JP5645839B2 - Cdc7キナーゼ阻害剤としてのチエノピリミジン - Google Patents

Cdc7キナーゼ阻害剤としてのチエノピリミジン Download PDF

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Publication number
JP5645839B2
JP5645839B2 JP2011537754A JP2011537754A JP5645839B2 JP 5645839 B2 JP5645839 B2 JP 5645839B2 JP 2011537754 A JP2011537754 A JP 2011537754A JP 2011537754 A JP2011537754 A JP 2011537754A JP 5645839 B2 JP5645839 B2 JP 5645839B2
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group
compound
mmol
substituent
optionally substituted
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Japanese (ja)
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JP2012519653A (ja
JP2012519653A5 (OSRAM
Inventor
裕哉 大黒
裕哉 大黒
修 倉澤
倉澤  修
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2011537754A 2009-03-05 2010-03-04 Cdc7キナーゼ阻害剤としてのチエノピリミジン Active JP5645839B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US15776009P 2009-03-05 2009-03-05
US61/157,760 2009-03-05
US29499110P 2010-01-14 2010-01-14
US61/294,991 2010-01-14
US29833810P 2010-01-26 2010-01-26
US61/298,338 2010-01-26
PCT/JP2010/054073 WO2010101302A1 (en) 2009-03-05 2010-03-04 Thienopyrimidine as cdc7 kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2012519653A JP2012519653A (ja) 2012-08-30
JP2012519653A5 JP2012519653A5 (OSRAM) 2013-03-07
JP5645839B2 true JP5645839B2 (ja) 2014-12-24

Family

ID=42112336

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011537754A Active JP5645839B2 (ja) 2009-03-05 2010-03-04 Cdc7キナーゼ阻害剤としてのチエノピリミジン

Country Status (4)

Country Link
US (1) US8691828B2 (OSRAM)
EP (1) EP2403857B1 (OSRAM)
JP (1) JP5645839B2 (OSRAM)
WO (1) WO2010101302A1 (OSRAM)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX353500B (es) 2010-02-17 2018-01-16 Takeda Pharmaceuticals Co Compuesto heterociclico.
EP2797927B1 (en) * 2011-12-30 2019-09-25 Hanmi Pharm. Co., Ltd. THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES
WO2015115355A1 (ja) 2014-01-31 2015-08-06 カルナバイオサイエンス株式会社 抗がん剤組成物
US10745410B2 (en) * 2017-05-21 2020-08-18 Zenji Research Laboratories Substituted [5,6]cyclic-4(3H)-pyrimidinones as anticancer agents
GB201807147D0 (en) 2018-05-01 2018-06-13 Oncologica Uk Ltd Therapeutic combination
NL2021185B1 (en) 2018-06-26 2020-01-06 Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis Combination Therapy and Use Thereof for Treating Cancer
WO2021113492A1 (en) * 2019-12-06 2021-06-10 Schrödinger, Inc. Cyclic compounds and methods of using same
CN117120447A (zh) * 2021-03-18 2023-11-24 薛定谔公司 环状化合物和其使用方法
TW202300150A (zh) * 2021-03-18 2023-01-01 美商薛定諤公司 環狀化合物及其使用方法
CN115260211B (zh) * 2021-04-29 2024-02-06 长春金赛药业有限责任公司 含噻吩稠环类衍生物、药物组合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1396488A1 (en) * 2001-05-23 2004-03-10 Mitsubishi Pharma Corporation Fused heterocyclic compound and medicinal use thereof
KR101099409B1 (ko) * 2003-06-06 2011-12-27 아렉시스 악티에볼라그 피부 상태 또는 암 치료를 위한 scce 저해제로서의융합된 헤테로사이클 화합물의 용도
US7279575B2 (en) 2003-08-08 2007-10-09 Pfizer Italia S.R.L. Pyrimidylpyrrole derivatives active as kinase inhibitors
WO2005014572A1 (en) 2003-08-08 2005-02-17 Pharmacia Italia S.P.A. Pyrimidylpyrrole derivatives active as kinase inhibitors
WO2005095386A1 (en) 2004-03-30 2005-10-13 Chiron Corporation Substituted thiophene derivatives as anti-cancer agents
JP2009501217A (ja) * 2005-07-15 2009-01-15 アストラゼネカ アクチボラグ 治療薬
US20070142414A1 (en) * 2005-12-16 2007-06-21 Pharmacia Italia S.P.A. N-substituted pyrrolopyridinones active as kinase inhibitors
ES2599054T3 (es) * 2006-12-13 2017-01-31 Aska Pharmaceutical Co., Ltd. Derivados de quinoxalina
EP2123301A4 (en) * 2006-12-13 2010-11-03 Aska Pharm Co Ltd Therapeutic agent for urinary tract disease

Also Published As

Publication number Publication date
EP2403857A1 (en) 2012-01-11
JP2012519653A (ja) 2012-08-30
WO2010101302A1 (en) 2010-09-10
US20120040981A1 (en) 2012-02-16
US8691828B2 (en) 2014-04-08
EP2403857B1 (en) 2013-12-04

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