JP5558810B2 - Ｒａｇｅ融合タンパク質、製剤及びその使用方法 - Google Patents

Ｒａｇｅ融合タンパク質、製剤及びその使用方法 Download PDF

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JP5558810B2
JP5558810B2 JP2009509615A JP2009509615A JP5558810B2 JP 5558810 B2 JP5558810 B2 JP 5558810B2 JP 2009509615 A JP2009509615 A JP 2009509615A JP 2009509615 A JP2009509615 A JP 2009509615A JP 5558810 B2 JP5558810 B2 JP 5558810B2
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rage
fusion protein
seq
formulation
rage fusion
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JP2009536201A5 (enExample
JP2009536201A (ja
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エム．エム． ムジャリ，アドナン
ロスライン，ロバート
エドワード ティアン，イエ
シー． ウェブスター，ジェフリー
ジェイ． ベンジャミン，エリック
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トランステック ファーマ，リミティド ライアビリティ カンパニー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A61P37/02—Immunomodulators
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Bioinformatics & Cheminformatics (AREA)
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  • Genetics & Genomics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Molecular Biology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
JP2009509615A 2006-05-05 2007-04-25 Ｒａｇｅ融合タンパク質、製剤及びその使用方法 Expired - Fee Related JP5558810B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79845506P 2006-05-05 2006-05-05
US60/798,455 2006-05-05
PCT/US2007/010125 WO2007130302A2 (en) 2006-05-05 2007-04-25 Rage fusion proteins, formulations, and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2009536201A JP2009536201A (ja) 2009-10-08
JP2009536201A5 JP2009536201A5 (enExample) 2010-06-17
JP5558810B2 true JP5558810B2 (ja) 2014-07-23

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US (2) US7981424B2 (enExample)
EP (2) EP2380983A3 (enExample)
JP (1) JP5558810B2 (enExample)
KR (1) KR20090008459A (enExample)
CN (1) CN101548012A (enExample)
AR (1) AR060862A1 (enExample)
AU (1) AU2007248784B2 (enExample)
BR (1) BRPI0711193A2 (enExample)
CA (1) CA2651348A1 (enExample)
DO (1) DOP2007000089A (enExample)
EA (1) EA017291B1 (enExample)
IL (1) IL194482A0 (enExample)
MX (1) MX2008013863A (enExample)
NL (1) NL2000626A1 (enExample)
NZ (1) NZ571692A (enExample)
PE (1) PE20080397A1 (enExample)
SG (1) SG171670A1 (enExample)
TW (1) TW200801036A (enExample)
UY (1) UY30324A1 (enExample)
WO (1) WO2007130302A2 (enExample)
ZA (1) ZA200809394B (enExample)

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AR060862A1 (es) 2008-07-16
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US20110282035A1 (en) 2011-11-17
US7981424B2 (en) 2011-07-19
TW200801036A (en) 2008-01-01
IL194482A0 (en) 2011-08-01
NZ571692A (en) 2012-01-12
EA200870502A1 (ru) 2009-06-30
WO2007130302A3 (en) 2008-04-03
US8344120B2 (en) 2013-01-01
EA017291B1 (ru) 2012-11-30
JP2009536201A (ja) 2009-10-08
US20080045455A1 (en) 2008-02-21
CA2651348A1 (en) 2007-11-15
WO2007130302A2 (en) 2007-11-15
PE20080397A1 (es) 2008-04-28
MX2008013863A (es) 2008-11-14
AU2007248784B2 (en) 2013-11-21
KR20090008459A (ko) 2009-01-21
AU2007248784A1 (en) 2007-11-15
DOP2007000089A (es) 2007-11-15
SG171670A1 (en) 2011-06-29
EP2380983A3 (en) 2012-12-05
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EP2021474A2 (en) 2009-02-11
UY30324A1 (es) 2008-01-02

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