CN100482657C - (-)-△9-反-四氢大麻酚的纯化方法 - Google Patents

(-)-△9-反-四氢大麻酚的纯化方法 Download PDF

Info

Publication number
CN100482657C
CN100482657C CNB2004800382570A CN200480038257A CN100482657C CN 100482657 C CN100482657 C CN 100482657C CN B2004800382570 A CNB2004800382570 A CN B2004800382570A CN 200480038257 A CN200480038257 A CN 200480038257A CN 100482657 C CN100482657 C CN 100482657C
Authority
CN
China
Prior art keywords
stationary phase
thc
carbon dioxide
mobile phase
phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004800382570A
Other languages
English (en)
Chinese (zh)
Other versions
CN1898230A (zh
Inventor
F·O·盖泽尔
J·J·基南
R·罗西
A·桑切斯
J·M·惠兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Johnson Matthey PLC
Original Assignee
Johnson Matthey PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson Matthey PLC filed Critical Johnson Matthey PLC
Publication of CN1898230A publication Critical patent/CN1898230A/zh
Application granted granted Critical
Publication of CN100482657C publication Critical patent/CN100482657C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB2004800382570A 2003-12-23 2004-12-17 (-)-△9-反-四氢大麻酚的纯化方法 Expired - Fee Related CN100482657C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0329635.7 2003-12-23
GBGB0329635.7A GB0329635D0 (en) 2003-12-23 2003-12-23 Process for purifying trans-tetrahydrocannabinol

Publications (2)

Publication Number Publication Date
CN1898230A CN1898230A (zh) 2007-01-17
CN100482657C true CN100482657C (zh) 2009-04-29

Family

ID=30776243

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800382570A Expired - Fee Related CN100482657C (zh) 2003-12-23 2004-12-17 (-)-△9-反-四氢大麻酚的纯化方法

Country Status (13)

Country Link
US (1) US7449589B2 (https=)
EP (1) EP1697340B1 (https=)
JP (1) JP5566565B2 (https=)
CN (1) CN100482657C (https=)
AT (1) ATE412644T1 (https=)
AU (1) AU2004303593B2 (https=)
CA (1) CA2549399C (https=)
DE (1) DE602004017506D1 (https=)
DK (1) DK1697340T3 (https=)
ES (1) ES2313118T3 (https=)
GB (1) GB0329635D0 (https=)
IL (1) IL176197A (https=)
WO (1) WO2005061480A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107405314A (zh) * 2015-02-27 2017-11-28 埃布公司 包含纯化的大麻素与至少一种类黄酮、萜或矿物质的组合的组合物
US10722490B2 (en) 2016-08-29 2020-07-28 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids
US10821147B2 (en) 2015-02-27 2020-11-03 Canopy Growth Corporation Printable cannabinoid and terpene compositions
US12485129B2 (en) 2016-08-29 2025-12-02 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI436991B (zh) * 2004-11-22 2014-05-11 歐 賽提克股份有限公司 用於純化反-（-）-△９-四氫大麻酚與反-（＋）-△９-四氫大麻酚之方法
TWI366460B (en) * 2005-06-16 2012-06-21 Euro Celtique Sa Cannabinoid active pharmaceutical ingredient for improved dosage forms
US8980940B2 (en) 2006-11-10 2015-03-17 Johnson Matthey Public Limited Company Stable cannabinoid compositions and methods for making and storing them
US8039509B2 (en) 2006-11-10 2011-10-18 Johnson Matthey Public Limited Company Composition comprising (−)-Δ9-trans-tetrahydrocannabinol
JP6087147B2 (ja) * 2009-06-22 2017-03-01 ジョンソン、マッセイ、パブリック、リミテッド、カンパニーＪｏｈｎｓｏｎ Ｍａｔｔｈｅｙ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ プロスタグランジンの精製方法
WO2012071389A2 (en) 2010-11-22 2012-05-31 Johnson Matthey Public Limited Company Stable cannabinoid compositions and methods for making and storing them
DK3455213T3 (da) 2016-05-13 2022-03-07 Symrise Ag Fremgangsmåde til at oprense cannabinoid-forbindelser via simulated moving bed-kromatografi
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
US11299470B2 (en) 2017-08-07 2022-04-12 Massachusetts Institute Of Technology Systems and methods for separating cannabis-derived compounds using chromatography with liquid or supercritical carbon dioxide
US10307392B2 (en) 2017-10-21 2019-06-04 Alexander Kariman Compound and method for treatment of diseases and disorders
EP3745884A1 (en) 2018-01-31 2020-12-09 Canopy Holdings, Llc Hemp powder
US10751380B2 (en) 2018-03-08 2020-08-25 Alexander Kariman Compound and method for treating spasms, inflammation and pain
US11324718B2 (en) 2018-10-09 2022-05-10 Sartorius Chromatography Equipment Method for purifying cannabinoids
CA3119729A1 (en) 2018-10-10 2020-04-16 Treehouse Biotech, Inc. Synthesis of cannabigerol
CN111848356A (zh) * 2019-04-30 2020-10-30 黑龙江阳光工业大麻研究院 一种大麻二酚的制备方法
EP4337356A1 (en) * 2021-05-13 2024-03-20 Grow Group Plc Method for selective recovery of lipophilic compounds
CN114814009B (zh) * 2022-04-07 2024-06-07 国家烟草质量监督检验中心 一种同时适用于新型烟草产品中酚类化合物及尿液中酚类化合物的代谢物的分析方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403126B1 (en) 1999-05-26 2002-06-11 Websar Innovations Inc. Cannabinoid extraction method
US20030050334A1 (en) 2001-04-30 2003-03-13 Murty Ram B. Process for extraction of Delta-9-Tetrahydrocannabinol and other related cannabinoids and preparation of specific strength marijuana cigarettes
GB0112752D0 (en) 2001-05-25 2001-07-18 Johnson Matthey Plc Synthesis of cannabinoids

