JP5646851B2 - エレクトロポレーション支援ワクチン投与及び追加投与を用いた免疫応答の増強方法 - Google Patents

エレクトロポレーション支援ワクチン投与及び追加投与を用いた免疫応答の増強方法 Download PDF

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JP5646851B2
JP5646851B2 JP2009537218A JP2009537218A JP5646851B2 JP 5646851 B2 JP5646851 B2 JP 5646851B2 JP 2009537218 A JP2009537218 A JP 2009537218A JP 2009537218 A JP2009537218 A JP 2009537218A JP 5646851 B2 JP5646851 B2 JP 5646851B2
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tissue
administration
muscle
skin
mammal
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JP2010510218A (ja
JP2010510218A5 (enExample
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マティーセン，イアコブ
トルン チェッレ，エリザベート
トルン チェッレ，エリザベート
チェケン，ルネ
ラブッセイ，ディートマール
リン，フェン
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ジェネトロニクス，インコーポレイティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
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  • Oncology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2009537218A 2006-11-17 2007-11-16 エレクトロポレーション支援ワクチン投与及び追加投与を用いた免疫応答の増強方法 Expired - Fee Related JP5646851B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85972406P 2006-11-17 2006-11-17
US60/859,724 2006-11-17
PCT/US2007/024051 WO2008063555A2 (en) 2006-11-17 2007-11-16 Methods of enhancing immune response using electroporation-assisted vaccination and boosting

Publications (3)

Publication Number Publication Date
JP2010510218A JP2010510218A (ja) 2010-04-02
JP2010510218A5 JP2010510218A5 (enExample) 2010-11-25
JP5646851B2 true JP5646851B2 (ja) 2014-12-24

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JP2009537218A Expired - Fee Related JP5646851B2 (ja) 2006-11-17 2007-11-16 エレクトロポレーション支援ワクチン投与及び追加投与を用いた免疫応答の増強方法

Country Status (8)

Country Link
US (1) US20100285040A1 (enExample)
EP (1) EP2091558B1 (enExample)
JP (1) JP5646851B2 (enExample)
KR (1) KR20090080941A (enExample)
CN (1) CN101522211A (enExample)
AU (1) AU2007322075B2 (enExample)
CA (1) CA2668649A1 (enExample)
WO (1) WO2008063555A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120130150A1 (en) 2009-06-24 2012-05-24 International Scientific Pty Ltd. apparatus and method of treatment utilizing a varying electromagnetic energization profile
KR101723605B1 (ko) * 2014-10-21 2017-04-07 진원생명과학 주식회사 대상포진 예방 및 치료용 dna 백신 조성물 및 이를 이용한 vzv 항원에 대한 t세포 활성화 방법
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US118956A (en) * 1871-09-12 Improvement in apparatus for the manufacture of extracts from hemlock and other
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US6009345A (en) 1992-08-17 1999-12-28 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
WO1998043702A2 (en) 1997-04-03 1998-10-08 Iacob Mathiesen Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle
TW368420B (en) 1997-11-04 1999-09-01 Genetronics Inc Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
US6972013B1 (en) 1998-07-13 2005-12-06 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
WO2000045823A1 (en) * 1999-02-08 2000-08-10 Chiron Corporation Electrically-mediated enhancement of dna vaccine immunity and efficacy in vivo
US7171264B1 (en) * 1999-05-10 2007-01-30 Genetronics, Inc. Intradermal delivery of active agents by needle-free injection and electroporation
GB9922361D0 (en) * 1999-09-21 1999-11-24 Isis Innovation Generating an immune response to an antigen
US20040241140A1 (en) * 2000-11-01 2004-12-02 Pavlakis George N. Expression vectors able to elicit improved immune response and methods of using same
CA2478614C (en) 2001-03-13 2013-01-15 University Of South Florida Electromanipulation device and method
BR0214280A (pt) * 2001-11-19 2005-01-11 Becton Dickinson Co Composição farmacêuticas em forma particulada
MXPA04005770A (es) * 2001-12-14 2005-05-17 Genetronics Inc Metodos para la inmunizacion con polinucleotidos asistida por particulas utilizando un campo electrico de impulsos.
JP4705591B2 (ja) * 2004-01-07 2011-06-22 バイオメディカル リサーチ モデルズ， インコーポレイテッド 抗原または免疫原に対する免疫応答を仕立てる方法。
CA3063263C (en) 2006-02-11 2024-01-16 Genetronics, Inc. Device and method for single-needle in vivo electroporation

Also Published As

Publication number Publication date
WO2008063555A2 (en) 2008-05-29
EP2091558A4 (en) 2012-07-04
EP2091558B1 (en) 2018-04-04
CA2668649A1 (en) 2008-05-29
US20100285040A1 (en) 2010-11-11
CN101522211A (zh) 2009-09-02
EP2091558A2 (en) 2009-08-26
AU2007322075B2 (en) 2013-07-25
JP2010510218A (ja) 2010-04-02
KR20090080941A (ko) 2009-07-27
WO2008063555A3 (en) 2008-11-06
AU2007322075A1 (en) 2008-05-29

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