant toxin fragments
US8790897B2 (en) * 1998-08-25 2014-07-29 Syntaxin Ltd. Treatment of mucus hypersecretion
CN107446053A (zh) 2008-06-12 2017-12-08 益普生生物创新有限公司 癌症的抑制
WO2012061086A2 (en) * 2010-10-25 2012-05-10 Niiki Pharma Inc. Method of treating neuroendocrine tumors
KR101519118B1 (ko) * 2013-07-23 2015-05-12 (주)피앤피바이오팜 고안정성 상피세포 성장인자 변이체
JP2018511346A (ja) 2015-03-31 2018-04-26 ブイエイチスクエアード リミテッド ポリペプチド
CA3255406A1 (en) 2015-03-31 2025-07-03 Sorriso Pharmaceuticals, Inc. Tnf-alpha binding polypeptides
WO2016156466A1 (en) 2015-03-31 2016-10-06 Vhsquared Limited Peptide construct having a protease-cleavable linker
TW201814045A (zh) 2016-09-16 2018-04-16 英商艾普森生物製藥有限公司 製造雙鏈梭狀芽孢桿菌神經毒素之方法
WO2018060351A1 (en) 2016-09-29 2018-04-05 Ipsen Biopharm Limited Hybrid neurotoxins
WO2018060453A1 (en) 2016-09-30 2018-04-05 Vhsquared Limited Compositions
EP3312290A1 (en) 2016-10-18 2018-04-25 Ipsen Biopharm Limited Cellular vamp cleavage assay
US11241480B2 (en) * 2017-01-26 2022-02-08 Washington University Methods for modulation of dietary and microbial exposure with compositions comprising an EGFR ligand
JP7229247B2 (ja) 2018-01-29 2023-02-27 イプセン バイオファーム リミテッド 非ニューロンsnare切断性ボツリヌス神経毒
GB201815817D0 (en) * 2018-09-28 2018-11-14 Ispen Biopharm Ltd Clostridial neurotoxins comprising and exogenous activation loop
GB201900621D0 (en) * 2019-01-16 2019-03-06 Ipsen Biopharm Ltd Labelled polypeptides
EP3958979A1 (en) * 2019-04-23 2022-03-02 Aurora Oncology Compositions and methods for treatment of distentable tissues
CN114466864B (zh) 2019-06-21 2024-12-27 索瑞索制药公司 多肽
JP7680377B2 (ja) 2019-06-21 2025-05-20 ソリッソ ファーマシューティカルズ,インク. ポリペプチド
WO2024249812A2 (en) * 2023-06-01 2024-12-05 Blaze Bioscience, Inc. Egf variants and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003A (en) * 1851-03-25 Improvement in scythe-tastenings
US8790897B2 (en) 1998-08-25 2014-07-29 Syntaxin Ltd. Treatment of mucus hypersecretion
GB9818548D0 (en) * 1998-08-25 1998-10-21 Microbiological Res Authority Treatment of mucas hypersecretion
US20080038274A1 (en) * 1999-09-23 2008-02-14 Foster Keith A Inhibition of secretion from non-neuronal cells
US7037504B2 (en) 2001-10-23 2006-05-02 Waratah Pharmaceuticals, Inc. Epidermal growth factor protein and gene, and methods of use therefor
US7514240B2 (en) * 2002-02-05 2009-04-07 Japan Science And Technology Agency EGR-EGFR complex
US8247531B2 (en) * 2006-03-20 2012-08-21 Cochran Jennifer R Mutant epidermal growth factor polypeptides, nucleic acids, and uses therefor
GB0725321D0 (en) * 2007-12-31 2008-02-06 Syntaxin Ltd Delivery vehicles

Also Published As

Publication number Publication date
PL2326665T3 (pl) 2014-03-31
ES2436816T3 (es) 2014-01-07
PT2326665E (pt) 2013-12-23
US8614069B2 (en) 2013-12-24
GB0815264D0 (en) 2008-09-24
EP2326665B1 (en) 2013-10-09
US20110177056A1 (en) 2011-07-21
WO2010020811A1 (en) 2010-02-25
EP2326665A1 (en) 2011-06-01
JP2012500018A (ja) 2012-01-05
DK2326665T3 (da) 2013-11-25

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