JP5617110B2 - 経口発毛促進剤 - Google Patents
経口発毛促進剤 Download PDFInfo
- Publication number
- JP5617110B2 JP5617110B2 JP2009276977A JP2009276977A JP5617110B2 JP 5617110 B2 JP5617110 B2 JP 5617110B2 JP 2009276977 A JP2009276977 A JP 2009276977A JP 2009276977 A JP2009276977 A JP 2009276977A JP 5617110 B2 JP5617110 B2 JP 5617110B2
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- Prior art keywords
- extract
- hair growth
- sample
- water
- camellia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000429 sodium aluminium silicate Substances 0.000 description 1
- 235000012217 sodium aluminium silicate Nutrition 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
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- 239000005720 sucrose Substances 0.000 description 1
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- 239000001648 tannin Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
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- 239000008513 turmeric extract Substances 0.000 description 1
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- 235000015192 vegetable juice Nutrition 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Inorganic Chemistry (AREA)
Description
(a)ノコギリヤシ果実抽出物は、二酸化炭素超臨界流体で抽出処理した抽出物。
(b)カボチャ種子抽出物は、二酸化炭素超臨界流体で抽出処理した抽出物。
(c)緑茶葉抽出物は、熱水抽出後、合成吸着剤で処理した、含水エタノール(含水率30%)可溶画分。
(d)ツバキ種子抽出物は、ツバキ種子の脱脂物を水及び/又は低級アルコールで抽出処理した水溶性成分を含む抽出物。
この経口発毛促進剤においては、ノコギリヤシ果実抽出物及びカボチャ種子抽出物はシクロデキストリンで包接されたものであることが望ましく、さらには、これらと血流改善作用物質とを併用するものがより一層望ましい。そして、この血流改善作用物質はツバキ種子の抽出物及び/又は緑茶葉の抽出物であることが好適であり、とりわけツバキ種子抽出物を用いることがより好ましく、該ツバキ種子抽出物はツバキ種子の脱脂物を水及び/又は低級アルコールで抽出処理して得られる水溶性成分を含むものであり、サポニン類を含有するものであることが最も望ましい態様である。また、本発明では、前記の経口発毛促進剤は飲食品として用いることが望ましく、その好適な形態は粉末状、顆粒状、錠剤状、カプセル状又は液体状のものである。
ノコギリヤシの乾燥果実10kgを粗粉砕し、超臨界流体抽出法(二酸化炭素、40〜45℃、20±3MPa)により油状のノコギリヤシ果実抽出物(試料1とする)1.8kgを得た。この抽出物の組成(GLC分析)は脂肪酸類(ラウリン酸及びオレイン酸を主成分とする炭素数6〜18の飽和及び不飽和脂肪酸):94.8%、脂肪族アルコール類(ヘキサコサノール、オクタコサノール等):0.2%、ステロール類(β−シトステロール、カンペステロール、スチグマステロール):0.3%等であった。
