JP5560040B2 - カプセル化された大豆エキストラクトおよびそれらの製造方法 - Google Patents
カプセル化された大豆エキストラクトおよびそれらの製造方法 Download PDFInfo
- Publication number
- JP5560040B2 JP5560040B2 JP2009535464A JP2009535464A JP5560040B2 JP 5560040 B2 JP5560040 B2 JP 5560040B2 JP 2009535464 A JP2009535464 A JP 2009535464A JP 2009535464 A JP2009535464 A JP 2009535464A JP 5560040 B2 JP5560040 B2 JP 5560040B2
- Authority
- JP
- Japan
- Prior art keywords
- soy extract
- encapsulated
- solution
- oligosaccharide
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Description
Claims (4)
- 下記の工程:
a)一種以上の大豆エキストラクトおよび大豆エキストラクト溶媒を含む大豆エキストラクト溶液を準備すること;
b)一種以上のオリゴ糖およびオリゴ糖溶媒を含むオリゴ糖溶液を準備することであって、その際、オリゴ糖は、α−シクロデキストリン、β−シクロデキストリン、γ−シクロデキストリンおよびそれらの組合せからなる群から選択される、該工程;
c)大豆エキストラクト溶液およびオリゴ糖溶液をカプセル化するための手段内で一緒にして大豆エキストラクトをオリゴ糖によってカプセル化し、カプセル化された大豆エキストラクト混合物を形成させること;
d)カプセル化された大豆エキストラクト混合物から不純物を沈殿させることであって、その際、カプセル化された大豆エキストラクト混合物のpHを調整して5以下にする、該工程;
e)沈殿させた不純物をカプセル化された大豆エキストラクト混合物から分離させること;
f)カプセル化された大豆エキストラクト混合物にアルカリを加えてpHを増大させそして次いで、イオン交換を行ってカプセル化された大豆エキストラクト混合物からイオン性成分を除くこと;および
g)カプセル化された大豆エキストラクト混合物を乾燥させること、
を含み、
その際、工程c)において大豆エキストラクト溶液およびオリゴ糖溶液を、50℃〜105℃、1,000rpm〜10,000rpmおよびpH6〜pH10で混合することによって、一緒にし、
その際、工程f)においてカチオン系交換樹脂、アニオン系交換樹脂およびそれらの組合せからなる群から選択される樹脂で上記のイオン交換が行われる、
カプセル化された大豆エキストラクトを製造する方法。 - 請求項1記載の方法によって造られたカプセル化された大豆エキストラクト。
- 一次不純物を1%未満含みおよび1%の溶液に基づいて99%〜100%の水への溶解度を有する、オリゴ糖によりカプセル化された一種以上の請求項2に記載のカプセル化された大豆エキストラクトを含むカプセル化された大豆エキストラクト。
- 大豆エキストラクトがイソフラボン誘導体である、請求項3記載のカプセル化された大豆エキストラクト。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86421706P | 2006-11-03 | 2006-11-03 | |
US60/864,217 | 2006-11-03 | ||
PCT/US2007/083323 WO2008057934A1 (en) | 2006-11-03 | 2007-11-01 | Encapsulated soy extracts and process for preparing same |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2010508820A JP2010508820A (ja) | 2010-03-25 |
JP2010508820A5 JP2010508820A5 (ja) | 2010-12-09 |
JP5560040B2 true JP5560040B2 (ja) | 2014-07-23 |
Family
ID=39364846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009535464A Expired - Fee Related JP5560040B2 (ja) | 2006-11-03 | 2007-11-01 | カプセル化された大豆エキストラクトおよびそれらの製造方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US20100055172A1 (ja) |
EP (1) | EP2077820A1 (ja) |
JP (1) | JP5560040B2 (ja) |
KR (1) | KR20090074813A (ja) |
CN (1) | CN101528198A (ja) |
AU (1) | AU2007317429B2 (ja) |
BR (1) | BRPI0719164A8 (ja) |
MX (1) | MX2009003128A (ja) |
WO (1) | WO2008057934A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9333192B2 (en) | 2010-02-15 | 2016-05-10 | Sinoveda Canada, Inc | Phytoestrogen product of red clover and pharmaceutical uses thereof |
WO2013050930A1 (en) * | 2011-10-02 | 2013-04-11 | Sinoveda Canada, Inc, | Development of a red clover phytoestrogen product for the prevention or treatment of osteoporosis |
JP6494187B2 (ja) * | 2014-06-19 | 2019-04-03 | 株式会社ファンケル | フラボノイド類含有粉末組成物 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU194858B (en) * | 1982-12-03 | 1988-03-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing dibenzo/b,d/pirane derivatives and pharmaceutical compositions containing them |
HU199444B (en) * | 1985-09-10 | 1990-02-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 7-isopropoxy-isoflavone-cyclodextrene inclusion complex and pharmaceutical compositions therefrom |
US5321014A (en) * | 1991-06-28 | 1994-06-14 | The United States Of America As Represented By The Department Of Health And Human Services | Molecular encapsulation and delivery of alkenes alkynes and long chain alkanes, to living mammalian cells |
US5472954A (en) * | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
