JP5597128B2 - Ｈ５トリインフルエンザの診断および監視に有用なｈ５亜型特異的結合タンパク質 - Google Patents

Ｈ５トリインフルエンザの診断および監視に有用なｈ５亜型特異的結合タンパク質 Download PDF

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JP5597128B2
JP5597128B2 JP2010508341A JP2010508341A JP5597128B2 JP 5597128 B2 JP5597128 B2 JP 5597128B2 JP 2010508341 A JP2010508341 A JP 2010508341A JP 2010508341 A JP2010508341 A JP 2010508341A JP 5597128 B2 JP5597128 B2 JP 5597128B2
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monoclonal antibody
antibody
binding protein
mab
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JP2010526880A (ja
JP2010526880A5 (enExample
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ホ，ユーエン・ファン
デュ，クィン・ユン
ヘ，ファン
クアン，ジミー・ウェイ−シン
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テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • C07K16/108—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2010508341A 2007-05-11 2007-05-11 Ｈ５トリインフルエンザの診断および監視に有用なｈ５亜型特異的結合タンパク質 Expired - Fee Related JP5597128B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SG2007/000134 WO2008140415A1 (en) 2007-05-11 2007-05-11 H5 subtype-specific binding proteins useful for h5 avian influenza diagnosis and surveillance

Publications (3)

Publication Number Publication Date
JP2010526880A JP2010526880A (ja) 2010-08-05
JP2010526880A5 JP2010526880A5 (enExample) 2012-06-28
JP5597128B2 true JP5597128B2 (ja) 2014-10-01

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JP2010508341A Expired - Fee Related JP5597128B2 (ja) 2007-05-11 2007-05-11 Ｈ５トリインフルエンザの診断および監視に有用なｈ５亜型特異的結合タンパク質

Country Status (8)

Country Link
US (3) US8540994B2 (enExample)
EP (2) EP2155787A4 (enExample)
JP (1) JP5597128B2 (enExample)
KR (1) KR101421460B1 (enExample)
CN (1) CN101687921A (enExample)
AU (1) AU2007353481B2 (enExample)
CA (1) CA2687147C (enExample)
WO (1) WO2008140415A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2155787A4 (en) * 2007-05-11 2010-06-16 Temasek Life Sciences Lab Ltd SPECIFIC TO THE H5-SUBTYPE BINDING PROTEINS SUITED TO THE DIAGNOSIS AND MONITORING OF THE H5 BIRGRAP
WO2009035412A1 (en) * 2007-09-13 2009-03-19 Temasek Life Sciences Laboratory Limited Monoclonal antibodies specific to hemagglutinin from influenza virus h5-subtype and uses thereof
JP5490696B2 (ja) * 2007-09-13 2014-05-14 テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド インフルエンザウイルスｈ５亜型またはｎ１亜型からのヘマグルチニンおよびノイラミニダーゼに特異的なモノクローナル抗体ならびにそれらの使用
EP2250197B1 (en) * 2008-02-05 2016-05-11 Temasek Life Sciences Laboratory Limited Binding protein and epitope-blocking elisa for the universal detection of h5-subtype influenza viruses
EP2379591A4 (en) 2008-12-24 2012-10-17 Temasek Life Sciences Lab Ltd FOR THE FUSION SPECTER FROM HEMAGLUTININE FROM INFLUENZA A VIRUS SPECIFIC MONOCLONAL ANTIBODIES AND APPLICATIONS THEREOF
WO2012054745A1 (en) 2010-10-20 2012-04-26 New York Blood Center, Inc. Influenza hemagglutinin-specific monoclonal antibodies for preventing and treating influenza virus infection
CN101993492B (zh) * 2010-11-25 2012-06-27 南京医科大学 抗H5N1型高致病性禽流感scFv抗体及其应用
JP2013087069A (ja) * 2011-10-17 2013-05-13 Toyobo Co Ltd Ｈ５亜型インフルエンザウイルスを特異的に認識するモノクローナル抗体
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
TWI702229B (zh) 2014-12-19 2020-08-21 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
WO2017083627A1 (en) 2015-11-13 2017-05-18 Visterra, Inc. Compositions and methods for treating and preventing influenza
US20170240617A1 (en) 2016-02-24 2017-08-24 Visterra, Inc. Formulations of antibody molecules to influenza virus
CA3088194A1 (en) 2018-01-26 2019-08-01 Regeneron Pharmaceuticals, Inc. Human antibodies to influenza hemagglutinin
WO2019241188A1 (en) * 2018-06-11 2019-12-19 Glaxosmithkline Consumer Healthcare Holdings (Us) Llc Antibody pairs for use in a rapid influenza b diagnostic test
US11230593B2 (en) 2019-03-25 2022-01-25 Visterra, Inc. Compositions and methods for treating and preventing influenza
KR102517114B1 (ko) * 2020-08-28 2023-04-03 원광대학교산학협력단 고병원성 조류 인플루엔자 바이러스 h5 아형에 특이적인 단클론항체 및 이를 이용한 신속 진단 키트
KR102605065B1 (ko) * 2021-10-14 2023-11-22 원광대학교산학협력단 고병원성 조류 인플루엔자 바이러스 h5n1에 특이적인 단클론항체 및 이를 이용한 신속 진단 키트

