JP5639586B2 - 抗菌性銀溶液 - Google Patents
抗菌性銀溶液 Download PDFInfo
- Publication number
- JP5639586B2 JP5639586B2 JP2011522355A JP2011522355A JP5639586B2 JP 5639586 B2 JP5639586 B2 JP 5639586B2 JP 2011522355 A JP2011522355 A JP 2011522355A JP 2011522355 A JP2011522355 A JP 2011522355A JP 5639586 B2 JP5639586 B2 JP 5639586B2
- Authority
- JP
- Japan
- Prior art keywords
- citrate
- silver
- solution
- ion concentration
- concentrated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229910052709 silver Inorganic materials 0.000 title claims description 106
- 239000004332 silver Substances 0.000 title claims description 106
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title description 28
- 230000000844 anti-bacterial effect Effects 0.000 title description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 390
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 claims description 145
- QUTYHQJYVDNJJA-UHFFFAOYSA-K trisilver;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Ag+].[Ag+].[Ag+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QUTYHQJYVDNJJA-UHFFFAOYSA-K 0.000 claims description 138
- -1 citrate ions Chemical class 0.000 claims description 134
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 84
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 64
- 238000000034 method Methods 0.000 claims description 42
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- 229940071575 silver citrate Drugs 0.000 claims description 22
- 239000003381 stabilizer Substances 0.000 claims description 21
- 238000004519 manufacturing process Methods 0.000 claims description 17
- 238000002156 mixing Methods 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 267
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 44
- 239000007864 aqueous solution Substances 0.000 description 36
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 30
- 239000002244 precipitate Substances 0.000 description 26
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 description 24
- 229910001961 silver nitrate Inorganic materials 0.000 description 22
- 239000002002 slurry Substances 0.000 description 21
- 230000037361 pathway Effects 0.000 description 17
- 239000007787 solid Substances 0.000 description 15
- 239000000126 substance Substances 0.000 description 13
- 230000015572 biosynthetic process Effects 0.000 description 12
- 238000001223 reverse osmosis Methods 0.000 description 12
- 229910001923 silver oxide Inorganic materials 0.000 description 12
- 239000000203 mixture Substances 0.000 description 11
- 238000001556 precipitation Methods 0.000 description 10
- 150000002500 ions Chemical class 0.000 description 9
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 8
- 239000000908 ammonium hydroxide Substances 0.000 description 8
- 230000000845 anti-microbial effect Effects 0.000 description 8
- 238000004090 dissolution Methods 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 239000007858 starting material Substances 0.000 description 8
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 7
- 101710134784 Agnoprotein Proteins 0.000 description 6
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 6
- 230000003247 decreasing effect Effects 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000001509 sodium citrate Substances 0.000 description 4
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 4
- 229940038773 trisodium citrate Drugs 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 150000001735 carboxylic acids Chemical class 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000000645 desinfectant Substances 0.000 description 3
- 230000000249 desinfective effect Effects 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000009533 lab test Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- VFWRGKJLLYDFBY-UHFFFAOYSA-N silver;hydrate Chemical compound O.[Ag].[Ag] VFWRGKJLLYDFBY-UHFFFAOYSA-N 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 240000001973 Ficus microcarpa Species 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000007429 general method Methods 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000009182 swimming Effects 0.000 description 2
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- RBNPOMFGQQGHHO-UHFFFAOYSA-N -2,3-Dihydroxypropanoic acid Natural products OCC(O)C(O)=O RBNPOMFGQQGHHO-UHFFFAOYSA-N 0.000 description 1
