JP5584865B2 - 抗ウイルス薬のための前駆体分子としての新規なヌクレオチド類似体 - Google Patents

抗ウイルス薬のための前駆体分子としての新規なヌクレオチド類似体 Download PDF

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Publication number
JP5584865B2
JP5584865B2 JP2009535833A JP2009535833A JP5584865B2 JP 5584865 B2 JP5584865 B2 JP 5584865B2 JP 2009535833 A JP2009535833 A JP 2009535833A JP 2009535833 A JP2009535833 A JP 2009535833A JP 5584865 B2 JP5584865 B2 JP 5584865B2
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Japan
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group
alkyl
alkali metal
compound
compounds
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JP2009535833A
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English (en)
Japanese (ja)
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JP2010510965A (ja
JP2010510965A5 (https=
Inventor
カナール、ブルーノ
アルバレス、カリーヌ
バラル、カリーヌ
ロメット、ジャン−ルイ
ネイツ、ヨハン
バルザリーニ、ヤン
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Katholieke Universiteit Leuven
Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
Original Assignee
Katholieke Universiteit Leuven
Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009535833A 2006-11-08 2007-11-08 抗ウイルス薬のための前駆体分子としての新規なヌクレオチド類似体 Expired - Fee Related JP5584865B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0609749A FR2908133B1 (fr) 2006-11-08 2006-11-08 Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
FR06/09749 2006-11-08
PCT/IB2007/004233 WO2008056264A2 (en) 2006-11-08 2007-11-08 Novel nucleotide analogues as percursor molecules for antivirals

Publications (3)

Publication Number Publication Date
JP2010510965A JP2010510965A (ja) 2010-04-08
JP2010510965A5 JP2010510965A5 (https=) 2010-09-09
JP5584865B2 true JP5584865B2 (ja) 2014-09-10

Family

ID=38018742

Family Applications (1)

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JP2009535833A Expired - Fee Related JP5584865B2 (ja) 2006-11-08 2007-11-08 抗ウイルス薬のための前駆体分子としての新規なヌクレオチド類似体

Country Status (6)

Country Link
US (1) US8884011B2 (https=)
EP (1) EP2086990A2 (https=)
JP (1) JP5584865B2 (https=)
CA (1) CA2669450C (https=)
FR (1) FR2908133B1 (https=)
WO (1) WO2008056264A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2559788B1 (en) * 2010-04-16 2015-10-14 National University Corporation Okayama University Method for directly producing phosphine derivative from phosphine oxide derivative
ES2874774T3 (es) 2011-12-22 2021-11-05 Geron Corp Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
CN104710424B (zh) * 2013-12-11 2017-03-01 河南师范大学 (r)‑(+)‑9‑(2‑羟丙基)腺嘌呤的制备方法
CN104725423A (zh) * 2013-12-18 2015-06-24 山东新时代药业有限公司 一种富马酸替诺福韦二吡呋酯的合成方法
CN105541910A (zh) * 2015-12-21 2016-05-04 山东金城医药化工股份有限公司 对甲苯磺酰氧甲基膦酸二乙酯的合成方法
CN107021985A (zh) * 2017-05-08 2017-08-08 四川理工学院 药物中间体r‑9‑[2‑(二乙氧基膦酰甲氧基)丙基]腺嘌呤的合成方法
WO2019120084A1 (zh) * 2017-12-21 2019-06-27 深圳市塔吉瑞生物医药有限公司 用于抗病毒的核苷类逆转录酶抑制剂
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
US4935427A (en) * 1987-12-31 1990-06-19 The United States Of America As Represented By The Department Of Health And Human Services Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents
US5072032A (en) * 1989-06-21 1991-12-10 Mckenna Charles E Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid
EP0481214B1 (en) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
CZ287745B6 (cs) 1991-10-11 2001-01-17 Ústav organické chemie a biochemie AV ČR Acyklické fosfonomethoxyalkylsubstituované alkenylové a alkinylové deriváty purinu a pyrimidinu
WO2003002580A1 (en) * 2001-06-29 2003-01-09 Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity
CN1523028A (zh) * 2003-02-18 2004-08-25 田镇华 一种新型的膦酸酯－核苷酸化合物
DE602004031115D1 (de) * 2003-06-16 2011-03-03 Acad Of Science Czech Republic Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
CN1634943A (zh) * 2004-11-05 2005-07-06 中国医学科学院医药生物技术研究所 一组非环核苷酸类似物及其合成方法和在抗病毒中的应用
WO2006114064A2 (en) * 2005-04-25 2006-11-02 Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic Use of compounds to enhance processivity of telomerase
CN100396689C (zh) * 2006-03-07 2008-06-25 中国医学科学院医药生物技术研究所 一组具有抑制hiv-1/hbv病毒复制活性的替诺福韦单酯化合物

Also Published As

Publication number Publication date
US8884011B2 (en) 2014-11-11
CA2669450A1 (en) 2008-05-15
EP2086990A2 (en) 2009-08-12
WO2008056264A3 (en) 2008-10-30
US20100099869A1 (en) 2010-04-22
JP2010510965A (ja) 2010-04-08
FR2908133B1 (fr) 2012-12-14
FR2908133A1 (fr) 2008-05-09
WO2008056264A2 (en) 2008-05-15
CA2669450C (en) 2016-02-09

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