JP5619284B2 - ロイコトリエン産生のオキサジアゾール阻害薬 - Google Patents
ロイコトリエン産生のオキサジアゾール阻害薬 Download PDFInfo
- Publication number
- JP5619284B2 JP5619284B2 JP2013524874A JP2013524874A JP5619284B2 JP 5619284 B2 JP5619284 B2 JP 5619284B2 JP 2013524874 A JP2013524874 A JP 2013524874A JP 2013524874 A JP2013524874 A JP 2013524874A JP 5619284 B2 JP5619284 B2 JP 5619284B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- independently
- mmol
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 0 C*(C)c1ncc(*)nc1 Chemical compound C*(C)c1ncc(*)nc1 0.000 description 8
- WWIWVEDEVQQYQJ-UHFFFAOYSA-N CC(C)(C[n]1ncc(C)c1)O Chemical compound CC(C)(C[n]1ncc(C)c1)O WWIWVEDEVQQYQJ-UHFFFAOYSA-N 0.000 description 1
- FAIDZBICGPSURU-UOEQQCKPSA-N CC(C)C(C)(/C(/N)=N/O)c(cc1)ccc1/C(/C=N)=C/N Chemical compound CC(C)C(C)(/C(/N)=N/O)c(cc1)ccc1/C(/C=N)=C/N FAIDZBICGPSURU-UOEQQCKPSA-N 0.000 description 1
- HKLLVZDMXHVTGI-ZMRRCTOZSA-N CC(C)C(C)(c1n[o]c(C2=CC=CNC2=O)n1)c(cc1)ccc1/C(/C=N)=C/N Chemical compound CC(C)C(C)(c1n[o]c(C2=CC=CNC2=O)n1)c(cc1)ccc1/C(/C=N)=C/N HKLLVZDMXHVTGI-ZMRRCTOZSA-N 0.000 description 1
- ITYASDLTGLEOGT-UHFFFAOYSA-N CC(C1CC1)(C(/N=C(/c1c[n](CC(N(C)C)=O)nc1)\O)=N)c(cc1)ccc1Br Chemical compound CC(C1CC1)(C(/N=C(/c1c[n](CC(N(C)C)=O)nc1)\O)=N)c(cc1)ccc1Br ITYASDLTGLEOGT-UHFFFAOYSA-N 0.000 description 1
- RUOAGOLLBRDFQS-JLRHHEFTSA-N CC(C1CC1)(C(/N=C(/c1c[n](CN(C)C)nc1)\O)=N)c(cc1)ccc1/C(/C=N)=C/N Chemical compound CC(C1CC1)(C(/N=C(/c1c[n](CN(C)C)nc1)\O)=N)c(cc1)ccc1/C(/C=N)=C/N RUOAGOLLBRDFQS-JLRHHEFTSA-N 0.000 description 1
- BPAWJNZZASDYLG-UHFFFAOYSA-N CC(C1CC1)(c1n[o]c(-c2c[nH]nc2)n1)c(cc1)ccc1-c1cnc(N)nc1 Chemical compound CC(C1CC1)(c1n[o]c(-c2c[nH]nc2)n1)c(cc1)ccc1-c1cnc(N)nc1 BPAWJNZZASDYLG-UHFFFAOYSA-N 0.000 description 1
- WIEHWYNBFBYKEC-WAYWQWQTSA-N CC/C=C\CC(C(C)C)F Chemical compound CC/C=C\CC(C(C)C)F WIEHWYNBFBYKEC-WAYWQWQTSA-N 0.000 description 1
- CIYNASNXDHFNPO-SNAWJCMRSA-N CO/C(/C=C)=C/N Chemical compound CO/C(/C=C)=C/N CIYNASNXDHFNPO-SNAWJCMRSA-N 0.000 description 1
- JOVGLRSLWFSVNB-COBSHVIPSA-N C[C@H]1C(C)C=CC1 Chemical compound C[C@H]1C(C)C=CC1 JOVGLRSLWFSVNB-COBSHVIPSA-N 0.000 description 1
- ZBTMRBYMKUEVEU-UHFFFAOYSA-N Cc(cc1)ccc1Br Chemical compound Cc(cc1)ccc1Br ZBTMRBYMKUEVEU-UHFFFAOYSA-N 0.000 description 1
- SZQCPPRPWDXLMM-UHFFFAOYSA-N Cc1c[n](C)nc1 Chemical compound Cc1c[n](C)nc1 SZQCPPRPWDXLMM-UHFFFAOYSA-N 0.000 description 1
- NOYVYANICCCMRE-UHFFFAOYSA-N Cc1c[n](C2COC2)nc1 Chemical compound Cc1c[n](C2COC2)nc1 NOYVYANICCCMRE-UHFFFAOYSA-N 0.000 description 1
- ASCCMGGNOJXQPO-UHFFFAOYSA-N Cc1c[n](CC(N(C)C)=O)nc1 Chemical compound Cc1c[n](CC(N(C)C)=O)nc1 ASCCMGGNOJXQPO-UHFFFAOYSA-N 0.000 description 1
- ICSNLGPSRYBMBD-UHFFFAOYSA-N Nc1ccccn1 Chemical compound Nc1ccccn1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 description 1
- TXJKATOSKLUITR-UHFFFAOYSA-N O=C(c1cnccn1)Cl Chemical compound O=C(c1cnccn1)Cl TXJKATOSKLUITR-UHFFFAOYSA-N 0.000 description 1
- FXIPUFZTJGDCEK-UHFFFAOYSA-N OC(c(cccn1)c1Cl)Cl Chemical compound OC(c(cccn1)c1Cl)Cl FXIPUFZTJGDCEK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37392510P | 2010-08-16 | 2010-08-16 | |
| US61/373,925 | 2010-08-16 | ||
| US201161492176P | 2011-06-01 | 2011-06-01 | |
