CA2669450C - Novel nucleotide analogues as percursor molecules for antivirals - Google Patents

Novel nucleotide analogues as percursor molecules for antivirals Download PDF

Info

Publication number
CA2669450C
CA2669450C CA2669450A CA2669450A CA2669450C CA 2669450 C CA2669450 C CA 2669450C CA 2669450 A CA2669450 A CA 2669450A CA 2669450 A CA2669450 A CA 2669450A CA 2669450 C CA2669450 C CA 2669450C
Authority
CA
Canada
Prior art keywords
group
compound
pharmaceutically acceptable
acceptable salt
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2669450A
Other languages
English (en)
French (fr)
Other versions
CA2669450A1 (en
Inventor
Bruno Canard
Karine Alvarez
Karine Barral
Jean-Louis Romette
Johan Neyts
Jan Balzarini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Katholieke Universiteit Leuven
Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
Original Assignee
Katholieke Universiteit Leuven
Aix Marseille Universite
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Katholieke Universiteit Leuven, Aix Marseille Universite, Centre National de la Recherche Scientifique CNRS filed Critical Katholieke Universiteit Leuven
Publication of CA2669450A1 publication Critical patent/CA2669450A1/en
Application granted granted Critical
Publication of CA2669450C publication Critical patent/CA2669450C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2669450A 2006-11-08 2007-11-08 Novel nucleotide analogues as percursor molecules for antivirals Expired - Fee Related CA2669450C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0609749A FR2908133B1 (fr) 2006-11-08 2006-11-08 Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
FR06/09749 2006-11-08
PCT/IB2007/004233 WO2008056264A2 (en) 2006-11-08 2007-11-08 Novel nucleotide analogues as percursor molecules for antivirals

Publications (2)

Publication Number Publication Date
CA2669450A1 CA2669450A1 (en) 2008-05-15
CA2669450C true CA2669450C (en) 2016-02-09

Family

ID=38018742

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2669450A Expired - Fee Related CA2669450C (en) 2006-11-08 2007-11-08 Novel nucleotide analogues as percursor molecules for antivirals

Country Status (6)

Country Link
US (1) US8884011B2 (https=)
EP (1) EP2086990A2 (https=)
JP (1) JP5584865B2 (https=)
CA (1) CA2669450C (https=)
FR (1) FR2908133B1 (https=)
WO (1) WO2008056264A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2559788B1 (en) * 2010-04-16 2015-10-14 National University Corporation Okayama University Method for directly producing phosphine derivative from phosphine oxide derivative
ES2874774T3 (es) 2011-12-22 2021-11-05 Geron Corp Análogos de guanina como sustratos de telomerasa y afectores de la longitud de los telómeros
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
CN104710424B (zh) * 2013-12-11 2017-03-01 河南师范大学 (r)‑(+)‑9‑(2‑羟丙基)腺嘌呤的制备方法
CN104725423A (zh) * 2013-12-18 2015-06-24 山东新时代药业有限公司 一种富马酸替诺福韦二吡呋酯的合成方法
CN105541910A (zh) * 2015-12-21 2016-05-04 山东金城医药化工股份有限公司 对甲苯磺酰氧甲基膦酸二乙酯的合成方法
CN107021985A (zh) * 2017-05-08 2017-08-08 四川理工学院 药物中间体r‑9‑[2‑(二乙氧基膦酰甲氧基)丙基]腺嘌呤的合成方法
WO2019120084A1 (zh) * 2017-12-21 2019-06-27 深圳市塔吉瑞生物医药有限公司 用于抗病毒的核苷类逆转录酶抑制剂
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
US4935427A (en) * 1987-12-31 1990-06-19 The United States Of America As Represented By The Department Of Health And Human Services Pyrimidine and purine 1,2-butadiene-4-ols as anti-retroviral agents
US5072032A (en) * 1989-06-21 1991-12-10 Mckenna Charles E Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid
EP0481214B1 (en) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
CZ287745B6 (cs) 1991-10-11 2001-01-17 Ústav organické chemie a biochemie AV ČR Acyklické fosfonomethoxyalkylsubstituované alkenylové a alkinylové deriváty purinu a pyrimidinu
WO2003002580A1 (en) * 2001-06-29 2003-01-09 Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic 6-`2-(phosphonomethoxy)alkoxy pyrimidine derivatives having antiviral activity
CN1523028A (zh) * 2003-02-18 2004-08-25 田镇华 一种新型的膦酸酯－核苷酸化合物
DE602004031115D1 (de) * 2003-06-16 2011-03-03 Acad Of Science Czech Republic Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
CN1634943A (zh) * 2004-11-05 2005-07-06 中国医学科学院医药生物技术研究所 一组非环核苷酸类似物及其合成方法和在抗病毒中的应用
WO2006114064A2 (en) * 2005-04-25 2006-11-02 Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic Use of compounds to enhance processivity of telomerase
CN100396689C (zh) * 2006-03-07 2008-06-25 中国医学科学院医药生物技术研究所 一组具有抑制hiv-1/hbv病毒复制活性的替诺福韦单酯化合物

Also Published As

Publication number Publication date
US8884011B2 (en) 2014-11-11
CA2669450A1 (en) 2008-05-15
EP2086990A2 (en) 2009-08-12
WO2008056264A3 (en) 2008-10-30
US20100099869A1 (en) 2010-04-22
JP2010510965A (ja) 2010-04-08
FR2908133B1 (fr) 2012-12-14
FR2908133A1 (fr) 2008-05-09
JP5584865B2 (ja) 2014-09-10
WO2008056264A2 (en) 2008-05-15

Similar Documents

Publication Publication Date Title
JP7786743B2 (ja) ４’－ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用
US20260053838A1 (en) Pharmaceutical compositions comprising substituted nucleotides and nucleosides for treating viral infections
CA2669450C (en) Novel nucleotide analogues as percursor molecules for antivirals
AU2022283772A1 (en) Methods for treating Filoviridae virus infections
RU2640582C2 (ru) Производные витамина в6 нуклеотидов, ациклических нуклеотидов и ациклических нуклеозидных фосфонатов
CA2550222C (en) Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases
CN111808136B (zh) 核苷酸类似物
WO2014124430A1 (en) Nucleotide and nucleoside therapeutic compositions and uses related thereto
US20100298256A1 (en) Antiviral compounds
CA2807584A1 (en) 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment
EP3539546A1 (en) Phosphonate analogs of hiv inhibitor compounds
MX2013000744A (es) Metodos y compuestos para tratar infecciones virales por paramyxoviridae.
JP2026027247A (ja) ４’－ハロゲン含有ヌクレオチドおよびヌクレオシド治療組成物ならびにそれらに関連する使用
WO2017106710A1 (en) Nucleotide and nucleoside therapeutic compositions and uses related thereto
US11192914B2 (en) Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
JP4545434B2 (ja) 抗ウイルス活性を有する６−‘２−（ホスホノメトキシ）アルコキシピリミジン誘導体
US10167302B2 (en) Phosphonate nucleosides useful in the treatment of viral diseases
Barral et al. Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication
WO2007059330A2 (en) Cubane nucleoside analogs

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20171108