JP2012519653A5 - - Google Patents
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- Publication number
- JP2012519653A5 JP2012519653A5 JP2011537754A JP2011537754A JP2012519653A5 JP 2012519653 A5 JP2012519653 A5 JP 2012519653A5 JP 2011537754 A JP2011537754 A JP 2011537754A JP 2011537754 A JP2011537754 A JP 2011537754A JP 2012519653 A5 JP2012519653 A5 JP 2012519653A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- substituent
- substituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001424 substituent group Chemical group 0.000 claims 24
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 12
- 125000005843 halogen group Chemical group 0.000 claims 12
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 11
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 9
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 9
- 125000003277 amino group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 4
- 229940002612 prodrug Drugs 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 125000004434 sulfur atom Chemical group 0.000 claims 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 2
- 102100034744 Cell division cycle 7-related protein kinase Human genes 0.000 claims 2
- 101000945740 Homo sapiens Cell division cycle 7-related protein kinase Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 150000001924 cycloalkanes Chemical class 0.000 claims 2
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
- LAEWHBYAMHWQBY-UHFFFAOYSA-N 1,2-dimethyl-6-(5-methyl-1h-pyrazol-4-yl)-2-(2,2,2-trifluoroethyl)-3h-thieno[3,2-d]pyrimidin-4-one Chemical compound S1C=2C(=O)NC(CC(F)(F)F)(C)N(C)C=2C=C1C=1C=NNC=1C LAEWHBYAMHWQBY-UHFFFAOYSA-N 0.000 claims 1
- KEGLXGGLMDEALO-UHFFFAOYSA-N 2'-fluoro-6-(5-methyl-1h-pyrazol-4-yl)spiro[1,3-dihydrothieno[3,2-d]pyrimidine-2,1'-cyclohexane]-4-one Chemical compound N1N=CC(C=2SC=3C(=O)NC4(C(CCCC4)F)NC=3C=2)=C1C KEGLXGGLMDEALO-UHFFFAOYSA-N 0.000 claims 1
- 125000005974 C6-C14 arylcarbonyl group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 0 **CCCI(*)*C([C@](*)[C@@]1O[C@@]1N)NC(*)* Chemical compound **CCCI(*)*C([C@](*)[C@@]1O[C@@]1N)NC(*)* 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15776009P | 2009-03-05 | 2009-03-05 | |
| US61/157,760 | 2009-03-05 | ||
| US29499110P | 2010-01-14 | 2010-01-14 | |
| US61/294,991 | 2010-01-14 | ||
| US29833810P | 2010-01-26 | 2010-01-26 | |
| US61/298,338 | 2010-01-26 | ||
| PCT/JP2010/054073 WO2010101302A1 (en) | 2009-03-05 | 2010-03-04 | Thienopyrimidine as cdc7 kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012519653A JP2012519653A (ja) | 2012-08-30 |
| JP2012519653A5 true JP2012519653A5 (OSRAM) | 2013-03-07 |
| JP5645839B2 JP5645839B2 (ja) | 2014-12-24 |
Family
ID=42112336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537754A Active JP5645839B2 (ja) | 2009-03-05 | 2010-03-04 | Ｃｄｃ７キナーゼ阻害剤としてのチエノピリミジン |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8691828B2 (OSRAM) |
| EP (1) | EP2403857B1 (OSRAM) |
| JP (1) | JP5645839B2 (OSRAM) |
| WO (1) | WO2010101302A1 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SMT201900385T1 (it) | 2010-02-17 | 2019-09-09 | Takeda Pharmaceuticals Co | Composto eterociclico |
| US9156852B2 (en) | 2011-12-30 | 2015-10-13 | Hanmi Pharm. Co., Ltd | Thieno[3,2-D]pyrimidine derivatives having inhibitory activity for protein kinases |
| JP6569908B2 (ja) | 2014-01-31 | 2019-09-04 | カルナバイオサイエンス株式会社 | 抗がん剤組成物 |
| WO2018217439A1 (en) * | 2017-05-21 | 2018-11-29 | Zhang Hai Jun | Substituted [5,6]cyclic-4(3h)-pyrimidinones as anticancer agents |
| GB201807147D0 (en) | 2018-05-01 | 2018-06-13 | Oncologica Uk Ltd | Therapeutic combination |
| NL2021185B1 (en) | 2018-06-26 | 2020-01-06 | Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis | Combination Therapy and Use Thereof for Treating Cancer |
| US20230101747A1 (en) * | 2019-12-06 | 2023-03-30 | Schrödinger, Inc. | Cyclic compounds and methods of using same |
| TW202300150A (zh) * | 2021-03-18 | 2023-01-01 | 美商薛定諤公司 | 環狀化合物及其使用方法 |
| CN115260211B (zh) * | 2021-04-29 | 2024-02-06 | 长春金赛药业有限责任公司 | 含噻吩稠环类衍生物、药物组合物及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2002094790A1 (ja) * | 2001-05-23 | 2004-09-09 | 三菱ウェルファーマ株式会社 | 縮合ヘテロ環化合物およびその医薬用途 |
| WO2004108139A2 (en) * | 2003-06-06 | 2004-12-16 | Arexis Ab | Use of fused heterocyclic compounds as scce inhibitors for the treatment of skin conditions or cancer |
| US7279575B2 (en) | 2003-08-08 | 2007-10-09 | Pfizer Italia S.R.L. | Pyrimidylpyrrole derivatives active as kinase inhibitors |
| EP1660475B1 (en) | 2003-08-08 | 2008-05-28 | Pfizer Italia S.r.l. | Pyrimidylpyrrole derivatives active as kinase inhibitors |
| EP1732919A1 (en) | 2004-03-30 | 2006-12-20 | Chiron Corporation | Substituted thiophene derivatives as anti-cancer agents |
| WO2007011284A1 (en) * | 2005-07-15 | 2007-01-25 | Astrazeneca Ab | Therapeutic agents |
| US20070142414A1 (en) | 2005-12-16 | 2007-06-21 | Pharmacia Italia S.P.A. | N-substituted pyrrolopyridinones active as kinase inhibitors |
| WO2008072779A1 (ja) * | 2006-12-13 | 2008-06-19 | Aska Pharmaceutical Co., Ltd. | キノキサリン誘導体 |
| JPWO2008072778A1 (ja) * | 2006-12-13 | 2010-04-02 | あすか製薬株式会社 | 尿路系疾患の処置剤 |
-
2010
- 2010-03-04 US US13/254,551 patent/US8691828B2/en active Active
- 2010-03-04 EP EP10710108.1A patent/EP2403857B1/en active Active
- 2010-03-04 JP JP2011537754A patent/JP5645839B2/ja active Active
- 2010-03-04 WO PCT/JP2010/054073 patent/WO2010101302A1/en not_active Ceased
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