JP5603343B2 - 関連する障害を処置するために有用なプロスタサイクリン（ｐｇｉ２）受容体モジュレーターとしてのピラゾリル置換炭酸誘導体 - Google Patents

関連する障害を処置するために有用なプロスタサイクリン（ｐｇｉ２）受容体モジュレーターとしてのピラゾリル置換炭酸誘導体 Download PDF

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JP5603343B2
JP5603343B2 JP2011538598A JP2011538598A JP5603343B2 JP 5603343 B2 JP5603343 B2 JP 5603343B2 JP 2011538598 A JP2011538598 A JP 2011538598A JP 2011538598 A JP2011538598 A JP 2011538598A JP 5603343 B2 JP5603343 B2 JP 5603343B2
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methyl
methoxy
cyclohexyl
phenyl
pyrazol
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JP2012509936A (ja
JP2012509936A5 (cg-RX-API-DMAC7.html
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トゥイ−アン トラン，
ジェイソン ビー． イバラ，
ヤン−ジュン シン，
ブレット ウルマン，
ニン ゾウ，
シー ツェン，
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アリーナ ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2011538598A 2008-11-26 2009-11-24 関連する障害を処置するために有用なプロスタサイクリン（ｐｇｉ２）受容体モジュレーターとしてのピラゾリル置換炭酸誘導体 Active JP5603343B2 (ja)

Applications Claiming Priority (3)

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US20039308P 2008-11-26 2008-11-26
US61/200,393 2008-11-26
PCT/US2009/006251 WO2010068242A1 (en) 2008-11-26 2009-11-24 Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto

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JP2012509936A JP2012509936A (ja) 2012-04-26
JP2012509936A5 JP2012509936A5 (cg-RX-API-DMAC7.html) 2012-12-27
JP5603343B2 true JP5603343B2 (ja) 2014-10-08

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US (6) US20110224262A1 (cg-RX-API-DMAC7.html)
EP (2) EP3342767B1 (cg-RX-API-DMAC7.html)
JP (1) JP5603343B2 (cg-RX-API-DMAC7.html)
KR (1) KR101707247B1 (cg-RX-API-DMAC7.html)
CN (1) CN102292321B (cg-RX-API-DMAC7.html)
AU (1) AU2009325117C1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0921369B8 (cg-RX-API-DMAC7.html)
CA (1) CA2744124C (cg-RX-API-DMAC7.html)
EA (1) EA022799B1 (cg-RX-API-DMAC7.html)
IL (1) IL212966A (cg-RX-API-DMAC7.html)
MX (1) MX2011005577A (cg-RX-API-DMAC7.html)
NZ (1) NZ593002A (cg-RX-API-DMAC7.html)
SG (1) SG171413A1 (cg-RX-API-DMAC7.html)
WO (1) WO2010068242A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201103813B (cg-RX-API-DMAC7.html)

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CA2744124C (en) 2008-11-26 2018-05-01 Arena Pharmaceuticals, Inc. Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto
PL2370413T3 (pl) 2008-12-08 2016-01-29 Arena Pharm Inc Modulatory receptora prostacykliny (PGI2) użyteczne w leczeniu zaburzeń z nimi związanych
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CN103958518B (zh) 2011-10-06 2017-07-04 拜耳知识产权有限责任公司 杂环基吡啶基吡唑/杂环基嘧啶基吡唑
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CN102292321A (zh) 2011-12-21
US20200392123A1 (en) 2020-12-17
EP2367797A1 (en) 2011-09-28
US10214518B2 (en) 2019-02-26
US20190270731A1 (en) 2019-09-05
AU2009325117A1 (en) 2010-06-17
US20140171469A1 (en) 2014-06-19
US9012478B2 (en) 2015-04-21
KR101707247B1 (ko) 2017-02-15
JP2012509936A (ja) 2012-04-26
SG171413A1 (en) 2011-07-28
NZ593002A (en) 2013-08-30
BRPI0921369B1 (pt) 2020-09-29
IL212966A (en) 2015-03-31
US20110224262A1 (en) 2011-09-15
CN102292321B (zh) 2015-08-12
WO2010068242A1 (en) 2010-06-17
US20150191455A1 (en) 2015-07-09
AU2009325117B2 (en) 2014-07-10
US11098034B2 (en) 2021-08-24
US10689372B2 (en) 2020-06-23
BRPI0921369A2 (pt) 2015-12-29
AU2009325117C1 (en) 2014-12-18
CA2744124C (en) 2018-05-01
EP3342767B1 (en) 2021-04-14
ZA201103813B (en) 2012-10-31
EP3342767A1 (en) 2018-07-04
EA022799B1 (ru) 2016-03-31
IL212966A0 (en) 2011-07-31
US20180030039A1 (en) 2018-02-01
MX2011005577A (es) 2011-08-03
US9663500B2 (en) 2017-05-30
EA201100846A1 (ru) 2012-01-30
HK1257652A1 (en) 2019-10-25
BRPI0921369B8 (pt) 2021-05-25
KR20110095914A (ko) 2011-08-25
CA2744124A1 (en) 2010-06-17

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