ペポカボチャ(Cucurbita melopepo L.)の乾燥種子10kgを粗粉砕し、製造例1と同様に超臨界流体抽出法により処理して油状のカボチャ種子抽出物(試料2とする)1.9kgを得た。この抽出物の脂質組成はグリセリド類(リノール酸及びオレイン酸を主成分とする炭素数14〜18の飽和及び不飽和脂肪酸のグリセリド):87.5%、スクアレン:0.6%、脂肪族アルコール類:0.1%(ヘキサコサノール、オクタコサノール等)、ステロール類(β−シトステロール、スチグマステロール、アベナステロール等):0.4%、トコフェロール類(β−及びγ−トコフェロール等):0.1%、微量のβ−カロテン等であった。
製造例1に記載のノコギリヤシ果実抽出物、製造例2に記載のカボチャ種子抽出物及びβ−シクロデキストリンの割合(質量比)を1:1:8として、常法により前記抽出物のシクロデキストリン包接物(試料3とする)を調製した。
長崎県五島産ヤブツバキの乾燥種子を粗粉砕して蒸煮後、圧搾して圧搾油を分離した圧搾粕を得た。次いで圧搾粕にノルマルヘキサンを加えて常法により抽出処理し、抽出液を分離して抽出粕を採取した。この抽出粕をノルマルヘキサンで洗浄して油分を取り除き脱脂物を採取した。この脱脂物1kgに水3Lを加え、常圧下、85℃に加熱して1時間適宜に撹拌した後、室温まで冷却し、濾過して濾液を分離した。この濾過残渣に再度水200mLを加えて同様に加熱、攪拌、冷却後、濾過して濾液を採取した。両濾液を合わせて減圧下に濃縮し、凍結乾燥及び粉砕して、水溶性成分からなる粉末状のツバキ種子抽出物(試料4とする)185gを得た。この抽出物は、これを常法により加水分解してHPLC分析したところ、サポニンのアグリコンであるサポゲニンを17.8%、フラボノールの一種であるケンフェロールを2.7%含むものであった。
製造例4に記載の方法で得た脱脂物1kgに含水エタノール(含水率35%)2Lを加え、80℃で1時間加熱還流した後、室温まで冷却し、濾過して濾液を分離した。この濾過残渣に再度含水エタノール(含水率35%)2Lを加えて同様に加熱し、冷却後、濾過して濾液を採取した。両濾液を合わせて減圧下に濃縮し、凍結乾燥及び粉砕して、水溶性成分を含む粉末(試料5とする)13.3gを得た。該粉末を製造例4と同様に加水分解してHPLC分析した結果、サポゲニン含量は13.1%であり、ケンフェロール含量は2.3%であった。
静岡県産の緑茶の乾燥葉1kgを粗細断し、水3Lを加えて、常圧下、85℃に加熱して20分間適宜に撹拌した後、室温まで冷却し、濾過して濾液を分離した。この濾過残渣に再度水2Lを加えて同様に加熱し、攪拌、冷却後、濾過して濾液を採取した。両濾液を合わせて減圧下に濃縮した。その濃縮溶液を、合成吸着剤のダイヤイオン(登録商標)HP−20(三菱化学(株)製)を充填したカラムクロマトグラフィーに供した。水5Lを通液して洗浄した後、含水エタノール(含水率30%)5Lを通液し、該含水エタノールに可溶の溶液を回収した。この溶液を減圧下に濃縮し、噴霧乾燥及び粉砕して、粉末状の緑茶葉抽出物(試料6とする)25gを得た。該粉末をHPLC分析した結果、カテキン類(エピガロカテキンガレートを主成分とし、ガロカテキンガレート、エピカテキンガレート、エピガロカテキン、カテキン、エピカテキン等)の含量は90.2%、カフェイン:0.1%等であった。
以下に述べる試験に参加することに同意が得られた被験者30名(24〜65歳、男性15名、女性15名)を1群5名に群分けして二重盲検法により血流測定試験を行った。まず、被験者を温度24±2℃、湿度50±10%に制御した恒温・恒湿の部屋に入室させ、10分間安静に待機させた。この後、試験試料を摂取する前の手の甲及び頭皮の血流量をレーザードップラー(Perimed社製、PeriScan PIM II)を用いて測定した。次に、対照群(プラセボ群)には、被験者が色で判別できないように着色したハードカプセル(ゼラチン製。以下同様)にデキストリンを充填したものを、その他の群には、前記同様に着色したハードカプセルに各試験試料を充填したものをそれぞれ水100mLとともに摂取してもらい、30分後、60分後に再び前記と同様に手の甲及び頭皮の血流量を測定した。なお、試験試料は、前記のツバキ種子抽出物(試料4、試料5)、緑茶葉抽出物(試料6)、市販のイチョウ葉抽出物(ビーエイチエヌ(株)製)、ドコサヘキサエン酸含有魚油(クローダジャパン(株)製、DHA含有油脂)とした。
