JP5566565B2 - (−)−δ9−トランス−テトラヒドロカンナビノールの精製方法 - Google Patents

(−)−δ9−トランス−テトラヒドロカンナビノールの精製方法 Download PDF

Info

Publication number
JP5566565B2
JP5566565B2 JP2006546314A JP2006546314A JP5566565B2 JP 5566565 B2 JP5566565 B2 JP 5566565B2 JP 2006546314 A JP2006546314 A JP 2006546314A JP 2006546314 A JP2006546314 A JP 2006546314A JP 5566565 B2 JP5566565 B2 JP 5566565B2
Authority
JP
Japan
Prior art keywords
stationary phase
trans
tetrahydrocannabinol
mixture
carbon dioxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2006546314A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007516271A5 (https=
JP2007516271A (ja
Inventor
フィオナ、オブロック、ガイザー
ジョン、ジェイムズ、キーナン
ロナルド、ロッシ
アルバート、サンチェス
ジョン、マイケル、ウェラン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson Matthey PLC
Original Assignee
Johnson Matthey PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson Matthey PLC filed Critical Johnson Matthey PLC
Publication of JP2007516271A publication Critical patent/JP2007516271A/ja
Publication of JP2007516271A5 publication Critical patent/JP2007516271A5/ja
Application granted granted Critical
Publication of JP5566565B2 publication Critical patent/JP5566565B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2006546314A 2003-12-23 2004-12-17 (−)−δ9−トランス−テトラヒドロカンナビノールの精製方法 Expired - Lifetime JP5566565B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0329635.7 2003-12-23
GBGB0329635.7A GB0329635D0 (en) 2003-12-23 2003-12-23 Process for purifying trans-tetrahydrocannabinol
PCT/GB2004/005394 WO2005061480A1 (en) 2003-12-23 2004-12-17 Process for purifying (-)-δ9-trans-tetrahydrocannabinol

Publications (3)

Publication Number Publication Date
JP2007516271A JP2007516271A (ja) 2007-06-21
JP2007516271A5 JP2007516271A5 (https=) 2014-01-23
JP5566565B2 true JP5566565B2 (ja) 2014-08-06

Family

ID=30776243

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006546314A Expired - Lifetime JP5566565B2 (ja) 2003-12-23 2004-12-17 (−)−δ9−トランス−テトラヒドロカンナビノールの精製方法

Country Status (13)

Country Link
US (1) US7449589B2 (https=)
EP (1) EP1697340B1 (https=)
JP (1) JP5566565B2 (https=)
CN (1) CN100482657C (https=)
AT (1) ATE412644T1 (https=)
AU (1) AU2004303593B2 (https=)
CA (1) CA2549399C (https=)
DE (1) DE602004017506D1 (https=)
DK (1) DK1697340T3 (https=)
ES (1) ES2313118T3 (https=)
GB (1) GB0329635D0 (https=)
IL (1) IL176197A (https=)
WO (1) WO2005061480A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI436991B (zh) * 2004-11-22 2014-05-11 歐 賽提克股份有限公司 用於純化反-(-)-△9-四氫大麻酚與反-(+)-△9-四氫大麻酚之方法
TWI366460B (en) * 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
US8980940B2 (en) 2006-11-10 2015-03-17 Johnson Matthey Public Limited Company Stable cannabinoid compositions and methods for making and storing them
US8039509B2 (en) 2006-11-10 2011-10-18 Johnson Matthey Public Limited Company Composition comprising (−)-Δ9-trans-tetrahydrocannabinol
JP6087147B2 (ja) * 2009-06-22 2017-03-01 ジョンソン、マッセイ、パブリック、リミテッド、カンパニーJohnson Matthey Public Limited Company プロスタグランジンの精製方法
WO2012071389A2 (en) 2010-11-22 2012-05-31 Johnson Matthey Public Limited Company Stable cannabinoid compositions and methods for making and storing them
EP3261629A4 (en) * 2015-02-27 2018-12-05 Ebbu, LLC Compositions comprising combinations of purified cannabinoids, with at least one flavonoid, terpene, or mineral
BR112017018316A2 (pt) 2015-02-27 2018-04-17 Ebbu Llc composições compreendendo combinações de canabinoides purificados, com pelo menos um flavonoide, terpeno ou mineral
DK3455213T3 (da) 2016-05-13 2022-03-07 Symrise Ag Fremgangsmåde til at oprense cannabinoid-forbindelser via simulated moving bed-kromatografi
US12485129B2 (en) 2016-08-29 2025-12-02 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids
WO2018044953A1 (en) 2016-08-29 2018-03-08 Ebbu, LLC Water soluble compositions comprising purified cannabinoids
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
US11299470B2 (en) 2017-08-07 2022-04-12 Massachusetts Institute Of Technology Systems and methods for separating cannabis-derived compounds using chromatography with liquid or supercritical carbon dioxide
US10307392B2 (en) 2017-10-21 2019-06-04 Alexander Kariman Compound and method for treatment of diseases and disorders
EP3745884A1 (en) 2018-01-31 2020-12-09 Canopy Holdings, Llc Hemp powder
US10751380B2 (en) 2018-03-08 2020-08-25 Alexander Kariman Compound and method for treating spasms, inflammation and pain
US11324718B2 (en) 2018-10-09 2022-05-10 Sartorius Chromatography Equipment Method for purifying cannabinoids
CA3119729A1 (en) 2018-10-10 2020-04-16 Treehouse Biotech, Inc. Synthesis of cannabigerol
CN111848356A (zh) * 2019-04-30 2020-10-30 黑龙江阳光工业大麻研究院 一种大麻二酚的制备方法
EP4337356A1 (en) * 2021-05-13 2024-03-20 Grow Group Plc Method for selective recovery of lipophilic compounds
CN114814009B (zh) * 2022-04-07 2024-06-07 国家烟草质量监督检验中心 一种同时适用于新型烟草产品中酚类化合物及尿液中酚类化合物的代谢物的分析方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403126B1 (en) 1999-05-26 2002-06-11 Websar Innovations Inc. Cannabinoid extraction method
US20030050334A1 (en) 2001-04-30 2003-03-13 Murty Ram B. Process for extraction of Delta-9-Tetrahydrocannabinol and other related cannabinoids and preparation of specific strength marijuana cigarettes
GB0112752D0 (en) 2001-05-25 2001-07-18 Johnson Matthey Plc Synthesis of cannabinoids

