JP5647099B2 - 認知症を治療するための使用及び組成物 - Google Patents
認知症を治療するための使用及び組成物 Download PDFInfo
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- JP5647099B2 JP5647099B2 JP2011501792A JP2011501792A JP5647099B2 JP 5647099 B2 JP5647099 B2 JP 5647099B2 JP 2011501792 A JP2011501792 A JP 2011501792A JP 2011501792 A JP2011501792 A JP 2011501792A JP 5647099 B2 JP5647099 B2 JP 5647099B2
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- A61K31/33—Heterocyclic compounds
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- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
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- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P25/00—Drugs for disorders of the nervous system
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Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
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- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| JP2016078787A Expired - Fee Related JP6427522B2 (ja) | 2008-03-27 | 2016-04-11 | 認知症を治療するための使用及び組成物 |
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| US8969402B2 (en) | 2006-11-15 | 2015-03-03 | Steven A. Rich | Combined acetylcholinesterase inhibitor and quaternary ammonium antimuscarinic therapy to alter progression of cognitive diseases |
| US20110201597A1 (en) | 2008-03-27 | 2011-08-18 | Chase Thomas N | Method and composition for treating alzheimer-type dementia |
| EP4088717A1 (en) * | 2008-03-27 | 2022-11-16 | Chase Pharmaceuticals Corporation | Use and composition for treating dementia |
| ES2742728T3 (es) | 2009-07-22 | 2020-02-17 | PureTech Health LLC | Composiciones para el tratamiento de trastornos mejorados por la activación del receptor muscarínico |
| EP2478099B1 (en) | 2009-09-18 | 2019-06-05 | Chase Pharmaceuticals Corporation | Combination for treating alzheimer-type dementia |
| JP2011213606A (ja) * | 2010-03-31 | 2011-10-27 | Sawai Pharmaceutical Co Ltd | ドネペジルを含有する固形製剤の製造方法 |
| JP2011213695A (ja) * | 2010-04-02 | 2011-10-27 | Taisho Pharm Ind Ltd | ドネペジル塩酸塩含有口腔内速崩壊錠 |
| AU2013312749B2 (en) * | 2012-09-05 | 2018-01-18 | Chase Pharmaceuticals Corporation | Anticholinergic neuroprotective composition and methods |
| US10149828B2 (en) * | 2015-01-09 | 2018-12-11 | Chase Pharmaceuticals Corporation | Oxybutynin transdermal therapeutic system combination |
| EP3265466A4 (en) * | 2015-03-06 | 2018-12-26 | Chase Pharmaceuticals Corporation | Peripheral-anticholinergic muscarinic agonist combination |
| EP3265128A4 (en) | 2015-03-06 | 2018-09-12 | Chase Pharmaceuticals Corporation | Oxybutynin transdermal therapeutic system muscarinic agonist combination |
| US10307409B2 (en) * | 2015-03-06 | 2019-06-04 | Chase Pharmaceuticals Corporation | Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system |
| MA43047A (fr) | 2015-06-15 | 2018-08-08 | Qaam Pharmaceuticals Llc | Sels d'acides gras de glycopyrronium et leurs procédés de production |
| US20180360845A1 (en) * | 2015-07-20 | 2018-12-20 | Chase Pharmaceuticals Corporation | Muscarinic combination of a selective m2-antagonist and a peripheral non-selective antagonist for treating hypocholinergic disorders |
| WO2017044693A1 (en) | 2015-09-11 | 2017-03-16 | Chase Pharmaceuticals Corporation | Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system |
| WO2017147104A1 (en) * | 2016-02-24 | 2017-08-31 | Chase Pharmaceuticals Corporation | Muscarinic m2-antagonist combinations |