JPH09309902A (ja) * | 1996-03-21 | 1997-12-02 | Fujitsuko Kk | イソフラボン誘導体の包接物及び該包接物を含む可食性組成物 |
US5847108A (en) * | 1996-03-21 | 1998-12-08 | Fujicco Co., Ltd. | Clathrate of isoflavone derivatives and edible composition comprising the same |
JPH10298175A (ja) * | 1997-05-01 | 1998-11-10 | Sunstar Inc | 水易溶性大豆イソフラボンの製造方法 |
WO1999006057A1 (en) * | 1997-07-30 | 1999-02-11 | Indena S.P.A. | Soya extract, process for its preparation and pharmaceutical composition |
US6320028B1 (en) * | 1997-10-15 | 2001-11-20 | Central Soya Company, Inc. | Soy isoflavone concentrate process and product |
US6369200B2 (en) * | 1997-10-15 | 2002-04-09 | Central Soya Company, Inc. | Soy isoflavone concentrate process and product |
ES2232107T3 (es) * | 1998-01-12 | 2005-05-16 | Nichimo Kabushiki Kaisha | Proceso para la preparacion de compuestos de isoflavona. |
US6703051B1 (en) * | 1998-10-13 | 2004-03-09 | Solae, Llc | Process for separating and recovering protein and isoflavones from a plant material |
JP4006133B2 (ja) * | 1999-05-17 | 2007-11-14 | 松谷化学工業株式会社 | 可溶性イソフラボン組成物及びその製造方法 |
IL131508A (en) * | 1999-08-19 | 2006-12-10 | David Cohen | Micronexulatory formulations and controlled dispersion of isoflavins from rich masses of sesame and other plants |
US7045163B2 (en) * | 2000-11-30 | 2006-05-16 | Kraft Foods Holdings, Inc. | Method of deflavoring soy-derived materials |
EP1443969A2 (en) * | 2001-10-18 | 2004-08-11 | Decode Genetics EHF | Non-inclusion cyclodextrin complexes |
WO2003092406A1 (en) * | 2002-05-02 | 2003-11-13 | Volker Kuellmer | Coated, agglomerated phytochemicals |
CN1232539C (zh) * | 2002-05-10 | 2005-12-21 | 刘云清 | 有机药物与倍他环糊精衍生物的配合物及其制备方法 |
WO2004021985A2 (en) * | 2002-09-09 | 2004-03-18 | Josef Pitha | Verifiable absorption drug delivery form based on cyclodextrins |
EP1560503A4 (en) * | 2002-11-15 | 2006-04-05 | Cargill Inc | COMPOSITIONS BASED ON SOLUBLE ISOFLAVIUM |
KR101195114B1 (ko) * | 2003-05-20 | 2012-10-25 | (주)하야시바라 생물화학연구소 | 수 가용성 이소플라본 조성물 및 그 제조 방법 및 그 용도 |
CN100584385C (zh) * | 2003-07-10 | 2010-01-27 | 协和发酵生化株式会社 | 片剂及其制备方法 |
US7718813B2 (en) * | 2003-08-15 | 2010-05-18 | Nature Pure Labs Sw, Inc. | Hydrolysis and purification of active plant compounds suitable for topical application |
US20050175745A1 (en) * | 2004-02-06 | 2005-08-11 | Jerzy Zawistowski | Method of preservation of a food prodcut and composition comprising one or more phytosterols and/or phytostanols useful for this purpose |
-
2007
- 2007-11-01 AU AU2007317429A patent/AU2007317429B2/en not_active Ceased
- 2007-11-01 EP EP07863781A patent/EP2077820A1/en active Pending
- 2007-11-01 JP JP2009535464A patent/JP5560040B2/ja not_active Expired - Fee Related
- 2007-11-01 US US12/444,418 patent/US20100055172A1/en not_active Abandoned
- 2007-11-01 KR KR1020097010730A patent/KR20090074813A/ko not_active Application Discontinuation
- 2007-11-01 CN CNA2007800400835A patent/CN101528198A/zh active Pending
- 2007-11-01 WO PCT/US2007/083323 patent/WO2008057934A1/en active Application Filing
- 2007-11-01 BR BRPI0719164A patent/BRPI0719164A8/pt not_active Application Discontinuation
- 2007-11-01 MX MX2009003128A patent/MX2009003128A/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
BRPI0719164A2 (pt) | 2014-02-04 |
AU2007317429A1 (en) | 2008-05-15 |
MX2009003128A (es) | 2009-04-06 |
CN101528198A (zh) | 2009-09-09 |
US20100055172A1 (en) | 2010-03-04 |
JP2010508820A (ja) | 2010-03-25 |
AU2007317429B2 (en) | 2013-03-28 |
WO2008057934A1 (en) | 2008-05-15 |
EP2077820A1 (en) | 2009-07-15 |
BRPI0719164A8 (pt) | 2017-11-07 |
KR20090074813A (ko) | 2009-07-07 |
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