| US61/492,176 | 2011-06-01 | ||
| PCT/US2011/047356 WO2012024150A1 (en) | 2010-08-16 | 2011-08-11 | Oxadiazole inhibitors of leukotriene production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013534245A JP2013534245A (ja) | 2013-09-02 |
| JP2013534245A5 JP2013534245A5 (enExample) | 2014-01-09 |
| JP5619284B2 true JP5619284B2 (ja) | 2014-11-05 |
Family
ID=44511591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013524874A Active JP5619284B2 (ja) | 2010-08-16 | 2011-08-11 | ロイコトリエン産生のオキサジアゾール阻害薬 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8658661B2 (enExample) |
| EP (1) | EP2606045B1 (enExample) |
| JP (1) | JP5619284B2 (enExample) |
| KR (1) | KR20130100105A (enExample) |
| CN (1) | CN103180314A (enExample) |
| AP (1) | AP2013006678A0 (enExample) |
| AR (1) | AR082696A1 (enExample) |
| AU (1) | AU2011292285A1 (enExample) |
| BR (1) | BR112013003439A2 (enExample) |
| CA (1) | CA2807364A1 (enExample) |
| CL (1) | CL2013000455A1 (enExample) |
| CO (1) | CO6680645A2 (enExample) |
| EA (1) | EA201300250A1 (enExample) |
| EC (1) | ECSP13012494A (enExample) |
| MX (1) | MX2013001872A (enExample) |
| NZ (1) | NZ605690A (enExample) |
| PE (1) | PE20130751A1 (enExample) |
| PH (1) | PH12013500301A1 (enExample) |
| SG (1) | SG187549A1 (enExample) |
| TW (1) | TW201238947A (enExample) |
| UY (1) | UY33557A (enExample) |
| WO (1) | WO2012024150A1 (enExample) |
| ZA (1) | ZA201300238B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015505550A (ja) * | 2012-02-01 | 2015-02-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害薬としてのフェニル−ｃ−オキサジアゾール誘導体併用療法 |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12013500301A1 (en) | 2010-08-16 | 2013-03-25 | Boehringer Ingelheim Int | Oxadiazole inhibitors of leukotriene production |
| EP2609092B1 (en) * | 2010-08-26 | 2015-04-01 | Boehringer Ingelheim International GmbH | Oxadiazole inhibitors of leukotriene production |
| AU2011305667A1 (en) * | 2010-09-23 | 2013-03-21 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| US8580825B2 (en) * | 2010-09-23 | 2013-11-12 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| WO2012082817A1 (en) * | 2010-12-16 | 2012-06-21 | Boehringer Ingelheim International Gmbh | Biarylamide inhibitors of leukotriene production |
| US9199904B2 (en) * | 2011-03-18 | 2015-12-01 | Boehringer Ingelheim International Gmbh | Process for preparing carboxylic acids |
| US9174980B2 (en) * | 2012-01-31 | 2015-11-03 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds as inhibitors of leukotriene production |
| US9029592B2 (en) * | 2012-02-09 | 2015-05-12 | Boehringer Ingelheim International Gmbh | Process for preparing carboxamidine compounds |
| EP2746279A1 (en) | 2012-12-19 | 2014-06-25 | Basf Se | Fungicidal imidazolyl and triazolyl compounds |
| EP2746256A1 (en) | 2012-12-19 | 2014-06-25 | Basf Se | Fungicidal imidazolyl and triazolyl compounds |
| WO2014095381A1 (en) | 2012-12-19 | 2014-06-26 | Basf Se | Fungicidal imidazolyl and triazolyl compounds |
| WO2014095249A1 (en) | 2012-12-19 | 2014-06-26 | Basf Se | Fungicidal imidazolyl and triazolyl compounds |
| EP2746277A1 (en) | 2012-12-19 | 2014-06-25 | Basf Se | Fungicidal imidazolyl and triazolyl compounds |