| US10479706B2 (en) * | 2016-06-03 | 2019-11-19 | Katz Water Tech, Llc | Apparatus, method and system for desalinating water |
| US20190269627A1 (en) | 2016-10-28 | 2019-09-05 | Chase Pharmaceuticals Corporation | Memantine combinations and use |
| JP2021522187A (ja) * | 2018-04-17 | 2021-08-30 | エルテーエス ローマン テラピー−ジステーメ アーゲー | ソリフェナシンの経皮投与のための経皮治療システム |
| PT3856182T (pt) | 2018-09-28 | 2026-03-10 | Karuna Therapeutics Inc | Composições e métodos para o tratamento de perturbações melhoradas pela ativação dos recetores muscarínicos |
| US20240024261A1 (en) * | 2020-09-21 | 2024-01-25 | Dr. Raymond Lab Inc | Pharmaceutical composition for improving cognitive ability or enhancing memory |
| CA3199724A1 (en) * | 2020-11-26 | 2022-06-02 | Yusheng Xiong | Anticholinergic agents |
| US12109202B2 (en) | 2021-01-29 | 2024-10-08 | Qaam Pharmaceuticals, Llc | Fixed dose combination of cholinesterase inhibitor and a quaternary ammonium antimuscarinic agent to treat neurodegenerative cognitive disorders |
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| GB795758A (en) | 1955-08-22 | 1958-05-28 | Pfizer & Co C | Amino esters and the preparation thereof |
| US3480626A (en) | 1967-05-18 | 1969-11-25 | Chem Fab Dr R Pfleger | Certain azoniaspironortropine derivatives |
| GB1204580A (en) | 1968-10-05 | 1970-09-09 | Aspro Nicholas Ltd | Pharmaceutical dosage forms |
| US3576388A (en) | 1968-12-05 | 1971-04-27 | Stauffer Wacker Silicone Corp | Electrical cable |
| DD106643A1 (enExample) | 1973-07-12 | 1974-06-20 | ||
| US4965074A (en) | 1985-03-05 | 1990-10-23 | Ciba-Geigy Corporation | Method of treating memory impairment |
| US4663318A (en) * | 1986-01-15 | 1987-05-05 | Bonnie Davis | Method of treating Alzheimer's disease |
| US4798841A (en) | 1987-03-31 | 1989-01-17 | Warner-Lambert Company | Tetrahydropyridine oxime cholinergic agents and method of treatment |
| GB8717446D0 (en) | 1987-07-23 | 1987-08-26 | Merck Sharp & Dohme | Chemical compounds |
| US5382600A (en) | 1988-01-22 | 1995-01-17 | Pharmacia Aktiebolag | 3,3-diphenylpropylamines and pharmaceutical compositions thereof |
| US4937239A (en) | 1989-02-13 | 1990-06-26 | Warner-Lambert Company | Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents |
| US5852029A (en) | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
| NO2005012I1 (no) | 1994-12-28 | 2005-06-06 | Debio Rech Pharma Sa | Triptorelin og farmasoytisk akseptable salter derav |
| GB9612710D0 (en) | 1996-06-18 | 1996-08-21 | Pfizer Ltd | Method of treatment |
| WO1999002154A1 (en) | 1997-07-09 | 1999-01-21 | Axonyx | Highly selective butyrylcholinesterase inhibitors for the treatment and diagnosis of alzheimer's disease and dementias |
| EP0976404A3 (en) * | 1998-07-30 | 2001-06-27 | Pfizer Products Inc. | A pharmaceutical composition for the prevention and treatment of diseases of cognitive dysfunction in a mammal |
| CA2310926C (en) | 2000-04-03 | 2002-10-15 | Janssen Pharmaceutica N.V. | A use of galantamine for the treatment of neuropsychiatric behaviour associated with alzheimer's disease |
| CA2436083A1 (en) * | 2001-02-08 | 2002-09-19 | Schering Corporation | Use of dual h3/m2 antagonists in the treatment of cognition deficit disorders |
| US8216609B2 (en) * | 2002-08-05 | 2012-07-10 | Torrent Pharmaceuticals Limited | Modified release composition of highly soluble drugs |
