DK2326665T3 - Ikke-cytotoksiske fusionproteiner, omfattende egf-muteiner - Google Patents

Ikke-cytotoksiske fusionproteiner, omfattende egf-muteiner

Info

Publication number
DK2326665T3
DK2326665T3 DK09785502.7T DK09785502T DK2326665T3 DK 2326665 T3 DK2326665 T3 DK 2326665T3 DK 09785502 T DK09785502 T DK 09785502T DK 2326665 T3 DK2326665 T3 DK 2326665T3
Authority
DK
Denmark
Prior art keywords
muteines
fusion proteins
including egf
cytotoxic fusion
cytotoxic
Prior art date
Application number
DK09785502.7T
Other languages
Danish (da)
English (en)
Inventor
Aimee Cossins
Ian Birch-Machin
Patrick Stancombe
John Chaddock
Matthew Beard
Original Assignee
Syntaxin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntaxin Ltd filed Critical Syntaxin Ltd
Application granted granted Critical
Publication of DK2326665T3 publication Critical patent/DK2326665T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
DK09785502.7T 2008-08-21 2009-08-19 Ikke-cytotoksiske fusionproteiner, omfattende egf-muteiner DK2326665T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0815264.7A GB0815264D0 (en) 2008-08-21 2008-08-21 Non-cytotoxic proteins
PCT/GB2009/051036 WO2010020811A1 (en) 2008-08-21 2009-08-19 Non-cytotoxic fusion proteins comprising egf muteins

Publications (1)

Publication Number Publication Date
DK2326665T3 true DK2326665T3 (da) 2013-11-25

Family

ID=39812369

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09785502.7T DK2326665T3 (da) 2008-08-21 2009-08-19 Ikke-cytotoksiske fusionproteiner, omfattende egf-muteiner

Country Status (9)

Country Link
US (1) US8614069B2 (enExample)
EP (1) EP2326665B1 (enExample)
JP (1) JP5658152B2 (enExample)
DK (1) DK2326665T3 (enExample)
ES (1) ES2436816T3 (enExample)
GB (1) GB0815264D0 (enExample)
PL (1) PL2326665T3 (enExample)
PT (1) PT2326665E (enExample)
WO (1) WO2010020811A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9617671D0 (en) * 1996-08-23 1996-10-02 Microbiological Res Authority Recombinant toxin fragments
US8790897B2 (en) * 1998-08-25 2014-07-29 Syntaxin Ltd. Treatment of mucus hypersecretion
CN107446053A (zh) 2008-06-12 2017-12-08 益普生生物创新有限公司 癌症的抑制
WO2012061086A2 (en) * 2010-10-25 2012-05-10 Niiki Pharma Inc. Method of treating neuroendocrine tumors
KR101519118B1 (ko) * 2013-07-23 2015-05-12 (주)피앤피바이오팜 고안정성 상피세포 성장인자 변이체
JP2018511346A (ja) 2015-03-31 2018-04-26 ブイエイチスクエアード リミテッド ポリペプチド
CA3255406A1 (en) 2015-03-31 2025-07-03 Sorriso Pharmaceuticals, Inc. Tnf-alpha binding polypeptides
WO2016156466A1 (en) 2015-03-31 2016-10-06 Vhsquared Limited Peptide construct having a protease-cleavable linker
TW201814045A (zh) 2016-09-16 2018-04-16 英商艾普森生物製藥有限公司 製造雙鏈梭狀芽孢桿菌神經毒素之方法
WO2018060351A1 (en) 2016-09-29 2018-04-05 Ipsen Biopharm Limited Hybrid neurotoxins
WO2018060453A1 (en) 2016-09-30 2018-04-05 Vhsquared Limited Compositions
EP3312290A1 (en) 2016-10-18 2018-04-25 Ipsen Biopharm Limited Cellular vamp cleavage assay
US11241480B2 (en) * 2017-01-26 2022-02-08 Washington University Methods for modulation of dietary and microbial exposure with compositions comprising an EGFR ligand
JP7229247B2 (ja) 2018-01-29 2023-02-27 イプセン バイオファーム リミテッド 非ニューロンｓｎａｒｅ切断性ボツリヌス神経毒
GB201815817D0 (en) * 2018-09-28 2018-11-14 Ispen Biopharm Ltd Clostridial neurotoxins comprising and exogenous activation loop
GB201900621D0 (en) * 2019-01-16 2019-03-06 Ipsen Biopharm Ltd Labelled polypeptides
EP3958979A1 (en) * 2019-04-23 2022-03-02 Aurora Oncology Compositions and methods for treatment of distentable tissues
CN114466864B (zh) 2019-06-21 2024-12-27 索瑞索制药公司 多肽
JP7680377B2 (ja) 2019-06-21 2025-05-20 ソリッソ ファーマシューティカルズ，インク． ポリペプチド
WO2024249812A2 (en) * 2023-06-01 2024-12-05 Blaze Bioscience, Inc. Egf variants and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8003A (en) * 1851-03-25 Improvement in scythe-tastenings
US8790897B2 (en) 1998-08-25 2014-07-29 Syntaxin Ltd. Treatment of mucus hypersecretion
GB9818548D0 (en) * 1998-08-25 1998-10-21 Microbiological Res Authority Treatment of mucas hypersecretion
US20080038274A1 (en) * 1999-09-23 2008-02-14 Foster Keith A Inhibition of secretion from non-neuronal cells
US7037504B2 (en) 2001-10-23 2006-05-02 Waratah Pharmaceuticals, Inc. Epidermal growth factor protein and gene, and methods of use therefor
US7514240B2 (en) * 2002-02-05 2009-04-07 Japan Science And Technology Agency EGR-EGFR complex
US8247531B2 (en) * 2006-03-20 2012-08-21 Cochran Jennifer R Mutant epidermal growth factor polypeptides, nucleic acids, and uses therefor
GB0725321D0 (en) * 2007-12-31 2008-02-06 Syntaxin Ltd Delivery vehicles