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107405314A (zh) * 2015-02-27 2017-11-28 埃布公司 包含纯化的大麻素与至少一种类黄酮、萜或矿物质的组合的组合物
US10821147B2 (en) 2015-02-27 2020-11-03 Canopy Growth Corporation Printable cannabinoid and terpene compositions
US10722490B2 (en) 2016-08-29 2020-07-28 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids
US10842773B2 (en) 2016-08-29 2020-11-24 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids
US11510897B2 (en) 2016-08-29 2022-11-29 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids
US12285405B2 (en) 2016-08-29 2025-04-29 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids
US12324801B2 (en) 2016-08-29 2025-06-10 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids
US12485129B2 (en) 2016-08-29 2025-12-02 Canopy Growth Corporation Water soluble compositions comprising purified cannabinoids

Also Published As

Publication number Publication date
WO2005061480A1 (en) 2005-07-07
JP5566565B2 (ja) 2014-08-06
CN1898230A (zh) 2007-01-17
AU2004303593B2 (en) 2010-12-23
IL176197A0 (en) 2006-10-05
ATE412644T1 (de) 2008-11-15
IL176197A (en) 2011-04-28
CA2549399C (en) 2012-12-04
EP1697340B1 (en) 2008-10-29
GB0329635D0 (en) 2004-01-28
DE602004017506D1 (de) 2008-12-11
ES2313118T3 (es) 2009-03-01
EP1697340A1 (en) 2006-09-06
DK1697340T3 (da) 2009-03-02
CA2549399A1 (en) 2005-07-07
AU2004303593A1 (en) 2005-07-07
US20070276031A1 (en) 2007-11-29
US7449589B2 (en) 2008-11-11
JP2007516271A (ja) 2007-06-21

Similar Documents

Publication Publication Date Title
CN100482657C (zh) (-)-△9-反-四氢大麻酚的纯化方法
DK2356987T3 (en) A method for purifying trans - (-) - Delta9 -tetrahydrocannabinol and trans - (+) - Delta9 -tetrahydrocannabinol
US11027218B2 (en) Purification and separation techniques for cannabinoids
EP0578723B1 (en) PROCESS FOR PURIFICATION OF HMG-CoA REDUCTASE INHIBITORS
CA2521829A1 (en) Process for extracting taxanes
JP2007516271A5 (https=)
AU760242B2 (en) Method for high yield extraction of paclitaxel from paclitaxel-containing material
JP2022531510A (ja) 非向精神性カンナビノイドを含有する包接物及びその調製方法
CA3092460C (en) ANALYTE SEPARATION POLYMER AND METHODS FOR PREPARING AND USING THIS POLYMER
CN102558103B (zh) 一种分离和纯化奥利司他的方法
US20220127213A1 (en) Method for selective separation, isolation and recovery of cannabidiol and cannabidiol-like meroterpene acids from complex matrices
MX2007000880A (es) Metodo enantioselectivo para separar derivados de acido 3-trifluorometil-2h-cromeno-3-carboxilico sustituido.
JP2000302797A (ja) アクテオシドの抽出法
MXPA06007277A (en) PROCESS FOR PURIFYING (-)-Delta9
BRPI0903275B1 (pt) Processo de extração e purificação de artemisinina a partir de massa sólida de artemisia annua utilizando dióxido de carbono
CN113831313A (zh) 一种高纯度香豆素衍生物的制备方法及其应用
US20080214661A1 (en) Process To Obtain Dibenzylbutyrolactonic, Tetrahydrofuranic Lignans And Their Synthetic And Semi-Synthetic Derivatives, Their Analgesic And Anti-Inflammatory Activities, Topical And/Or Systemic Formulations Containing Said Lignans And Their Respective Therapeutic Method
JP2000053668A (ja) タキサン化合物含有成分の精製方法
CN119285516A (zh) 一种马沙骨化醇的纯化方法
JP2578421B2 (ja) 脂溶性化合物の抽出分画法およびその装置
JPH08208651A (ja) スコウレリンの製造方法
JP2009519938A (ja) （ｒ）−トフィソパムを単離する方法
WO2008098329A4 (en) Pharmaceutical composition, pharmaceutical product, obtaining processes of pharmaceutical compounds and use of such compounds for treating erectile dysfunction

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090429

Termination date: 20141217

EXPY Termination of patent right or utility model