- AFENDNXGAFYKQO-UHFFFAOYSA-N 2-hydroxybutyric acid Chemical compound CCC(O)C(O)=O AFENDNXGAFYKQO-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 201000004569 Blindness Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- RBNPOMFGQQGHHO-UWTATZPHSA-N D-glyceric acid Chemical compound OC[C@@H](O)C(O)=O RBNPOMFGQQGHHO-UWTATZPHSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 208000001860 Eye Infections Diseases 0.000 description 1
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 description 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000032770 biofilm formation Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 208000011323 eye infectious disease Diseases 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 150000003378 silver Chemical class 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/191,477 US8399028B2 (en) | 2008-08-14 | 2008-08-14 | Antimicrobial silver solutions |
| US12/191,477 | 2008-08-14 | ||
| PCT/CA2009/001042 WO2010017623A1 (en) | 2008-08-14 | 2009-07-15 | Antimicrobial silver solutions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011530542A JP2011530542A (ja) | 2011-12-22 |
| JP2011530542A5 JP2011530542A5 (enExample) | 2012-09-06 |
| JP5639586B2 true JP5639586B2 (ja) | 2014-12-10 |
Family
ID=41668601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522355A Expired - Fee Related JP5639586B2 (ja) | 2008-08-14 | 2009-07-15 | 抗菌性銀溶液 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8399028B2 (enExample) |
| EP (1) | EP2323673B1 (enExample) |
| JP (1) | JP5639586B2 (enExample) |
| CN (1) | CN102149393B (enExample) |
| AU (1) | AU2009281655B2 (enExample) |
| BR (1) | BRPI0917806A2 (enExample) |
| CA (1) | CA2733509C (enExample) |
| RU (1) | RU2011109191A (enExample) |
| WO (1) | WO2010017623A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0802626A2 (pt) * | 2008-06-06 | 2011-08-30 | Pure Bioscience | aplicações agrìcolas de di-hidrogênio citrato de prata |
| US8900519B2 (en) * | 2012-07-27 | 2014-12-02 | Mark D. Krosney | Air sterilization and disinfection apparatus and method |
| US11000622B2 (en) | 2012-07-27 | 2021-05-11 | Aeroclean Technologies, Llc | UV sterilization apparatus, system, and method for forced-air patient heating systems |
| RU2532328C1 (ru) * | 2013-10-23 | 2014-11-10 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | Средство, обладающее антибактериальной активностью |
| CN106581052B (zh) * | 2015-04-24 | 2020-11-06 | 中国科学院上海巴斯德研究所 | 柠檬酸根离子和铁离子在抑制rna病毒中的应用 |
| WO2017043359A1 (ja) * | 2015-09-08 | 2017-03-16 | 株式会社タイキ | 噴霧用消臭剤 |
| EP3675919A4 (en) | 2017-08-31 | 2021-06-23 | Aeroclean Technologies, LLC | AIR TREATMENT SYSTEM AND METHOD |
| CN111205312B (zh) * | 2020-03-31 | 2021-03-16 | 榫卯科技服务(温州)有限公司 | 一种抗菌稀土配合物材料以及制备方法 |
| KR20210125682A (ko) * | 2020-04-09 | 2021-10-19 | 긴미라이 가부시키가이샤 | 마스크용 제균수를 제조하는 방법, 마스크용 제균수, 및 마스크를 제균하는 방법. |
| US11850336B2 (en) | 2020-05-22 | 2023-12-26 | Molekule Group, Inc. | UV sterilization apparatus, system, and method for aircraft air systems |
| WO2021261467A1 (ja) | 2020-06-23 | 2021-12-30 | 佐々木化学工業株式会社 | クエン酸水素二銀含有組成物及びその製造方法、並びにこれを用いた抗菌剤又は抗ウイルス剤及びその製造方法 |
| EP4210774A4 (en) | 2020-09-14 | 2024-10-09 | Aeroclean Technologies, LLC | INTEGRATED AIR SANITIZER AND SURFACE DISINFECTION DEVICE |
| US11779675B2 (en) | 2020-10-19 | 2023-10-10 | Molekule Group, Inc. | Air sterilization insert for heating, ventilation, and air conditioning (HVAC) systems |
| JP7710732B2 (ja) * | 2021-04-16 | 2025-07-22 | 佐々木化学工業株式会社 | クエン酸水素二銀含有組成物及びその製造方法、並びにこれを用いた抗菌剤又は抗ウイルス剤及びその製造方法 |
| CN114766520A (zh) * | 2022-05-20 | 2022-07-22 | 千藤(南京)环保科技有限公司 | 一种柠檬酸三银组合物、制备方法及用途 |
| TWI866400B (zh) * | 2023-08-17 | 2024-12-11 | 洪氏生化科技股份有限公司 | 用於環境清消之抗微生物組合物製作方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2345134A (en) * | 1939-11-27 | 1944-03-28 | Nat Aluminate Corp | Sodium aluminate product and process of producing the same |
| US3702298A (en) * | 1970-09-10 | 1972-11-07 | Eco Sciences Inc | Method of disinfecting with divalent and trivalent metal germicide |
| US3826639A (en) * | 1971-02-16 | 1974-07-30 | Basf Ag | Agent for keeping cut flowers fresh |
| US4291125A (en) * | 1980-01-16 | 1981-09-22 | Greatbatch W | Method for electronic control of infections using silver ions |