Also Published As

Publication number Publication date
PL2326665T3 (pl) 2014-03-31
ES2436816T3 (es) 2014-01-07
PT2326665E (pt) 2013-12-23
US8614069B2 (en) 2013-12-24
GB0815264D0 (en) 2008-09-24
EP2326665B1 (en) 2013-10-09
US20110177056A1 (en) 2011-07-21
WO2010020811A1 (en) 2010-02-25
EP2326665A1 (en) 2011-06-01
JP2012500018A (ja) 2012-01-05
JP5658152B2 (ja) 2015-01-21

Similar Documents

Publication Publication Date Title
DK2326665T3 (da) Ikke-cytotoksiske fusionproteiner, omfattende egf-muteiner
NO2021006I1 (no) Quofenix, delafloksacin
HRP20151058T1 (xx) Ariloazol-2-il-cijanoetilamino-spojevi, postupak njihove proizvodnje i postupak njihove uporabe
BRPI0918430A2 (pt) 4-fenil-1h-pirazóis inseticidas.
BRPI0818912A2 (pt) Criação colaborativa
EP2272042A4 (en) SMART CAR COMPLETION
ATE513831T1 (de) Pyridinä3,4-büpyrazinone
BRPI0922391A2 (pt) pneumático.
DK3118221T3 (da) Proteiner
HRP20150107T1 (xx) Derivati dioksabiciklo[3.2.1]oktan-2,3,4-triola
FI20085893A0 (fi) Kasvihuone
UY33125A (es) Diaza-espiro-[5,5]-undecanos
DK2344471T3 (da) 7-piperidinalkyl-3,4-dihydroquinolon-derivat
BRPI0919898A2 (pt) 4,5,6,7-tetra-hidrotienopiridinas substituídas como moduladores de kcnq2/3
BRPI0923418A2 (pt) pneumático.
BRPI0917446A2 (pt) derivados de acilaminobenzamida.
BRPI0923387A2 (pt) pneumático.
FR2940007B1 (fr) Taille-haie
BRPI0913009A2 (pt) Composição germicida em microemulsão
PT2277578T (pt) Nebulizador.
FR2944701B1 (fr) Composition coloree.
FR2932857B1 (fr) Agrafe.
IT1396642B1 (it) Statore.
HRP20150021T1 (xx) Spojevi fenantrenona, pripravci i postupci
FI20086063A0 (fi) Merkintäväline