JP5646124B1 - 新規乳酸菌、並びに新規乳酸菌を含有する医薬、飲食品、及び飼料 - Google Patents
新規乳酸菌、並びに新規乳酸菌を含有する医薬、飲食品、及び飼料 Download PDFInfo
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Abstract
Description
前記医薬は、免疫賦活用であることを好ましい態様としている。
また前記医薬は、抗ウイルス用であることを好ましい態様としている。
前記抗ウイルス用である医薬は、抗インフルエンザ・ウイルス用であることを好ましい態様としている。
本発明はまた、前記菌株を含む飼料を提供する。
前記IL−12産生促進剤は、飲食品の形態であることを好ましい態様としている。
本発明は、ラクトバチルス・パラカゼイに属する乳酸菌の新規菌株である、ラクトバチルス・パラカゼイ(Lactobacillus paracasei)MCC1849(NITE BP-01633)株である。以下、同菌株を「本発明の乳酸菌」、「本発明の菌株」、又は単にMCC1849株と記載することがある。
本発明の乳酸菌は、ヒト糞便を分離源として分離された。同菌株の菌学的性質は、後述の実施例1に示す。同菌株は、2013年6月6日に、独立行政法人製品評価技術基盤機構特許微生物寄託センター(〒292-0818 千葉県木更津市かずさ鎌足2−5−8 122号室)に、NITE P-01633の受託番号で寄託され、2014年1月31日にブダペスト条約に基づく国際寄託に移管され、NITE BP-01633の受託番号が付与されている。
また、本発明のIL-12産生促進剤は、免疫賦活剤、抗ウイルス剤として用いることができる。抗ウイルス剤の対象となるウイルスは、該ウイルスに起因する疾患を、IL-12産生促進又は免疫賦活により予防もしくは治療できるものであれば特に制限されず、例えばインフルエンザウイルスが挙げられる。
本発明の医薬の適用として具体的には、例えば、アレルギー症状、例えば食物アレルギー、気管支喘息、じんま疹、鼻炎、花粉症、アナフィラキシーショック等の緩和の他、感染症に対する抵抗力の増進、癌の予防、進行の防止等が挙げられる。また、本発明の医薬又はIL-12産生促進剤は、抗腫癌剤、日和見感染症の予防剤又は治療剤、アレルギー疾患予防剤、又は治療剤として広く利用することができる。
本発明の免疫抑制剤は、単独で投与してもよいし、他の医薬、例えば他の免疫抑制剤等と併用してもよい。
食品又は飲料の原料としては、通常の飲料や食品に用いられている原料を使用することができる。製造された飲食品は、経口的に摂取することが可能である。
具体的には、本発明の飲食品に係る商品又は商品の包装に上記用途を記載する行為、商品又は商品の包装に上記用途を記載したものを譲渡し、引渡し、譲渡若しくは引渡しのために展示し、輸入する行為、商品に関する広告、価格表若しくは取引書類に上記用途を記載して展示し、若しくは頒布し、又はこれらを内容とする情報に上記用途を記載して電磁気的(インターネット等)方法により提供する行為等が例示でき、特に包装、容器、カタログ、パンフレット、POP等の販売現場における宣伝材、その他の書類等への表示が好ましい。
MCC1849株は、ヒト糞便サンプルから分離した。同株の菌学的性質として、細胞の形態、運動性、胞子形成、グラム染色性、カタラーゼ、グルコースからのガスの産生、及び、糖の発酵性を表1に示す。糖の発酵性は、細菌同定キットAPI 50CH(シスメックス・ビオメリュー社)を用いて調べた。キットに付属のマニュアル記載の方法にしたがって一晩培養後の菌液を各基質を含む培地に接種し、これを37℃のインキュベーターで培養し、培養1日目および2日目に各基質の糖発酵性状を評価した。
これらの菌学的性質を表1に示す。この結果から、MCC1849株はラクトバチルス・パラカゼイと判定された。
したがって、MCC1849株はラクトバチルス・パラカゼイであることが確認された。
実施例1に記載のラクトバチルス・パラカゼイMCC1849株、及び、高いIL-12産生誘導能を持つことが知られているラクトバチルス・パラカゼイFERM BP-11313株(国際公開2012/133827)、並びに他の乳酸菌の菌株であるラクトバチルス・ラムノーサス(Lactobacillus rhamnosus)ATCC53103株、ラクトバチルス・ジョンソニ(Lactobacillus johnsonii)JCM2012株、ラクトバチルス・プランタルム(Lactobacillus plantarum)JCM1149株、ラクトバチルス・ブルガリカス(Lactobacillus bulgaricus)ATCC11842株を対象に、RNase処理または細胞壁分解酵素処理の有無が乳酸菌のIL-12産生誘導能に及ぼす影響を、マウス脾細胞を用いて評価した。
2日後に培養上清を回収し、培養上清中のIL-12 p70(p40-p35ヘテロダイマー)の濃度を、測定キット(Mouse IL-12 p70 DuoSet。R&D Systems社製)を用いて測定した。
MCC1849株投与によるインフルエンザ・ウイルス感染予防作用を、マウスを用いて調べた。
MCC1849株をMRS培地で16時間培養し、菌体を蒸留水で2回洗浄した後に蒸留水に懸濁し、蔗糖およびグルタミン酸ソーダを添加し、凍結乾燥を行った。凍結乾燥した菌体を生理食塩水で1×1010 cfu/mlに懸濁したものをMCC1849株生菌液とした。
軽度の感染 :1
中程度の感染:2
重度の感染 :3
死亡 :4
各項目のスコアの平均値を、マウスの個体ごとの症状スコア(Symptom score)とした。
Claims (9)
- ラクトバチルス・パラカゼイMCC1849(NITE BP−01633)株。
- 請求項1に記載の菌株を含む医薬。
- 免疫賦活用である、請求項2に記載の医薬。
- 抗ウイルス用である、請求項2に記載の医薬。
- ウイルスがインフルエンザ・ウイルスである、請求項4に記載の医薬。
- 請求項1に記載の菌株を含む飲食品。
- 請求項1に記載の菌株を含む飼料。
- 請求項1に記載の菌株を含むIL−12産生促進剤。
- 飲食品の形態である、請求項8に記載のIL−12産生促進剤。
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---|---|---|---|---|