| CN103724279B (zh) * | 2014-01-20 | 2016-04-06 | 新发药业有限公司 | 一步成环制备2-甲基-4-氨基-5-氨基甲基嘧啶的便捷合成方法 |
| WO2015140130A1 (en) * | 2014-03-17 | 2015-09-24 | Remynd Nv | Oxadiazole compounds |
| IL291418B2 (en) | 2022-03-16 | 2024-05-01 | Anima Biotech Inc | Substances that function as modulators of cMYC-mRNA translation and their uses for cancer treatment |
| JP2023140319A (ja) | 2022-03-22 | 2023-10-04 | アッヴィ・インコーポレイテッド | ブルトン型チロシンキナーゼを分解するためのピリミジン |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3141019A (en) * | 1964-07-14 | Chaohj | ||
| NL302339A (enExample) * | 1963-03-22 | |||
| JP2719742B2 (ja) * | 1991-04-30 | 1998-02-25 | 株式会社大塚製薬工場 | フェニルチアゾール誘導体 |
| AU742145B2 (en) * | 1997-07-10 | 2001-12-20 | Janssen Pharmaceutica N.V. | IL-5 inhibiting 6-azauracil derivatives |
| EP0987265A1 (en) * | 1998-09-18 | 2000-03-22 | Janssen Pharmaceutica N.V. | Interleukin-5 inhibiting 6-azauracil derivatives |
| KR100795484B1 (ko) | 1999-08-06 | 2008-01-16 | 얀센 파마슈티카 엔.브이. | 인터루킨-5를 저해하는 6-아자우라실 유도체 |
| US7319108B2 (en) | 2004-01-25 | 2008-01-15 | Sanofi-Aventis Deutschland Gmbh | Aryl-substituted heterocycles, process for their preparation and their use as medicaments |
| EP1814877B1 (en) * | 2004-10-18 | 2009-03-11 | Merck & Co., Inc. | Diphenyl substituted alkanes as flap inhibitors |
| EP1912992A1 (en) * | 2005-08-10 | 2008-04-23 | SmithKline Beecham Corporation | Xanthine derivatives as selective hm74a agonists |
| GB0516464D0 (en) * | 2005-08-10 | 2005-09-14 | Smithkline Beecham Corp | Novel compounds |
| GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| US20070219206A1 (en) * | 2005-11-04 | 2007-09-20 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| AU2007238878A1 (en) | 2006-04-11 | 2007-10-25 | Merck Sharp & Dohme Corp. | Diaryl substituted alkanes |
| WO2007130499A2 (en) * | 2006-05-01 | 2007-11-15 | Virobay, Inc. | Antiviral agents |
| EP2452683A3 (en) * | 2006-06-26 | 2012-08-22 | Amgen Inc. | Methods for treating atherosclerosis |
| WO2008030369A1 (en) * | 2006-09-01 | 2008-03-13 | Merck & Co., Inc. | Inhibitors of 5 -lipoxygenase activating protein ( flap) |
| FR2906866A1 (fr) * | 2006-10-10 | 2008-04-11 | Felix Ifrah | Luminaire comprenant au moins un moyen d'eclairage dont l'activation s'effectue par l'emission d'un rayonnement lumineux |
| WO2008050200A1 (en) * | 2006-10-24 | 2008-05-02 | Pfizer Products Inc. | Oxadiazole compounds as calcium channel antagonists |
| AU2008241313A1 (en) | 2007-04-20 | 2008-10-30 | Merck Frosst Canada Ltd. | Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase |
| EP2546232A1 (en) | 2007-06-20 | 2013-01-16 | Merck Sharp & Dohme Corp. | Diphenyl Substituted Alkanes |
| WO2009048547A1 (en) | 2007-10-10 | 2009-04-16 | Merck & Co., Inc. | Diphenyl substituted cycloalkanes |
| EP2393811A1 (en) * | 2009-02-04 | 2011-12-14 | Pfizer Inc. | 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6h)-one derivatives |
| EP2568809A4 (en) | 2010-05-12 | 2013-11-06 | Univ Vanderbilt | HETEROCYCLIC ALLOSTERE SULFON MGLUR4 POTENTIATORS, COMPOSITIONS AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTIONS |
| PH12013500301A1 (en) | 2010-08-16 | 2013-03-25 | Boehringer Ingelheim Int | Oxadiazole inhibitors of leukotriene production |