| SE432194B (sv) * | 1980-09-17 | 1984-03-26 | Landstingens Inkopscentral | Fukthemmande och bakteriedodande absorptionskropp for urin och faeces, vilken innehaller ett vattenlosligt kopparsalt |
| US4608183A (en) * | 1985-01-14 | 1986-08-26 | Board Of Governors Of Wayne State University | Synergistic antimicrobial or biocidal mixtures including isothiazolones |
| US4666616A (en) * | 1985-04-30 | 1987-05-19 | Board Of Governers Of Wayne State University | Synergistic antimicrobial or biocidal mixtures |
| CH673225A5 (enExample) * | 1986-04-22 | 1990-02-28 | Sanosil Ag | |
| US4780216A (en) * | 1986-11-19 | 1988-10-25 | Olin Corporation | Calcium hypochlorite sanitizing compositions |
| GB2236115A (en) * | 1989-09-20 | 1991-03-27 | Shell Int Research | Process for preparing silver powder |
| US5017295A (en) * | 1990-05-01 | 1991-05-21 | N. Jonas & Co., Inc. | Divalent silver bactericide for water treatment |
| US5078902A (en) * | 1991-05-09 | 1992-01-07 | N. Jonas & Co., Inc. | Divalent silver halide bactericide |
| US5073382A (en) * | 1991-05-09 | 1991-12-17 | N. Jonas & Co., Inc. | Divalent silver alkaline bactericide compositions |
| US5089275A (en) * | 1991-05-09 | 1992-02-18 | N. Jonas & Co., Inc. | Stabilized divalent silver bactericides |
| JPH07502489A (ja) * | 1991-09-20 | 1995-03-16 | シィミラサン コーポレイション | 薬剤組成物用防腐剤 |
| US5681575A (en) * | 1992-05-19 | 1997-10-28 | Westaim Technologies Inc. | Anti-microbial coating for medical devices |
| GEP20002074B (en) * | 1992-05-19 | 2000-05-10 | Westaim Tech Inc Ca | Modified Material and Method for its Production |
| US5332511A (en) * | 1993-06-25 | 1994-07-26 | Olin Corporation | Process of sanitizing swimming pools, spas and, hot tubs |
| ES2297895T5 (es) * | 1997-10-10 | 2012-07-03 | Pure Bioscience | Desinfectante y método de preparación |
| NZ512267A (en) * | 1998-11-09 | 2003-11-28 | Ira Jay Newman | Ionic silver complex |
| US7261905B2 (en) * | 1999-04-07 | 2007-08-28 | Pure Bioscience | Disinfectant and method of making |
| US6242009B1 (en) * | 1999-04-20 | 2001-06-05 | Kareem I. Batarseh | Microbicidal formulations and methods to control microorganisms |
| FR2792500B1 (fr) * | 1999-04-23 | 2004-05-21 | Internat Redox Dev | Composition aqueuse, notamment sous forme de gel, a base de ho2f , acides et ions metalliques, procede de preparation notamment quand lesdits ions sont ag2+ et utilisation dans le domaine de la desinfection et/ou du traitement de surface |
| US6686324B2 (en) * | 1999-11-26 | 2004-02-03 | Virox Technologies, Inc. | Low-foaming hydrogen peroxide cleaning solution for organic soils |
| US6890953B2 (en) * | 2000-04-06 | 2005-05-10 | Innovative Medical Services | Process for treating water |
| AU2004267997B2 (en) * | 2003-08-28 | 2010-06-03 | Pure Bioscience | Silver dihydrogen citrate compositions comprising a second antimicrobial agent |
| US20060051430A1 (en) * | 2004-09-07 | 2006-03-09 | Arata Andrew B | Silver dihydrogen citrate compositions |
-
2008
- 2008-08-14 US US12/191,477 patent/US8399028B2/en active Active
-
2009
- 2009-07-15 CN CN200980135700.9A patent/CN102149393B/zh not_active Expired - Fee Related
- 2009-07-15 EP EP09806258.1A patent/EP2323673B1/en not_active Not-in-force
- 2009-07-15 CA CA2733509A patent/CA2733509C/en active Active
- 2009-07-15 JP JP2011522355A patent/JP5639586B2/ja not_active Expired - Fee Related
- 2009-07-15 WO PCT/CA2009/001042 patent/WO2010017623A1/en not_active Ceased
- 2009-07-15 RU RU2011109191/15A patent/RU2011109191A/ru not_active Application Discontinuation
- 2009-07-15 AU AU2009281655A patent/AU2009281655B2/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2323673A4 (en) | 2011-10-26 |
| US20100040699A1 (en) | 2010-02-18 |
| US8399028B2 (en) | 2013-03-19 |
| EP2323673A1 (en) | 2011-05-25 |
| WO2010017623A1 (en) | 2010-02-18 |
| EP2323673B1 (en) | 2013-08-14 |
| RU2011109191A (ru) | 2012-09-20 |
| BRPI0917806A2 (pt) | 2016-03-01 |
| CN102149393A (zh) | 2011-08-10 |
| AU2009281655A1 (en) | 2010-02-18 |
| AU2009281655B2 (en) | 2015-04-09 |
| JP2011530542A (ja) | 2011-12-22 |
| CA2733509A1 (en) | 2010-02-18 |
| HK1155077A1 (en) | 2012-05-11 |
| CA2733509C (en) | 2013-11-12 |
| CN102149393B (zh) | 2014-03-12 |
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