Also Published As

Publication number Publication date
WO2005061480A1 (en) 2005-07-07
CN1898230A (zh) 2007-01-17
AU2004303593B2 (en) 2010-12-23
IL176197A0 (en) 2006-10-05
ATE412644T1 (de) 2008-11-15
IL176197A (en) 2011-04-28
CA2549399C (en) 2012-12-04
EP1697340B1 (en) 2008-10-29
GB0329635D0 (en) 2004-01-28
DE602004017506D1 (de) 2008-12-11
ES2313118T3 (es) 2009-03-01
EP1697340A1 (en) 2006-09-06
CN100482657C (zh) 2009-04-29
DK1697340T3 (da) 2009-03-02
CA2549399A1 (en) 2005-07-07
AU2004303593A1 (en) 2005-07-07
US20070276031A1 (en) 2007-11-29
US7449589B2 (en) 2008-11-11
JP2007516271A (ja) 2007-06-21

Similar Documents

Publication Publication Date Title
JP5566565B2 (ja) (−)−δ9−トランス−テトラヒドロカンナビノールの精製方法
DK2356987T3 (en) A method for purifying trans - (-) - Delta9 -tetrahydrocannabinol and trans - (+) - Delta9 -tetrahydrocannabinol
JP7408045B2 (ja) 非向精神性カンナビノイドを含有する包接物及びその調製方法
JP2007516271A5 (https=)
US20060074254A1 (en) Process for extracting taxanes
US20230295067A1 (en) Methods for obtaining compounds from a plant or fungus material, respective compositions, and uses thereof
CN100371709C (zh) 一种用液相色谱法分离测定匹伐他汀及其光学异构体的方法
US20220127213A1 (en) Method for selective separation, isolation and recovery of cannabidiol and cannabidiol-like meroterpene acids from complex matrices
US20060020022A1 (en) Enantioselective separation method
KR101067314B1 (ko) 3,5-디하이드록시-6-헵테노에이트 제조 방법
JP2000302797A (ja) アクテオシドの抽出法
MXPA06007277A (en) PROCESS FOR PURIFYING (-)-Delta9
BRPI0903275B1 (pt) Processo de extração e purificação de artemisinina a partir de massa sólida de artemisia annua utilizando dióxido de carbono
Lienne et al. Optimization of the direct chiral separation of potential cytotoxic α-methylene-γ-butyrolactones and α-methylene-γ-butyrolactams by liquid chromatography
EP4431169A1 (en) Method of purifying cannabinoid components from plant extracts
JP3634929B2 (ja) 高速液体クロマトグラフィー用充填剤の製造法
CN113004125A (zh) 一种高纯cbd大麻二酚的纯化制备方法
JP2578421B2 (ja) 脂溶性化合物の抽出分画法およびその装置
FR2926547A1 (fr) 5-[1-(decahydro-7-hydroxy-1,1,3a,7-tetramethyl-1h- cyclopropa[a]naphtalen-4-yl)-3-methylbutyl]-2,4,6-trihydroxy -1,3-benzenedicarboxaldehyde en tant que medicaments.
CN119285516A (zh) 一种马沙骨化醇的纯化方法
JP2009519938A (ja) (r)−トフィソパムを単離する方法
JP2005515060A (ja) 非水溶媒を用いた不純物を含む材料の精製
WO2015004686A2 (en) A process for purification of efavirenz and intermediates thereof using chromatographic methods
HK1146695A (en) 5-[1'-(decahydro-7-hydroxy-1,1,3a,7-tetramet-1h-cyclopropa[a]naphtalen-4-yl)-3'-methylbutyl]-2,4,6-trihydroxy-1,3-benzenedicarboxaldehyde used as drugs

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071112

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110218

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110518

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110525

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110620

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110627

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110719

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20111028

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20130813

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20130902

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20130905

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20131128

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140428

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20140618

R150 Certificate of patent or registration of utility model

Ref document number: 5566565

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: R3D02

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term