JP5550101B2 - トラマドールの副作用の低減薬の製造におけるトラマドールおよびｐｄｅ阻害剤の使用方法 - Google Patents

トラマドールの副作用の低減薬の製造におけるトラマドールおよびｐｄｅ阻害剤の使用方法 Download PDF

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Publication number
JP5550101B2
JP5550101B2 JP2009549685A JP2009549685A JP5550101B2 JP 5550101 B2 JP5550101 B2 JP 5550101B2 JP 2009549685 A JP2009549685 A JP 2009549685A JP 2009549685 A JP2009549685 A JP 2009549685A JP 5550101 B2 JP5550101 B2 JP 5550101B2
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Prior art keywords
tramadol
pharmaceutically acceptable
acceptable salt
sildenafil
inhibitor
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Expired - Fee Related
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JP2009549685A
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Japanese (ja)
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JP2010518168A (ja
JP2010518168A5 (enExample
Inventor
バー−オー、デイビッド
ビリヤード、ケビン
ブイ． ウィンクラー、ジェームス
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Vyrix Pharmaceuticals Inc
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Vyrix Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009549685A 2007-02-12 2008-02-12 トラマドールの副作用の低減薬の製造におけるトラマドールおよびｐｄｅ阻害剤の使用方法 Expired - Fee Related JP5550101B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88938007P 2007-02-12 2007-02-12
US60/889,380 2007-02-12
PCT/US2008/053722 WO2008100933A2 (en) 2007-02-12 2008-02-12 Reducing side effects of tramadol

Publications (3)

Publication Number Publication Date
JP2010518168A JP2010518168A (ja) 2010-05-27
JP2010518168A5 JP2010518168A5 (enExample) 2012-01-26
JP5550101B2 true JP5550101B2 (ja) 2014-07-16

Family

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JP2009549685A Expired - Fee Related JP5550101B2 (ja) 2007-02-12 2008-02-12 トラマドールの副作用の低減薬の製造におけるトラマドールおよびｐｄｅ阻害剤の使用方法

Country Status (16)

Country Link
US (3) US20080261991A1 (enExample)
EP (2) EP2486921A1 (enExample)
JP (1) JP5550101B2 (enExample)
KR (2) KR20130122023A (enExample)
CN (1) CN101674728A (enExample)
AU (1) AU2008216363B2 (enExample)
BR (1) BRPI0807281A2 (enExample)
CA (1) CA2677691C (enExample)
DK (1) DK2114147T3 (enExample)
ES (1) ES2384127T3 (enExample)
MX (1) MX2009008511A (enExample)
NZ (1) NZ579170A (enExample)
PL (1) PL2114147T3 (enExample)
SG (1) SG178775A1 (enExample)
WO (1) WO2008100933A2 (enExample)
ZA (1) ZA200906187B (enExample)

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US10022321B2 (en) 2016-06-30 2018-07-17 Revogenex Ireland Ltd. Intravenous administration of tramadol
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Also Published As

Publication number Publication date
PL2114147T3 (pl) 2012-10-31
SG178775A1 (en) 2012-03-29
CA2677691A1 (en) 2008-08-21
JP2010518168A (ja) 2010-05-27
EP2114147B9 (en) 2013-04-10
MX2009008511A (es) 2010-01-20
BRPI0807281A2 (pt) 2014-04-29
US20080261991A1 (en) 2008-10-23
CA2677691C (en) 2012-07-31
US20130338166A1 (en) 2013-12-19
KR20090127277A (ko) 2009-12-10
ZA200906187B (en) 2013-02-27
ES2384127T3 (es) 2012-06-29
EP2114147B1 (en) 2012-05-16
EP2114147A2 (en) 2009-11-11
KR20130122023A (ko) 2013-11-06
CN101674728A (zh) 2010-03-17
DK2114147T3 (da) 2012-06-25
AU2008216363A1 (en) 2008-08-21
HK1131730A1 (en) 2010-02-05
WO2008100933A2 (en) 2008-08-21
US20120018333A1 (en) 2012-01-26
EP2486921A1 (en) 2012-08-15
KR101497509B1 (ko) 2015-03-03
WO2008100933A3 (en) 2008-10-16
NZ579170A (en) 2012-05-25
AU2008216363B2 (en) 2014-05-08
EP2114147A4 (en) 2010-04-07

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