JP5575114B2 - シュウ酸エスシタロプラムを含む粒状物 - Google Patents
シュウ酸エスシタロプラムを含む粒状物 Download PDFInfo
- Publication number
- JP5575114B2 JP5575114B2 JP2011507826A JP2011507826A JP5575114B2 JP 5575114 B2 JP5575114 B2 JP 5575114B2 JP 2011507826 A JP2011507826 A JP 2011507826A JP 2011507826 A JP2011507826 A JP 2011507826A JP 5575114 B2 JP5575114 B2 JP 5575114B2
- Authority
- JP
- Japan
- Prior art keywords
- granular material
- filler
- escitalopram
- mass
- escitalopram oxalate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Description
ことが判明した。
Claims (10)
- 100μm未満の平均粒径を有するシュウ酸エスシタロプラム粒子と、少なくとも1種の充填剤とを含む粒状物であって、
前記充填剤は、前記充填剤の全質量に対して少なくとも50質量%のラクトースを含み、セルロースを含まないことを特徴とする粒状物。 - 少なくとも1種のバインダーをさらに含むことを特徴とする、請求項1に記載の粒状物。
- 100μm未満の平均粒径を有するシュウ酸エスシタロプラム粒子を少なくとも1種の充填剤と共に造粒する、粒状物の製造方法であって、
前記充填剤は、前記充填剤の全質量に対して少なくとも50質量%のラクトースを含み、セルロースを含まないことを特徴とする粒状物の製造方法。 - シュウ酸エスシタロプラム粒子を少なくとも1種の充填剤と共に湿式造粒する、請求項3に記載の粒状物の製造方法。
- シュウ酸エスシタロプラム粒子を少なくとも1種の充填剤及び少なくとも1種のバインダーと共に湿式造粒する、請求項4に記載の粒状物の製造方法。
- 請求項3〜5のいずれか1項に記載の方法によって製造される粒状物。
- 請求項1、2及び6のいずれか1項に記載の粒状物を含むことを特徴とする錠剤。
- 請求項1、2及び6のいずれか1項に記載の粒状物を圧縮することによって得られる錠剤。
- 請求項1、2及び6のいずれか1項に記載の粒状物を含むことを特徴とするカプセル。
- カプセルのシェル内に請求項1、2及び6のいずれか1項に記載の粒状物を充填することによって得られるカプセル。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08008614A EP2116231A1 (en) | 2008-05-07 | 2008-05-07 | Granulate comprising escitalopram oxalate |
EP08008614.3 | 2008-05-07 | ||
PCT/EP2009/003214 WO2009135649A1 (en) | 2008-05-07 | 2009-05-05 | Granulate comprising escitalopram oxalate |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011520798A JP2011520798A (ja) | 2011-07-21 |
JP5575114B2 true JP5575114B2 (ja) | 2014-08-20 |
Family
ID=39731669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011507826A Expired - Fee Related JP5575114B2 (ja) | 2008-05-07 | 2009-05-05 | シュウ酸エスシタロプラムを含む粒状物 |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP2116231A1 (ja) |
JP (1) | JP5575114B2 (ja) |
CN (1) | CN102026626B (ja) |
AU (1) | AU2009243734B2 (ja) |
BR (1) | BRPI0912253A2 (ja) |
CA (1) | CA2722802C (ja) |
EA (1) | EA201001740A1 (ja) |
WO (1) | WO2009135649A1 (ja) |
ZA (1) | ZA201007554B (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20120448A1 (it) | 2012-01-30 | 2013-07-31 | Carthesia Sas | Composizione liofilizzata di escitalopram ossalato per somministrazione sublinguale |
CN104523638B (zh) * | 2014-11-28 | 2020-02-21 | 浙江华海药业股份有限公司 | 含有草酸艾司西酞普兰的片剂及其制备方法 |
WO2018190294A1 (ja) * | 2017-04-10 | 2018-10-18 | 東和薬品株式会社 | エスシタロプラム医薬組成物 |
CN107441053A (zh) * | 2017-06-21 | 2017-12-08 | 山东京卫制药有限公司 | 一种草酸艾司西酞普兰片的制备方法 |
JP7453859B2 (ja) | 2020-06-22 | 2024-03-21 | 東和薬品株式会社 | エスシタロプラム錠剤 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1526331A (en) | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
GB8814057D0 (en) | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
TR200400189T2 (tr) | 2001-07-31 | 2004-12-21 | H.Lundbeck A/S | Esitalopram içeren kristal yapılı bileşim. |
WO2005084643A1 (en) * | 2004-03-05 | 2005-09-15 | H. Lundbeck A/S | Crystalline composition containing escitalopram oxalate |
EP1901714A2 (en) * | 2005-05-20 | 2008-03-26 | Aurobindo Pharma Limited | Pharmaceutical dosage forms comprising escitalopram in form of granules |
CA2672925A1 (en) * | 2006-10-20 | 2008-04-24 | Ratiopharm Gmbh | Escitalopram and solid pharmaceutical composition comprising the same |
-
2008
- 2008-05-07 EP EP08008614A patent/EP2116231A1/en not_active Withdrawn
-
2009
- 2009-05-05 CA CA2722802A patent/CA2722802C/en not_active Expired - Fee Related
- 2009-05-05 EP EP09741868A patent/EP2276466A1/en not_active Withdrawn
- 2009-05-05 WO PCT/EP2009/003214 patent/WO2009135649A1/en active Application Filing
- 2009-05-05 JP JP2011507826A patent/JP5575114B2/ja not_active Expired - Fee Related
- 2009-05-05 CN CN2009801163304A patent/CN102026626B/zh not_active Expired - Fee Related
- 2009-05-05 EA EA201001740A patent/EA201001740A1/ru unknown
- 2009-05-05 BR BRPI0912253A patent/BRPI0912253A2/pt active Search and Examination
- 2009-05-05 AU AU2009243734A patent/AU2009243734B2/en not_active Ceased
-
2010
- 2010-10-22 ZA ZA2010/07554A patent/ZA201007554B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN102026626A (zh) | 2011-04-20 |
ZA201007554B (en) | 2012-01-25 |
EA201001740A1 (ru) | 2011-06-30 |
CA2722802C (en) | 2016-06-07 |
EP2116231A1 (en) | 2009-11-11 |
CN102026626B (zh) | 2013-01-09 |
EP2276466A1 (en) | 2011-01-26 |
WO2009135649A1 (en) | 2009-11-12 |
JP2011520798A (ja) | 2011-07-21 |
CA2722802A1 (en) | 2009-11-12 |
AU2009243734A1 (en) | 2009-11-12 |
AU2009243734B2 (en) | 2014-02-27 |
BRPI0912253A2 (pt) | 2015-10-06 |
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