JP5649454B2 - ミトコンドリア病の処置のための（ヘテロ）アリール−ｐ−キノン誘導体 - Google Patents
ミトコンドリア病の処置のための（ヘテロ）アリール−ｐ−キノン誘導体 Download PDFInfo
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- JP5649454B2 JP5649454B2 JP2010542313A JP2010542313A JP5649454B2 JP 5649454 B2 JP5649454 B2 JP 5649454B2 JP 2010542313 A JP2010542313 A JP 2010542313A JP 2010542313 A JP2010542313 A JP 2010542313A JP 5649454 B2 JP5649454 B2 JP 5649454B2
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- Prior art keywords
- hydroxy
- alkyl
- methylbutyl
- dione
- diene
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- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 103
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 87
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- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
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- C07C50/00—Quinones
- C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
- C07C50/28—Quinones containing groups having oxygen atoms singly bound to carbon atoms with monocyclic quinoid structure
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
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- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
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| PCT/US2009/030229 WO2009089224A1 (en) | 2008-01-08 | 2009-01-06 | (HET) ARYL-p-QUINONE DERIVATIVES FOR TREATMENT OF MITOCHONDRIAL DISEASES |
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| US20140275045A1 (en) | 2013-03-15 | 2014-09-18 | Edison Pharmaceuticals, Inc. | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| EP3004071A1 (en) | 2013-05-31 | 2016-04-13 | Edison Pharmaceuticals, Inc. | Carboxylic acid derivatives for treatment of oxidative stress disorders |
-
2009
- 2009-01-06 US US12/811,694 patent/US8952071B2/en not_active Expired - Fee Related
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- 2009-01-06 EP EP09700856.9A patent/EP2237664A4/en not_active Withdrawn
- 2009-01-06 WO PCT/US2009/030229 patent/WO2009089224A1/en not_active Ceased
- 2009-01-06 EA EA201001119A patent/EA023618B1/ru not_active IP Right Cessation
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2013
- 2013-12-26 JP JP2013268441A patent/JP2014058569A/ja not_active Withdrawn
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2014
- 2014-12-30 US US14/586,516 patent/US9486435B2/en not_active Expired - Fee Related
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015110674A (ja) * | 2008-09-10 | 2015-06-18 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化還元活性治療剤を用いての広汎性発達障害の処置 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009089224A1 (en) | 2009-07-16 |
| EA023618B1 (ru) | 2016-06-30 |
| US20150297551A1 (en) | 2015-10-22 |
| EP2237664A1 (en) | 2010-10-13 |
| JP2011509298A (ja) | 2011-03-24 |
| JP2014058569A (ja) | 2014-04-03 |
| US9486435B2 (en) | 2016-11-08 |
| US20110046219A1 (en) | 2011-02-24 |
| CA2708961C (en) | 2017-03-28 |
| EP2237664A4 (en) | 2013-05-22 |
| JP2016034979A (ja) | 2016-03-17 |
| EA201001119A1 (ru) | 2011-02-28 |
| CA2708961A1 (en) | 2009-07-16 |
| US8952071B2 (en) | 2015-02-10 |
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