JP5599610B2 - Ｈｓｐ９０の阻害による神経変性疾患の処置 - Google Patents

Ｈｓｐ９０の阻害による神経変性疾患の処置 Download PDF

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Publication number
JP5599610B2
JP5599610B2 JP2009518602A JP2009518602A JP5599610B2 JP 5599610 B2 JP5599610 B2 JP 5599610B2 JP 2009518602 A JP2009518602 A JP 2009518602A JP 2009518602 A JP2009518602 A JP 2009518602A JP 5599610 B2 JP5599610 B2 JP 5599610B2
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tau
hsp90
brain
protein
mice
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JP2009542716A (ja
JP2009542716A5 (enExample
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チオシス、ガブリエラ
グリーンガード、ポール
ドウ、フェイ
ルオ、ウェンジー
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Rockefeller University
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Rockefeller University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009518602A 2006-06-30 2007-07-02 Ｈｓｐ９０の阻害による神経変性疾患の処置 Expired - Fee Related JP5599610B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80642706P 2006-06-30 2006-06-30
US60/806,427 2006-06-30
PCT/US2007/072671 WO2008005937A2 (en) 2006-06-30 2007-07-02 Treatment of neurodegenerative diseases through inhibiton of hsp90

Related Child Applications (1)

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JP2013058040A Division JP5824698B2 (ja) 2006-06-30 2013-03-21 Ｈｓｐ９０の阻害による神経変性疾患の処置

Publications (3)

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JP2009542716A JP2009542716A (ja) 2009-12-03
JP2009542716A5 JP2009542716A5 (enExample) 2010-09-02
JP5599610B2 true JP5599610B2 (ja) 2014-10-01

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JP2009518602A Expired - Fee Related JP5599610B2 (ja) 2006-06-30 2007-07-02 Ｈｓｐ９０の阻害による神経変性疾患の処置
JP2013058040A Expired - Fee Related JP5824698B2 (ja) 2006-06-30 2013-03-21 Ｈｓｐ９０の阻害による神経変性疾患の処置
JP2015174609A Pending JP2016028063A (ja) 2006-06-30 2015-09-04 Ｈｓｐ９０の阻害による神経変性疾患の処置
JP2017110721A Expired - Fee Related JP6427227B2 (ja) 2006-06-30 2017-06-05 Ｈｓｐ９０の阻害による神経変性疾患の処置
JP2018202024A Expired - Fee Related JP6585266B2 (ja) 2006-06-30 2018-10-26 Ｈｓｐ９０の阻害による神経変性疾患の処置

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JP2013058040A Expired - Fee Related JP5824698B2 (ja) 2006-06-30 2013-03-21 Ｈｓｐ９０の阻害による神経変性疾患の処置
JP2015174609A Pending JP2016028063A (ja) 2006-06-30 2015-09-04 Ｈｓｐ９０の阻害による神経変性疾患の処置
JP2017110721A Expired - Fee Related JP6427227B2 (ja) 2006-06-30 2017-06-05 Ｈｓｐ９０の阻害による神経変性疾患の処置
JP2018202024A Expired - Fee Related JP6585266B2 (ja) 2006-06-30 2018-10-26 Ｈｓｐ９０の阻害による神経変性疾患の処置

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US (5) US10336757B2 (enExample)
EP (2) EP2034839B1 (enExample)
JP (5) JP5599610B2 (enExample)
AU (1) AU2007269144B2 (enExample)
CA (1) CA2656202C (enExample)
DK (1) DK2034839T3 (enExample)
ES (1) ES2645095T3 (enExample)
WO (1) WO2008005937A2 (enExample)

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JP5616336B2 (ja) 2008-06-26 2014-10-29 オルファザイム エーピーエスＯｒｐｈａｚｙｍｅ Ａｐｓ 酵素活性の調節因子としてのＨｓｐ７０の使用
CN102458402B (zh) 2009-06-12 2013-10-02 百时美施贵宝公司 用作激酶调节剂的烟酰胺化合物
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JP2009542716A (ja) 2009-12-03
US20140378452A1 (en) 2014-12-25
US20240158397A1 (en) 2024-05-16
US20230060990A1 (en) 2023-03-02
AU2007269144A1 (en) 2008-01-10
JP6585266B2 (ja) 2019-10-02
EP3305297A1 (en) 2018-04-11
JP2017214379A (ja) 2017-12-07
US20090298857A1 (en) 2009-12-03
WO2008005937A3 (en) 2008-12-11
JP2016028063A (ja) 2016-02-25
EP2034839B1 (en) 2017-08-23
CA2656202A1 (en) 2008-01-10
WO2008005937A2 (en) 2008-01-10
EP2034839A2 (en) 2009-03-18
JP2019038829A (ja) 2019-03-14
US20190389864A1 (en) 2019-12-26
US10336757B2 (en) 2019-07-02
JP2013177389A (ja) 2013-09-09
US12473288B2 (en) 2025-11-18
JP6427227B2 (ja) 2018-11-21
AU2007269144B2 (en) 2013-05-16
ES2645095T3 (es) 2017-12-04
CA2656202C (en) 2018-01-16
JP5824698B2 (ja) 2015-11-25
DK2034839T3 (en) 2017-12-04
EP2034839A4 (en) 2012-08-29

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