CA2687147C - H5 subtype-specific binding proteins useful for h5 avian influenza diagnosis and surveillance - Google Patents

H5 subtype-specific binding proteins useful for h5 avian influenza diagnosis and surveillance Download PDF

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Publication number
CA2687147C
CA2687147C CA2687147A CA2687147A CA2687147C CA 2687147 C CA2687147 C CA 2687147C CA 2687147 A CA2687147 A CA 2687147A CA 2687147 A CA2687147 A CA 2687147A CA 2687147 C CA2687147 C CA 2687147C
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Prior art keywords
antibody
subtype
binding protein
binding
avian influenza
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CA2687147A
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English (en)
French (fr)
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CA2687147A1 (en
Inventor
Ho Yuen Fern
Du Qing Yun
He Fang
Jimmy Kwang Hwei Sing
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Temasek Life Sciences Laboratory
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Temasek Life Sciences Laboratory
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Publication of CA2687147A1 publication Critical patent/CA2687147A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/11—Orthomyxoviridae, e.g. influenza virus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2687147A 2007-05-11 2007-05-11 H5 subtype-specific binding proteins useful for h5 avian influenza diagnosis and surveillance Active CA2687147C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SG2007/000134 WO2008140415A1 (en) 2007-05-11 2007-05-11 H5 subtype-specific binding proteins useful for h5 avian influenza diagnosis and surveillance

Publications (2)

Publication Number Publication Date
CA2687147A1 CA2687147A1 (en) 2008-11-20
CA2687147C true CA2687147C (en) 2016-08-23

Family

ID=40002472

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2687147A Active CA2687147C (en) 2007-05-11 2007-05-11 H5 subtype-specific binding proteins useful for h5 avian influenza diagnosis and surveillance

Country Status (8)

Country Link
US (3) US8540994B2 (enExample)
EP (2) EP2363415B1 (enExample)
JP (1) JP5597128B2 (enExample)
KR (1) KR101421460B1 (enExample)
CN (1) CN101687921A (enExample)
AU (1) AU2007353481B2 (enExample)
CA (1) CA2687147C (enExample)
WO (1) WO2008140415A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5597128B2 (ja) * 2007-05-11 2014-10-01 テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド Ｈ５トリインフルエンザの診断および監視に有用なｈ５亜型特異的結合タンパク質
US8383121B2 (en) * 2007-09-13 2013-02-26 Temasek Life Sciences Laboratory Limited Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof
JP5490695B2 (ja) * 2007-09-13 2014-05-14 テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド インフルエンザウイルスｈ５亜型からのヘマグルチニンに特異的なモノクローナル抗体およびそれらの使用
JP5490725B2 (ja) * 2008-02-05 2014-05-14 テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド Ｈ５亜型インフルエンザウイルスの普遍的な検出のための結合タンパク質およびエピトープブロッキングｅｌｉｓａ
AU2008365616A1 (en) * 2008-12-24 2011-08-11 Temasek Life Sciences Laboratory Limited Monoclonal antibodies specific to the fusion peptide from hemagglutinin from influenza A viruses and uses thereof
US8900585B2 (en) 2010-10-20 2014-12-02 New York Blood Center, Inc. Influenza hemagglutinin-specific monoclonal antibodies for preventing and treating influenza virus infection
CN101993492B (zh) * 2010-11-25 2012-06-27 南京医科大学 抗H5N1型高致病性禽流感scFv抗体及其应用
JP2013087069A (ja) * 2011-10-17 2013-05-13 Toyobo Co Ltd Ｈ５亜型インフルエンザウイルスを特異的に認識するモノクローナル抗体
US9969794B2 (en) 2012-05-10 2018-05-15 Visterra, Inc. HA binding agents
TWI701258B (zh) 2014-12-19 2020-08-11 美商再生元醫藥公司 流行性感冒病毒血球凝集素之人類抗體
WO2017083627A1 (en) 2015-11-13 2017-05-18 Visterra, Inc. Compositions and methods for treating and preventing influenza
CA3015347A1 (en) 2016-02-24 2017-08-31 Visterra, Inc. Formulations of antibody molecules to influenza virus
SG11202006379UA (en) 2018-01-26 2020-07-29 Regeneron Pharma Human antibodies to influenza hemagglutinin
CN112334481A (zh) * 2018-06-11 2021-02-05 葛兰素史克消费保健（美国）控股有限责任公司 用于快速乙型流感诊断测试的抗体对
EP3946613A1 (en) 2019-03-25 2022-02-09 Visterra, Inc. Compositions and methods for treating and preventing influenza
KR102517114B1 (ko) * 2020-08-28 2023-04-03 원광대학교산학협력단 고병원성 조류 인플루엔자 바이러스 h5 아형에 특이적인 단클론항체 및 이를 이용한 신속 진단 키트
KR102605065B1 (ko) * 2021-10-14 2023-11-22 원광대학교산학협력단 고병원성 조류 인플루엔자 바이러스 h5n1에 특이적인 단클론항체 및 이를 이용한 신속 진단 키트