| US7427280B2 (en) * | 2002-09-06 | 2008-09-23 | Medtronic, Inc. | Method, system and device for treating disorders of the pelvic floor by delivering drugs to various nerves or tissues |
| US6974820B2 (en) | 2002-11-06 | 2005-12-13 | Bridge Pharma, Inc. | Methods for treating urinary incontinence and other disorders using trospium |
| CN1520818A (zh) | 2003-02-09 | 2004-08-18 | ɽ����Ҷ��Ȼҩ���о���������˾ | 治疗老年性痴呆的胆碱酯酶抑制剂药物组合物 |
| US8299062B2 (en) | 2003-09-17 | 2012-10-30 | Franklin Volvovitz | Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction |
| GB0322140D0 (en) * | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
| JP2007517905A (ja) | 2004-01-16 | 2007-07-05 | ワイス | アゾールを含有するベータアミロイド産生のヘテロ環式スルホンアミド阻害剤 |
| KR20060124712A (ko) | 2004-02-20 | 2006-12-05 | 노파르티스 아게 | 신경퇴행 및 인지 장애를 치료하기 위한 ｄｐｐ ⅳ 억제제 |
| AR051950A1 (es) | 2004-11-10 | 2007-02-21 | Osmotica Pharmaceutical Argent | Comprimido multicapa con capas que se separan |
| CA2592605C (en) | 2004-12-27 | 2010-12-07 | Eisai R&D Management Co., Ltd. | Method for stabilizing anti-dementia drug |
| US7390816B2 (en) | 2005-06-21 | 2008-06-24 | Bridge Pharma, Inc. | Methods for treating urinary incontinence in patients suffering from memory disorders |
| US20070004766A1 (en) | 2005-07-01 | 2007-01-04 | Aberg A K G | Methods for relaxation of smooth muscle contractions using Trospium |
| US20070224259A1 (en) | 2005-09-21 | 2007-09-27 | Gupta Anil K | Anti-inflammatory pharmaceutical composition |
| ATE544444T1 (de) | 2005-10-11 | 2012-02-15 | Yissum Res Dev Co | Zusammensetzungen für die nasale abgabe |
| CN101472877A (zh) * | 2006-04-21 | 2009-07-01 | 惠氏公司 | 制备手性纯氨基醇中间体、其衍生物及其用途 |
| WO2008033299A2 (en) * | 2006-09-12 | 2008-03-20 | Adolor Corporation | Use of n-containing spirocompounds for the enhancement of cognitive function |
| US20080090808A1 (en) | 2006-10-17 | 2008-04-17 | Franklin Volvovitz | Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction |
| US8097633B2 (en) * | 2006-11-15 | 2012-01-17 | Rich Steven A | Uses for quaternary ammonium anticholinergic muscarinic receptor antagonists in patients being treated for cognitive impairment or acute delirium |
| EP4088717A1 (en) * | 2008-03-27 | 2022-11-16 | Chase Pharmaceuticals Corporation | Use and composition for treating dementia |
| EP2478099B1 (en) * | 2009-09-18 | 2019-06-05 | Chase Pharmaceuticals Corporation | Combination for treating alzheimer-type dementia |
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| EP2271218A4 (en) | 2011-05-18 |
| US9044472B2 (en) | 2015-06-02 |
| EP2271218A1 (en) | 2011-01-12 |
| EP4088717A1 (en) | 2022-11-16 |
| CA2718411A1 (en) | 2009-10-01 |
| JP2014114295A (ja) | 2014-06-26 |
| US20150224096A1 (en) | 2015-08-13 |
| US20190091214A1 (en) | 2019-03-28 |
| JP2011518776A (ja) | 2011-06-30 |
| US20140275036A1 (en) | 2014-09-18 |
| MX2010010460A (es) | 2010-12-15 |
| US20130158012A1 (en) | 2013-06-20 |
| CA2718411C (en) | 2016-02-16 |
| MX347901B (es) | 2017-05-18 |
| EP3178477A1 (en) | 2017-06-14 |
| ES2634421T3 (es) | 2017-09-27 |
| US8404701B2 (en) | 2013-03-26 |
| EP2271218B1 (en) | 2017-05-24 |
| WO2009120277A1 (en) | 2009-10-01 |
| US20110021503A1 (en) | 2011-01-27 |
| JP6427522B2 (ja) | 2018-11-21 |
| DK2271218T3 (en) | 2017-09-11 |
| AU2009229372C1 (en) | 2017-02-02 |
| AU2009229372B2 (en) | 2014-09-25 |
| AU2009229372A1 (en) | 2009-10-01 |
| MX344177B (es) | 2016-12-08 |
| JP2016179980A (ja) | 2016-10-13 |
| PL2271218T3 (pl) | 2017-10-31 |
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