JP5568471B2 - 抗腫瘍活性を有するａｋｔ／ｐｋｂの阻害剤 - Google Patents
抗腫瘍活性を有するａｋｔ／ｐｋｂの阻害剤 Download PDFInfo
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- JP5568471B2 JP5568471B2 JP2010516297A JP2010516297A JP5568471B2 JP 5568471 B2 JP5568471 B2 JP 5568471B2 JP 2010516297 A JP2010516297 A JP 2010516297A JP 2010516297 A JP2010516297 A JP 2010516297A JP 5568471 B2 JP5568471 B2 JP 5568471B2
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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| EP2173352B1 (en) * | 2007-07-12 | 2016-09-07 | University of South Florida | Inhibitors of akt/pkb with anti-tumor activity |
| JP5856843B2 (ja) | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ，インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
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| WO2012135759A1 (en) | 2011-04-01 | 2012-10-04 | Genentech, Inc. | Combinations of akt inhibitor compounds and abiraterone, and methods of use |
| CN103858007B (zh) * | 2011-04-01 | 2017-03-29 | 基因泰克公司 | 用于预测对癌症治疗的敏感性的生物标记 |
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| US4559157A (en) * | 1983-04-21 | 1985-12-17 | Creative Products Resource Associates, Ltd. | Cosmetic applicator useful for skin moisturizing |
| LU84979A1 (fr) | 1983-08-30 | 1985-04-24 | Oreal | Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux |
| US4820508A (en) | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
| US4992478A (en) | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
| US5167649A (en) | 1988-08-22 | 1992-12-01 | Zook Gerald P | Drug delivery system for the removal of dermal lesions |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| JP4407008B2 (ja) * | 2000-05-11 | 2010-02-03 | パナソニック株式会社 | カラー画像形成装置 |
| UA72612C2 (en) | 2000-07-06 | 2005-03-15 | Pyrido[2.3-d]pyrimidine and pyrimido[4.5-d]pyrimidine nucleoside analogues, prodrugs and method for inhibiting growth of neoplastic cells | |
| MXPA04010983A (es) * | 2002-05-06 | 2005-02-14 | Genelabs Tech Inc | Derivados de nucleosidos para tratar infecciones por el virus de la hepatitis c. |
| US8435959B2 (en) * | 2004-03-29 | 2013-05-07 | University Of South Florida | Effective treatment of tumors and cancer with triciribine and related compounds |
| WO2008094321A2 (en) * | 2006-10-04 | 2008-08-07 | Universtiy Of South Florida | Akt sensitization of cancer cells |
| EP2173352B1 (en) | 2007-07-12 | 2016-09-07 | University of South Florida | Inhibitors of akt/pkb with anti-tumor activity |
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| EP2173352A2 (en) | 2010-04-14 |
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| WO2009009793A2 (en) | 2009-01-15 |
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| US9359347B2 (en) | 2016-06-07 |
| CA2695330C (en) | 2017-06-13 |
| AU2008274956A1 (en) | 2009-01-15 |
| CN101743007A (zh) | 2010-06-16 |
| MX2010000474A (es) | 2010-06-23 |
| KR20100066438A (ko) | 2010-06-17 |
| US20090028855A1 (en) | 2009-01-29 |
| KR101618037B1 (ko) | 2016-05-04 |
| CN101743007B (zh) | 2015-04-08 |
| CA2695330A1 (en) | 2009-01-15 |
| EP2173352B1 (en) | 2016-09-07 |
| US8183249B2 (en) | 2012-05-22 |
| WO2009009793A3 (en) | 2009-03-26 |
| EP2173352A4 (en) | 2011-07-27 |
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