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US6824780B1 (en) * 1999-10-29 2004-11-30 Genentech, Inc. Anti-tumor antibody compositions and methods of use
US7083912B2 (en) * 2002-05-31 2006-08-01 Penn State Research Foundation MAb-based Dot-ELISA method and assay kit for the detection of viruses
AU2002951692A0 (en) * 2002-09-23 2002-10-17 Vital Biotech (Hong Kong) Limited Improvements in or relating to vaccines
US7037707B2 (en) * 2003-09-04 2006-05-02 St. Jude Children's Research Hospital Method for generating influenza viruses and vaccines
BRPI0518728A2 (pt) * 2004-12-09 2008-12-02 Univ Pittsburgh vacinas para a resposta rÁpida À pandemia de gripe aviÁria
US20070065452A1 (en) * 2005-07-25 2007-03-22 Avianax Therapeutic antibodies for treatment and prophylaxis of transmittable viral diseases
US7871626B2 (en) * 2005-08-04 2011-01-18 St. Jude Children's Research Hospital Modified influenza virus for monitoring and improving vaccine efficiency
US20070087338A1 (en) * 2005-10-17 2007-04-19 Rangarajan Sampath Compositions for use in identification of influenza viruses
US20070092524A1 (en) * 2005-10-21 2007-04-26 Jacob Nusbacher Method for the treatment and prophylaxis of avian influenza infection
CN101379397A (zh) * 2006-01-26 2009-03-04 Hx诊断公司 H5亚型禽流感病毒血凝素蛋白的单克隆抗体或其结合活性片段及其用途
WO2007129984A1 (en) * 2006-05-05 2007-11-15 Temasek Life Sciences Laboratory Limited Biomolecule surface display and uses thereof
US7728110B2 (en) 2006-05-19 2010-06-01 Amgen, Inc. Antibodies to SARS coronavirus
JP5597128B2 (ja) * 2007-05-11 2014-10-01 テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド Ｈ５トリインフルエンザの診断および監視に有用なｈ５亜型特異的結合タンパク質
US8383121B2 (en) * 2007-09-13 2013-02-26 Temasek Life Sciences Laboratory Limited Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus H5-subtype or N1-subtype and uses thereof
JP5490695B2 (ja) * 2007-09-13 2014-05-14 テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド インフルエンザウイルスｈ５亜型からのヘマグルチニンに特異的なモノクローナル抗体およびそれらの使用
JP5490725B2 (ja) * 2008-02-05 2014-05-14 テマセック・ライフ・サイエンシズ・ラボラトリー・リミテッド Ｈ５亜型インフルエンザウイルスの普遍的な検出のための結合タンパク質およびエピトープブロッキングｅｌｉｓａ
AU2008365616A1 (en) * 2008-12-24 2011-08-11 Temasek Life Sciences Laboratory Limited Monoclonal antibodies specific to the fusion peptide from hemagglutinin from influenza A viruses and uses thereof

Also Published As

Publication number Publication date
US8637644B2 (en) 2014-01-28
WO2008140415A9 (en) 2009-01-15
EP2363415B1 (en) 2013-07-31
US8637645B2 (en) 2014-01-28
US20130004944A1 (en) 2013-01-03
CN101687921A (zh) 2010-03-31
EP2155787A1 (en) 2010-02-24
US20130004943A1 (en) 2013-01-03
KR20100049506A (ko) 2010-05-12
AU2007353481A1 (en) 2008-11-20
KR101421460B1 (ko) 2014-07-30
EP2363415A3 (en) 2011-12-14
JP5597128B2 (ja) 2014-10-01
WO2008140415A1 (en) 2008-11-20
HK1161725A1 (en) 2012-08-03
EP2363415A2 (en) 2011-09-07
EP2155787A4 (en) 2010-06-16
CA2687147A1 (en) 2008-11-20
US20110003278A1 (en) 2011-01-06
US8540994B2 (en) 2013-09-24
AU2007353481B2 (en) 2013-08-29
JP2010526880A (ja) 2010-08-05

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