JP2019104686A (ja) * | 2017-12-08 | 2019-06-27 | キッコーマン株式会社 | 抗インフルエンザウイルス剤及びそれを含む組成物 |
JP2020137476A (ja) * | 2019-02-28 | 2020-09-03 | 森永乳業株式会社 | 乳酸菌を含有する乳入り飲食品 |
WO2024004138A1 (ja) * | 2022-06-30 | 2024-01-04 | 森永乳業株式会社 | 飲料及び飲料の製造方法 |
WO2024004139A1 (ja) * | 2022-06-30 | 2024-01-04 | 森永乳業株式会社 | 発酵乳及び発酵乳の製造方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040047849A1 (en) | 2002-09-11 | 2004-03-11 | Genmont Biotech Inc. | Use of some lactobacillus strains in treating allergy |
JP4847038B2 (ja) | 2005-04-11 | 2011-12-28 | ゲンモント バイオテック インコーポレイティド | ラクトバチルス・パラカゼイの新規微生物株gm−080及びアレルギー関連疾患を処置するためのその使用 |
JP2008245569A (ja) | 2007-03-30 | 2008-10-16 | Kirin Holdings Co Ltd | 高抗アレルギー活性を有する乳酸菌組成物及び該乳酸菌の製造方法 |
CA2694354C (en) | 2007-07-04 | 2018-01-16 | Kikkoman Corporation | Lactic acid bacteria-derived double-stranded rna |
JP5209294B2 (ja) | 2007-12-25 | 2013-06-12 | 株式会社ヤクルト本社 | インターロイキン12産生促進剤 |
FR2930264B1 (fr) | 2008-04-18 | 2013-02-22 | Gervais Danone Sa | Nouvelle souche de lactobacillus paracasei subsp. paracasei dotee de proprietes antimicrobiennes et immunomodulatrices. |
US20100196341A1 (en) | 2009-02-05 | 2010-08-05 | Syngen Biotech Co., Ltd. | Novel Lactobacillus paracasei subsp. paracasei SG96, a Bacteriostatic Composition Containing the same and Use Thereof |
US8765706B2 (en) | 2009-09-02 | 2014-07-01 | Kyoto Prefectural Public University Corporation | Composition comprising rna derived from lactic acid bacterium as effective component |
KR101178217B1 (ko) | 2009-10-28 | 2012-09-07 | 씨제이제일제당 (주) | 신규한 락토바실러스 플란타룸 및 이를 포함하는 조성물 |
TWI418356B (zh) | 2009-12-23 | 2013-12-11 | Lytone Enterprise Inc | 可作為免疫調節劑之副乾酪乳酸桿菌lt12 |
JP5261617B2 (ja) | 2011-03-31 | 2013-08-14 | 森永乳業株式会社 | 新規乳酸菌、並びに新規乳酸菌を含有する医薬、飲食品、及び飼料 |
PL2990045T3 (pl) | 2014-08-26 | 2017-05-31 | Chr. Hansen A/S | Bifidobacterium animalis podgat. lactis do stosowania w zmniejszaniu bólu brzucha u kobiet po menopauzie |
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2014
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JP2019104686A (ja) * | 2017-12-08 | 2019-06-27 | キッコーマン株式会社 | 抗インフルエンザウイルス剤及びそれを含む組成物 |
JP7123552B2 (ja) | 2017-12-08 | 2022-08-23 | キッコーマン株式会社 | 抗インフルエンザウイルス剤及びそれを含む組成物 |
JP2020137476A (ja) * | 2019-02-28 | 2020-09-03 | 森永乳業株式会社 | 乳酸菌を含有する乳入り飲食品 |
JP7272822B2 (ja) | 2019-02-28 | 2023-05-12 | 森永乳業株式会社 | 乳酸菌を含有する乳入り飲食品 |
WO2024004138A1 (ja) * | 2022-06-30 | 2024-01-04 | 森永乳業株式会社 | 飲料及び飲料の製造方法 |
WO2024004139A1 (ja) * | 2022-06-30 | 2024-01-04 | 森永乳業株式会社 | 発酵乳及び発酵乳の製造方法 |
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JPWO2015004949A1 (ja) | 2017-03-02 |
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BR122022016606B1 (pt) | 2023-01-24 |
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