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US6824780B1 (en) * 1999-10-29 2004-11-30 Genentech, Inc. Anti-tumor antibody compositions and methods of use
AU2003238767A1 (en) * 2002-05-31 2003-12-19 Penn State Research Foundation Dot-elisa for the detection of animal viruses
AU2002951692A0 (en) * 2002-09-23 2002-10-17 Vital Biotech (Hong Kong) Limited Improvements in or relating to vaccines
US7037707B2 (en) * 2003-09-04 2006-05-02 St. Jude Children's Research Hospital Method for generating influenza viruses and vaccines
WO2006063101A2 (en) * 2004-12-09 2006-06-15 University Of Pittsburgh Of The Commonwealth System Of Higher Education Vaccines for the rapid response to pandemic avian influenza
AU2006285306B2 (en) * 2005-07-25 2012-07-19 Avianax, Llc. Therapeutic antibodies for treatment and prophylaxis of transmittable viral diseases
US7871626B2 (en) * 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
WO2007047778A2 (en) * 2005-10-17 2007-04-26 Isis Pharmaceuticals, Inc. Compositions for use in identification of influenza viruses
US20070092524A1 (en) * 2005-10-21 2007-04-26 Jacob Nusbacher Method for the treatment and prophylaxis of avian influenza infection
JP2009524434A (ja) * 2006-01-26 2009-07-02 エイチエックス・ダイアグノスティックス・インコーポレイテッド トリインフルエンザウイルス亜型ｈ５ヘマグルチニンに結合するモノクローナル抗体およびそれらの使用
US20120045473A1 (en) * 2006-05-05 2012-02-23 Temasek Life Sciences Laboratory Limited Biomolecule Surface Display and Uses Thereof
US7728110B2 (en) * 2006-05-19 2010-06-01 Amgen, Inc. Antibodies to SARS coronavirus
EP2155787A4 (en) * 2007-05-11 2010-06-16 Temasek Life Sciences Lab Ltd SPECIFIC TO THE H5-SUBTYPE BINDING PROTEINS SUITED TO THE DIAGNOSIS AND MONITORING OF THE H5 BIRGRAP
JP5490696B2 (ja) * 2007-09-13 2014-05-14 テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド インフルエンザウイルスｈ５亜型またはｎ１亜型からのヘマグルチニンおよびノイラミニダーゼに特異的なモノクローナル抗体ならびにそれらの使用
WO2009035412A1 (en) * 2007-09-13 2009-03-19 Temasek Life Sciences Laboratory Limited Monoclonal antibodies specific to hemagglutinin from influenza virus h5-subtype and uses thereof
EP2250197B1 (en) * 2008-02-05 2016-05-11 Temasek Life Sciences Laboratory Limited Binding protein and epitope-blocking elisa for the universal detection of h5-subtype influenza viruses
EP2379591A4 (en) * 2008-12-24 2012-10-17 Temasek Life Sciences Lab Ltd FOR THE FUSION SPECTER FROM HEMAGLUTININE FROM INFLUENZA A VIRUS SPECIFIC MONOCLONAL ANTIBODIES AND APPLICATIONS THEREOF

Also Published As

Publication number Publication date
EP2155787A4 (en) 2010-06-16
US20130004943A1 (en) 2013-01-03
US20130004944A1 (en) 2013-01-03
AU2007353481A1 (en) 2008-11-20
EP2155787A1 (en) 2010-02-24
CA2687147A1 (en) 2008-11-20
CN101687921A (zh) 2010-03-31
US20110003278A1 (en) 2011-01-06
US8540994B2 (en) 2013-09-24
US8637645B2 (en) 2014-01-28
EP2363415A3 (en) 2011-12-14
JP2010526880A (ja) 2010-08-05
EP2363415A2 (en) 2011-09-07
KR101421460B1 (ko) 2014-07-30
WO2008140415A1 (en) 2008-11-20
EP2363415B1 (en) 2013-07-31
KR20100049506A (ko) 2010-05-12
US8637644B2 (en) 2014-01-28
AU2007353481B2 (en) 2013-08-29
HK1161725A1 (en) 2012-08-03
WO2008140415A9 (en) 2009-01-15
CA2687147C (en) 2016-08-23

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