以下の試験に参加することに同意が得られた40〜65歳の頭頂部の毛髪が薄い78名(男性:40名、女性:38名)を被験者として、1群6名に群分けして、二重盲検法により試験を行った。対照群には被験者が判別できないように着色したハードカプセルにデキストリンを充填したものを、その他の群には同様に着色したハードカプセルにそれぞれの試料を300mg充填したものを毎日1個、6ヵ月間経口摂取させ、毛髪本数、毛髪成長速度及び毛髪径に及ぼす影響を次の方法により評価した。すなわち、毛髪本数は、デジタルマイクロスコープ((株)ハイロックス製、KH−3000)を用いて頭頂部の所定部位の拡大写真を撮影した後、1cm2あたりの毛髪数を測定した。毛髪成長速度は、まず、試験最終日より3日前に頭頂部の所定部位を毛刈りし、前記デジタルマイクロスコープにて拡大写真を撮影し、毛髪の長さを解析した。次に、毛刈りから72時間後の毛の長さを上記同様の方法で測定した。72時間で伸長した毛髪の長さを24時間あたりに換算し、これを毛髪成長速度(μm/24hr)とした。又、毛髪径は、所定部位の毛刈りを行った後、刈りとった毛髪を上記と同様に拡大写真を撮影し、毛髪の太さを解析した。尚、これらの測定はプラセボ及びそれぞれの試料を摂取させる前と、6ヵ月間摂取させた後に実施した。
前記の試料1及び試料2(混合比:1/1)、試料3及び試料4(混合比:2/1)、試料3及び試料5(混合比:1/1)、試料3及び試料6(混合比:2/1)、試料3及び試料4及び試料6(混合比:1/1/1)のいずれか1種:200部に、ミツロウ:40部及び月見草油(英国エファモール社製):50部を加え、加熱混合して均質化後、カプセル充填機に供して、常法により1粒あたり内容量が250mgのゼラチン被覆ソフトカプセル製剤を試作した。このカプセル製剤は経口摂取可能な栄養補助食品、医薬品又は動物用飼料として利用することができる。
前記の試料3、試料3及び試料4(混合比:1/1)、試料3及び試料5(混合比:3/1)、試料3及び試料6(混合比:1/1)、試料3及び試料4及び試料6(混合比:2/1/1)のいずれか1種をカプセル充填機に供して、常法により1粒あたり内容量が200mgのゼラチン被覆ハードカプセル製剤を試作した。このカプセル製剤は経口摂取可能な栄養補助食品、医薬品又は動物用飼料として利用することができる。
前記の試料3、試料3及び試料4(混合比:3/1)、試料3及び試料5(混合比:2/1)、試料3及び試料6(混合比:3/1)、試料3及び試料4及び試料6(混合比:3/2/1)のいずれか1種:30部、カルボキシメチルセルロース:70部、コーンスターチ:40部、マンニトール:20部、リン酸三カルシウム:30部、パントテン酸カルシウム:10部及びブドウ茎抽出物(BioseraeLab社製、Resveravine):10部を混合機に仕込み、10分間攪拌混合した。この混合物を直打式打錠機に供して直径7mm、高さ4mm、150mg/個の素錠を作成し、次いでコーティング機でシェラック被膜を形成させて錠剤を試作した。この錠剤は経口摂取可能な栄養補助食品、医薬品又はペット用飼料として利用することができる。
市販の栄養ドリンク100mLに試料3及び試料4(混合比:2/1)、試料3及び試料5(混合比:3/1)、試料3及び試料6(混合比:1/1)のいずれか1種:250mgを加えて十分に混合し飲料を試作した。これは冷蔵庫で6ヵ月間保存しても外観及び風味に異状及び違和感は認められなかった。本品は発毛、育毛、養毛等のための飲料やドリンク剤として利用することができる。
Claims (4)
- ノコギリヤシ果実抽出物及びカボチャ種子抽出物のシクロデキストリン包接物と、血流改善作用物質としての緑茶葉抽出物及び/又はツバキ種子抽出物とを有効成分として含有してなる、薄毛を改善するための経口発毛促進剤であって、以下の(a)〜(d)を満たす前記剤。
(a)ノコギリヤシ果実抽出物は、二酸化炭素超臨界流体で抽出処理した抽出物。
(b)カボチャ種子抽出物は、二酸化炭素超臨界流体で抽出処理した抽出物。
(c)緑茶葉抽出物は、熱水抽出後、合成吸着剤で処理した、含水エタノール(含水率30%)可溶画分。
(d)ツバキ種子抽出物は、ツバキ種子の脱脂物を水及び/又は低級アルコールで抽出処理した水溶性成分を含む抽出物。 - ツバキ種子抽出物がサポニン類を含有するものである請求項1に記載の経口発毛促進剤。
- 医薬品又は医薬部外品として使用する請求項1又は2に記載の経口発毛促進剤。
- 形態が粉末、顆粒、錠剤、カプセル又は液体である請求項3に記載の経口発毛促進剤。
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