JP5564268B2 - 成長因子と結合する融合タンパク質 - Google Patents

成長因子と結合する融合タンパク質 Download PDF

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JP5564268B2
JP5564268B2 JP2009551284A JP2009551284A JP5564268B2 JP 5564268 B2 JP5564268 B2 JP 5564268B2 JP 2009551284 A JP2009551284 A JP 2009551284A JP 2009551284 A JP2009551284 A JP 2009551284A JP 5564268 B2 JP5564268 B2 JP 5564268B2
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daap
vegf
polypeptide
nucleic acid
tie2
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JP2010518871A5 (OSRAM
JP2010518871A (ja
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キム，ハク‐ズー
コー，ヤン，ジュン
キム，ホ‐ミン
ジュン，キーフーン
ジョン，チューンジョー
コー，ゴー，ヤン
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アプロジェン アイエヌシー．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Plant Pathology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
JP2009551284A 2007-02-27 2008-02-27 成長因子と結合する融合タンパク質 Active JP5564268B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89176907P 2007-02-27 2007-02-27
US60/891,769 2007-02-27
PCT/IB2008/000901 WO2008132568A2 (en) 2007-02-27 2008-02-27 Fusion proteins binding to growth factors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014042371A Division JP5952847B2 (ja) 2007-02-27 2014-03-05 成長因子と結合する融合タンパク質

Publications (3)

Publication Number Publication Date
JP2010518871A JP2010518871A (ja) 2010-06-03
JP2010518871A5 JP2010518871A5 (OSRAM) 2011-04-14
JP5564268B2 true JP5564268B2 (ja) 2014-07-30

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JP2009551284A Active JP5564268B2 (ja) 2007-02-27 2008-02-27 成長因子と結合する融合タンパク質
JP2014042371A Active JP5952847B2 (ja) 2007-02-27 2014-03-05 成長因子と結合する融合タンパク質

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Country Status (11)

Country Link
US (1) US10259860B2 (OSRAM)
EP (1) EP2126092B1 (OSRAM)
JP (2) JP5564268B2 (OSRAM)
KR (1) KR101220245B1 (OSRAM)
CN (2) CN108546301B (OSRAM)
AU (1) AU2008243928B2 (OSRAM)
CA (1) CA2679658C (OSRAM)
DK (1) DK2126092T3 (OSRAM)
ES (1) ES2688623T3 (OSRAM)
IL (1) IL200593B (OSRAM)
WO (1) WO2008132568A2 (OSRAM)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014138602A (ja) * 2007-02-27 2014-07-31 Aprogen Inc 成長因子と結合する融合タンパク質

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US8268314B2 (en) 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014138602A (ja) * 2007-02-27 2014-07-31 Aprogen Inc 成長因子と結合する融合タンパク質

Also Published As

Publication number Publication date
CN108546301B (zh) 2021-09-07
CA2679658A1 (en) 2008-11-06
KR20100005202A (ko) 2010-01-14
CA2679658C (en) 2018-11-27
EP2126092B1 (en) 2018-07-18
IL200593A0 (en) 2011-08-01
US20080242587A1 (en) 2008-10-02
ES2688623T3 (es) 2018-11-05
AU2008243928B2 (en) 2012-08-09
IL200593B (en) 2020-08-31
JP5952847B2 (ja) 2016-07-13
AU2008243928A1 (en) 2008-11-06
WO2008132568A2 (en) 2008-11-06
JP2010518871A (ja) 2010-06-03
CN101679988A (zh) 2010-03-24
EP2126092A2 (en) 2009-12-02
DK2126092T3 (en) 2018-10-22
CN101679988B (zh) 2018-05-11
CN108546301A (zh) 2018-09-18
KR101220245B1 (ko) 2013-01-18
US10259860B2 (en) 2019-04-16
EP2126092A4 (en) 2010-08-11
WO2008132568A3 (en) 2008-12-31
JP2014138602A (ja) 2014-07-31

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