| EP2609092B1 (en) | 2010-08-26 | 2015-04-01 | Boehringer Ingelheim International GmbH | Oxadiazole inhibitors of leukotriene production |
| US8580825B2 (en) | 2010-09-23 | 2013-11-12 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
-
2011
- 2011-08-11 PH PH1/2013/500301A patent/PH12013500301A1/en unknown
- 2011-08-11 CA CA2807364A patent/CA2807364A1/en not_active Abandoned
- 2011-08-11 EA EA201300250A patent/EA201300250A1/ru unknown
- 2011-08-11 AP AP2013006678A patent/AP2013006678A0/xx unknown
- 2011-08-11 PE PE2013000279A patent/PE20130751A1/es not_active Application Discontinuation
- 2011-08-11 SG SG2013003694A patent/SG187549A1/en unknown
- 2011-08-11 KR KR1020137003938A patent/KR20130100105A/ko not_active Withdrawn
- 2011-08-11 EP EP11748842.9A patent/EP2606045B1/en active Active
- 2011-08-11 CN CN2011800500399A patent/CN103180314A/zh active Pending
- 2011-08-11 BR BR112013003439A patent/BR112013003439A2/pt not_active IP Right Cessation
- 2011-08-11 WO PCT/US2011/047356 patent/WO2012024150A1/en not_active Ceased
- 2011-08-11 JP JP2013524874A patent/JP5619284B2/ja active Active
- 2011-08-11 NZ NZ605690A patent/NZ605690A/en not_active IP Right Cessation
- 2011-08-11 AU AU2011292285A patent/AU2011292285A1/en not_active Abandoned
- 2011-08-11 MX MX2013001872A patent/MX2013001872A/es not_active Application Discontinuation
- 2011-08-12 US US13/208,582 patent/US8658661B2/en active Active
- 2011-08-15 UY UY0001033557A patent/UY33557A/es not_active Application Discontinuation
- 2011-08-15 AR ARP110102966A patent/AR082696A1/es unknown
- 2011-08-15 TW TW100129127A patent/TW201238947A/zh unknown
-
2013
- 2013-01-10 ZA ZA2013/00238A patent/ZA201300238B/en unknown
- 2013-02-14 CL CL2013000455A patent/CL2013000455A1/es unknown
- 2013-02-15 CO CO13031460A patent/CO6680645A2/es not_active Application Discontinuation
- 2013-03-15 EC ECSP13012494 patent/ECSP13012494A/es unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015505550A (ja) * | 2012-02-01 | 2015-02-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロイコトリエン生成の阻害薬としてのフェニル−ｃ−オキサジアゾール誘導体併用療法 |
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| Publication number | Publication date |
|---|---|
| PE20130751A1 (es) | 2013-06-21 |
| SG187549A1 (en) | 2013-03-28 |
| US20120220561A1 (en) | 2012-08-30 |
| CA2807364A1 (en) | 2012-02-23 |
| BR112013003439A2 (pt) | 2019-09-24 |
| CN103180314A (zh) | 2013-06-26 |
| EP2606045A1 (en) | 2013-06-26 |
| TW201238947A (en) | 2012-10-01 |
| AU2011292285A1 (en) | 2013-01-31 |
| ECSP13012494A (es) | 2013-04-30 |
| AP2013006678A0 (en) | 2013-01-31 |
| AR082696A1 (es) | 2012-12-26 |
| US8658661B2 (en) | 2014-02-25 |
| KR20130100105A (ko) | 2013-09-09 |
| ZA201300238B (en) | 2014-06-25 |
| MX2013001872A (es) | 2013-09-02 |
| EA201300250A1 (ru) | 2013-08-30 |
| NZ605690A (en) | 2014-06-27 |
| EP2606045B1 (en) | 2016-01-06 |
| CO6680645A2 (es) | 2013-05-31 |
| UY33557A (es) | 2012-03-30 |
| WO2012024150A1 (en) | 2012-02-23 |
| CL2013000455A1 (es) | 2013-05-03 |
| JP2013534245A (ja) | 2013-09-02 |
| PH12013500301A1 (en) | 2013-03-25 |
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