CN101522211A - 使用电穿孔辅助疫苗接种和加强免疫来增强免疫反应的方法 - Google Patents

使用电穿孔辅助疫苗接种和加强免疫来增强免疫反应的方法 Download PDF

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Publication number
CN101522211A
CN101522211A CNA200780037742XA CN200780037742A CN101522211A CN 101522211 A CN101522211 A CN 101522211A CN A200780037742X A CNA200780037742X A CN A200780037742XA CN 200780037742 A CN200780037742 A CN 200780037742A CN 101522211 A CN101522211 A CN 101522211A
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CN
China
Prior art keywords
tissue
mammal
muscle
inject
electroporation
Prior art date
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Pending
Application number
CNA200780037742XA
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English (en)
Chinese (zh)
Inventor
雅各布·马蒂森
伊丽莎白·托伦·谢尔勒
鲁内·谢肯
戴尔特墨·拉布塞
林峰
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Genetronics Inc
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Genetronics Inc
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Publication date
Application filed by Genetronics Inc filed Critical Genetronics Inc
Publication of CN101522211A publication Critical patent/CN101522211A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CNA200780037742XA 2006-11-17 2007-11-16 使用电穿孔辅助疫苗接种和加强免疫来增强免疫反应的方法 Pending CN101522211A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85972406P 2006-11-17 2006-11-17
US60/859,724 2006-11-17

Publications (1)

Publication Number Publication Date
CN101522211A true CN101522211A (zh) 2009-09-02

Family

ID=39430332

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA200780037742XA Pending CN101522211A (zh) 2006-11-17 2007-11-16 使用电穿孔辅助疫苗接种和加强免疫来增强免疫反应的方法

Country Status (8)

Country Link
US (1) US20100285040A1 (enExample)
EP (1) EP2091558B1 (enExample)
JP (1) JP5646851B2 (enExample)
KR (1) KR20090080941A (enExample)
CN (1) CN101522211A (enExample)
AU (1) AU2007322075B2 (enExample)
CA (1) CA2668649A1 (enExample)
WO (1) WO2008063555A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010148440A1 (en) 2009-06-24 2010-12-29 International Scientific Pty Ltd An apparatus and method of treatment utilizing a varying electromagnetic energisation profile
KR101723605B1 (ko) * 2014-10-21 2017-04-07 진원생명과학 주식회사 대상포진 예방 및 치료용 dna 백신 조성물 및 이를 이용한 vzv 항원에 대한 t세포 활성화 방법
US10233419B2 (en) 2016-06-30 2019-03-19 Zymergen Inc. Apparatuses and methods for electroporation

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US118956A (en) * 1871-09-12 Improvement in apparatus for the manufacture of extracts from hemlock and other
US5273525A (en) 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US6009345A (en) 1992-08-17 1999-12-28 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
US6110161A (en) 1997-04-03 2000-08-29 Electrofect As Method for introducing pharmaceutical drugs and nucleic acids into skeletal muscle
TW368420B (en) 1997-11-04 1999-09-01 Genetronics Inc Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
US6972013B1 (en) 1998-07-13 2005-12-06 Genetronics, Inc. Enhanced delivery of naked DNA to skin by non-invasive in vivo electroporation
EP1148885A4 (en) * 1999-02-08 2002-05-08 Chiron Corp ELECTRICALLY INDUCED INCREASE IN IMMUNITY AND EFFECTIVENESS OF IN VIVO DNA VACCINES
US7171264B1 (en) * 1999-05-10 2007-01-30 Genetronics, Inc. Intradermal delivery of active agents by needle-free injection and electroporation
GB9922361D0 (en) * 1999-09-21 1999-11-24 Isis Innovation Generating an immune response to an antigen
ES2386884T3 (es) * 2000-11-01 2012-09-04 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Vectores de expresión capaces de inducir respuesta inmunomejorada y métodos para usarlos
CA2478614C (en) 2001-03-13 2013-01-15 University Of South Florida Electromanipulation device and method
WO2003072016A2 (en) * 2001-11-19 2003-09-04 Becton, Dickinson And Company Pharmaceutical compositions in particulate form
EP1474153A4 (en) * 2001-12-14 2005-12-14 Genetronics Inc PARTICLE-ASSISTED IMMUNIZATION METHODS BASED ON THE USE OF A PULSE ELECTRIC FIELD
US20060035853A1 (en) * 2004-01-07 2006-02-16 Biomedical Research Models, Inc. Methods for tailoring the immune response to an antigen or immunogen
EP1981581B1 (en) 2006-02-11 2016-04-13 Genetronics, Inc. Device for single-needle in vivo electroporation

Also Published As

Publication number Publication date
WO2008063555A3 (en) 2008-11-06
EP2091558B1 (en) 2018-04-04
EP2091558A2 (en) 2009-08-26
WO2008063555A2 (en) 2008-05-29
KR20090080941A (ko) 2009-07-27
JP5646851B2 (ja) 2014-12-24
US20100285040A1 (en) 2010-11-11
CA2668649A1 (en) 2008-05-29
AU2007322075A1 (en) 2008-05-29
AU2007322075B2 (en) 2013-07-25
JP2010510218A (ja) 2010-04-02
EP2091558A4 (en) 2012-07-04

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