JP5642149B2 - ヒスタミンｈ３受容体モジュレーターの調製プロセス - Google Patents

ヒスタミンｈ３受容体モジュレーターの調製プロセス Download PDF

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Publication number
JP5642149B2
JP5642149B2 JP2012500921A JP2012500921A JP5642149B2 JP 5642149 B2 JP5642149 B2 JP 5642149B2 JP 2012500921 A JP2012500921 A JP 2012500921A JP 2012500921 A JP2012500921 A JP 2012500921A JP 5642149 B2 JP5642149 B2 JP 5642149B2
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compound
formula
organic solvent
molar equivalents
reacted
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Japanese (ja)
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JP2012520889A (ja
Inventor
ブロジーニ，デイエゴ
ルレク，ビト
ロフナー，スザンネ
マニ，ニーラカンダ・エス
マウラー，アドリアン
ピツペル，ダニエル・ジエイ
ヤング，ラナ
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2012500921A 2009-03-18 2010-03-17 ヒスタミンｈ３受容体モジュレーターの調製プロセス Active JP5642149B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16117709P 2009-03-18 2009-03-18
US61/161,177 2009-03-18
PCT/US2010/027638 WO2010107897A2 (en) 2009-03-18 2010-03-17 Process for the preparation of histamine h3 receptor modulators

Publications (2)

Publication Number Publication Date
JP2012520889A JP2012520889A (ja) 2012-09-10
JP5642149B2 true JP5642149B2 (ja) 2014-12-17

Family

ID=42315639

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012500921A Active JP5642149B2 (ja) 2009-03-18 2010-03-17 ヒスタミンｈ３受容体モジュレーターの調製プロセス

Country Status (18)

Country Link
US (4) US8748596B2 (pl)
EP (3) EP3216784B1 (pl)
JP (1) JP5642149B2 (pl)
CN (1) CN102428070B (pl)
AU (1) AU2010226711B2 (pl)
CA (2) CA2965059C (pl)
CY (2) CY1119437T1 (pl)
DK (2) DK2429996T3 (pl)
ES (2) ES2625261T3 (pl)
HR (2) HRP20170776T1 (pl)
HU (2) HUE032345T2 (pl)
LT (2) LT3216784T (pl)
MX (3) MX2011009784A (pl)
PL (2) PL3216784T3 (pl)
PT (2) PT2429996T (pl)
SI (2) SI3216784T1 (pl)
TR (1) TR201902858T4 (pl)
WO (1) WO2010107897A2 (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2625261T3 (es) 2009-03-18 2017-07-19 Janssen Pharmaceutica, N.V. Procedimiento para la preparación de moduladores de receptores H3 de histamina
KR101427221B1 (ko) * 2012-08-29 2014-08-13 주식회사 에스텍파마 플루복사민 자유 염기의 정제방법 및 이를 이용한 고순도 플루복사민 말레이트의 제조방법
CN104447867B (zh) * 2013-09-17 2017-12-26 江苏天士力帝益药业有限公司 一种噻吩并哌啶衍生物、制备方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5724346B2 (pl) * 1973-06-22 1982-05-24
PL215454B1 (pl) * 2002-10-23 2013-12-31 Janssen Pharmaceutica Nv Pochodne piperazynylobenzamidu, ich zastosowanie oraz kompozycja farmaceutyczna je zawierajaca
US7777031B2 (en) 2006-05-30 2010-08-17 Janssen Pharmaceutica Nv Substituted pyridyl amide compounds as modulators of the histamine H3 receptor
BRPI0820481A2 (pt) 2007-11-20 2015-06-16 Janssen Pharmaceutica Nv Composotos cicloalquilóxi e heterocicloalquilóxi piridina como moduladores do receptor de h3 de histamina
ES2625261T3 (es) 2009-03-18 2017-07-19 Janssen Pharmaceutica, N.V. Procedimiento para la preparación de moduladores de receptores H3 de histamina

Also Published As

Publication number Publication date
HUE044837T2 (hu) 2019-11-28
US20140343279A1 (en) 2014-11-20
ES2625261T3 (es) 2017-07-19
DK3216784T3 (en) 2019-04-08
MX347775B (es) 2017-05-11
TR201902858T4 (tr) 2019-03-21
US10323002B2 (en) 2019-06-18
AU2010226711A1 (en) 2011-10-13
AU2010226711B2 (en) 2015-06-18
JP2012520889A (ja) 2012-09-10
HUE032345T2 (en) 2017-09-28
US20180022704A1 (en) 2018-01-25
SI2429996T1 (sl) 2017-08-31
EP3492451A3 (en) 2019-07-31
EP2429996B1 (en) 2017-03-08
EP3492451B1 (en) 2021-11-03
WO2010107897A3 (en) 2011-04-14
US20170057919A1 (en) 2017-03-02
EP3216784B1 (en) 2018-12-26
PL3216784T3 (pl) 2019-07-31
MX2011009784A (es) 2011-09-30
PT3216784T (pt) 2019-04-01
US9518021B2 (en) 2016-12-13
CA2755335C (en) 2018-09-18
CN102428070A (zh) 2012-04-25
CN102428070B (zh) 2015-05-06
LT3216784T (lt) 2019-03-25
PL2429996T3 (pl) 2017-08-31
US8748596B2 (en) 2014-06-10
HRP20170776T1 (hr) 2017-08-11
CY1121556T1 (el) 2020-05-29
CA2965059C (en) 2020-04-28
EP3216784A1 (en) 2017-09-13
EP2429996A2 (en) 2012-03-21
ES2714852T3 (es) 2019-05-30
US20120029189A1 (en) 2012-02-02
WO2010107897A2 (en) 2010-09-23
CA2755335A1 (en) 2010-09-23
DK2429996T3 (en) 2017-06-19
SI3216784T1 (sl) 2019-05-31
HRP20190476T1 (hr) 2019-05-03
US9809547B2 (en) 2017-11-07
PT2429996T (pt) 2017-06-12
LT2429996T (lt) 2017-06-12
CA2965059A1 (en) 2010-09-23
EP3492451A2 (en) 2019-06-05
CY1119437T1 (el) 2018-03-07
MX349489B (es) 2017-07-31

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